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Items: 15

1.

A flow cytometry-based screen identifies MBNL1 modulators that rescue splicing defects in myotonic dystrophy type I.

Zhang F, Bodycombe NE, Haskell KM, Sun YL, Wang ET, Morris CA, Jones LH, Wood LD, Pletcher MT.

Hum Mol Genet. 2017 Aug 15;26(16):3056-3068. doi: 10.1093/hmg/ddx190.

2.

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay.

Bray MA, Gustafsdottir SM, Rohban MH, Singh S, Ljosa V, Sokolnicki KL, Bittker JA, Bodycombe NE, Dancík V, Hasaka TP, Hon CS, Kemp MM, Li K, Walpita D, Wawer MJ, Golub TR, Schreiber SL, Clemons PA, Shamji AF, Carpenter AE.

Gigascience. 2017 Dec 1;6(12):1-5. doi: 10.1093/gigascience/giw014.

3.

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, Hon CS, Munoz B, Liefeld T, Dančík V, Haber DA, Clish CB, Bittker JA, Palmer M, Wagner BK, Clemons PA, Shamji AF, Schreiber SL.

Nat Chem Biol. 2016 Feb;12(2):109-16. doi: 10.1038/nchembio.1986. Epub 2015 Dec 14.

4.

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J, Alexander B, Li A, Montgomery P, Wawer MJ, Kuru N, Kotz JD, Hon CS, Munoz B, Liefeld T, Dančík V, Bittker JA, Palmer M, Bradner JE, Shamji AF, Clemons PA, Schreiber SL.

Cancer Discov. 2015 Nov;5(11):1210-23. doi: 10.1158/2159-8290.CD-15-0235. Epub 2015 Oct 19.

5.

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.

Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V, Narayan R, Subramanian A, Winckler W, Golub TR, Carpenter AE, Shamji AF, Schreiber SL, Clemons PA.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):10911-6. doi: 10.1073/pnas.1410933111. Epub 2014 Jul 14.

6.

Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.

Dančík V, Carrel H, Bodycombe NE, Seiler KP, Fomina-Yadlin D, Kubicek ST, Hartwell K, Shamji AF, Wagner BK, Clemons PA.

J Biomol Screen. 2014 Jun;19(5):771-81. doi: 10.1177/1087057113520226. Epub 2014 Jan 24.

7.

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, Stransky N, Kryukov GV, Dancik V, Barretina J, Garraway LA, Hon CS, Munoz B, Bittker JA, Stockwell BR, Khabele D, Stern AM, Clemons PA, Shamji AF, Schreiber SL.

Cell. 2013 Aug 29;154(5):1151-1161. doi: 10.1016/j.cell.2013.08.003.

8.

Utility-aware screening with clique-oriented prioritization.

Swamidass SJ, Calhoun BT, Bittker JA, Bodycombe NE, Clemons PA.

J Chem Inf Model. 2012 Jan 23;52(1):29-37. doi: 10.1021/ci2003285. Epub 2011 Dec 20.

9.

A small-molecule screening strategy to identify suppressors of statin myopathy.

Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK.

ACS Chem Biol. 2011 Sep 16;6(9):900-4. doi: 10.1021/cb200206w. Epub 2011 Jul 15.

10.

Enhancing the rate of scaffold discovery with diversity-oriented prioritization.

Swamidass SJ, Calhoun BT, Bittker JA, Bodycombe NE, Clemons PA.

Bioinformatics. 2011 Aug 15;27(16):2271-8. doi: 10.1093/bioinformatics/btr369. Epub 2011 Jun 17.

11.

Master data management: getting your house in order.

Seiler KP, Bodycombe NE, Hawkins T, Shell R, Lemon A, de Souza A, Clemons PA.

Comb Chem High Throughput Screen. 2011 Nov;14(9):749-56.

PMID:
21631416
12.

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.

Clemons PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, Schreiber SL.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18787-92. doi: 10.1073/pnas.1012741107. Epub 2010 Oct 18.

13.

Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.

Chou DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, Wagner BK.

ACS Chem Biol. 2010 Aug 20;5(8):729-34. doi: 10.1021/cb100129d.

14.

An economic framework to prioritize confirmatory tests after a high-throughput screen.

Swamidass SJ, Bittker JA, Bodycombe NE, Ryder SP, Clemons PA.

J Biomol Screen. 2010 Jul;15(6):680-6. doi: 10.1177/1087057110372803. Epub 2010 Jun 14.

15.

ChemBank: a small-molecule screening and cheminformatics resource database.

Seiler KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S, Brudz S, Sullivan JP, Muhlich J, Serrano M, Ferraiolo P, Tolliday NJ, Schreiber SL, Clemons PA.

Nucleic Acids Res. 2008 Jan;36(Database issue):D351-9. Epub 2007 Oct 18.

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