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Items: 1 to 50 of 340

1.

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.

Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P.

Sci Rep. 2018 Jul 16;8(1):10705. doi: 10.1038/s41598-018-29058-6.

2.

The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction.

Bode MF, Auriemma AC, Grover SP, Hisada Y, Rennie A, Bode WD, Vora R, Subramaniam S, Cooley B, Andrade-Gordon P, Antoniak S, Mackman N.

Thromb Res. 2018 Jul;167:128-134. doi: 10.1016/j.thromres.2018.05.015. Epub 2018 May 17.

PMID:
29843086
3.

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.

Debela M, Magdolen V, Bode W, Brandstetter H, Goettig P.

Biol Chem. 2016 Dec 1;397(12):1251-1264. doi: 10.1515/hsz-2016-0205.

4.

Prominent R wave in ECG lead V1 predicts improvement of left ventricular ejection fraction after cardiac resynchronization therapy in patients with or without left bundle branch block.

Bode WD, Bode MF, Gettes L, Jensen BC, Mounsey JP, Chung EH.

Heart Rhythm. 2015 Oct;12(10):2141-7. doi: 10.1016/j.hrthm.2015.06.001. Epub 2015 Jun 3.

PMID:
26048194
5.

Left atrial appendage occlusion for prevention of stroke in nonvalvular atrial fibrillation: a meta-analysis.

Bode WD, Patel N, Gehi AK.

J Interv Card Electrophysiol. 2015 Jun;43(1):79-89. doi: 10.1007/s10840-015-9988-1. Epub 2015 Feb 25.

PMID:
25711953
6.

Current approaches to antiarrhythmic therapy in heart failure.

Rose-Jones LJ, Bode WD, Gehi AK.

Heart Fail Clin. 2014 Oct;10(4):635-52. doi: 10.1016/j.hfc.2014.07.010. Epub 2014 Aug 14. Review.

PMID:
25217438
7.

Simvastatin effects on skeletal muscle: study design and validity.

Bode WD, Simpson RJ Jr.

J Am Coll Cardiol. 2013 Jun 11;61(23):2392-3. doi: 10.1016/j.jacc.2013.02.038. Epub 2013 Mar 22. No abstract available.

8.

[A woman with an ulcer of the leg].

Schol-Gelok S, Bode WA.

Ned Tijdschr Geneeskd. 2012;156(43):A4129. Dutch.

PMID:
23095477
9.

Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane.

Arolas JL, Broder C, Jefferson T, Guevara T, Sterchi EE, Bode W, Stöcker W, Becker-Pauly C, Gomis-Rüth FX.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16131-6. doi: 10.1073/pnas.1211076109. Epub 2012 Sep 17.

10.

Predictors for neoplastic progression in patients with Barrett's Esophagus: a prospective cohort study.

Sikkema M, Looman CW, Steyerberg EW, Kerkhof M, Kastelein F, van Dekken H, van Vuuren AJ, Bode WA, van der Valk H, Ouwendijk RJ, Giard R, Lesterhuis W, Heinhuis R, Klinkenberg EC, Meijer GA, ter Borg F, Arends JW, Kolkman JJ, van Baarlen J, de Vries RA, Mulder AH, van Tilburg AJ, Offerhaus GJ, ten Kate FJ, Kusters JG, Kuipers EJ, Siersema PD.

Am J Gastroenterol. 2011 Jul;106(7):1231-8. doi: 10.1038/ajg.2011.153. Epub 2011 May 17.

PMID:
21577245
11.

A standard orientation for metallopeptidases.

Gomis-Rüth FX, Botelho TO, Bode W.

Biochim Biophys Acta. 2012 Jan;1824(1):157-63. doi: 10.1016/j.bbapap.2011.04.014. Epub 2011 Apr 30. Review.

12.

The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions.

Tochowicz A, Goettig P, Evans R, Visse R, Shitomi Y, Palmisano R, Ito N, Richter K, Maskos K, Franke D, Svergun D, Nagase H, Bode W, Itoh Y.

J Biol Chem. 2011 Mar 4;286(9):7587-600. doi: 10.1074/jbc.M110.178434. Epub 2010 Dec 30.

13.

Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.

Wisniewska M, Goettig P, Maskos K, Belouski E, Winters D, Hecht R, Black R, Bode W.

J Mol Biol. 2008 Sep 19;381(5):1307-19. doi: 10.1016/j.jmb.2008.06.088. Epub 2008 Jul 7.

PMID:
18638486
14.

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P.

Biol Chem. 2008 Jun;389(6):623-32. doi: 10.1515/BC.2008.075. Review.

PMID:
18627343
15.

Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).

Pallarès I, Fernández D, Comellas-Bigler M, Fernández-Recio J, Ventura S, Avilés FX, Bode W, Vendrell J.

Acta Crystallogr D Biol Crystallogr. 2008 Jul;D64(Pt 7):784-91. doi: 10.1107/S0907444908013474. Epub 2008 Jun 18.

PMID:
18566513
16.

A pro-inflammatory genotype predisposes to Barrett's esophagus.

Moons LM, Kusters JG, van Delft JH, Kuipers EJ, Gottschalk R, Geldof H, Bode WA, Stoof J, van Vliet AH, Ketelslegers HB, Kleinjans JC, Siersema PD.

Carcinogenesis. 2008 May;29(5):926-31. doi: 10.1093/carcin/bgm241. Epub 2008 Jan 12.

PMID:
18192685
17.

The role of endorectal ultrasound in therapeutic decision-making for local vs. transabdominal resection of rectal tumors.

Doornebosch PG, Bronkhorst PJ, Hop WC, Bode WA, Sing AK, de Graaf EJ.

Dis Colon Rectum. 2008 Jan;51(1):38-42. Epub 2007 Nov 21.

PMID:
18038181
18.

Macrocyclic statine-based inhibitors of BACE-1.

Barazza A, Götz M, Cadamuro SA, Goettig P, Willem M, Steuber H, Kohler T, Jestel A, Reinemer P, Renner C, Bode W, Moroder L.

Chembiochem. 2007 Nov 23;8(17):2078-91.

PMID:
17963207
19.

Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue.

Friedrich R, Riester D, Göttig P, Thürk M, Schwienhorst A, Bode W.

Eur J Med Chem. 2008 Jun;43(6):1330-5. Epub 2007 Sep 9.

PMID:
17950494
20.

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.

Debela M, Hess P, Magdolen V, Schechter NM, Steiner T, Huber R, Bode W, Goettig P.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16086-91. Epub 2007 Oct 1.

21.

Structural basis of the zinc inhibition of human tissue kallikrein 5.

Debela M, Goettig P, Magdolen V, Huber R, Schechter NM, Bode W.

J Mol Biol. 2007 Nov 2;373(4):1017-31. Epub 2007 Aug 24.

PMID:
17881000
22.

Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.

Tochowicz A, Maskos K, Huber R, Oltenfreiter R, Dive V, Yiotakis A, Zanda M, Pourmotabbed T, Bode W, Goettig P.

J Mol Biol. 2007 Aug 24;371(4):989-1006. Epub 2007 May 31. Erratum in: J Mol Biol. 2009 May 15;388(4):917-8. Pourmotabbed, Tayebeh [added].

PMID:
17599356
23.

COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma.

Moons LM, Kuipers EJ, Rygiel AM, Groothuismink AZ, Geldof H, Bode WA, Krishnadath KK, Bergman JJ, van Vliet AH, Siersema PD, Kusters JG.

Am J Gastroenterol. 2007 Nov;102(11):2373-9. Epub 2007 Jun 20.

PMID:
17581270
24.

Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2.

Maskos K, Lang R, Tschesche H, Bode W.

J Mol Biol. 2007 Mar 2;366(4):1222-31. Epub 2006 Dec 1.

PMID:
17196980
25.

Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.

Keil C, Maskos K, Than M, Hoopes JT, Huber R, Tan F, Deddish PA, Erdös EG, Skidgel RA, Bode W.

J Mol Biol. 2007 Feb 16;366(2):504-16. Epub 2006 Nov 11.

PMID:
17157876
26.

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.

Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P.

J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3.

PMID:
16950394
27.

Pore-forming scissors? A first structural glimpse of gamma-secretase.

Steiner H, Than M, Bode W, Haass C.

Trends Biochem Sci. 2006 Sep;31(9):491-3. Epub 2006 Aug 4.

PMID:
16890442
28.

Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase.

Steinmetzer T, Schweinitz A, Stürzebecher A, Dönnecke D, Uhland K, Schuster O, Steinmetzer P, Müller F, Friedrich R, Than ME, Bode W, Stürzebecher J.

J Med Chem. 2006 Jul 13;49(14):4116-26.

PMID:
16821772
29.

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences.

Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, Goettig P.

J Biol Chem. 2006 Sep 1;281(35):25678-88. Epub 2006 Jun 1.

30.

The structure of thrombin: a janus-headed proteinase.

Bode W.

Semin Thromb Hemost. 2006 Apr;32 Suppl 1:16-31. Review.

PMID:
16673263
31.

Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR).

Beaufort N, Debela M, Creutzburg S, Kellermann J, Bode W, Schmitt M, Pidard D, Magdolen V.

Biol Chem. 2006 Feb;387(2):217-22.

PMID:
16497155
32.

Structure and interaction modes of thrombin.

Bode W.

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):122-30. Epub 2006 Feb 15. Review.

PMID:
16480903
33.

X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.

Rohr KB, Selwood T, Marquardt U, Huber R, Schechter NM, Bode W, Than ME.

J Mol Biol. 2006 Mar 17;357(1):195-209. Epub 2005 Dec 28.

PMID:
16414069
34.

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

Engel M, Hoffmann T, Manhart S, Heiser U, Chambre S, Huber R, Demuth HU, Bode W.

J Mol Biol. 2006 Jan 27;355(4):768-83. Epub 2005 Nov 22.

PMID:
16330047
35.

Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors.

Bayés A, Comellas-Bigler M, Rodríguez de la Vega M, Maskos K, Bode W, Aviles FX, Jongsma MA, Beekwilder J, Vendrell J.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16602-7. Epub 2005 Oct 31.

36.

Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions.

Panizzi P, Friedrich R, Fuentes-Prior P, Kroh HK, Briggs J, Tans G, Bode W, Bock PE.

J Biol Chem. 2006 Jan 13;281(2):1169-78. Epub 2005 Oct 17.

37.

Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes.

Panizzi P, Friedrich R, Fuentes-Prior P, Richter K, Bock PE, Bode W.

J Biol Chem. 2006 Jan 13;281(2):1179-87. Epub 2005 Oct 17.

38.

Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation.

Friedrich R, Panizzi P, Kawabata S, Bode W, Bock PE, Fuentes-Prior P.

J Biol Chem. 2006 Jan 13;281(2):1188-95. Epub 2005 Oct 17.

39.

The NC1 dimer of human placental basement membrane collagen IV: does a covalent crosslink exist?

Than ME, Bourenkov GP, Henrich S, Mann K, Bode W.

Biol Chem. 2005 Aug;386(8):759-66.

PMID:
16201871
40.

Mutations of the PC2 substrate binding pocket alter enzyme specificity.

Kacprzak MM, Than ME, Juliano L, Juliano MA, Bode W, Lindberg I.

J Biol Chem. 2005 Sep 9;280(36):31850-8. Epub 2005 Jul 7.

41.

Thrombin inhibitors identified by computer-assisted multiparameter design.

Riester D, Wirsching F, Salinas G, Keller M, Gebinoga M, Kamphausen S, Merkwirth C, Goetz R, Wiesenfeldt M, Stürzebecher J, Bode W, Friedrich R, Thürk M, Schwienhorst A.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8597-602. Epub 2005 Jun 3.

42.

The structure of thrombin, a chameleon-like proteinase.

Bode W.

J Thromb Haemost. 2005 Nov;3(11):2379-88. Epub 2005 May 9. Review. No abstract available.

43.

Crystal structure of the E. coli dipeptidyl carboxypeptidase Dcp: further indication of a ligand-dependent hinge movement mechanism.

Comellas-Bigler M, Lang R, Bode W, Maskos K.

J Mol Biol. 2005 May 27;349(1):99-112. Epub 2005 Mar 25.

PMID:
15876371
44.

The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1 specificity pocket.

Than ME, Henrich S, Bourenkov GP, Bartunik HD, Huber R, Bode W.

Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):505-12. Epub 2005 Apr 20.

PMID:
15858259
45.

Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits.

Geerts H, Guillaumat PO, Grantham C, Bode W, Anciaux K, Sachak S.

Brain Res. 2005 Feb 8;1033(2):186-93.

PMID:
15694923
46.

X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.

Jozic D, Bourenkov G, Lim NH, Visse R, Nagase H, Bode W, Maskos K.

J Biol Chem. 2005 Mar 11;280(10):9578-85. Epub 2004 Dec 15.

47.

Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity.

Henrich S, Lindberg I, Bode W, Than ME.

J Mol Biol. 2005 Jan 14;345(2):211-27.

PMID:
15571716
48.

The staphylocoagulase family of zymogen activator and adhesion proteins.

Panizzi P, Friedrich R, Fuentes-Prior P, Bode W, Bock PE.

Cell Mol Life Sci. 2004 Nov;61(22):2793-8.

49.

Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP.

Keil C, Huber R, Bode W, Than ME.

Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1614-7. Epub 2004 Aug 26.

PMID:
15333934
50.

1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase.

Comellas-Bigler M, Maskos K, Huber R, Oyama H, Oda K, Bode W.

Structure. 2004 Jul;12(7):1313-23.

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