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Items: 1 to 50 of 168

1.

Embryonic and fetal development of the white-lipped peccary (Tayassu pecari).

de Andrade RDS, Monteiro FOB, El Bizri HR, Pantoja L, Bodmer R, Valsecchi J, Mayor P.

Theriogenology. 2018 Oct 1;119:163-174. doi: 10.1016/j.theriogenology.2018.07.006. Epub 2018 Jul 10.

PMID:
30015145
2.

A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies.

Gonçalves S, Patat J, Guida MC, Lachaussée N, Arrondel C, Helmstädter M, Boyer O, Gribouval O, Gubler MC, Mollet G, Rio M, Charbit M, Bole-Feysot C, Nitschke P, Huber TB, Wheeler PG, Haynes D, Juusola J, Billette de Villemeur T, Nava C, Afenjar A, Keren B, Bodmer R, Antignac C, Simons M.

PLoS Genet. 2018 May 16;14(5):e1007386. doi: 10.1371/journal.pgen.1007386. eCollection 2018 May.

3.

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy.

Walls SM, Cammarato A, Chatfield DA, Ocorr K, Harris GL, Bodmer R.

Cell Rep. 2018 Mar 6;22(10):2702-2715. doi: 10.1016/j.celrep.2018.02.034.

4.

The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila.

Zeng Q, Wan Y, Zhu P, Zhao M, Jiang F, Chen J, Tang M, Zhu X, Li Y, Zha H, Wang Y, Hu M, Mo X, Zhang Y, Chen Y, Chen Y, Ye X, Bodmer R, Ocorr K, Jiang Z, Zhuang J, Yuan W, Wu X.

Curr Mol Med. 2018 Mar 9;17(7):509-517. doi: 10.2174/1566524018666180212145714.

5.

Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila.

Zarndt R, Walls SM, Ocorr K, Bodmer R.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001706. doi: 10.1161/CIRCGENETICS.117.001706.

PMID:
28986453
6.

TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan.

Melkani GC, Bhide S, Han A, Vyas J, Livelo C, Bodmer R, Bernstein SI.

FEBS Lett. 2017 Nov;591(21):3447-3458. doi: 10.1002/1873-3468.12860. Epub 2017 Oct 10.

PMID:
28963798
7.

High Fat Diet Feeding and High Throughput Triacylglyceride Assay in Drosophila Melanogaster.

Diop SB, Birse RT, Bodmer R.

J Vis Exp. 2017 Sep 13;(127). doi: 10.3791/56029.

8.

Major shifts in Amazon wildlife populations from recent intensification of floods and drought.

Bodmer R, Mayor P, Antunez M, Chota K, Fang T, Puertas P, Pittet M, Kirkland M, Walkey M, Rios C, Perez-Peña P, Henderson P, Bodmer W, Bicerra A, Zegarra J, Docherty E.

Conserv Biol. 2018 Apr;32(2):333-344. doi: 10.1111/cobi.12993. Epub 2018 Jan 12.

PMID:
28766738
9.

Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo.

Gan Z, Powell FL, Zambon AC, Buchholz KS, Fu Z, Ocorr K, Bodmer R, Moya EA, Stowe JC, Haddad GG, McCulloch AD.

J Physiol. 2017 Sep 1;595(17):5797-5813. doi: 10.1113/JP274556. Epub 2017 Jul 27.

PMID:
28688178
10.

SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila.

Zanon A, Kalvakuri S, Rakovic A, Foco L, Guida M, Schwienbacher C, Serafin A, Rudolph F, Trilck M, Grünewald A, Stanslowsky N, Wegner F, Giorgio V, Lavdas AA, Bodmer R, Pramstaller PP, Klein C, Hicks AA, Pichler I, Seibler P.

Hum Mol Genet. 2017 Jul 1;26(13):2412-2425. doi: 10.1093/hmg/ddx132.

PMID:
28379402
11.

Experimental Evolution and Heart Function in Drosophila.

Shahrestani P, Burke MK, Birse R, Kezos JN, Ocorr K, Mueller LD, Rose MR, Bodmer R.

Physiol Biochem Zool. 2017 Mar/Apr;90(2):281-293. doi: 10.1086/689288. Epub 2016 Nov 21.

PMID:
28277957
12.

Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline.

Blice-Baum AC, Zambon AC, Kaushik G, Viswanathan MC, Engler AJ, Bodmer R, Cammarato A.

Aging Cell. 2017 Feb;16(1):93-103. doi: 10.1111/acel.12543.

13.

Expression patterns of cardiac aging in Drosophila.

Cannon L, Zambon AC, Cammarato A, Zhang Z, Vogler G, Munoz M, Taylor E, Cartry J, Bernstein SI, Melov S, Bodmer R.

Aging Cell. 2017 Feb;16(1):82-92. doi: 10.1111/acel.12559.

14.

Assessment of mammal reproduction for hunting sustainability through community-based sampling of species in the wild.

Mayor P, El Bizri H, Bodmer RE, Bowler M.

Conserv Biol. 2017 Aug;31(4):912-923. doi: 10.1111/cobi.12870. Epub 2017 Mar 7.

PMID:
27917537
15.

Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.

Sessions AO, Kaushik G, Parker S, Raedschelders K, Bodmer R, Van Eyk JE, Engler AJ.

Matrix Biol. 2017 Oct;62:15-27. doi: 10.1016/j.matbio.2016.10.008. Epub 2016 Oct 25.

PMID:
27793636
16.

52 Genetic Loci Influencing Myocardial Mass.

van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Mateo Leach I, Eijgelsheim M, Sotoodehnia N, Hayward C, Sorice R, Meirelles O, Lyytikäinen LP, Polašek O, Tanaka T, Arking DE, Ulivi S, Trompet S, Müller-Nurasyid M, Smith AV, Dörr M, Kerr KF, Magnani JW, Del Greco M F, Zhang W, Nolte IM, Silva CT, Padmanabhan S, Tragante V, Esko T, Abecasis GR, Adriaens ME, Andersen K, Barnett P, Bis JC, Bodmer R, Buckley BM, Campbell H, Cannon MV, Chakravarti A, Chen LY, Delitala A, Devereux RB, Doevendans PA, Dominiczak AF, Ferrucci L, Ford I, Gieger C, Harris TB, Haugen E, Heinig M, Hernandez DG, Hillege HL, Hirschhorn JN, Hofman A, Hubner N, Hwang SJ, Iorio A, Kähönen M, Kellis M, Kolcic I, Kooner IK, Kooner JS, Kors JA, Lakatta EG, Lage K, Launer LJ, Levy D, Lundby A, Macfarlane PW, May D, Meitinger T, Metspalu A, Nappo S, Naitza S, Neph S, Nord AS, Nutile T, Okin PM, Olsen JV, Oostra BA, Penninger JM, Pennacchio LA, Pers TH, Perz S, Peters A, Pinto YM, Pfeufer A, Pilia MG, Pramstaller PP, Prins BP, Raitakari OT, Raychaudhuri S, Rice KM, Rossin EJ, Rotter JI, Schafer S, Schlessinger D, Schmidt CO, Sehmi J, Silljé HHW, Sinagra G, Sinner MF, Slowikowski K, Soliman EZ, Spector TD, Spiering W, Stamatoyannopoulos JA, Stolk RP, Strauch K, Tan ST, Tarasov KV, Trinh B, Uitterlinden AG, van den Boogaard M, van Duijn CM, van Gilst WH, Viikari JS, Visscher PM, Vitart V, Völker U, Waldenberger M, Weichenberger CX, Westra HJ, Wijmenga C, Wolffenbuttel BH, Yang J, Bezzina CR, Munroe PB, Snieder H, Wright AF, Rudan I, Boyer LA, Asselbergs FW, van Veldhuisen DJ, Stricker BH, Psaty BM, Ciullo M, Sanna S, Lehtimäki T, Wilson JF, Bandinelli S, Alonso A, Gasparini P, Jukema JW, Kääb S, Gudnason V, Felix SB, Heckbert SR, de Boer RA, Newton-Cheh C, Hicks AA, Chambers JC, Jamshidi Y, Visel A, Christoffels VM, Isaacs A, Samani NJ, de Bakker PIW.

J Am Coll Cardiol. 2016 Sep 27;68(13):1435-1448. doi: 10.1016/j.jacc.2016.07.729.

17.

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.

Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI.

J Mol Biol. 2016 Jun 5;428(11):2446-2461. doi: 10.1016/j.jmb.2016.04.021. Epub 2016 Apr 20.

18.

The canonical Wingless signaling pathway is required but not sufficient for inflow tract formation in the Drosophila melanogaster heart.

Trujillo GV, Nodal DH, Lovato CV, Hendren JD, Helander LA, Lovato TL, Bodmer R, Cripps RM.

Dev Biol. 2016 May 1;413(1):16-25. doi: 10.1016/j.ydbio.2016.03.013. Epub 2016 Mar 13.

19.

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development.

Del Álamo JC, Lemons D, Serrano R, Savchenko A, Cerignoli F, Bodmer R, Mercola M.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1717-27. doi: 10.1016/j.bbamcr.2016.03.003. Epub 2016 Mar 4. Review.

20.

SPARC-Dependent Cardiomyopathy in Drosophila.

Hartley PS, Motamedchaboki K, Bodmer R, Ocorr K.

Circ Cardiovasc Genet. 2016 Apr;9(2):119-29. doi: 10.1161/CIRCGENETICS.115.001254. Epub 2016 Feb 2.

21.

Gaining Insights into Diabetic Cardiomyopathy from Drosophila.

Diop SB, Bodmer R.

Trends Endocrinol Metab. 2015 Nov;26(11):618-627. doi: 10.1016/j.tem.2015.09.009. Epub 2015 Oct 16. Review.

22.

Cardiac responses to hypoxia and reoxygenation in Drosophila.

Zarndt R, Piloto S, Powell FL, Haddad GG, Bodmer R, Ocorr K.

Am J Physiol Regul Integr Comp Physiol. 2015 Dec 1;309(11):R1347-57. doi: 10.1152/ajpregu.00164.2015. Epub 2015 Sep 16.

23.

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes.

Ivy JR, Drechsler M, Catterson JH, Bodmer R, Ocorr K, Paululat A, Hartley PS.

PLoS One. 2015 Aug 24;10(8):e0134620. doi: 10.1371/journal.pone.0134620. eCollection 2015.

24.

Cellular Mechanisms of Drosophila Heart Morphogenesis.

Vogler G, Bodmer R.

J Cardiovasc Dev Dis. 2015 Mar 1;2(1):2-16.

25.

Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster.

Hardy CM, Birse RT, Wolf MJ, Yu L, Bodmer R, Gibbs AG.

Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R658-67. doi: 10.1152/ajpregu.00160.2015. Epub 2015 Jul 1.

26.

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A, Engler AJ.

Sci Transl Med. 2015 Jun 17;7(292):292ra99. doi: 10.1126/scitranslmed.aaa5843.

27.

Genetic manipulation of cardiac ageing.

Cannon L, Bodmer R.

J Physiol. 2016 Apr 15;594(8):2075-83. doi: 10.1113/JP270563. Epub 2015 Jul 14. Review.

28.

Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila.

Sen A, Kalvakuri S, Bodmer R, Cox RT.

Dis Model Mech. 2015 Jun;8(6):577-89. doi: 10.1242/dmm.019208. Epub 2015 Apr 20.

29.

Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.

Martínez-Morentin L, Martínez L, Piloto S, Yang H, Schon EA, Garesse R, Bodmer R, Ocorr K, Cervera M, Arredondo JJ.

Hum Mol Genet. 2015 Jul 1;24(13):3608-22. doi: 10.1093/hmg/ddv106. Epub 2015 Mar 19.

30.

PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase.

Diop SB, Bisharat-Kernizan J, Birse RT, Oldham S, Ocorr K, Bodmer R.

Cell Rep. 2015 Mar 4. pii: S2211-1247(15)00168-0. doi: 10.1016/j.celrep.2015.02.022. [Epub ahead of print]

31.

Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.

Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):355-67. doi: 10.1165/rcmb.2014-0235OC.

32.

Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis.

Vogler G, Liu J, Iafe TW, Migh E, Mihály J, Bodmer R.

J Cell Biol. 2014 Sep 29;206(7):909-22. doi: 10.1083/jcb.201405075.

33.

Methods to assess Drosophila heart development, function and aging.

Ocorr K, Vogler G, Bodmer R.

Methods. 2014 Jun 15;68(1):265-72. doi: 10.1016/j.ymeth.2014.03.031. Epub 2014 Apr 12. Review.

34.

Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster.

Reed LK, Lee K, Zhang Z, Rashid L, Poe A, Hsieh B, Deighton N, Glassbrook N, Bodmer R, Gibson G.

Genetics. 2014 Jun;197(2):781-93. doi: 10.1534/genetics.114.163857. Epub 2014 Mar 25.

35.

ROS regulate cardiac function via a distinct paracrine mechanism.

Lim HY, Wang W, Chen J, Ocorr K, Bodmer R.

Cell Rep. 2014 Apr 10;7(1):35-44. doi: 10.1016/j.celrep.2014.02.029. Epub 2014 Mar 20.

36.

Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster.

Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG.

Mol Metab. 2013 Oct 23;3(1):42-54. doi: 10.1016/j.molmet.2013.10.003. eCollection 2014 Feb.

37.

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging.

Nishimura M, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan H, Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen M, Ocorr K.

Aging Cell. 2014 Jun;13(3):431-40. doi: 10.1111/acel.12193. Epub 2014 Jan 9.

38.

Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis.

Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K, Melkani GC.

Rare Dis. 2014 Nov 3;2(1):e968003. doi: 10.4161/2167549X.2014.968003. eCollection 2014.

39.

Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.

Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K.

PLoS Genet. 2013;9(12):e1004024. doi: 10.1371/journal.pgen.1004024. Epub 2013 Dec 19.

40.

Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1.

Kumsta C, Ching TT, Nishimura M, Davis AE, Gelino S, Catan HH, Yu X, Chu CC, Ong B, Panowski SH, Baird N, Bodmer R, Hsu AL, Hansen M.

Aging Cell. 2014 Jun;13(3):419-30. doi: 10.1111/acel.12189. Epub 2014 Jan 9.

41.

The role of pygopus in the differentiation of intracardiac valves in Drosophila.

Tang M, Yuan W, Bodmer R, Wu X, Ocorr K.

Genesis. 2014 Jan;52(1):19-28. doi: 10.1002/dvg.22724. Epub 2013 Nov 21.

42.

Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila.

Taghli-Lamallem O, Jagla K, Chamberlain JS, Bodmer R.

Exp Gerontol. 2014 Jan;49:26-34. doi: 10.1016/j.exger.2013.10.015. Epub 2013 Nov 12.

43.

Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.

Tang M, Yuan W, Fan X, Liu M, Bodmer R, Ocorr K, Wu X.

Circ Cardiovasc Genet. 2013 Oct;6(5):472-80. doi: 10.1161/CIRCGENETICS.113.000253. Epub 2013 Sep 17.

44.

Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen.

Harpaz N, Ordan E, Ocorr K, Bodmer R, Volk T.

PLoS Genet. 2013 Jun;9(6):e1003597. doi: 10.1371/journal.pgen.1003597. Epub 2013 Jun 27.

45.

Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis.

Nirala NK, Rahman M, Walls SM, Singh A, Zhu LJ, Bamba T, Fukusaki E, Srideshikan SM, Harris GL, Ip YT, Bodmer R, Acharya UR.

PLoS Genet. 2013 Jun;9(6):e1003556. doi: 10.1371/journal.pgen.1003556. Epub 2013 Jun 20.

46.

Whole-Genome rVISTA: a tool to determine enrichment of transcription factor binding sites in gene promoters from transcriptomic data.

Dubchak I, Munoz M, Poliakov A, Salomonis N, Minovitsky S, Bodmer R, Zambon AC.

Bioinformatics. 2013 Aug 15;29(16):2059-61. doi: 10.1093/bioinformatics/btt318. Epub 2013 Jun 4.

47.

Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster.

Zhang Z, Hsieh B, Poe A, Anderson J, Ocorr K, Gibson G, Bodmer R.

PLoS One. 2013 Apr 29;8(4):e62909. doi: 10.1371/journal.pone.0062909. Print 2013.

48.

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.

Rahman MM, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D.

Aging Cell. 2013 Aug;12(4):554-62. doi: 10.1111/acel.12078. Epub 2013 May 16.

49.

A Drosophila model of high sugar diet-induced cardiomyopathy.

Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R.

PLoS Genet. 2013;9(1):e1003175. doi: 10.1371/journal.pgen.1003175. Epub 2013 Jan 10.

50.

APJ acts as a dual receptor in cardiac hypertrophy.

Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P.

Nature. 2012 Aug 16;488(7411):394-8. doi: 10.1038/nature11263.

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