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Fit-For-Purpose PD-L1 Biomarker Testing For Patient Selection in Immuno-Oncology: Guidelines For Clinical Laboratories From the Canadian Association of Pathologists-Association Canadienne Des Pathologistes (CAP-ACP).

Cheung CC, Barnes P, Bigras G, Boerner S, Butany J, Calabrese F, Couture C, Deschenes J, El-Zimaity H, Fischer G, Fiset PO, Garratt J, Geldenhuys L, Gilks CB, Ilie M, Ionescu D, Lim HJ, Manning L, Mansoor A, Riddell R, Ross C, Roy-Chowdhuri S, Spatz A, Swanson PE, Tron VA, Tsao MS, Wang H, Xu Z, Torlakovic EE; Canadian Association of Pathologists-Association Canadienne Des Pathologistes’ National Standards Committee for High Complexity Testing (CAP-ACP NSCHCT).

Appl Immunohistochem Mol Morphol. 2019 Oct 3. doi: 10.1097/PAI.0000000000000800. [Epub ahead of print]


Anaplastic lymphoma kinase 5A4 immunohistochemistry as a diagnostic assay in lung cancer: A Canadian reference testing center's results in population-based reflex testing.

Fiset PO, Labbé C, Young K, Craddock KJ, Smith AC, Tanguay J, Pintilie M, Wang R, Torlakovic E, Cheung C, da Cunha Santos G, Ko HM, Boerner SL, Hwang DM, Leighl NB, Tsao MS.

Cancer. 2019 Aug 7. doi: 10.1002/cncr.32422. [Epub ahead of print]


Challenges with Novel Clinical Trial Designs: Master Protocols.

Cecchini M, Rubin EH, Blumenthal GM, Ayalew K, Burris HA, Russell-Einhorn M, Dillon H, Lyerly HK, Reaman GH, Boerner S, LoRusso PM.

Clin Cancer Res. 2019 Apr 1;25(7):2049-2057. doi: 10.1158/1078-0432.CCR-18-3544. Epub 2019 Jan 29.


The key protein of endosomal mRNP transport Rrm4 binds translational landmark sites of cargo mRNAs.

Olgeiser L, Haag C, Boerner S, Ule J, Busch A, Koepke J, König J, Feldbrügge M, Zarnack K.

EMBO Rep. 2019 Jan;20(1). pii: e46588. doi: 10.15252/embr.201846588. Epub 2018 Dec 14.


Performance of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Isolated Mediastinal and Hilar Lymphadenopathy.

Tyan CC, Machuca T, Czarnecka K, Ko HM, da Cunha Santos G, Boerner SL, Pierre A, Cypel M, Waddell T, Darling G, de Perrot M, Keshavjee S, Geddie W, Yasufuku K.

Respiration. 2017;94(5):457-464. doi: 10.1159/000479745. Epub 2017 Sep 13.


A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma.

Goncalves PH, Heilbrun LK, Barrett MT, Kummar S, Hansen AR, Siu LL, Piekarz RL, Sukari AW, Chao J, Pilat MJ, Smith DW, Casetta L, Boerner SA, Chen A, Lenkiewicz E, Malasi S, LoRusso PM.

Oncotarget. 2017 May 16;8(20):32918-32929. doi: 10.18632/oncotarget.16464.


Use of cytological samples of metastatic melanoma for ancillary studies.

Ko HM, Saieg MA, da Cunha Santos G, Kamel-Reid S, Boerner SL, Geddie WR.

Cytopathology. 2017 Jun;28(3):221-227. doi: 10.1111/cyt.12419. Epub 2017 Feb 20.


Synchronous Papillary Carcinoma of Thyroid and Lung.

Wang T, Blumer I, Boerner S, Asa SL.

Endocr Pathol. 2016 Sep;27(3):268-70. doi: 10.1007/s12022-016-9435-6. No abstract available.


Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors.

LoRusso PM, Li J, Burger A, Heilbrun LK, Sausville EA, Boerner SA, Smith D, Pilat MJ, Zhang J, Tolaney SM, Cleary JM, Chen AP, Rubinstein L, Boerner JL, Bowditch A, Cai D, Bell T, Wolanski A, Marrero AM, Zhang Y, Ji J, Ferry-Galow K, Kinders RJ, Parchment RE, Shapiro GI.

Clin Cancer Res. 2016 Jul 1;22(13):3227-37. doi: 10.1158/1078-0432.CCR-15-0652. Epub 2016 Feb 3.


Computational Analysis of LncRNA from cDNA Sequences.

Boerner S, McGinnis KM.

Methods Mol Biol. 2016;1402:255-269. doi: 10.1007/978-1-4939-3378-5_20.


The Canadian Area of Focused Competence (AFC) in Cytopathology experience: the first four years.

Weir MM, Boerner SL, Auger M.

J Am Soc Cytopathol. 2016 Nov - Dec;5(6):309-312. doi: 10.1016/j.jasc.2016.10.003. Epub 2016 Nov 16.


Next-Generation Sequencing to Guide Clinical Trials.

Siu LL, Conley BA, Boerner S, LoRusso PM.

Clin Cancer Res. 2015 Oct 15;21(20):4536-44. doi: 10.1158/1078-0432.CCR-14-3215. Review.


Patient-derived tumor xenograft models established from samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration.

Nakajima T, Geddie W, Anayama T, Ko HM, da Cunha Santos G, Boerner S, Wang T, Wang YH, Li M, Pham NA, Tsao MS, Yasufuku K.

Lung Cancer. 2015 Aug;89(2):110-4. doi: 10.1016/j.lungcan.2015.05.018. Epub 2015 Jun 3.


Pilot Trial of Selecting Molecularly Guided Therapy for Patients with Non-V600 BRAF-Mutant Metastatic Melanoma: Experience of the SU2C/MRA Melanoma Dream Team.

LoRusso PM, Boerner SA, Pilat MJ, Forman KM, Zuccaro CY, Kiefer JA, Liang WS, Hunsberger S, Redman BG, Markovic SN, Sekulic A, Bryce AH, Joseph RW, Cowey CL, Fecher LA, Sosman JA, Chapman PB, Schwartz GK, Craig DW, Carpten JD, Trent JM.

Mol Cancer Ther. 2015 Aug;14(8):1962-71. doi: 10.1158/1535-7163.MCT-15-0153. Epub 2015 Jun 10.


Achievements and challenges of molecular targeted therapy in melanoma.

Sullivan R, LoRusso P, Boerner S, Dummer R.

Am Soc Clin Oncol Educ Book. 2015:177-86. doi: 10.14694/EdBook_AM.2015.35.177. Review.


Thyroid Biopsy Specialists: A Quality Initiative to Reduce Wait Times and Improve Adequacy Rates.

Ghai S, Lee SY, Bret PM, Menezes RJ, Boerner SL, Jia Y, Maan KA, Boci R, Javed W, Atri M.

Radiology. 2015 Sep;276(3):894-9. doi: 10.1148/radiol.2015140620. Epub 2015 Apr 20.


Multiplex sequencing for EZH2, CD79B, and MYD88 mutations using archival cytospin preparations from B-cell non-Hodgkin lymphoma aspirates previously tested for MYC rearrangement and IGH/BCL2 translocation.

Santos Gda C, Saieg MA, Ko HM, Geddie WR, Boerner SL, Craddock KJ, Crump M, Bailey D.

Cancer Cytopathol. 2015 Jul;123(7):413-20. doi: 10.1002/cncy.21535. Epub 2015 Mar 23.


Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer.

Boerner JL, Nechiporchik N, Mueller KL, Polin L, Heilbrun L, Boerner SA, Zoratti GL, Stark K, LoRusso PM, Burger A.

PLoS One. 2015 Mar 16;10(3):e0119614. doi: 10.1371/journal.pone.0119614. eCollection 2015.


Evaluation of indeterminate thyroid cytology by second-opinion diagnosis or repeat fine-needle aspiration: which is the best approach?

Gerhard R, Boerner SL.

Acta Cytol. 2015;59(1):43-50. doi: 10.1159/000369332. Epub 2015 Jan 17.


Sample features associated with success rates in population-based EGFR mutation testing.

Shiau CJ, Babwah JP, da Cunha Santos G, Sykes JR, Boerner SL, Geddie WR, Leighl NB, Wei C, Kamel-Reid S, Hwang DM, Tsao MS.

J Thorac Oncol. 2014 Jul;9(7):947-56. doi: 10.1097/JTO.0000000000000196.


The value of second opinion in thyroid cytology: a review.

Gerhard R, Boerner SL.

Cancer Cytopathol. 2014 Aug;122(8):611-9. doi: 10.1002/cncy.21436. Epub 2014 May 28. Review.


Cytomorphological and clinicopathological spectrum of pulmonary marginal zone lymphoma: the utility of immunophenotyping, PCR and FISH studies.

Ko HM, Geddie WR, Boerner SL, Rogalla P, da Cunha Santos G.

Cytopathology. 2014 Aug;25(4):250-8. doi: 10.1111/cyt.12119. Epub 2013 Nov 21.


Infrared microspectroscopy detects protein misfolding cyclic amplification (PMCA)-induced conformational alterations in hamster scrapie progeny seeds.

Daus ML, Wagenführ K, Thomzig A, Boerner S, Hermann P, Hermelink A, Beekes M, Lasch P.

J Biol Chem. 2013 Dec 6;288(49):35068-80. doi: 10.1074/jbc.M113.497131. Epub 2013 Oct 25.


Epstein-Barr virus encoded RNA detected by in situ hybridization using cytological preparations.

Garady C, Saieg MA, Ko HM, Geddie WR, Boerner SL, da Cunha Santos G.

Cytopathology. 2014 Apr;25(2):101-7. doi: 10.1111/cyt.12073. Epub 2013 Jun 3.



Hunsberger S, Rubinstein L, Boerner SA, LoRusso P.

J Natl Cancer Inst. 2013 Jul 3;105(13):993-4. doi: 10.1093/jnci/djt126. Epub 2013 May 30. No abstract available.


Towards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays.

Boerner S, Wagenführ K, Daus ML, Thomzig A, Beekes M.

Lab Anim. 2013 Apr;47(2):106-15. doi: 10.1177/0023677213476856. Epub 2013 Mar 11.


Subclassification of lymphoproliferative disorders in serous effusions: a 10-year experience.

Tong LC, Ko HM, Saieg MA, Boerner S, Geddie WR, da Cunha Santos G.

Cancer Cytopathol. 2013 May;121(5):261-70.


EZH2 and CD79B mutational status over time in B-cell non-Hodgkin lymphomas detected by high-throughput sequencing using minimal samples.

Saieg MA, Geddie WR, Boerner SL, Bailey D, Crump M, da Cunha Santos G.

Cancer Cytopathol. 2013 Jul;121(7):377-86. doi: 10.1002/cncy.21262. Epub 2013 Jan 29.


Meta-analysis of the relationship between dose and benefit in phase I targeted agent trials.

Gupta S, Hunsberger S, Boerner SA, Rubinstein L, Royds R, Ivy P, LoRusso P.

J Natl Cancer Inst. 2012 Dec 19;104(24):1860-6. doi: 10.1093/jnci/djs439. Epub 2012 Nov 19.


Accelerating cancer therapy development: the importance of combination strategies and collaboration. Summary of an Institute of Medicine workshop.

LoRusso PM, Canetta R, Wagner JA, Balogh EP, Nass SJ, Boerner SA, Hohneker J.

Clin Cancer Res. 2012 Nov 15;18(22):6101-9. doi: 10.1158/1078-0432.CCR-12-2455. Epub 2012 Oct 12.


Computational identification and functional predictions of long noncoding RNA in Zea mays.

Boerner S, McGinnis KM.

PLoS One. 2012;7(8):e43047. doi: 10.1371/journal.pone.0043047. Epub 2012 Aug 16.


CFTR biomarkers: time for promotion to surrogate end-point.

De Boeck K, Kent L, Davies J, Derichs N, Amaral M, Rowe SM, Middleton P, de Jonge H, Bronsveld I, Wilschanski M, Melotti P, Danner-Boucher I, Boerner S, Fajac I, Southern K, de Nooijer RA, Bot A, de Rijke Y, de Wachter E, Leal T, Vermeulen F, Hug MJ, Rault G, Nguyen-Khoa T, Barreto C, Proesmans M, Sermet-Gaudelus I; European Cystic Fibrosis Society Clinical Trial Network Standardisation Committee.

Eur Respir J. 2013 Jan;41(1):203-16. doi: 10.1183/09031936.00057512. Epub 2012 Aug 9. Review.


Cyto-histologic agreement in pathologic subtyping of non small cell lung carcinoma: review of 602 fine needle aspirates with follow-up surgical specimens over a nine year period and analysis of factors underlying failure to subtype.

da Cunha Santos G, Lai SW, Saieg MA, Geddie WR, Pintilie M, Tsao MS, Boerner SL, Hwang D.

Lung Cancer. 2012 Sep;77(3):501-6. doi: 10.1016/j.lungcan.2012.05.091. Epub 2012 May 31.


The use of FTA cards for preserving unfixed cytological material for high-throughput molecular analysis.

Saieg MA, Geddie WR, Boerner SL, Liu N, Tsao M, Zhang T, Kamel-Reid S, da Cunha Santos G.

Cancer Cytopathol. 2012 Jun 25;120(3):206-14. doi: 10.1002/cncy.20205. Epub 2012 Jan 24.


CT screening for lung cancer: implication of lung biopsy recommendations.

Wagnetz U, Menezes RJ, Boerner S, Paul NS, Wagnetz D, Keshavjee S, Roberts HC.

AJR Am J Roentgenol. 2012 Feb;198(2):351-8. doi: 10.2214/AJR.11.6726.


Fine-needle aspiration of a pharyngoesophageal diverticulum mimicking a calcified thyroid nodule on ultrasonography.

Ko HM, Boerner SL, Geddie WR.

Diagn Cytopathol. 2013 Aug;41(8):752-3. doi: 10.1002/dc.22818. Epub 2012 Jan 12. Review. No abstract available.


A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer.

Yasufuku K, Pierre A, Darling G, de Perrot M, Waddell T, Johnston M, da Cunha Santos G, Geddie W, Boerner S, Le LW, Keshavjee S.

J Thorac Cardiovasc Surg. 2011 Dec;142(6):1393-400.e1. doi: 10.1016/j.jtcvs.2011.08.037. Epub 2011 Oct 2.


A new gene expression signature, the ClinicoMolecular Triad Classification, may improve prediction and prognostication of breast cancer at the time of diagnosis.

Wang DY, Done SJ, McCready DR, Boerner S, Kulkarni S, Leong WL.

Breast Cancer Res. 2011 Sep 22;13(5):R92. doi: 10.1186/bcr3017.


Maximizing the yield of lymph node cytology: Lessons learned from rapid onsite evaluation of image- and endoscopic-guided biopsies of hilar and mediastinal lymph nodes.

da Cunha Santos G, Boerner SL, Geddie WR.

Cancer Cytopathol. 2011 Dec 25;119(6):361-6. doi: 10.1002/cncy.20166. Epub 2011 Jun 29.


Clinical development of vascular disrupting agents: what lessons can we learn from ASA404?

Lorusso PM, Boerner SA, Hunsberger S.

J Clin Oncol. 2011 Aug 1;29(22):2952-5. doi: 10.1200/JCO.2011.36.1311. Epub 2011 Jun 27. No abstract available.


Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens.

Sadi AM, Wang DY, Youngson BJ, Miller N, Boerner S, Done SJ, Leong WL.

BMC Cancer. 2011 Jun 16;11:253:1-13. doi: 10.1186/1471-2407-11-25.


Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection.

Pritzkow S, Wagenführ K, Daus ML, Boerner S, Lemmer K, Thomzig A, Mielke M, Beekes M.

PLoS One. 2011;6(5):e20384. doi: 10.1371/journal.pone.0020384. Epub 2011 May 27.


Diagnosis and subclassification of lymphomas and non-neoplastic lesions involving mediastinal lymph nodes using endobronchial ultrasound-guided transbronchial needle aspiration.

Ko HM, da Cunha Santos G, Darling G, Pierre A, Yasufuku K, Boerner SL, Geddie WR.

Diagn Cytopathol. 2013 Dec;41(12):1023-30. doi: 10.1002/dc.21741. Epub 2011 May 31.


Cytomorphologic findings of B-cell lymphomas with concurrent IGH/BCL2 and MYC rearrangements (dual-translocation lymphomas).

da Cunha Santos G, Ko HM, Saieg MA, Boerner SL, Lai SW, Bailey D, Geddie WR.

Cancer Cytopathol. 2011 Aug 25;119(4):254-62. doi: 10.1002/cncy.20156. Epub 2011 May 10.


Negative images of crystalline immunoglobulin in crystal storing histiocytosis: A potential cytologic mimic of mycobacteria in smears.

Ko HM, da Cunha Santos G, Boerner SL, Bailey DJ, Geddie WR.

Diagn Cytopathol. 2012 Oct;40(10):916-9. doi: 10.1002/dc.21677. Epub 2011 May 4.


Making the investigational oncology pipeline more efficient and effective: are we headed in the right direction?

LoRusso PM, Anderson AB, Boerner SA, Averbuch SD.

Clin Cancer Res. 2010 Dec 15;16(24):5956-62. doi: 10.1158/1078-0432.CCR-10-1279. Review.


Translating clinical trials into meaningful outcomes.

LoRusso PM, Schnipper LE, Stewart DJ, Boerner SA, Averbuch SD, Wolf W.

Clin Cancer Res. 2010 Dec 15;16(24):5951-5. doi: 10.1158/1078-0432.CCR-10-2632. Review.


Histologic artifacts in abdominal, vaginal, laparoscopic, and robotic hysterectomy specimens: a blinded, retrospective review.

Krizova A, Clarke BA, Bernardini MQ, James S, Kalloger SE, Boerner SL, Mulligan AM.

Am J Surg Pathol. 2011 Jan;35(1):115-26. doi: 10.1097/PAS.0b013e31820273dc.


The role of phosphoinositide 3-kinase in breast cancer: an overview.

LoRusso PM, Boerner SA.

Clin Breast Cancer. 2010 Nov;10 Suppl 3:S56-8. doi: 10.3816/CBC.2010.s.012. Review. No abstract available.


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