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Nanodiscs Incorporating Native β1 Adrenergic Receptor as a Novel Approach for the Detection of Pathological Autoantibodies in Patients with Dilated Cardiomyopathy.

Sun R, Mak S, Haschemi J, Horn P, Boege F, Luppa PB.

J Appl Lab Med. 2019 Nov;4(3):391-403. doi: 10.1373/jalm.2018.028225. Epub 2019 May 28.


Relevant effects of beta1-adrenoceptor autoantibodies in chronic heart failure.

Boivin-Jahns V, Jahns R, Boege F.

Front Biosci (Landmark Ed). 2018 Jun 1;23:2146-2156.


β1AAb Determined by Peptide ELISA: A Signal in the Noise?

Boege F, Westenfeld R, Jahns R.

J Am Coll Cardiol. 2017 Aug 8;70(6):807-808. doi: 10.1016/j.jacc.2017.03.617. No abstract available.


Comment on Shahadevan et al. "The relationship of single strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens".

Boege F.

Biomarkers. 2017 Nov;22(7):698-699. doi: 10.1080/1354750X.2017.1306755. Epub 2017 Mar 24. No abstract available.


Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams.

Raschke S, Spickermann S, Toncian T, Swantusch M, Boeker J, Giesen U, Iliakis G, Willi O, Boege F.

Sci Rep. 2016 Aug 31;6:32441. doi: 10.1038/srep32441.


Crosstalk of clock gene expression and autophagy in aging.

Kalfalah F, Janke L, Schiavi A, Tigges J, Ix A, Ventura N, Boege F, Reinke H.

Aging (Albany NY). 2016 Aug 28;8(9):1876-1895. doi: 10.18632/aging.101018.


A possible link between nutritional uptake of ubiquitous topoisomerase inhibitors and autism?

Marko D, Boege F.

Int J Dev Neurosci. 2016 Oct;53:8-9. doi: 10.1016/j.ijdevneu.2016.06.003. Epub 2016 Jun 11. No abstract available.


Impact of common β1-adrenergic receptor polymorphisms on the interaction with agonistic autoantibodies in dilated cardiomyopathy.

Bornholz B, Hanzen B, Reinke Y, Felix SB, Boege F.

Int J Cardiol. 2016 Jul 1;214:83-5. doi: 10.1016/j.ijcard.2016.03.032. Epub 2016 Mar 21. No abstract available.


Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing.

Fuellen G, Schofield P, Flatt T, Schulz RJ, Boege F, Kraft K, Rimbach G, Ibrahim S, Tietz A, Schmidt C, Köhling R, Simm A.

Gerontology. 2016;62(4):409-16. doi: 10.1159/000442746. Epub 2015 Dec 17. Review.


Detection of DCM-associated β1-adrenergic receptor autoantibodies requires functional readouts or native human β1-receptors as targets.

Bornholz B, Hanzen B, Reinke Y, Felix SB, Jahns R, Schimke I, Wallukat G, Boege F.

Int J Cardiol. 2016 Jan 1;202:728-30. doi: 10.1016/j.ijcard.2015.10.068. Epub 2015 Oct 9. No abstract available.


A standardised FACS assay based on native, receptor transfected cells for the clinical diagnosis and monitoring of β1-adrenergic receptor autoantibodies in human heart disease.

Bornholz B, Benninghaus T, Reinke Y, Felix SB, Roggenbuck D, Jahns-Boivin V, Jahns R, Boege F.

Clin Chem Lab Med. 2016 Apr;54(4):683-91. doi: 10.1515/cclm-2015-0603.


Questionable Validity of Peptide-Based ELISA Strategies in the Diagnostics of Cardiopathogenic Autoantibodies That Activate G-Protein-Coupled Receptors.

Jahns R, Boege F.

Cardiology. 2015;131(3):149-50. doi: 10.1159/000376546. Epub 2015 Apr 29. No abstract available.


Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.

Kalfalah FM, Berg E, Christensen MO, Linka RM, Dirks WG, Boege F, Mielke C.

Cell Cycle. 2015;14(11):1704-15. doi: 10.1080/15384101.2014.1000182.


Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin.

Waldera Lupa DM, Kalfalah F, Safferling K, Boukamp P, Poschmann G, Volpi E, Götz-Rösch C, Bernerd F, Haag L, Huebenthal U, Fritsche E, Boege F, Grabe N, Tigges J, Stühler K, Krutmann J.

J Invest Dermatol. 2015 Aug;135(8):1954-1968. doi: 10.1038/jid.2015.120. Epub 2015 Mar 27.


Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors.

Kalfalah F, Seggewiß S, Walter R, Tigges J, Moreno-Villanueva M, Bürkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Royer-Pokora B, Boege F.

Aging (Albany NY). 2015 Feb;7(2):110-22.


Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts.

Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K.

Aging (Albany NY). 2014 Oct;6(10):856-78.


miR-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.

Röck K, Tigges J, Sass S, Schütze A, Florea AM, Fender AC, Theis FJ, Krutmann J, Boege F, Fritsche E, Reifenberger G, Fischer JW.

J Invest Dermatol. 2015 Feb;135(2):369-377. doi: 10.1038/jid.2014.422. Epub 2014 Sep 29.


Diagnostic and therapeutic aspects of β1-adrenergic receptor autoantibodies in human heart disease.

Bornholz B, Roggenbuck D, Jahns R, Boege F.

Autoimmun Rev. 2014 Sep;13(9):954-62. doi: 10.1016/j.autrev.2014.08.021. Epub 2014 Aug 20. Review.


Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation.

Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Köhrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F.

Exp Gerontol. 2014 Aug;56:59-68. doi: 10.1016/j.exger.2014.03.017. Epub 2014 Mar 31.


The hallmarks of fibroblast ageing.

Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F.

Mech Ageing Dev. 2014 Jun;138:26-44. doi: 10.1016/j.mad.2014.03.004. Epub 2014 Mar 29. Review.


DNA topoisomerases in mtDNA maintenance and ageing.

Sobek S, Boege F.

Exp Gerontol. 2014 Aug;56:135-41. doi: 10.1016/j.exger.2014.01.009. Epub 2014 Jan 15. Review.


Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I.

Sobek S, Dalla Rosa I, Pommier Y, Bornholz B, Kalfalah F, Zhang H, Wiesner RJ, von Kleist-Retzow JC, Hillebrand F, Schaal H, Mielke C, Christensen MO, Boege F.

Nucleic Acids Res. 2013 Nov;41(21):9848-57. doi: 10.1093/nar/gkt768. Epub 2013 Aug 27.


Adaptive and maladaptive responses in skin: mild heat exposure protects against UVB-induced photoaging in mice.

Haarmann-Stemmann T, Boege F, Krutmann J.

J Invest Dermatol. 2013 Apr;133(4):868-71. doi: 10.1038/jid.2012.435.


Impact of human autoantibodies on β1-adrenergic receptor conformation, activity, and internalization.

Bornholz B, Weidtkamp-Peters S, Schmitmeier S, Seidel CA, Herda LR, Felix SB, Lemoine H, Hescheler J, Nguemo F, Schäfer C, Christensen MO, Mielke C, Boege F.

Cardiovasc Res. 2013 Mar 1;97(3):472-80. doi: 10.1093/cvr/cvs350. Epub 2012 Dec 3.


Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state.

Tiwari VK, Burger L, Nikoletopoulou V, Deogracias R, Thakurela S, Wirbelauer C, Kaut J, Terranova R, Hoerner L, Mielke C, Boege F, Murr R, Peters AH, Barde YA, Schübeler D.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E934-43. doi: 10.1073/pnas.1119798109. Epub 2012 Apr 2.


Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function.

Herda LR, Felix SB, Boege F.

Br J Pharmacol. 2012 Jun;166(3):847-57. doi: 10.1111/j.1476-5381.2012.01828.x. Review.


XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV.

Berg E, Christensen MO, Dalla Rosa I, Wannagat E, Jänicke RU, Rösner LM, Dirks WG, Boege F, Mielke C.

DNA Repair (Amst). 2011 Dec 10;10(12):1232-42. doi: 10.1016/j.dnarep.2011.09.012. Epub 2011 Oct 5.


Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence.

Kalfalah FM, Mielke C, Christensen MO, Baechler S, Marko D, Boege F.

Mol Nutr Food Res. 2011 May;55 Suppl 1:S127-42. doi: 10.1002/mnfr.201000509. Epub 2011 Mar 24.


Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1.

Fehr M, Baechler S, Kropat C, Mielke C, Boege F, Pahlke G, Marko D.

Mycotoxin Res. 2010 Nov;26(4):247-56. doi: 10.1007/s12550-010-0063-6. Epub 2010 Jul 27.


Mitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements.

Kawamura R, Pope LH, Christensen MO, Sun M, Terekhova K, Boege F, Mielke C, Andersen AH, Marko JF.

J Cell Biol. 2010 Mar 8;188(5):653-63. doi: 10.1083/jcb.200910085. Epub 2010 Mar 1.


Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO.

Nucleic Acids Res. 2009 Oct;37(19):6414-28. doi: 10.1093/nar/gkp708. Epub 2009 Aug 31.


Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform.

Fehr M, Pahlke G, Fritz J, Christensen MO, Boege F, Altemöller M, Podlech J, Marko D.

Mol Nutr Food Res. 2009 Apr;53(4):441-51. doi: 10.1002/mnfr.200700379.


Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas.

Mielke C, Kalfalah FM, Christensen MO, Boege F.

DNA Repair (Amst). 2007 Dec 1;6(12):1757-63. Epub 2007 Aug 31.


C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.

Linka RM, Porter AC, Volkov A, Mielke C, Boege F, Christensen MO.

Nucleic Acids Res. 2007;35(11):3810-22. Epub 2007 May 25.


Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity.

Habermeyer M, Fritz J, Barthelmes HU, Christensen MO, Larsen MK, Boege F, Marko D.

Chem Res Toxicol. 2005 Sep;18(9):1395-404.


TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.

Barthelmes HU, Habermeyer M, Christensen MO, Mielke C, Interthal H, Pouliot JJ, Boege F, Marko D.

J Biol Chem. 2004 Dec 31;279(53):55618-25. Epub 2004 Oct 19.


Inferring a system model of subcellular topoisomerase II beta localization dynamics.

Athale CA, Christensen MO, Eils R, Boege F, Mielke C.

OMICS. 2004 Summer;8(2):167-75.


Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.

Mielke C, Christensen MO, Barthelmes HU, Boege F.

J Biol Chem. 2004 May 14;279(20):20559-62. Epub 2004 Mar 23.


Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.

Christensen MO, Krokowski RM, Barthelmes HU, Hock R, Boege F, Mielke C.

J Biol Chem. 2004 May 21;279(21):21873-82. Epub 2004 Mar 9.


Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro.

Christensen MO, Barthelmes HU, Boege F, Mielke C.

Nucleic Acids Res. 2003 Dec 15;31(24):7255-63.


The N-terminal domain anchors human topoisomerase I at fibrillar centers of nucleoli and nucleolar organizer regions of mitotic chromosomes.

Christensen MO, Barthelmes HU, Boege F, Mielke C.

J Biol Chem. 2002 Sep 27;277(39):35932-8. Epub 2002 Jul 15.


Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.

Christensen MO, Larsen MK, Barthelmes HU, Hock R, Andersen CL, Kjeldsen E, Knudsen BR, Westergaard O, Boege F, Mielke C.

J Cell Biol. 2002 Apr 1;157(1):31-44. Epub 2002 Apr 1.


Changes in mobility account for camptothecin-induced subnuclear relocation of topoisomerase I.

Christensen MO, Barthelmes HU, Feineis S, Knudsen BR, Andersen AH, Boege F, Mielke C.

J Biol Chem. 2002 May 3;277(18):15661-5. Epub 2002 Mar 20.


Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells.

Barthelmes HU, Niederberger E, Roth T, Schulte K, Tang WC, Boege F, Fiebig HH, Eisenbrand G, Marko D.

Br J Cancer. 2001 Nov 16;85(10):1585-91.


Residues within the N-terminal domain of human topoisomerase I play a direct role in relaxation.

Lisby M, Olesen JR, Skouboe C, Krogh BO, Straub T, Boege F, Velmurugan S, Martensen PM, Andersen AH, Jayaram M, Westergaard O, Knudsen BR.

J Biol Chem. 2001 Jun 8;276(23):20220-7. Epub 2001 Mar 29.


Immunofluorescent imaging of beta 1- and beta 2-adrenergic receptors in rat kidney.

Boivin V, Jahns R, Gambaryan S, Ness W, Boege F, Lohse MJ.

Kidney Int. 2001 Feb;59(2):515-31.


Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies.

Jahns R, Boivin V, Krapf T, Wallukat G, Boege F, Lohse MJ.

J Am Coll Cardiol. 2000 Oct;36(4):1280-7.


Active DNA topoisomerase IIalpha is a component of the salt-stable centrosome core.

Barthelmes HU, Grue P, Feineis S, Straub T, Boege F.

J Biol Chem. 2000 Dec 8;275(49):38823-30.


PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices.

Straub T, Knudsen BR, Boege F.

Biochemistry. 2000 Jun 27;39(25):7552-8.


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