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Items: 1 to 50 of 133

1.

Shank2 Mutant Mice Display Hyperactivity Insensitive to Methylphenidate and Reduced Flexibility in Social Motivation, but Normal Social Recognition.

Ey E, Torquet N, de Chaumont F, Lévi-Strauss J, Ferhat AT, Le Sourd AM, Boeckers TM, Bourgeron T.

Front Mol Neurosci. 2018 Oct 4;11:365. doi: 10.3389/fnmol.2018.00365. eCollection 2018.

2.

Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9.

Commisso B, Ding L, Varadi K, Gorges M, Bayer D, Boeckers TM, Ludolph AC, Kassubek J, Müller OJ, Roselli F.

Elife. 2018 Aug 23;7. pii: e36892. doi: 10.7554/eLife.36892.

3.

Nutrient limitation affects presynaptic structures through dissociable Bassoon autophagic degradation and impaired vesicle release.

Catanese A, Garrido D, Walther P, Roselli F, Boeckers TM.

J Cereb Blood Flow Metab. 2018 Nov;38(11):1924-1939. doi: 10.1177/0271678X18786356. Epub 2018 Jul 4.

PMID:
29972341
4.

Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models.

Heise C, Preuss JM, Schroeder JC, Battaglia CR, Kolibius J, Schmid R, Kreutz MR, Kas MJH, Burbach JPH, Boeckers TM.

Front Mol Neurosci. 2018 Jun 19;11:212. doi: 10.3389/fnmol.2018.00212. eCollection 2018.

5.

Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism.

Modi ME, Brooks JM, Guilmette ER, Beyna M, Graf R, Reim D, Schmeisser MJ, Boeckers TM, O'Donnell P, Buhl DL.

Front Mol Neurosci. 2018 Jun 19;11:107. doi: 10.3389/fnmol.2018.00107. eCollection 2018.

6.

NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons.

Higelin J, Catanese A, Semelink-Sedlacek LL, Oeztuerk S, Lutz AK, Bausinger J, Barbi G, Speit G, Andersen PM, Ludolph AC, Demestre M, Boeckers TM.

Stem Cell Res. 2018 Jul;30:150-162. doi: 10.1016/j.scr.2018.06.005. Epub 2018 Jun 12.

7.

NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.

Ouali Alami N, Schurr C, Olde Heuvel F, Tang L, Li Q, Tasdogan A, Kimbara A, Nettekoven M, Ottaviani G, Raposo C, Röver S, Rogers-Evans M, Rothenhäusler B, Ullmer C, Fingerle J, Grether U, Knuesel I, Boeckers TM, Ludolph A, Wirth T, Roselli F, Baumann B.

EMBO J. 2018 Aug 15;37(16). pii: e98697. doi: 10.15252/embj.201798697. Epub 2018 Jun 6.

8.

Aripiprazole Selectively Reduces Motor Tics in a Young Animal Model for Tourette's Syndrome and Comorbid Attention Deficit and Hyperactivity Disorder.

Rizzo F, Nespoli E, Abaei A, Bar-Gad I, Deelchand DK, Fegert J, Rasche V, Hengerer B, Boeckers TM.

Front Neurol. 2018 Feb 13;9:59. doi: 10.3389/fneur.2018.00059. eCollection 2018.

9.

Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.

Ponna SK, Ruskamo S, Myllykoski M, Keller C, Boeckers TM, Kursula P.

J Neurochem. 2018 Jun;145(6):449-463. doi: 10.1111/jnc.14322. Epub 2018 Jun 10.

PMID:
29473168
10.

Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain.

Hagmeyer S, Cristóvão JS, Mulvihill JJE, Boeckers TM, Gomes CM, Grabrucker AM.

Front Mol Neurosci. 2018 Jan 17;10:456. doi: 10.3389/fnmol.2017.00456. eCollection 2017.

11.

Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder.

Grabrucker S, Haderspeck JC, Sauer AK, Kittelberger N, Asoglu H, Abaei A, Rasche V, Schön M, Boeckers TM, Grabrucker AM.

Front Mol Neurosci. 2018 Jan 15;10:450. doi: 10.3389/fnmol.2017.00450. eCollection 2017.

12.

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.

Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A.

Nat Commun. 2018 Jan 23;9(1):335. doi: 10.1038/s41467-017-02299-1.

13.

Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury.

Chandrasekar A, Heuvel FO, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja B, Huber-Lang M, Roselli F.

Int Immunopharmacol. 2017 Oct;51:66-75. doi: 10.1016/j.intimp.2017.08.002. Epub 2017 Aug 12.

PMID:
28806641
14.

Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1H-NMR spectroscopy study at 11.7T.

Rizzo F, Abaei A, Nespoli E, Fegert JM, Hengerer B, Rasche V, Boeckers TM.

Transl Psychiatry. 2017 Aug 1;7(8):e1189. doi: 10.1038/tp.2017.167.

15.

Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC.

Sauer AK, Pfaender S, Hagmeyer S, Tarana L, Mattes AK, Briel F, Küry S, Boeckers TM, Grabrucker AM.

Biometals. 2017 Oct;30(5):643-661. doi: 10.1007/s10534-017-0033-y. Epub 2017 Jul 17.

16.

Structure of an unconventional SH3 domain from the postsynaptic density protein Shank3 at ultrahigh resolution.

Ponna SK, Myllykoski M, Boeckers TM, Kursula P.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):806-812. doi: 10.1016/j.bbrc.2017.06.121. Epub 2017 Jun 21.

PMID:
28647360
17.

Object Phobia and Altered RhoA Signaling in Amygdala of Mice Lacking RICH2.

Sarowar T, Grabrucker S, Boeckers TM, Grabrucker AM.

Front Mol Neurosci. 2017 Jun 8;10:180. doi: 10.3389/fnmol.2017.00180. eCollection 2017.

18.

Visions and reality: the idea of competence-oriented assessment for German medical students is not yet realised in licensing examinations.

Huber-Lang M, Palmer A, Grab C, Boeckers A, Boeckers TM, Oechsner W.

GMS J Med Educ. 2017 May 15;34(2):Doc25. doi: 10.3205/zma001102. eCollection 2017.

19.

Cerebellar and Striatal Pathologies in Mouse Models of Autism Spectrum Disorder.

Peter S, De Zeeuw CI, Boeckers TM, Schmeisser MJ.

Adv Anat Embryol Cell Biol. 2017;224:103-119. doi: 10.1007/978-3-319-52498-6_6. Review.

PMID:
28551753
20.

Homer1b/c clustering is impaired in Phelan-McDermid Syndrome iPSCs derived neurons.

Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C.

Mol Psychiatry. 2017 May;22(5):637. doi: 10.1038/mp.2017.82. No abstract available.

PMID:
28428614
21.

Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.

Pfaender S, Sauer AK, Hagmeyer S, Mangus K, Linta L, Liebau S, Bockmann J, Huguet G, Bourgeron T, Boeckers TM, Grabrucker AM.

Sci Rep. 2017 Mar 27;7:45190. doi: 10.1038/srep45190.

22.

Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder.

Reim D, Distler U, Halbedl S, Verpelli C, Sala C, Bockmann J, Tenzer S, Boeckers TM, Schmeisser MJ.

Front Mol Neurosci. 2017 Feb 14;10:26. doi: 10.3389/fnmol.2017.00026. eCollection 2017.

23.

FUS Mislocalization and Vulnerability to DNA Damage in ALS Patients Derived hiPSCs and Aging Motoneurons.

Higelin J, Demestre M, Putz S, Delling JP, Jacob C, Lutz AK, Bausinger J, Huber AK, Klingenstein M, Barbi G, Speit G, Huebers A, Weishaupt JH, Hermann A, Liebau S, Ludolph AC, Boeckers TM.

Front Cell Neurosci. 2016 Dec 26;10:290. doi: 10.3389/fncel.2016.00290. eCollection 2016.

24.

An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation.

Rothe M, Kanwal N, Dietmann P, Seigfried FA, Hempel A, Schütz D, Reim D, Engels R, Linnemann A, Schmeisser MJ, Bockmann J, Kühl M, Boeckers TM, Kühl SJ.

Development. 2017 Jan 15;144(2):321-333. doi: 10.1242/dev.147462. Epub 2016 Dec 19.

25.

Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice.

Lim CS, Kim H, Yu NK, Kang SJ, Kim T, Ko HG, Lee J, Yang JE, Ryu HH, Park T, Gim J, Nam HJ, Baek SH, Wegener S, Schmitz D, Boeckers TM, Lee MG, Kim E, Lee JH, Lee YS, Kaang BK.

Neuropharmacology. 2017 Jan;112(Pt A):104-112. doi: 10.1016/j.neuropharm.2016.08.016. Epub 2016 Aug 17.

PMID:
27544825
26.

TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome.

Forde NJ, Kanaan AS, Widomska J, Padmanabhuni SS, Nespoli E, Alexander J, Rodriguez Arranz JI, Fan S, Houssari R, Nawaz MS, Rizzo F, Pagliaroli L, Zilhäo NR, Aranyi T, Barta C, Boeckers TM, Boomsma DI, Buisman WR, Buitelaar JK, Cath D, Dietrich A, Driessen N, Drineas P, Dunlap M, Gerasch S, Glennon J, Hengerer B, van den Heuvel OA, Jespersgaard C, Möller HE, Müller-Vahl KR, Openneer TJ, Poelmans G, Pouwels PJ, Scharf JM, Stefansson H, Tümer Z, Veltman DJ, van der Werf YD, Hoekstra PJ, Ludolph A, Paschou P.

Front Neurosci. 2016 Aug 23;10:384. doi: 10.3389/fnins.2016.00384. eCollection 2016.

27.

Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice.

Peter S, Ten Brinke MM, Stedehouder J, Reinelt CM, Wu B, Zhou H, Zhou K, Boele HJ, Kushner SA, Lee MG, Schmeisser MJ, Boeckers TM, Schonewille M, Hoebeek FE, De Zeeuw CI.

Nat Commun. 2016 Sep 1;7:12627. doi: 10.1038/ncomms12627.

28.

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling.

Liu X, Huai J, Endle H, Schlüter L, Fan W, Li Y, Richers S, Yurugi H, Rajalingam K, Ji H, Cheng H, Rister B, Horta G, Baumgart J, Berger H, Laube G, Schmitt U, Schmeisser MJ, Boeckers TM, Tenzer S, Vlachos A, Deller T, Nitsch R, Vogt J.

Dev Cell. 2016 Aug 8;38(3):275-90. doi: 10.1016/j.devcel.2016.06.019. Epub 2016 Jul 21.

29.

Activity and circadian rhythm influence synaptic Shank3 protein levels in mice.

Sarowar T, Chhabra R, Vilella A, Boeckers TM, Zoli M, Grabrucker AM.

J Neurochem. 2016 Sep;138(6):887-95. doi: 10.1111/jnc.13709. Epub 2016 Jul 15.

30.

Effect of didactically qualified student tutors on their tutees' academic performance and tutor evaluation in the gross anatomy course.

Horneffer A, Fassnacht U, Oechsner W, Huber-Lang M, Boeckers TM, Boeckers A.

Ann Anat. 2016 Nov;208:170-178. doi: 10.1016/j.aanat.2016.05.008. Epub 2016 Jun 17.

PMID:
27328407
31.

The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons.

Reim D, Weis TM, Halbedl S, Delling JP, Grabrucker AM, Boeckers TM, Schmeisser MJ.

Front Synaptic Neurosci. 2016 May 24;8:13. doi: 10.3389/fnsyn.2016.00013. eCollection 2016.

32.

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells.

Pfaender S, Föhr K, Lutz AK, Putz S, Achberger K, Linta L, Liebau S, Boeckers TM, Grabrucker AM.

Neural Plast. 2016;2016:3760702. doi: 10.1155/2016/3760702. Epub 2016 May 9.

33.

Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.

Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM.

Front Cell Neurosci. 2016 Apr 26;10:106. doi: 10.3389/fncel.2016.00106. eCollection 2016.

34.

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.

Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C.

Mol Psychiatry. 2017 May;22(5):784. doi: 10.1038/mp.2016.70. Epub 2016 Apr 26. No abstract available.

PMID:
27113996
35.

Addressing the Complexity of Tourette's Syndrome through the Use of Animal Models.

Nespoli E, Rizzo F, Boeckers TM, Hengerer B, Ludolph AG.

Front Neurosci. 2016 Apr 8;10:133. doi: 10.3389/fnins.2016.00133. eCollection 2016. Review.

36.

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.

Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C.

Mol Psychiatry. 2017 May;22(5):689-702. doi: 10.1038/mp.2016.30. Epub 2016 Mar 29. Erratum in: Mol Psychiatry. 2017 May;22(5):784.

37.

Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency.

Grabrucker S, Boeckers TM, Grabrucker AM.

Front Behav Neurosci. 2016 Mar 3;10:37. doi: 10.3389/fnbeh.2016.00037. eCollection 2016.

38.

Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.

Sarowar T, Grabrucker S, Föhr K, Mangus K, Eckert M, Bockmann J, Boeckers TM, Grabrucker AM.

Mol Brain. 2016 Mar 11;9:28. doi: 10.1186/s13041-016-0206-6.

39.

4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells.

Naujock M, Stanslowsky N, Bufler S, Naumann M, Reinhardt P, Sterneckert J, Kefalakes E, Kassebaum C, Bursch F, Lojewski X, Storch A, Frickenhaus M, Boeckers TM, Putz S, Demestre M, Liebau S, Klingenstein M, Ludolph AC, Dengler R, Kim KS, Hermann A, Wegner F, Petri S.

Stem Cells. 2016 Jun;34(6):1563-75. doi: 10.1002/stem.2354. Epub 2016 Mar 28.

40.

Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.

Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM.

Front Cell Neurosci. 2016 Jan 12;9:496. doi: 10.3389/fncel.2015.00496. eCollection 2015.

41.

Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals.

Halbedl S, Schoen M, Feiler MS, Boeckers TM, Schmeisser MJ.

J Neurochem. 2016 Apr;137(1):26-32. doi: 10.1111/jnc.13523. Epub 2016 Jan 24.

42.

Genetic Animal Models for Autism Spectrum Disorder.

Schroeder JC, Reim D, Boeckers TM, Schmeisser MJ.

Curr Top Behav Neurosci. 2017;30:311-324. doi: 10.1007/7854_2015_407. Review.

PMID:
26602248
43.

Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.

Dolnik A, Kanwal N, Mackert S, Halbedl S, Proepper C, Bockmann J, Schoen M, Boeckers TM, Kühl SJ, Schmeisser MJ.

J Neurochem. 2016 Jan;136(1):28-35. doi: 10.1111/jnc.13353. Epub 2015 Oct 8.

44.

Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo.

Chhabra R, Ruozi B, Vilella A, Belletti D, Mangus K, Pfaender S, Sarowar T, Boeckers TM, Zoli M, Forni F, Vandelli MA, Tosi G, Grabrucker AM.

CNS Neurol Disord Drug Targets. 2015;14(8):1041-53.

PMID:
26295815
45.

Formation and characterisation of neuromuscular junctions between hiPSC derived motoneurons and myotubes.

Demestre M, Orth M, Föhr KJ, Achberger K, Ludolph AC, Liebau S, Boeckers TM.

Stem Cell Res. 2015 Sep;15(2):328-36. doi: 10.1016/j.scr.2015.07.005. Epub 2015 Jul 26.

46.

Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging.

Japtok J, Lojewski X, Naumann M, Klingenstein M, Reinhardt P, Sterneckert J, Putz S, Demestre M, Boeckers TM, Ludolph AC, Liebau S, Storch A, Hermann A.

Neurobiol Dis. 2015 Oct;82:420-429. doi: 10.1016/j.nbd.2015.07.017. Epub 2015 Aug 4.

PMID:
26253605
47.

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).

von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA.

PLoS One. 2015 Jun 8;10(6):e0129047. doi: 10.1371/journal.pone.0129047. eCollection 2015.

48.

Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID.

Cochoy DM, Kolevzon A, Kajiwara Y, Schoen M, Pascual-Lucas M, Lurie S, Buxbaum JD, Boeckers TM, Schmeisser MJ.

Mol Autism. 2015 Apr 29;6:23. doi: 10.1186/s13229-015-0020-5. eCollection 2015.

49.

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.

Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH.

Nat Neurosci. 2015 May;18(5):631-6. doi: 10.1038/nn.4000. Epub 2015 Mar 24.

PMID:
25803835
50.

Effects of trace metal profiles characteristic for autism on synapses in cultured neurons.

Hagmeyer S, Mangus K, Boeckers TM, Grabrucker AM.

Neural Plast. 2015;2015:985083. doi: 10.1155/2015/985083. Epub 2015 Feb 23.

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