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Items: 10

1.

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells.

Schmidt SF, Madsen JG, Frafjord KØ, Poulsen Ll, Salö S, Boergesen M, Loft A, Larsen BD, Madsen MS, Holst JJ, Maechler P, Dalgaard LT, Mandrup S.

Cell Rep. 2016 Aug 30;16(9):2359-72. doi: 10.1016/j.celrep.2016.07.063. Epub 2016 Aug 18.

2.

Peroxisome proliferator-activated receptor γ and C/EBPα synergistically activate key metabolic adipocyte genes by assisted loading.

Madsen MS, Siersbæk R, Boergesen M, Nielsen R, Mandrup S.

Mol Cell Biol. 2014 Mar;34(6):939-54. doi: 10.1128/MCB.01344-13. Epub 2013 Dec 30.

3.

Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation.

Taxvig C, Dreisig K, Boberg J, Nellemann C, Schelde AB, Pedersen D, Boergesen M, Mandrup S, Vinggaard AM.

Mol Cell Endocrinol. 2012 Sep 25;361(1-2):106-15. doi: 10.1016/j.mce.2012.03.021. Epub 2012 Apr 14.

PMID:
22526026
4.

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites.

Boergesen M, Pedersen TÅ, Gross B, van Heeringen SJ, Hagenbeek D, Bindesbøll C, Caron S, Lalloyer F, Steffensen KR, Nebb HI, Gustafsson JÅ, Stunnenberg HG, Staels B, Mandrup S.

Mol Cell Biol. 2012 Feb;32(4):852-67. doi: 10.1128/MCB.06175-11. Epub 2011 Dec 12.

5.

ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.

Boergesen M, Poulsen Ll, Schmidt SF, Frigerio F, Maechler P, Mandrup S.

J Biol Chem. 2011 Apr 15;286(15):13214-25. doi: 10.1074/jbc.M110.215467. Epub 2011 Jan 31.

6.

MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.

Grøntved L, Madsen MS, Boergesen M, Roeder RG, Mandrup S.

Mol Cell Biol. 2010 May;30(9):2155-69. doi: 10.1128/MCB.01238-09. Epub 2010 Mar 1.

7.

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction.

Ravnskjaer K, Frigerio F, Boergesen M, Nielsen T, Maechler P, Mandrup S.

J Lipid Res. 2010 Jun;51(6):1370-9. doi: 10.1194/jlr.M001123. Epub 2009 Nov 30.

8.

Peroxisome proliferator-activated receptor-alpha is a functional target of p63 in adult human keratinocytes.

Pozzi S, Boergesen M, Sinha S, Mandrup S, Mantovani R.

J Invest Dermatol. 2009 Oct;129(10):2376-85. doi: 10.1038/jid.2009.92. Epub 2009 May 21. Erratum in: J Invest Dermatol. 2010 Mar;130(3):908.

9.

Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation.

Ravnskjaer K, Boergesen M, Dalgaard LT, Mandrup S.

J Mol Endocrinol. 2006 Apr;36(2):289-99.

PMID:
16595700
10.

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P, Mandrup S.

Endocrinology. 2005 Aug;146(8):3266-76. Epub 2005 May 5.

PMID:
15878969

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