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Items: 5

1.

Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat.

Boehn SN, Spahn S, Neudecker S, Keppler A, Bihoreau MT, Kränzlin B, Pandey P, Hoffmann SC, Li L, Torres VE, Gröne HJ, Gretz N.

Nephrol Dial Transplant. 2013 Aug;28(8):2045-58. doi: 10.1093/ndt/gft014. Epub 2013 Mar 29.

2.

Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

Schroeder K, Bremm KD, Alépée N, Bessems JG, Blaauboer B, Boehn SN, Burek C, Coecke S, Gombau L, Hewitt NJ, Heylings J, Huwyler J, Jaeger M, Jagelavicius M, Jarrett N, Ketelslegers H, Kocina I, Koester J, Kreysa J, Note R, Poth A, Radtke M, Rogiers V, Scheel J, Schulz T, Steinkellner H, Toeroek M, Whelan M, Winkler P, Diembeck W.

Toxicol In Vitro. 2011 Apr;25(3):589-604. doi: 10.1016/j.tiv.2010.12.005. Epub 2010 Dec 15. Review.

3.

Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease.

Pandey P, Brors B, Srivastava PK, Bott A, Boehn SN, Groene HJ, Gretz N.

BMC Genomics. 2008 Dec 23;9:624. doi: 10.1186/1471-2164-9-624.

4.

Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty.

Li L, Boehn SN, Yu X, Zhang Q, Kenzelmann M, Techel D, Mohamed SA, Jakob P, Kraenzlin B, Hoffmann S, Gretz N.

BMC Genomics. 2007 Jul 9;8:221.

5.

Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat.

Brown JH, Bihoreau MT, Hoffmann S, Kränzlin B, Tychinskaya I, Obermüller N, Podlich D, Boehn SN, Kaisaki PJ, Megel N, Danoy P, Copley RR, Broxholme J, Witzgall R, Lathrop M, Gretz N, Gauguier D.

J Am Soc Nephrol. 2005 Dec;16(12):3517-26. Epub 2005 Oct 5.

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