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Toxicity testing in the 21st century: progress in the past decade and future perspectives.

Krewski D, Andersen ME, Tyshenko MG, Krishnan K, Hartung T, Boekelheide K, Wambaugh JF, Jones D, Whelan M, Thomas R, Yauk C, Barton-Maclaren T, Cote I.

Arch Toxicol. 2020 Jan;94(1):1-58. doi: 10.1007/s00204-019-02613-4. Epub 2019 Dec 17. Review.


Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange.

Kelsey KT, Rytel M, Dere E, Butler R, Eliot M, Huse SM, Houseman EA, Koestler DC, Boekelheide K.

Environ Health. 2019 Oct 29;18(1):91. doi: 10.1186/s12940-019-0533-z.


Trichloroethylene exposure alters dimethylated histone three lysine four in protein kinase A signaling pathway chromatin of rat sperm†.

Stermer AR, Wilson SK, Klein D, Hall SJ, Boekelheide K.

Biol Reprod. 2019 Nov 21;101(5):875-877. doi: 10.1093/biolre/ioz155.


Corrigendum to "Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells" [Toxicol. Lett. 290 (2018) 55-61].

Spade DJ, Bai CY, Lambright C, Conley JM, Boekelheide K, Gray LE.

Toxicol Lett. 2019 Oct 1;313:208. doi: 10.1016/j.toxlet.2019.06.001. Epub 2019 Jun 26. No abstract available.


A human-derived prostate co-culture microtissue model using epithelial (RWPE-1) and stromal (WPMY-1) cell lines.

Dent MP, Madnick SJ, Hall S, Vantangoli Policelli M, Bars C, Li H, Amin A, Carmichael PL, Martin FL, Boekelheide K.

Toxicol In Vitro. 2019 Oct;60:203-211. doi: 10.1016/j.tiv.2019.05.023. Epub 2019 May 30.


Spermatozoal large RNA content is associated with semen characteristics, sociodemographic and lifestyle factors.

Bianchi E, Boekelheide K, Sigman M, Braun JM, Eliot M, Hall SJ, Dere E, Hwang K.

PLoS One. 2019 May 23;14(5):e0216584. doi: 10.1371/journal.pone.0216584. eCollection 2019.


Differential toxicity of water versus gavage exposure to trichloroethylene in rats.

Stermer AR, Klein D, Wilson SK, Dalaijamts C, Bai CY, Hall SJ, Madnick S, Bianchi E, Chiu WA, Boekelheide K.

Environ Toxicol Pharmacol. 2019 May;68:1-3. doi: 10.1016/j.etap.2019.02.003. Epub 2019 Feb 16.


Small RNAs in Rat Sperm Are a Predictive and Sensitive Biomarker of Exposure to the Testicular Toxicant Ethylene Glycol Monomethyl Ether.

Stermer AR, Reyes G, Hall SJ, Boekelheide K.

Toxicol Sci. 2019 Jun 1;169(2):399-408. doi: 10.1093/toxsci/kfz041.


All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity.

Spade DJ, Hall SJ, Wortzel JD, Reyes G, Boekelheide K.

Toxicol Sci. 2019 Mar 1;168(1):149-159. doi: 10.1093/toxsci/kfy283.


All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate.

Spade DJ, Dere E, Hall SJ, Schorl C, Freiman RN, Boekelheide K.

Toxicol Sci. 2019 Feb 1;167(2):546-558. doi: 10.1093/toxsci/kfy260.


Effects of continuous bisphenol A exposure from early gestation on 90 day old rat testes function and sperm molecular profiles: A CLARITY-BPA consortium study.

Dere E, Anderson LM, Huse SM, Spade DJ, McDonnell-Clark E, Madnick SJ, Hall SJ, Camacho L, Lewis SM, Vanlandingham MM, Boekelheide K.

Toxicol Appl Pharmacol. 2018 May 15;347:1-9. doi: 10.1016/j.taap.2018.03.021. Epub 2018 Mar 26.


Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells.

Spade DJ, Bai CY, Lambright C, Conley JM, Boekelheide K, Gray LE.

Toxicol Lett. 2018 Jun 15;290:55-61. doi: 10.1016/j.toxlet.2018.03.018. Epub 2018 Mar 20. Erratum in: Toxicol Lett. 2019 Oct 1;313:208.


Localization of dimethylated histone three lysine four in the Rattus norvegicus sperm genome.

Wilson S, Dere E, Klein D, Schorl C, Hall S, Boekelheide K.

Biol Reprod. 2018 Aug 1;99(2):266-268. doi: 10.1093/biolre/ioy051.


High-quality human and rat spermatozoal RNA isolation for functional genomic studies.

Bianchi E, Stermer A, Boekelheide K, Sigman M, Hall SJ, Reyes G, Dere E, Hwang K.

Andrology. 2018 Mar;6(2):374-383. doi: 10.1111/andr.12471. Epub 2018 Feb 22.


Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat.

Dai MS, Hall SJ, Vantangoli Policelli MM, Boekelheide K, Spade DJ.

Andrology. 2017 Nov;5(6):1141-1152. doi: 10.1111/andr.12409. Epub 2017 Aug 22.


Ghrelin modulates testicular damage in a cryptorchid mouse model.

Bianchi E, Boekelheide K, Sigman M, Hall SJ, Hwang K.

PLoS One. 2017 May 18;12(5):e0177995. doi: 10.1371/journal.pone.0177995. eCollection 2017.


Identification of sperm mRNA biomarkers associated with testis injury during preclinical testing of pharmaceutical compounds.

Dere E, Spade DJ, Hall SJ, Altemus A, Smith JD, Phillips JA, Moffit JS, Blanchard KT, Boekelheide K.

Toxicol Appl Pharmacol. 2017 Apr 1;320:1-7. doi: 10.1016/j.taap.2017.02.001. Epub 2017 Feb 4.


The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.

Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS.

Environ Health Perspect. 2016 Nov;124(11):1671-1682. Epub 2016 Apr 19. Review.


Erratum: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.

Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ Jr, Li HH, Livi CB, Madnick S, Maertens A, Rosenberg M, Yager JD, Zhao L, Hartung T.

Sci Rep. 2016 Sep 14;6:33011. doi: 10.1038/srep33011. No abstract available.


Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity.

Pendse SN, Maertens A, Rosenberg M, Roy D, Fasani RA, Vantangoli MM, Madnick SJ, Boekelheide K, Fornace AJ, Odwin SA, Yager JD, Hartung T, Andersen ME, McMullen PD.

Arch Toxicol. 2017 Apr;91(4):1749-1762. doi: 10.1007/s00204-016-1824-6. Epub 2016 Sep 3.


From the Cover: Sperm Molecular Biomarkers Are Sensitive Indicators of Testicular Injury following Subchronic Model Toxicant Exposure.

Dere E, Wilson SK, Anderson LM, Boekelheide K.

Toxicol Sci. 2016 Oct;153(2):327-40. doi: 10.1093/toxsci/kfw137. Epub 2016 Jul 27.


Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.

Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ Jr, Li HH, Livi CB, Madnick S, Maertens A, Rosenberg M, Yager JD, Zhao L, Hartung T.

Sci Rep. 2016 Jul 26;6:28994. doi: 10.1038/srep28994. Erratum in: Sci Rep. 2016 Sep 14;6:33011.


Estradiol Exposure Differentially Alters Monolayer versus Microtissue MCF-7 Human Breast Carcinoma Cultures.

Vantangoli MM, Madnick SJ, Wilson S, Boekelheide K.

PLoS One. 2016 Jul 5;11(7):e0157997. doi: 10.1371/journal.pone.0157997. eCollection 2016.


Intra- and inter-individual differences in human sperm DNA methylation.

Dere E, Huse S, Hwang K, Sigman M, Boekelheide K.

Andrology. 2016 Sep;4(5):832-42. doi: 10.1111/andr.12170. Epub 2016 Apr 18.


Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGF-β Signaling Pathway.

Bianchi E, Boekelheide K, Sigman M, Lamb DJ, Hall SJ, Hwang K.

PLoS One. 2016 Apr 15;11(4):e0153968. doi: 10.1371/journal.pone.0153968. eCollection 2016.


Morphologic effects of estrogen stimulation on 3D MCF-7 microtissues.

Vantangoli MM, Wilson S, Madnick SJ, Huse SM, Boekelheide K.

Toxicol Lett. 2016 Apr 25;248:1-8. doi: 10.1016/j.toxlet.2016.02.012. Epub 2016 Feb 24.


Ghrelin ameliorates adhesions in a postsurgical mouse model.

Bianchi E, Boekelheide K, Sigman M, Lamb DJ, Hall SJ, Hwang K.

J Surg Res. 2016 Mar;201(1):226-34. doi: 10.1016/j.jss.2015.10.044. Epub 2015 Nov 5.


Patterns of gene expression and DNA methylation in human fetal and adult liver.

Huse SM, Gruppuso PA, Boekelheide K, Sanders JA.

BMC Genomics. 2015 Nov 21;16:981. doi: 10.1186/s12864-015-2066-3.


Into the depths: Techniques for in vitro three-dimensional microtissue visualization.

Kabadi PK, Vantangoli MM, Rodd AL, Leary E, Madnick SJ, Morgan JR, Kane A, Boekelheide K.

Biotechniques. 2015 Nov 1;59(5):279-86. doi: 10.2144/000114353. eCollection 2015 Nov.


Intussusceptive-like angiogenesis in human fetal lung xenografts: Link with bronchopulmonary dysplasia-associated microvascular dysangiogenesis?

De Paepe ME, Chu S, Hall SJ, McDonnell-Clark E, Heger NE, Schorl C, Mao Q, Boekelheide K.

Exp Lung Res. 2015;41(9):477-88. doi: 10.3109/01902148.2015.1080321.


Di-n-Butyl Phthalate Induces Multinucleated Germ Cells in the Rat Fetal Testis Through a Nonproliferative Mechanism.

Spade DJ, Hall SJ, Wilson S, Boekelheide K.

Biol Reprod. 2015 Nov;93(5):110. doi: 10.1095/biolreprod.115.131615. Epub 2015 Sep 23.


MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels.

Vantangoli MM, Madnick SJ, Huse SM, Weston P, Boekelheide K.

PLoS One. 2015 Aug 12;10(8):e0135426. doi: 10.1371/journal.pone.0135426. eCollection 2015.


Architecture of Chimeric Spheroids Controls Drug Transport.

Curran S, Vantangoli MM, Boekelheide K, Morgan JR.

Cancer Microenviron. 2015 Aug;8(2):101-9. doi: 10.1007/s12307-015-0171-0. Epub 2015 Aug 4.


Developmental exposure to estrogen alters differentiation and epigenetic programming in a human fetal prostate xenograft model.

Saffarini CM, McDonnell-Clark EV, Amin A, Huse SM, Boekelheide K.

PLoS One. 2015 Mar 23;10(3):e0122290. doi: 10.1371/journal.pone.0122290. eCollection 2015.


The human toxome project.

Bouhifd M, Andersen ME, Baghdikian C, Boekelheide K, Crofton KM, Fornace AJ Jr, Kleensang A, Li H, Livi C, Maertens A, McMullen PD, Rosenberg M, Thomas R, Vantangoli M, Yager JD, Zhao L, Hartung T.

ALTEX. 2015;32(2):112-24. doi: 10.14573/altex.1502091. Epub 2015 Mar 4.


A human fetal prostate xenograft model of developmental estrogenization.

Saffarini CM, McDonnell-Clark EV, Amin A, Boekelheide K.

Int J Toxicol. 2015 Mar-Apr;34(2):119-28. doi: 10.1177/1091581815569364. Epub 2015 Jan 29.


Xenotransplantation models to study the effects of toxicants on human fetal tissues.

Spade DJ, McDonnell EV, Heger NE, Sanders JA, Saffarini CM, Gruppuso PA, De Paepe ME, Boekelheide K.

Birth Defects Res B Dev Reprod Toxicol. 2014 Dec;101(6):410-22. doi: 10.1002/bdrb.21131. Epub 2014 Dec 4. Review.


Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay.

Spade DJ, Hall SJ, Saffarini CM, Huse SM, McDonnell EV, Boekelheide K.

Toxicol Sci. 2014 Mar;138(1):148-60. doi: 10.1093/toxsci/kft266. Epub 2013 Nov 27.


Biomarkers of chemotherapy-induced testicular damage.

Dere E, Anderson LM, Hwang K, Boekelheide K.

Fertil Steril. 2013 Nov;100(5):1192-202. doi: 10.1016/j.fertnstert.2013.09.017. Review.


Cumulative risk: toxicity and interactions of physical and chemical stressors.

Rider CV, Boekelheide K, Catlin N, Gordon CJ, Morata T, Selgrade MK, Sexton K, Simmons JE.

Toxicol Sci. 2014 Jan;137(1):3-11. doi: 10.1093/toxsci/kft228. Epub 2013 Oct 23.


Practice-based evidence informs environmental health policy and regulation: a case study of residential lead-soil contamination in Rhode Island.

Thompson MR, Burdon A, Boekelheide K.

Sci Total Environ. 2014 Jan 15;468-469:514-22. doi: 10.1016/j.scitotenv.2013.07.094. Epub 2013 Sep 17.


SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures.

Dere E, Anderson LM, Coulson M, McIntyre BS, Boekelheide K, Chapin RE.

Toxicol Sci. 2013 Dec;136(2):265-73. doi: 10.1093/toxsci/kft207. Epub 2013 Sep 19.


Maturation of the developing human fetal prostate in a rodent xenograft model.

Saffarini CM, McDonnell EV, Amin A, Spade DJ, Huse SM, Kostadinov S, Hall SJ, Boekelheide K.

Prostate. 2013 Dec;73(16):1761-75. doi: 10.1002/pros.22713. Epub 2013 Aug 30.


The current status of biomarkers for predicting toxicity.

Campion S, Aubrecht J, Boekelheide K, Brewster DW, Vaidya VS, Anderson L, Burt D, Dere E, Hwang K, Pacheco S, Saikumar J, Schomaker S, Sigman M, Goodsaid F.

Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1391-408. doi: 10.1517/17425255.2013.827170. Epub 2013 Aug 21. Review.


Assuring safety without animal testing: the case for the human testis in vitro.

Chapin RE, Boekelheide K, Cortvrindt R, van Duursen MB, Gant T, Jegou B, Marczylo E, van Pelt AM, Post JN, Roelofs MJ, Schlatt S, Teerds KJ, Toppari J, Piersma AH.

Reprod Toxicol. 2013 Aug;39:63-8. doi: 10.1016/j.reprotox.2013.04.004. Epub 2013 Apr 21.


The new revolution in toxicology: the good, the bad, and the ugly.

Davis M, Boekelheide K, Boverhof DR, Eichenbaum G, Hartung T, Holsapple MP, Jones TW, Richard AM, Watkins PB.

Ann N Y Acad Sci. 2013 Mar;1278:11-24. doi: 10.1111/nyas.12086.


Evidence-based toxicology for the 21st century: opportunities and challenges.

Stephens ML, Andersen M, Becker RA, Betts K, Boekelheide K, Carney E, Chapin R, Devlin D, Fitzpatrick S, Fowle JR 3rd, Harlow P, Hartung T, Hoffmann S, Holsapple M, Jacobs A, Judson R, Naidenko O, Pastoor T, Patlewicz G, Rowan A, Scherer R, Shaikh R, Simon T, Wolf D, Zurlo J.

ALTEX. 2013;30(1):74-103. doi: 10.14573/altex.2013.1.074.


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