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Items: 1 to 50 of 73

1.

Non-invasive Imaging and Modeling of Liver Regeneration After Partial Hepatectomy.

Zafarnia S, Mrugalla A, Rix A, Doleschel D, Gremse F, Wolf SD, Buyel JF, Albrecht U, Bode JG, Kiessling F, Lederle W.

Front Physiol. 2019 Jul 17;10:904. doi: 10.3389/fphys.2019.00904. eCollection 2019.

2.

Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide.

Ehlting C, Rex J, Albrecht U, Deenen R, Tiedje C, Köhrer K, Sawodny O, Gaestel M, Häussinger D, Bode JG.

Sci Rep. 2019 Jul 30;9(1):11021. doi: 10.1038/s41598-019-46791-8.

3.

Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver.

Qvartskhava N, Jin CJ, Buschmann T, Albrecht U, Bode JG, Monhasery N, Oenarto J, Bidmon HJ, Görg B, Häussinger D.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6313-6318. doi: 10.1073/pnas.1813100116. Epub 2019 Mar 12.

4.

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication.

Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D.

J Biol Chem. 2019 May 3;294(18):7388-7402. doi: 10.1074/jbc.RA119.007656. Epub 2019 Mar 12.

PMID:
30862675
5.

IL-1β and TNFα Differentially Influence NF-κB Activity and FasL-Induced Apoptosis in Primary Murine Hepatocytes During LPS-Induced Inflammation.

Rex J, Lutz A, Faletti LE, Albrecht U, Thomas M, Bode JG, Borner C, Sawodny O, Merfort I.

Front Physiol. 2019 Feb 20;10:117. doi: 10.3389/fphys.2019.00117. eCollection 2019.

6.

HCV modifies EGF signalling and upregulates production of CXCR2 ligands: Role in inflammation and antiviral immune response.

Groepper C, Rufinatscha K, Schröder N, Stindt S, Ehlting C, Albrecht U, Bock HH, Bartenschlager R, Häussinger D, Bode JG.

J Hepatol. 2018 Sep;69(3):594-602. doi: 10.1016/j.jhep.2018.04.005. Epub 2018 Apr 27.

PMID:
29705238
7.

Reprogramming of pro-inflammatory human macrophages to an anti-inflammatory phenotype by bile acids.

Wammers M, Schupp AK, Bode JG, Ehlting C, Wolf S, Deenen R, Köhrer K, Häussinger D, Graf D.

Sci Rep. 2018 Jan 10;8(1):255. doi: 10.1038/s41598-017-18305-x.

8.

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.

Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.

Front Physiol. 2017 Oct 9;8:775. doi: 10.3389/fphys.2017.00775. eCollection 2017.

9.

BMP-9 interferes with liver regeneration and promotes liver fibrosis.

Breitkopf-Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, Wiercinska E, Cai C, Li Q, Wan F, Hellerbrand C, Valous NA, Hahnel M, Ehlting C, Bode JG, Müller-Bohl S, Klingmüller U, Altenöder J, Ilkavets I, Goumans MJ, Hawinkels LJ, Lee SJ, Wieland M, Mogler C, Ebert MP, Herrera B, Augustin H, Sánchez A, Dooley S, Ten Dijke P.

Gut. 2017 May;66(5):939-954. doi: 10.1136/gutjnl-2016-313314. Epub 2017 Mar 23.

PMID:
28336518
10.

IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.

Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmüller U, Häussinger D, Timmer J, Bode JG.

J Biol Chem. 2017 Apr 14;292(15):6291-6302. doi: 10.1074/jbc.M117.775023. Epub 2017 Feb 21.

11.

Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction.

Beuke K, Schildberg FA, Pinna F, Albrecht U, Liebe R, Bissinger M, Schirmacher P, Dooley S, Bode JG, Knolle PA, Kummer U, Breuhahn K, Sahle S.

FEBS J. 2017 Mar;284(5):796-813. doi: 10.1111/febs.14022. Epub 2017 Feb 17.

12.

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;39(4):1271-80. doi: 10.1159/000447832. Epub 2016 Sep 8.

13.

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.

Rex J, Albrecht U, Ehlting C, Thomas M, Zanger UM, Sawodny O, Häussinger D, Ederer M, Feuer R, Bode JG.

PLoS Comput Biol. 2016 Jul 27;12(7):e1005018. doi: 10.1371/journal.pcbi.1005018. eCollection 2016 Jul.

14.

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.

Stindt S, Cebula P, Albrecht U, Keitel V, Schulte am Esch J, Knoefel WT, Bartenschlager R, Häussinger D, Bode JG.

PLoS One. 2016 Feb 17;11(2):e0148711. doi: 10.1371/journal.pone.0148711. eCollection 2016.

15.

Modeling the LPS-induced effects on transcription factor activation and gene expression in murine macrophages.

Sanwald J, Albrecht U, Wagenpfeil J, Thomas M, Sawodny O, Bode JG, Feuer R.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:3989-92. doi: 10.1109/EMBC.2015.7319268.

PMID:
26737168
16.

MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections.

Ehlting C, Trilling M, Tiedje C, Le-Trilling VTK, Albrecht U, Kluge S, Zimmermann A, Graf D, Gaestel M, Hengel H, Häussinger D, Bode JG.

J Hepatol. 2016 Feb;64(2):380-389. doi: 10.1016/j.jhep.2015.08.012. Epub 2015 Aug 20.

PMID:
26299622
17.

Reply to Letter: "Infusion of CD133+ Bone Marrow-Derived Stem Cell After Selective Portal Vein Embolization Enhances Functional Hepatic Reserves After Extended Right Hepatectomy".

Schulte am Esch J, Schmelzle M, Duhme C, Fuerst G, Robson SC, Bode JG, Krieg A, Topp SA, Haeussinger D, Knoefel WT.

Ann Surg. 2016 Mar;263(3):e44-5. doi: 10.1097/SLA.0000000000000849. No abstract available.

18.

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.

Qvartskhava N, Lang PA, Görg B, Pozdeev VI, Ortiz MP, Lang KS, Bidmon HJ, Lang E, Leibrock CB, Herebian D, Bode JG, Lang F, Häussinger D.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5521-6. doi: 10.1073/pnas.1423968112. Epub 2015 Apr 13.

19.

Severe liver fibrosis caused by Schistosoma mansoni: management and treatment with a transjugular intrahepatic portosystemic shunt.

Richter J, Bode JG, Blondin D, Kircheis G, Kubitz R, Holtfreter MC, Müller-Stöver I, Breuer M, Hüttig F, Antoch G, Häussinger D.

Lancet Infect Dis. 2015 Jun;15(6):731-7. doi: 10.1016/S1473-3099(15)70009-5. Epub 2015 Mar 11. Review.

PMID:
25769268
20.

Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.

Ehlting C, Böhmer O, Hahnel MJ, Thomas M, Zanger UM, Gaestel M, Knoefel WT, Schulte Am Esch J, Häussinger D, Bode JG.

Cell Signal. 2015 Mar;27(3):555-67. doi: 10.1016/j.cellsig.2014.12.016. Epub 2015 Jan 3.

PMID:
25562430
21.

Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy.

Brenndörfer ED, Brass A, Karthe J, Ahlén G, Bode JG, Sällberg M.

J Immunol. 2014 Feb 15;192(4):1671-80. doi: 10.4049/jimmunol.1301077. Epub 2014 Jan 17.

22.

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages.

Haselow K, Bode JG, Wammers M, Ehlting C, Keitel V, Kleinebrecht L, Schupp AK, Häussinger D, Graf D.

J Leukoc Biol. 2013 Dec;94(6):1253-64. doi: 10.1189/jlb.0812396. Epub 2013 Aug 29.

PMID:
23990628
23.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.

24.

[Hepatic cholestasis resulting from a long-standing enterothorax: a case report].

Ambe P, Häussinger D, Schneitler V, Bode JG, Lanzman RS, Knoefel WT, Vallböhmer D.

Z Gastroenterol. 2013 Mar;51(3):287-9. doi: 10.1055/s-0032-1330528. Epub 2013 Mar 13. German.

PMID:
23487357
25.

[Colonoscopic polypectomy for prevention of colorectal cancer. Follow-up investigation of the National Polyp Study].

Bode JG, Nitschmann S.

Internist (Berl). 2013 Feb;54(2):263-4. doi: 10.1007/s00108-012-3207-2. German. No abstract available.

PMID:
23325120
26.

The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis.

Bode JG, Ehlting C, Häussinger D.

Cell Signal. 2012 Jun;24(6):1185-94. doi: 10.1016/j.cellsig.2012.01.018. Epub 2012 Feb 4. Review.

PMID:
22330073
27.

Infusion of CD133+ bone marrow-derived stem cells after selective portal vein embolization enhances functional hepatic reserves after extended right hepatectomy: a retrospective single-center study.

am Esch JS, Schmelzle M, Fürst G, Robson SC, Krieg A, Duhme C, Tustas RY, Alexander A, Klein HM, Topp SA, Bode JG, Häussinger D, Eisenberger CF, Knoefel WT.

Ann Surg. 2012 Jan;255(1):79-85. doi: 10.1097/SLA.0b013e31823d7d08.

PMID:
22156926
28.

Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling.

Bode JG, Albrecht U, Häussinger D, Heinrich PC, Schaper F.

Eur J Cell Biol. 2012 Jun-Jul;91(6-7):496-505. doi: 10.1016/j.ejcb.2011.09.008. Epub 2011 Nov 16. Review.

PMID:
22093287
29.

Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor.

Dittrich A, Khouri C, Sackett SD, Ehlting C, Böhmer O, Albrecht U, Bode JG, Trautwein C, Schaper F.

Hepatology. 2012 Jan;55(1):256-66. doi: 10.1002/hep.24655.

PMID:
21898505
30.

Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production.

Brenndörfer ED, Brass A, Söderholm J, Frelin L, Aleman S, Bode JG, Sällberg M.

Gut. 2012 Apr;61(4):589-96. doi: 10.1136/gut.2010.232116. Epub 2011 Aug 3.

PMID:
21813471
31.

Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.

Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG.

J Biol Chem. 2011 Jul 8;286(27):24113-24. doi: 10.1074/jbc.M111.235275. Epub 2011 May 17.

32.

c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: a prerequisite for replication.

Pfannkuche A, Büther K, Karthe J, Poenisch M, Bartenschlager R, Trilling M, Hengel H, Willbold D, Häussinger D, Bode JG.

Hepatology. 2011 Apr;53(4):1127-36. doi: 10.1002/hep.24214.

PMID:
21480319
33.

Inhibition of interferon-α-induced signaling by hyperosmolarity and hydrophobic bile acids.

Graf D, Haselow K, Münks I, Bode JG, Häussinger D.

Biol Chem. 2010 Oct;391(10):1175-87. doi: 10.1515/BC.2010.108.

PMID:
21028968
34.

Anti-tumor necrosis factor α treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C.

Brenndörfer ED, Weiland M, Frelin L, Derk E, Ahlén G, Jiao J, Bode JG, Sällberg M.

Hepatology. 2010 Nov;52(5):1553-63. doi: 10.1002/hep.23870.

PMID:
20886569
35.
36.

Genome-wide comparison between IL-17 and combined TNF-alpha/IL-17 induced genes in primary murine hepatocytes.

Sparna T, Rétey J, Schmich K, Albrecht U, Naumann K, Gretz N, Fischer HP, Bode JG, Merfort I.

BMC Genomics. 2010 Apr 7;11:226. doi: 10.1186/1471-2164-11-226.

37.

Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.

Radtke S, Wüller S, Yang XP, Lippok BE, Mütze B, Mais C, de Leur HS, Bode JG, Gaestel M, Heinrich PC, Behrmann I, Schaper F, Hermanns HM.

J Cell Sci. 2010 Mar 15;123(Pt 6):947-59. doi: 10.1242/jcs.065326.

38.

Diagnostic and prognostic values of critical flicker frequency determination as new diagnostic tool for objective HE evaluation in patients undergoing TIPS implantation.

Kircheis G, Bode JG, Hilger N, Kramer T, Schnitzler A, Häussinger D.

Eur J Gastroenterol Hepatol. 2009 Dec;21(12):1383-94. doi: 10.1097/MEG.0b013e328310e0c3.

PMID:
19738480
39.

Interplay between host cell and hepatitis C virus in regulating viral replication.

Bode JG, Brenndörfer ED, Karthe J, Häussinger D.

Biol Chem. 2009 Oct;390(10):1013-32. doi: 10.1515/BC.2009.118. Review.

PMID:
19642875
40.

Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphatase.

Brenndörfer ED, Karthe J, Frelin L, Cebula P, Erhardt A, Schulte am Esch J, Hengel H, Bartenschlager R, Sällberg M, Häussinger D, Bode JG.

Hepatology. 2009 Jun;49(6):1810-20. doi: 10.1002/hep.22857.

PMID:
19475692
41.

Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.

Pauli EK, Schmolke M, Wolff T, Viemann D, Roth J, Bode JG, Ludwig S.

PLoS Pathog. 2008 Nov;4(11):e1000196. doi: 10.1371/journal.ppat.1000196. Epub 2008 Nov 7.

42.

Hepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response.

Bode JG, Brenndörfer ED, Häussinger D.

Biol Chem. 2008 Oct;389(10):1283-98. doi: 10.1515/BC.2008.147. Review.

PMID:
18713016
43.

Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130.

Graf D, Haselow K, Münks I, Bode JG, Häussinger D.

Arch Biochem Biophys. 2008 Sep 15;477(2):330-8. doi: 10.1016/j.abb.2008.06.009. Epub 2008 Jun 19.

PMID:
18593565
44.

Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene.

Albrecht U, Yang X, Asselta R, Keitel V, Tenchini ML, Ludwig S, Heinrich PC, Häussinger D, Schaper F, Bode JG.

Cell Signal. 2007 Sep;19(9):1866-78. Epub 2007 May 1.

PMID:
17543500
45.

Caspases and receptor cleavage.

Graf D, Bode JG, Häussinger D.

Arch Biochem Biophys. 2007 Jun 15;462(2):162-70. Epub 2007 Apr 10. Review.

PMID:
17482137
46.

Subversion of innate host antiviral strategies by the hepatitis C virus.

Bode JG, Brenndörfer ED, Häussinger D.

Arch Biochem Biophys. 2007 Jun 15;462(2):254-65. Epub 2007 Apr 16. Review.

PMID:
17467654
47.

Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade.

Ehlting C, Lai WS, Schaper F, Brenndörfer ED, Matthes RJ, Heinrich PC, Ludwig S, Blackshear PJ, Gaestel M, Häussinger D, Bode JG.

J Immunol. 2007 Mar 1;178(5):2813-26.

48.

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.

Ehrhardt C, Wolff T, Pleschka S, Planz O, Beermann W, Bode JG, Schmolke M, Ludwig S.

J Virol. 2007 Apr;81(7):3058-67. Epub 2007 Jan 17.

49.

Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver.

Graf D, Kohlmann C, Haselow K, Gehrmann T, Bode JG, Häussinger D.

Hepatology. 2006 Nov;44(5):1206-17.

PMID:
17058237
50.

Predictors of short-term success of antiretroviral therapy in HIV infection.

Oette M, Kroidl A, Göbels K, Stabbert A, Menge M, Sagir A, Kuschak D, O'hanley T, Bode JG, Häussinger D.

J Antimicrob Chemother. 2006 Jul;58(1):147-53. Epub 2006 May 10.

PMID:
16687458

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