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Items: 1 to 50 of 85

1.

Phenylhydrazides as inhibitors of Leishmania amazonensis arginase and antileishmanial activity.

Crizanto de Lima E, Castelo-Branco FS, Maquiaveli CC, Farias AB, Rennó MN, Boechat N, Silva ER.

Bioorg Med Chem. 2019 Sep 1;27(17):3853-3859. doi: 10.1016/j.bmc.2019.07.022. Epub 2019 Jul 11.

PMID:
31311700
2.

In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents.

Von Trompowsky ACM, Conde TR, Lemos RC, Quaresma BMC, Pitombeira MCS, de Carvalho AS, Boechat N, Salomão K, de Castro SL, Zamith HPDS.

Mem Inst Oswaldo Cruz. 2019;114:e190017. doi: 10.1590/0074-02760190017. Epub 2019 Jun 27.

3.

New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors.

Feitosa LM, da Silva ER, Hoelz LVB, Souza DL, Come JAASS, Cardoso-Santos C, Batista MM, Soeiro MNC, Boechat N, Pinheiro LCS.

Bioorg Med Chem. 2019 Jul 15;27(14):3061-3069. doi: 10.1016/j.bmc.2019.05.026. Epub 2019 May 17.

PMID:
31176565
4.

Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors.

Gonzaga DTG, Oliveira FH, von Ranke NL, Pinho GQ, Salles JP, Bello ML, Rodrigues CR, Castro HC, de Souza HVCM, Reis CRC, Leme RPP, Mafra JCM, Pinheiro LCS, Hoelz LVB, Boechat N, Faria RX.

Front Chem. 2019 Apr 30;7:261. doi: 10.3389/fchem.2019.00261. eCollection 2019.

5.

Safety assessment of MEFAS: an innovative hybrid salt of mefloquine and artesunate for malaria treatment.

de Lima DA, Andreotti CEL, Antiquera Ferreira F, Pauli KB, da Silva GR, Ribeiro RCL, Dalsenter PR, Boechat N, Gasparotto Junior A, Lourenço ELB, Lívero FADR.

Drug Chem Toxicol. 2019 May 7:1-6. doi: 10.1080/01480545.2019.1607371. [Epub ahead of print]

PMID:
31060457
6.

Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi.

Simões-Silva MR, De Araújo JS, Peres RB, Da Silva PB, Batista MM, De Azevedo LD, Bastos MM, Bahia MT, Boechat N, Soeiro MNC.

Parasitology. 2019 Jul;146(8):1006-1012. doi: 10.1017/S0031182019000234. Epub 2019 Mar 12.

PMID:
30859917
7.

New hybrid trifluoromethylquinolines as antiplasmodium agents.

da Silva RMRJ, Gandi MO, Mendonça JS, Carvalho AS, Coutinho JP, Aguiar ACC, Krettli AU, Boechat N.

Bioorg Med Chem. 2019 Mar 15;27(6):1002-1008. doi: 10.1016/j.bmc.2019.01.044. Epub 2019 Feb 2.

PMID:
30737133
8.

Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo.

de Freitas CS, Higa LM, Sacramento CQ, Ferreira AC, Reis PA, Delvecchio R, Monteiro FL, Barbosa-Lima G, James Westgarth H, Vieira YR, Mattos M, Rocha N, Hoelz LVB, Leme RPP, Bastos MM, Rodrigues GOL, Lopes CEM, Queiroz-Junior CM, Lima CX, Costa VV, Teixeira MM, Bozza FA, Bozza PT, Boechat N, Tanuri A, Souza TML.

PLoS Negl Trop Dis. 2019 Jan 30;13(1):e0007072. doi: 10.1371/journal.pntd.0007072. eCollection 2019 Jan.

9.

Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.

Ferreira AC, Reis PA, de Freitas CS, Sacramento CQ, Villas Bôas Hoelz L, Bastos MM, Mattos M, Rocha N, Gomes de Azevedo Quintanilha I, da Silva Gouveia Pedrosa C, Rocha Quintino Souza L, Correia Loiola E, Trindade P, Rangel Vieira Y, Barbosa-Lima G, de Castro Faria Neto HC, Boechat N, Rehen SK, Brüning K, Bozza FA, Bozza PT, Souza TML.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01389-18. doi: 10.1128/AAC.01389-18. Print 2019 Feb.

10.

New Efavirenz Derivatives and 1,2,3-Triazolyl-phosphonates as Inhibitors of Reverse Transcriptase of HIV-1.

Costa CCP, Boechat N, Bastos MM, da Silva FC, Marttorelli A, Souza TML, Baptista MS, Hoelz LVB, Cafffarena ER.

Curr Top Med Chem. 2018;18(17):1494-1505. doi: 10.2174/1568026618666181029150118.

PMID:
30370848
11.

The use of variable temperature 13 C solid-state MAS NMR and GIPAW DFT calculations to explore the dynamics of diethylcarbamazine citrate.

Venâncio T, Oliveira LM, Pawlak T, Ellena J, Boechat N, Brown SP.

Magn Reson Chem. 2019 May;57(5):200-210. doi: 10.1002/mrc.4790. Epub 2018 Oct 15.

PMID:
30114322
12.

Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malaria.

Hoelz LV, Calil FA, Nonato MC, Pinheiro LC, Boechat N.

Future Med Chem. 2018 Aug 1;10(15):1853-1874. doi: 10.4155/fmc-2017-0250. Epub 2018 Jul 18. Review.

PMID:
30019917
13.

Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives.

Pinheiro LCS, Feitosa LM, Silveira FFD, Boechat N.

An Acad Bras Cienc. 2018;90(1 Suppl 2):1251-1271. doi: 10.1590/0001-3765201820170830. Review.

14.

New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations.

Leite DI, Fontes FV, Bastos MM, Hoelz LVB, Bianco MDCAD, de Oliveira AP, da Silva PB, da Silva CF, Batista DDGJ, da Gama ANS, Peres RB, Villar JDF, Soeiro MNC, Boechat N.

Chem Biol Drug Des. 2018 Sep;92(3):1670-1682. doi: 10.1111/cbdd.13333. Epub 2018 Jun 13.

PMID:
29745048
15.

New hydrazides derivatives of isoniazid against Mycobacterium tuberculosis: Higher potency and lower hepatocytotoxicity.

Castelo-Branco FS, de Lima EC, Domingos JLO, Pinto AC, Lourenço MCS, Gomes KM, Costa-Lima MM, Araujo-Lima CF, Aiub CAF, Felzenszwalb I, Costa TEMM, Penido C, Henriques MG, Boechat N.

Eur J Med Chem. 2018 Feb 25;146:529-540. doi: 10.1016/j.ejmech.2018.01.071. Epub 2018 Jan 31.

PMID:
29407978
16.

Recently reported biological activities of pyrazole compounds.

Faria JV, Vegi PF, Miguita AGC, Dos Santos MS, Boechat N, Bernardino AMR.

Bioorg Med Chem. 2017 Nov 1;25(21):5891-5903. doi: 10.1016/j.bmc.2017.09.035. Epub 2017 Sep 23. Review.

PMID:
28988624
17.

Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil.

Salgado VCL, Luiz RR, Boechat N, Schorr BC, Leão IS, Nunes T, Zaltman C.

World J Gastroenterol. 2017 Aug 14;23(30):5549-5556. doi: 10.3748/wjg.v23.i30.5549.

18.

Corrigendum: The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication.

Sacramento CQ, de Melo GR, de Freitas CS, Rocha N, Hoelz LVB, Miranda M, Fintelman-Rodrigues N, Marttorelli A, Ferreira AC, Barbosa-Lima G, Abrantes JL, Vieira YR, Bastos MM, Volotão EM, Nunes EP, Tschoeke DA, Leomil L, Loiola EC, Trindade P, Rehen SK, Bozza FA, Bozza PT, Boechat N, Thompson FL, de Filippis AMB, Brüning K, Souza TML.

Sci Rep. 2017 Apr 24;7:46772. doi: 10.1038/srep46772. No abstract available.

19.

Probing intermolecular interactions in a diethylcarbamazine citrate salt by fast MAS 1H solid-state NMR spectroscopy and GIPAW calculations.

Venâncio T, Oliveira LM, Ellena J, Boechat N, Brown SP.

Solid State Nucl Magn Reson. 2017 Oct;87:73-79. doi: 10.1016/j.ssnmr.2017.02.006. Epub 2017 Mar 2.

PMID:
28342733
20.

A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil.

Duarte TA, Nery JS, Boechat N, Pereira SM, Simonsen V, Oliveira M, Gomes MGM, Penha-Gonçalves C, Barreto ML, Barbosa T.

Braz J Infect Dis. 2017 May - Jun;21(3):317-324. doi: 10.1016/j.bjid.2017.01.005. Epub 2017 Feb 24. Review.

21.

The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication.

Sacramento CQ, de Melo GR, de Freitas CS, Rocha N, Hoelz LV, Miranda M, Fintelman-Rodrigues N, Marttorelli A, Ferreira AC, Barbosa-Lima G, Abrantes JL, Vieira YR, Bastos MM, de Mello Volotão E, Nunes EP, Tschoeke DA, Leomil L, Loiola EC, Trindade P, Rehen SK, Bozza FA, Bozza PT, Boechat N, Thompson FL, de Filippis AM, Brüning K, Souza TM.

Sci Rep. 2017 Jan 18;7:40920. doi: 10.1038/srep40920. Erratum in: Sci Rep. 2017 Apr 24;7:46772.

22.

Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors.

Azeredo LFSP, Coutinho JP, Jabor VAP, Feliciano PR, Nonato MC, Kaiser CR, Menezes CMS, Hammes ASO, Caffarena ER, Hoelz LVB, de Souza NB, Pereira GAN, Cerávolo IP, Krettli AU, Boechat N.

Eur J Med Chem. 2017 Jan 27;126:72-83. doi: 10.1016/j.ejmech.2016.09.073. Epub 2016 Sep 30.

PMID:
27744189
23.

Design, synthesis and anti-P. falciparum activity of pyrazolopyridine-sulfonamide derivatives.

Silva TB, Bernardino AMR, Ferreira MLG, Rogerio KR, Carvalho LJM, Boechat N, Pinheiro LCS.

Bioorg Med Chem. 2016 Sep 15;24(18):4492-4498. doi: 10.1016/j.bmc.2016.07.049. Epub 2016 Jul 25.

24.

On the Thermal Stability of the Diethylcarbamazine-Fortified Table Salt Used in the Control of Lymphatic Filariasis.

Honorato SB, da Silva CC, de Oliveira YS, Mendonça JS, Boechat N, Ellena J, Ayala AP.

J Pharm Sci. 2016 Aug;105(8):2437-43. doi: 10.1016/j.xphs.2016.06.003. Epub 2016 Jul 7.

PMID:
27397435
25.

New pentasubstituted pyrrole hybrid atorvastatin-quinoline derivatives with antiplasmodial activity.

Carvalho RC, Martins WA, Silva TP, Kaiser CR, Bastos MM, Pinheiro LC, Krettli AU, Boechat N.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):1881-4. doi: 10.1016/j.bmcl.2016.03.027. Epub 2016 Mar 9.

PMID:
26988303
26.

Transmission-Blocking Potential of MEFAS, a Hybrid Compound Derived from Artesunate and Mefloquine.

Penna-Coutinho J, Almela MJ, Miguel-Blanco C, Herreros E, Sá PM, Boechat N, Krettli AU.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3145-7. doi: 10.1128/AAC.02216-15. Print 2016 May.

27.

Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry.

Bastos MM, Costa CCP, Bezerra TC, da Silva FC, Boechat N.

Eur J Med Chem. 2016 Jan 27;108:455-465. doi: 10.1016/j.ejmech.2015.11.025. Epub 2015 Nov 25. Review.

PMID:
26708112
28.

Anti-Plasmodium falciparum activity of quinoline-sulfonamide hybrids.

Pinheiro LC, Boechat N, Ferreira Mde L, Júnior CC, Jesus AM, Leite MM, Souza NB, Krettli AU.

Bioorg Med Chem. 2015 Sep 1;23(17):5979-84. doi: 10.1016/j.bmc.2015.06.056. Epub 2015 Jul 2.

PMID:
26190461
29.

Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group.

Boechat N, Carvalho AS, Salomão K, Castro SL, Araujo-Lima CF, Mello FV, Felzenszwalb I, Aiub CA, Conde TR, Zamith HP, Skupin R, Haufe G.

Mem Inst Oswaldo Cruz. 2015 Jun;110(4):492-9. doi: 10.1590/0074-02760140248. Epub 2015 May 26.

30.

Novel selective inhibitor of Leishmania (Leishmania) amazonensis arginase.

da Silva ER, Boechat N, Pinheiro LC, Bastos MM, Costa CC, Bartholomeu JC, da Costa TH.

Chem Biol Drug Des. 2015 Nov;86(5):969-78. doi: 10.1111/cbdd.12566. Epub 2015 May 14.

PMID:
25845502
31.

Strain classification of Mycobacterium tuberculosis isolates in Brazil based on genotypes obtained by spoligotyping, mycobacterial interspersed repetitive unit typing and the presence of large sequence and single nucleotide polymorphism.

Vasconcellos SE, Acosta CC, Gomes LL, Conceição EC, Lima KV, de Araujo MI, Leite Mde L, Tannure F, Caldas PC, Gomes HM, Santos AR, Gomgnimbou MK, Sola C, Couvin D, Rastogi N, Boechat N, Suffys PN.

PLoS One. 2014 Oct 14;9(10):e107747. doi: 10.1371/journal.pone.0107747. eCollection 2014.

32.

Tuberculin skin test and ELISPOT/T. SPOT.TB in children and adolescents with juvenile idiopathic arthritis.

Sztajnbok F, Boechat NL, Ribeiro SB, Oliveira SK, Sztajnbok DC, Sant'Anna CC.

Pediatr Rheumatol Online J. 2014 May 22;12:17. doi: 10.1186/1546-0096-12-17. eCollection 2014.

33.

New compounds hybrids 1h-1,2,3-triazole-quinoline against Plasmodium falciparum.

Boechat N, Ferreira Mde L, Pinheiro LC, Jesus AM, Leite MM, Júnior CC, Aguiar AC, de Andrade IM, Krettli AU.

Chem Biol Drug Des. 2014 Sep;84(3):325-32. doi: 10.1111/cbdd.12321. Epub 2014 Jun 5.

PMID:
24803084
34.

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme.

Carvalho AS, Salomão K, Castro SL, Conde TR, Zamith HP, Caffarena ER, Hall BS, Wilkinson SR, Boechat N.

Mem Inst Oswaldo Cruz. 2014 Jun;109(3):315-23. Epub 2014 Mar 18.

35.

Evaluation of genotoxic effects of new molecules with possible trypanocidal activity for Chagas disease treatment.

Mello FV, Carvalho AS, Bastos MM, Boechat N, Aiub CA, Felzenszwalb I.

ScientificWorldJournal. 2013 Nov 7;2013:287319. doi: 10.1155/2013/287319. eCollection 2013.

36.

Editorial: new developments in the search for agents to treat tuberculosis.

Boechat N.

Curr Top Med Chem. 2013;13(22):2807. No abstract available.

PMID:
24111910
37.

Fluorinated compounds against Mycobacterium tuberculosis.

Boechat N, Bastos MM.

Curr Top Med Chem. 2013;13(22):2885-904. Review.

PMID:
24111908
38.

An update on the chemistry and medicinal chemistry of novel antimycobacterial compounds.

Branco FS, Pinto AC, Boechat N.

Curr Top Med Chem. 2013;13(22):2808-49. Review.

PMID:
24111907
39.

Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole.

Honorato SB, Mendonça JS, Boechat N, Oliveira AC, Mendes Filho J, Ellena J, Ayala AP.

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:389-94. doi: 10.1016/j.saa.2013.08.096. Epub 2013 Sep 5.

PMID:
24076454
40.

SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil.

Lopes JS, Marques I, Soares P, Nebenzahl-Guimaraes H, Costa J, Miranda A, Duarte R, Alves A, Macedo R, Duarte TA, Barbosa T, Oliveira M, Nery JS, Boechat N, Pereira SM, Barreto ML, Pereira-Leal J, Gomes MG, Penha-Goncalves C.

Infect Genet Evol. 2013 Aug;18:238-46. doi: 10.1016/j.meegid.2013.04.028. Epub 2013 May 3.

PMID:
23648425
41.

Novel 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivatives: a patent review (2008 - 2011).

Ferreira VF, da Rocha DR, da Silva FC, Ferreira PG, Boechat NA, Magalhães JL.

Expert Opin Ther Pat. 2013 Mar;23(3):319-31. doi: 10.1517/13543776.2013.749862. Epub 2013 Jan 6. Review.

PMID:
23289412
42.

Tuberculosis caused by RDRio Mycobacterium tuberculosis is not associated with differential clinical features.

Barbosa Cde B, Lazzarini LC, Elias AR, Leung JA, Ribeiro SB, da Silva MG, Duarte RS, Suffys P, Gomes HM, Kritski AL, Lapa E Silva JR, Ho JL, Boéchat N.

Int J Tuberc Lung Dis. 2012 Oct;16(10):1377-82. doi: 10.5588/ijtld.11.0709. Epub 2012 Aug 3.

43.

New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents.

Boechat N, Pinheiro LC, Silva TS, Aguiar AC, Carvalho AS, Bastos MM, Costa CC, Pinheiro S, Pinto AC, Mendonça JS, Dutra KD, Valverde AL, Santos-Filho OA, Ceravolo IP, Krettli AU.

Molecules. 2012 Jul 10;17(7):8285-302. doi: 10.3390/molecules17078285.

44.

Identification of Brazilian expertise in the fight against some neglected tropical diseases.

Magalhães JL, Boechat N, Antunes AM.

Rev Soc Bras Med Trop. 2012 Jun;45(3):415-7. No abstract available.

45.

CoMFA/CoMSIA 3D-QSAR of pyrimidine inhibitors of Pneumocystis carinii dihydrofolate reductase.

Santos-Filho OA, Forge D, Hoelz LV, de Freitas GB, Marinho TO, Araújo JQ, Albuquerque MG, de Alencastro RB, Boechat N.

J Mol Model. 2012 Sep;18(9):4061-72. doi: 10.1007/s00894-012-1399-y. Epub 2012 Apr 14.

PMID:
22527273
46.

Interleukin-10 and interferon-gamma patterns during tuberculosis treatment: possible association with recurrence.

Lago PM, Boéchat N, Migueis DP, Almeida AS, Lazzarini LC, Saldanha MM, Kritski AL, Ho JL, Lapa e Silva JR.

Int J Tuberc Lung Dis. 2012 May;16(5):656-9. doi: 10.5588/ijtld.11.0707. Epub 2012 Mar 8.

47.

Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation.

Duarte TA, Noronha-Dutra AA, Nery JS, Ribeiro SB, Pitanga TN, Lapa E Silva JR, Arruda S, Boéchat N.

Tuberculosis (Edinb). 2012 May;92(3):218-25. doi: 10.1016/j.tube.2012.02.007. Epub 2012 Mar 4.

PMID:
22391089
48.

[1-(3-Chloro-phen-yl)-1H-1,2,3-triazol-4-yl]methanol hemihydrate.

Boechat N, Ferreira Mde L, Bastos MM, Wardell JL, Wardell SM, Tiekink ER.

Acta Crystallogr Sect E Struct Rep Online. 2011 Nov;67(Pt 11):o2934-5. doi: 10.1107/S1600536811041560. Epub 2011 Oct 12.

49.

Identification of Mycobacterium bovis among mycobacterial isolates from human clinical specimens at a university hospital in Rio de Janeiro, Brazil.

Sobral LF, Duarte RS, Vieira GB, Silva MG, Boechat N, Fonseca Lde S.

J Bras Pneumol. 2011 Sep-Oct;37(5):664-8. English, Portuguese.

50.

Design and synthesis of new N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes.

Boechat N, Pinheiro LC, Santos-Filho OA, Silva IC.

Molecules. 2011 Sep 20;16(9):8083-97. doi: 10.3390/molecules16098083.

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