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Items: 1 to 50 of 516

1.

Single-molecule DNA-mapping and whole-genome sequencing of individual cells.

Marie R, Pedersen JN, Bærlocher L, Koprowska K, Pødenphant M, Sabatel C, Zalkovskij M, Mironov A, Bilenberg B, Ashley N, Flyvbjerg H, Bodmer WF, Kristensen A, Mir KU.

Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11192-11197. doi: 10.1073/pnas.1804194115. Epub 2018 Oct 15.

PMID:
30322920
2.

Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.

Ashley N, Ouaret D, Bodmer WF.

J Pathol. 2018 Oct 10. doi: 10.1002/path.5179. [Epub ahead of print]

PMID:
30306567
3.

Sequencing of human genomes extracted from single cancer cells isolated in a valveless microfluidic device.

Marie R, Pødenphant M, Koprowska K, Bærlocher L, Vulders RCM, Wilding J, Ashley N, McGowan SJ, van Strijp D, van Hemert F, Olesen T, Agersnap N, Bilenberg B, Sabatel C, Schira J, Kristensen A, Bodmer W, van der Zaag PJ, Mir KU.

Lab Chip. 2018 Jun 26;18(13):1891-1902. doi: 10.1039/c8lc00169c.

PMID:
29873383
4.

Author Correction: The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.

Gilbert E, O'Reilly S, Merrigan M, McGettigan D, Molloy AM, Brody LC, Bodmer W, Hutnik K, Ennis S, Lawson DJ, Wilson JF, Cavalleri GL.

Sci Rep. 2018 May 3;8(1):7208. doi: 10.1038/s41598-018-24846-6.

5.

Genetics of the human face: Identification of large-effect single gene variants.

Crouch DJM, Winney B, Koppen WP, Christmas WJ, Hutnik K, Day T, Meena D, Boumertit A, Hysi P, Nessa A, Spector TD, Kittler J, Bodmer WF.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E676-E685. doi: 10.1073/pnas.1708207114. Epub 2018 Jan 4.

6.

A Haldane perspective from a Fisher student.

Bodmer WF.

J Genet. 2017 Nov;96(5):743-746. No abstract available.

7.

The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.

Gilbert E, O'Reilly S, Merrigan M, McGettigan D, Molloy AM, Brody LC, Bodmer W, Hutnik K, Ennis S, Lawson DJ, Wilson JF, Cavalleri GL.

Sci Rep. 2017 Dec 8;7(1):17199. doi: 10.1038/s41598-017-17124-4. Erratum in: Sci Rep. 2018 May 3;8(1):7208.

8.

Major shifts in Amazon wildlife populations from recent intensification of floods and drought.

Bodmer R, Mayor P, Antunez M, Chota K, Fang T, Puertas P, Pittet M, Kirkland M, Walkey M, Rios C, Perez-Peña P, Henderson P, Bodmer W, Bicerra A, Zegarra J, Docherty E.

Conserv Biol. 2018 Apr;32(2):333-344. doi: 10.1111/cobi.12993. Epub 2018 Jan 12.

PMID:
28766738
9.

Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid.

Hulikova A, Black N, Hsia LT, Wilding J, Bodmer WF, Swietach P.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5344-53. doi: 10.1073/pnas.1610954113. Epub 2016 Aug 19.

10.

Paul Ichiro Terasaki (1929-2016): Inventor of the microcytotoxicity assay and pioneer tissue typer.

Bodmer WF.

HLA. 2016 May;87(5):333-7. doi: 10.1111/tan.12809. No abstract available.

PMID:
27101942
11.

Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers.

Hsia LT, Ashley N, Ouaret D, Wang LM, Wilding J, Bodmer WF.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2162-71. doi: 10.1073/pnas.1603534113. Epub 2016 Mar 28.

12.

A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors.

Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, Bodmer W, Lehmann S, Hofer T, Hosse RJ, Moessner E, Ast O, Bruenker P, Grau-Richards S, Schaller T, Seidl A, Gerdes C, Perro M, Nicolini V, Steinhoff N, Dudal S, Neumann S, von Hirschheydt T, Jaeger C, Saro J, Karanikas V, Klein C, Umaña P.

Clin Cancer Res. 2016 Jul 1;22(13):3286-97. doi: 10.1158/1078-0432.CCR-15-1696. Epub 2016 Feb 9.

13.

Separation of cancer cells from white blood cells by pinched flow fractionation.

Pødenphant M, Ashley N, Koprowska K, Mir KU, Zalkovskij M, Bilenberg B, Bodmer W, Kristensen A, Marie R.

Lab Chip. 2015 Dec 21;15(24):4598-606. doi: 10.1039/c5lc01014d. Epub 2015 Oct 29.

PMID:
26510401
14.

A Mathematician's Odyssey.

Bodmer W.

Annu Rev Genomics Hum Genet. 2015;16:1-29. doi: 10.1146/annurev-genom-090314-045856. Epub 2015 Apr 29.

PMID:
25939053
15.

The fine-scale genetic structure of the British population.

Leslie S, Winney B, Hellenthal G, Davison D, Boumertit A, Day T, Hutnik K, Royrvik EC, Cunliffe B; Wellcome Trust Case Control Consortium 2; International Multiple Sclerosis Genetics Consortium, Lawson DJ, Falush D, Freeman C, Pirinen M, Myers S, Robinson M, Donnelly P, Bodmer W.

Nature. 2015 Mar 19;519(7543):309-314. doi: 10.1038/nature14230.

16.

The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation.

Jones MF, Hara T, Francis P, Li XL, Bilke S, Zhu Y, Pineda M, Subramanian M, Bodmer WF, Lal A.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1550-8. doi: 10.1073/pnas.1503370112. Epub 2015 Mar 16.

17.

Genetic characterization of human populations: from ABO to a genetic map of the British people.

Bodmer W.

Genetics. 2015 Feb;199(2):267-79. doi: 10.1534/genetics.114.173062. Review.

18.

Molecular genetics research in sub-Saharan Africa: how can the international community help?

Bekele E, Bodmer WF, Bradman N, Craig IW, Makani J, Povey S, Rotimi C.

Hugo J. 2014 Dec;8(1):2. doi: 10.1186/s11568-014-0002-2. Epub 2014 Sep 17.

19.

Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling.

Gao S, Bajrami I, Verrill C, Kigozi A, Ouaret D, Aleksic T, Asher R, Han C, Allen P, Bailey D, Feller S, Kashima T, Athanasou N, Blay JY, Schmitz S, Machiels JP, Upile N, Jones TM, Thalmann G, Ashraf SQ, Wilding JL, Bodmer WF, Middleton MR, Ashworth A, Lord CJ, Macaulay VM.

Cancer Res. 2014 Oct 15;74(20):5866-77. doi: 10.1158/0008-5472.CAN-14-0806. Epub 2014 Aug 28.

20.

Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays.

Ashley N, Jones M, Ouaret D, Wilding J, Bodmer WF.

J Pathol. 2014 Sep;234(1):34-45. doi: 10.1002/path.4371. Epub 2014 Jul 7.

PMID:
24797403
21.

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Mouradov D, Sloggett C, Jorissen RN, Love CG, Li S, Burgess AW, Arango D, Strausberg RL, Buchanan D, Wormald S, O'Connor L, Wilding JL, Bicknell D, Tomlinson IP, Bodmer WF, Mariadason JM, Sieber OM.

Cancer Res. 2014 Jun 15;74(12):3238-47. doi: 10.1158/0008-5472.CAN-14-0013. Epub 2014 Apr 22.

22.

Cancer cell lines for drug discovery and development.

Wilding JL, Bodmer WF.

Cancer Res. 2014 May 1;74(9):2377-84. doi: 10.1158/0008-5472.CAN-13-2971. Epub 2014 Apr 9. Review.

23.

Stem cell differentiation and lumen formation in colorectal cancer cell lines and primary tumors.

Ashley N, Yeung TM, Bodmer WF.

Cancer Res. 2013 Sep 15;73(18):5798-809. doi: 10.1158/0008-5472.CAN-13-0454. Epub 2013 Jul 18.

24.

Myofibroblast activation in colorectal cancer lymph node metastases.

Yeung TM, Buskens C, Wang LM, Mortensen NJ, Bodmer WF.

Br J Cancer. 2013 May 28;108(10):2106-15. doi: 10.1038/bjc.2013.209. Epub 2013 May 7.

25.

Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.

Ashraf SQ, Nicholls AM, Wilding JL, Ntouroupi TG, Mortensen NJ, Bodmer WF.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21046-51. doi: 10.1073/pnas.1218750110. Epub 2012 Dec 3.

26.

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer.

Lefevre JH, Bonilla C, Colas C, Winney B, Johnstone E, Tonks S, Day T, Hutnik K, Boumertit A, Soubrier F, Midgley R, Kerr D, Parc Y, Bodmer WF.

J Hum Genet. 2012 Nov 26;57(11):709-716. doi: 10.1038/jhg.2012.99. Epub 2012 Aug 9.

27.

The peopling of Europe and the cautionary tale of Y chromosome lineage R-M269.

Busby GB, Brisighelli F, Sánchez-Diz P, Ramos-Luis E, Martinez-Cadenas C, Thomas MG, Bradley DG, Gusmão L, Winney B, Bodmer W, Vennemann M, Coia V, Scarnicci F, Tofanelli S, Vona G, Ploski R, Vecchiotti C, Zemunik T, Rudan I, Karachanak S, Toncheva D, Anagnostou P, Ferri G, Rapone C, Hervig T, Moen T, Wilson JF, Capelli C.

Proc Biol Sci. 2012 Mar 7;279(1730):884-92. doi: 10.1098/rspb.2011.1044. Epub 2011 Aug 24.

28.

People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population.

Winney B, Boumertit A, Day T, Davison D, Echeta C, Evseeva I, Hutnik K, Leslie S, Nicodemus K, Royrvik EC, Tonks S, Yang X, Cheshire J, Longley P, Mateos P, Groom A, Relton C, Bishop DT, Black K, Northwood E, Parkinson L, Frayling TM, Steele A, Sampson JR, King T, Dixon R, Middleton D, Jennings B, Bowden R, Donnelly P, Bodmer W.

Eur J Hum Genet. 2012 Feb;20(2):203-10. doi: 10.1038/ejhg.2011.127. Epub 2011 Aug 10.

29.

Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells.

Yeung TM, Gandhi SC, Bodmer WF.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4382-7. doi: 10.1073/pnas.1014519107. Epub 2011 Feb 23.

30.

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients.

Bonilla C, Lefèvre JH, Winney B, Johnstone E, Tonks S, Colas C, Day T, Hutnik K, Boumertit A, Midgley R, Kerr D, Parc Y, Bodmer WF.

J Hum Genet. 2011 Jan;56(1):58-63. doi: 10.1038/jhg.2010.144. Epub 2010 Nov 25.

31.

Replication error deficient and proficient colorectal cancer gene expression differences caused by 3'UTR polyT sequence deletions.

Wilding JL, McGowan S, Liu Y, Bodmer WF.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21058-63. doi: 10.1073/pnas.1015604107. Epub 2010 Nov 19.

32.

On the proportion of cancer stem cells in a tumour.

Johnston MD, Maini PK, Jonathan Chapman S, Edwards CM, Bodmer WF.

J Theor Biol. 2010 Oct 21;266(4):708-11. doi: 10.1016/j.jtbi.2010.07.031. Epub 2010 Aug 3.

PMID:
20678505
33.

MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.

Lefevre JH, Colas C, Coulet F, Bonilla C, Mourra N, Flejou JF, Tiret E, Bodmer W, Soubrier F, Parc Y.

Fam Cancer. 2010 Dec;9(4):589-94. doi: 10.1007/s10689-010-9367-0.

PMID:
20640893
34.

5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.

Bracht K, Nicholls AM, Liu Y, Bodmer WF.

Br J Cancer. 2010 Jul 27;103(3):340-6. doi: 10.1038/sj.bjc.6605780. Epub 2010 Jul 6.

35.

Rare genetic variants and the risk of cancer.

Bodmer W, Tomlinson I.

Curr Opin Genet Dev. 2010 Jun;20(3):262-7. doi: 10.1016/j.gde.2010.04.016. Review.

PMID:
20554195
36.

Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.

Carvajal-Carmona LG, Churchman M, Bonilla C, Walther A, Lefèvre JH, Kerr D, Dunlop M, Houlston R, Bodmer WF, Tomlinson I.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7858-62. doi: 10.1073/pnas.1002816107. Epub 2010 Apr 5.

37.

Nomenclature for factors of the HLA system, 2010.

Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J.

Tissue Antigens. 2010 Apr;75(4):291-455. doi: 10.1111/j.1399-0039.2010.01466.x. Review. No abstract available.

38.

Linkage disequilibrium and age of HLA region SNPs in relation to classic HLA gene alleles within Europe.

Evseeva I, Nicodemus KK, Bonilla C, Tonks S, Bodmer WF.

Eur J Hum Genet. 2010 Aug;18(8):924-32. doi: 10.1038/ejhg.2010.32. Epub 2010 Mar 31.

39.

An update to HLA nomenclature, 2010.

Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J.

Bone Marrow Transplant. 2010 May;45(5):846-8. doi: 10.1038/bmt.2010.79. Epub 2010 Mar 29.

PMID:
20348972
40.

Commentary: Connections between genetics and statistics: a commentary on Fisher's 1951 Bateson lecture--'Statistical Methods in Genetics'.

Bodmer WF.

Int J Epidemiol. 2010 Apr;39(2):340-4. doi: 10.1093/ije/dyq014. Epub 2010 Feb 22. No abstract available.

PMID:
20176586
41.

Cancer stem cells from colorectal cancer-derived cell lines.

Yeung TM, Gandhi SC, Wilding JL, Muschel R, Bodmer WF.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3722-7. doi: 10.1073/pnas.0915135107. Epub 2010 Feb 2.

42.

Humanised IgG1 antibody variants targeting membrane-bound carcinoembryonic antigen by antibody-dependent cellular cytotoxicity and phagocytosis.

Ashraf SQ, Umana P, Mössner E, Ntouroupi T, Brünker P, Schmidt C, Wilding JL, Mortensen NJ, Bodmer WF.

Br J Cancer. 2009 Nov 17;101(10):1758-68. doi: 10.1038/sj.bjc.6605355.

43.

Sam Karlin: a personal appreciation.

Bodmer W.

Theor Popul Biol. 2009 Jun;75(4):230-2.

PMID:
19496242
44.

Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1.

Chan CW, Wong NA, Liu Y, Bicknell D, Turley H, Hollins L, Miller CJ, Wilding JL, Bodmer WF.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1936-41. doi: 10.1073/pnas.0812904106. Epub 2009 Feb 2.

45.

Detection of circulating tumour cells in peripheral blood with an automated scanning fluorescence microscope.

Ntouroupi TG, Ashraf SQ, McGregor SB, Turney BW, Seppo A, Kim Y, Wang X, Kilpatrick MW, Tsipouras P, Tafas T, Bodmer WF.

Br J Cancer. 2008 Sep 2;99(5):789-95. doi: 10.1038/sj.bjc.6604545.

46.

Mutations in the AXIN1 gene in advanced prostate cancer.

Yardy GW, Bicknell DC, Wilding JL, Bartlett S, Liu Y, Winney B, Turner GD, Brewster SF, Bodmer WF.

Eur Urol. 2009 Sep;56(3):486-94. doi: 10.1016/j.eururo.2008.05.029. Epub 2008 May 23.

PMID:
18514389
47.

Common and rare variants in multifactorial susceptibility to common diseases.

Bodmer W, Bonilla C.

Nat Genet. 2008 Jun;40(6):695-701. doi: 10.1038/ng.f.136. Review.

48.

Genetic instability is not a requirement for tumor development.

Bodmer W, Bielas JH, Beckman RA.

Cancer Res. 2008 May 15;68(10):3558-60; discussion 3560-1. doi: 10.1158/0008-5472.CAN-07-6544. Review. No abstract available. Erratum in: Cancer Res. 2008 Jun 15;68(12):4958. Bielas, Jason H [added]; Beckman, Robert A [added].

49.

Targeted killing of colorectal cancer cell lines by a humanised IgG1 monoclonal antibody that binds to membrane-bound carcinoembryonic antigen.

Conaghan P, Ashraf S, Tytherleigh M, Wilding J, Tchilian E, Bicknell D, Mortensen NJ, Bodmer W.

Br J Cancer. 2008 Apr 8;98(7):1217-25. doi: 10.1038/sj.bjc.6604289. Epub 2008 Mar 18.

50.

PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging.

Hennig BJ, Fry AE, Hirai K, Tahara H, Tamori A, Moller M, Hopkin J, Hill AV, Bodmer W, Beverley P, Tchilian E.

Tissue Antigens. 2008 May;71(5):458-63. doi: 10.1111/j.1399-0039.2008.01014.x. Epub 2008 Feb 28.

PMID:
18312479

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