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Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells.

Ma C, Zu X, Liu K, Bode AM, Dong Z, Liu Z, Kim DJ.

Mol Cells. 2019 Sep 30;42(9):628-636. doi: 10.14348/molcells.2019.0038.


Fluvastatin inhibits HMG-CoA reductase and prevents non-small cell lung carcinogenesis.

Zhang T, Bai R, Wang Q, Wang K, Li X, Liu K, Ryu J, Wang T, Chang X, Ma W, Bode AM, Xia Q, Song Y, Dong Z.

Cancer Prev Res (Phila). 2019 Sep 25. pii: canprevres.0211.2019. doi: 10.1158/1940-6207.CAPR-19-0211. [Epub ahead of print]


Scutellarin suppresses patient-derived xenograft tumor growth by directly targeting AKT in esophageal squamous cell carcinoma.

Liu F, Zu X, Xie X, Zhang Y, Liu K, Chen H, Wang T, Bode AM, Dong Z, Kim DJ.

Cancer Prev Res (Phila). 2019 Sep 25. pii: canprevres.0244.2019. doi: 10.1158/1940-6207.CAPR-19-0244. [Epub ahead of print]


The Role of Deubiquitinases in Oncovirus and Host Interactions.

Li Y, Shi F, Hu J, Xie L, Bode AM, Cao Y.

J Oncol. 2019 Jul 18;2019:2128410. doi: 10.1155/2019/2128410. eCollection 2019. Review.


Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer.

Cheng C, Zhuo S, Zhang B, Zhao X, Liu Y, Liao C, Quan J, Li Z, Bode AM, Cao Y, Luo X.

Int J Biol Sci. 2019 Jun 4;15(8):1654-1663. doi: 10.7150/ijbs.33837. eCollection 2019. Review.


CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction.

Yeung YT, Fan S, Lu B, Yin S, Yang S, Nie W, Wang M, Zhou L, Li T, Li X, Bode AM, Dong Z.

Carcinogenesis. 2019 Jun 25. pii: bgz113. doi: 10.1093/carcin/bgz113. [Epub ahead of print]


Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells.

Zu X, Xie X, Zhang Y, Liu K, Bode AM, Dong Z, Kim DJ.

Phytother Res. 2019 Sep;33(9):2337-2346. doi: 10.1002/ptr.6415. Epub 2019 Jun 21.


EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter.

Shi F, Zhou M, Shang L, Du Q, Li Y, Xie L, Liu X, Tang M, Luo X, Fan J, Zhou J, Gao Q, Qiu S, Wu W, Zhang X, Bode AM, Cao Y.

Theranostics. 2019 Apr 13;9(9):2424-2438. doi: 10.7150/thno.30941. eCollection 2019.


Purpurogallin is a novel mitogen-activated protein kinase kinase 1/2 inhibitor that suppresses esophageal squamous cell carcinoma growth in vitro and in vivo.

Xie X, Zu X, Liu F, Wang T, Wang X, Chen H, Liu K, Wang P, Liu F, Zheng Y, Bode AM, Dong Z, Kim DJ.

Mol Carcinog. 2019 Jul;58(7):1248-1259. doi: 10.1002/mc.23007. Epub 2019 May 17.


Inhibition of LTA4H by bestatin in human and mouse colorectal cancer.

Zhao S, Yao K, Li D, Liu K, Jin G, Yan M, Wu Q, Chen H, Shin SH, Bai R, Wang G, Bode AM, Dong Z, Guo Z, Dong Z.

EBioMedicine. 2019 Jun;44:361-374. doi: 10.1016/j.ebiom.2019.05.008. Epub 2019 May 10.


Cell growth inhibition by 3-deoxysappanchalcone is mediated by directly targeting the TOPK signaling pathway in colon cancer.

Zhao R, Huang H, Choi BY, Liu X, Zhang M, Zhou S, Song M, Yin F, Chen H, Shim JH, Bode AM, Dong Z, Lee MH.

Phytomedicine. 2019 Aug;61:152813. doi: 10.1016/j.phymed.2018.12.036. Epub 2018 Dec 31.


Analysis of hydrophobic and hydrophilic moments of short penetrating peptides for enhancing mitochondrial localization: prediction and validation.

Pirisinu M, Blasco P, Tian X, Sen Y, Bode AM, Liu K, Dong Z.

FASEB J. 2019 Jul;33(7):7970-7984. doi: 10.1096/fj.201802748RR. Epub 2019 Mar 27.


The PGC-1/ERR network and its role in precision oncology.

De Vitto H, Bode AM, Dong Z.

NPJ Precis Oncol. 2019 Mar 21;3:9. doi: 10.1038/s41698-019-0081-6. eCollection 2019. Review.


CRISPR/Cas9 - An evolving biological tool kit for cancer biology and oncology.

Tian X, Gu T, Patel S, Bode AM, Lee MH, Dong Z.

NPJ Precis Oncol. 2019 Mar 18;3:8. doi: 10.1038/s41698-019-0080-7. eCollection 2019. Review.


Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo.

Liu X, Song M, Wang P, Zhao R, Chen H, Zhang M, Shi Y, Liu K, Liu F, Yang R, Li E, Bode AM, Dong Z, Lee MH.

Int J Cancer. 2019 Aug 15;145(4):1007-1019. doi: 10.1002/ijc.32285. Epub 2019 Apr 3.


Posttranslational regulation of PGC-1α and its implication in cancer metabolism.

Luo X, Liao C, Quan J, Cheng C, Zhao X, Bode AM, Cao Y.

Int J Cancer. 2019 Sep 15;145(6):1475-1483. doi: 10.1002/ijc.32253. Epub 2019 Mar 26. Review.


AKT as a Therapeutic Target for Cancer.

Song M, Bode AM, Dong Z, Lee MH.

Cancer Res. 2019 Mar 15;79(6):1019-1031. doi: 10.1158/0008-5472.CAN-18-2738. Epub 2019 Feb 26. Review.


Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma.

Zhao Z, Jin G, Yao K, Liu K, Liu F, Chen H, Wang K, Gorja DR, Reddy K, Bode AM, Guo Z, Dong Z.

Mol Carcinog. 2019 Jun;58(6):1056-1067. doi: 10.1002/mc.22993. Epub 2019 Mar 1.


3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.

Tian X, Liu K, Zu X, Ma F, Li Z, Lee M, Chen H, Li Y, Zhao Y, Liu F, Oi N, Bode AM, Dong Z, Kim DJ.

Cancer Lett. 2019 Apr 28;448:20-30. doi: 10.1016/j.canlet.2019.01.031. Epub 2019 Feb 1.


Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2.

Wang L, Wang X, Chen H, Zu X, Ma F, Liu K, Bode AM, Dong Z, Kim DJ.

Phytother Res. 2019 Mar;33(3):640-650. doi: 10.1002/ptr.6253. Epub 2018 Dec 10.


Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth.

Liu F, Zu X, Xie X, Liu K, Chen H, Wang T, Liu F, Bode AM, Zheng Y, Dong Z, Kim DJ.

Mol Carcinog. 2019 Apr;58(4):533-543. doi: 10.1002/mc.22948. Epub 2018 Dec 21.


Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo.

Xie X, Liu K, Liu F, Chen H, Wang X, Zu X, Ma X, Wang T, Wu Q, Zheng Y, Bode AM, Dong Z, Kim DJ.

Cancer Lett. 2019 Feb 1;442:126-136. doi: 10.1016/j.canlet.2018.10.016. Epub 2018 Nov 2.


Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2.

Wang L, Zhang Y, Liu K, Chen H, Yang R, Ma X, Kim HG, Bode AM, Kim DJ, Dong Z.

Oncotarget. 2018 Feb 6;9(76):34200-34212. doi: 10.18632/oncotarget.24409. eCollection 2018 Sep 28.


Mitochondrial network structure homeostasis and cell death.

Xie LL, Shi F, Tan Z, Li Y, Bode AM, Cao Y.

Cancer Sci. 2018 Dec;109(12):3686-3694. doi: 10.1111/cas.13830. Epub 2018 Nov 16. Review.


Recent advances in precision oncology research.

Bode AM, Dong Z.

NPJ Precis Oncol. 2018 Apr 16;2:11. doi: 10.1038/s41698-018-0055-0. eCollection 2018. No abstract available.


Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer.

Li J, He Y, Tan Z, Lu J, Li L, Song X, Shi F, Xie L, You S, Luo X, Li N, Li Y, Liu X, Tang M, Weng X, Yi W, Fan J, Zhou J, Qiang G, Qiu S, Wu W, Bode AM, Cao Y.

Theranostics. 2018 Jul 16;8(15):4050-4061. doi: 10.7150/thno.21524. eCollection 2018.


The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K.

Zhang T, Wang Q, Fredimoses M, Gao G, Wang K, Chen H, Wang T, Oi N, Zykova TA, Reddy K, Yao K, Ma W, Chang X, Lee MH, Rathore MG, Bode AM, Ashida H, Lippman SM, Dong Z.

Cancer Prev Res (Phila). 2018 Oct;11(10):607-620. doi: 10.1158/1940-6207.CAPR-18-0092. Epub 2018 Jul 6.


Targeting PRPK and TOPK for skin cancer prevention and therapy.

Roh E, Lee MH, Zykova TA, Zhu F, Nadas J, Kim HG, Bae KB, Li Y, Cho YY, Curiel-Lewandrowski C, Einspahr J, Dickinson SE, Bode AM, Dong Z.

Oncogene. 2018 Oct;37(42):5633-5647. doi: 10.1038/s41388-018-0350-9. Epub 2018 Jun 14.


Addressing the challenges of applying precision oncology.

Shin SH, Bode AM, Dong Z.

NPJ Precis Oncol. 2017 Sep 4;1(1):28. doi: 10.1038/s41698-017-0032-z. eCollection 2017. Review.


DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma.

Luo X, Hong L, Cheng C, Li N, Zhao X, Shi F, Liu J, Fan J, Zhou J, Bode AM, Cao Y.

Cell Death Dis. 2018 May 23;9(6):619. doi: 10.1038/s41419-018-0662-2.


Therapies based on targeting Epstein-Barr virus lytic replication for EBV-associated malignancies.

Li H, Hu J, Luo X, Bode AM, Dong Z, Cao Y.

Cancer Sci. 2018 Jul;109(7):2101-2108. doi: 10.1111/cas.13634. Epub 2018 Jun 13. Review.


TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis.

Wang Q, Gao G, Zhang T, Yao K, Chen H, Park MH, Yamamoto H, Wang K, Ma W, Malakhova M, Bode AM, Dong Z.

Cancer Res. 2018 Jul 15;78(14):3982-3994. doi: 10.1158/0008-5472.CAN-18-0429. Epub 2018 May 10.


Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy.

Tan Z, Xiao L, Tang M, Bai F, Li J, Li L, Shi F, Li N, Li Y, Du Q, Lu J, Weng X, Yi W, Zhang H, Fan J, Zhou J, Gao Q, Onuchic JN, Bode AM, Luo X, Cao Y.

Theranostics. 2018 Mar 22;8(9):2329-2347. doi: 10.7150/thno.21451. eCollection 2018.


Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell Carcinoma In Vitro and Patient-Derived Xenografts In Vivo.

Song M, Liu X, Liu K, Zhao R, Huang H, Shi Y, Zhang M, Zhou S, Xie H, Chen H, Li Y, Zheng Y, Wu Q, Liu F, Li E, Bode AM, Dong Z, Lee MH.

Mol Cancer Ther. 2018 Jul;17(7):1540-1553. doi: 10.1158/1535-7163.MCT-17-0823. Epub 2018 Apr 25.


RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation.

Yao K, Lee SY, Peng C, Lim DY, Yamamoto H, Ryu J, Lim TG, Chen H, Jin G, Zhao Z, Han Y, Ma WY, Bode AM, Dong Z.

Oncogene. 2018 Jun;37(26):3501-3513. doi: 10.1038/s41388-018-0167-6. Epub 2018 Mar 22.


Targeting PRPK Function Blocks Colon Cancer Metastasis.

Zykova T, Zhu F, Wang L, Li H, Lim DY, Yao K, Roh E, Yoon SP, Kim HG, Bae KB, Wen W, Shin SH, Nadas J, Li Y, Ma W, Bode AM, Dong Z.

Mol Cancer Ther. 2018 May;17(5):1101-1113. doi: 10.1158/1535-7163.MCT-17-0628. Epub 2018 Feb 26.


IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer.

Li JJ, Li R, Wang W, Zhang B, Song X, Zhang C, Gao Y, Liao Q, He Y, You S, Tan Z, Luo X, Li Y, Tang M, Weng X, Yi W, Peng S, Liu S, Tan Y, Bode AM, Cao Y.

Mol Oncol. 2018 May;12(5):602-610. doi: 10.1002/1878-0261.12182. Epub 2018 Mar 25.


Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice.

Blohm-Mangone K, Burkett NB, Tahsin S, Myrdal PB, Aodah A, Ho B, Janda J, McComas M, Saboda K, Roe DJ, Dong Z, Bode AM, Petricoin EF 3rd, Calvert VS, Curiel-Lewandrowski C, Alberts DS, Wondrak GT, Dickinson SE.

Cancer Prev Res (Phila). 2018 May;11(5):265-278. doi: 10.1158/1940-6207.CAPR-17-0349. Epub 2018 Feb 1.


Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization.

Yeung YT, Yin S, Lu B, Fan S, Yang R, Bai R, Zhang C, Bode AM, Liu K, Dong Z.

EBioMedicine. 2018 Feb;28:51-61. doi: 10.1016/j.ebiom.2018.01.017. Epub 2018 Feb 2.


Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination.

Liu X, Li Y, Peng S, Yu X, Li W, Shi F, Luo X, Tang M, Tan Z, Bode AM, Cao Y.

Cell Death Dis. 2018 Jan 19;9(2):53. doi: 10.1038/s41419-017-0081-9.


Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA.

Bai F, Liu K, Li H, Wang J, Zhu J, Hao P, Zhu L, Zhang S, Shan L, Ma W, Bode AM, Zhang W, Li H, Dong Z.

Nucleic Acids Res. 2018 Jan 25;46(2):546-557. doi: 10.1093/nar/gkx1241.


Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light.

Einspahr JG, Curiel-Lewandrowski C, Calvert VS, Stratton SP, Alberts DS, Warneke J, Hu C, Saboda K, Wagener EL, Dickinson S, Dong Z, Bode AM, PetricoinIII EF.

NPJ Precis Oncol. 2017;1. pii: 34. doi: 10.1038/s41698-017-0037-7. Epub 2017 Sep 21.


Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells.

Bae KB, Yu DH, Lee KY, Yao K, Ryu J, Lim DY, Zykova TA, Kim MO, Bode AM, Dong Z.

Stem Cell Reports. 2017 Dec 12;9(6):2050-2064. doi: 10.1016/j.stemcr.2017.10.017. Epub 2017 Nov 16.


RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth.

Yao K, Peng C, Zhang Y, Zykova TA, Lee MH, Lee SY, Rao E, Chen H, Ryu J, Wang L, Zhang Y, Gao G, He W, Ma WY, Liu K, Bode AM, Dong Z, Li B, Dong Z.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12791-12796. doi: 10.1073/pnas.1710756114. Epub 2017 Nov 13.


The CUG-translated WT1, not AUG-WT1, is an oncogene.

Lee KY, Jeon YJ, Kim HG, Ryu J, Lim DY, Jung SK, Yu DH, Chen H, Bode AM, Dong Z.

Carcinogenesis. 2017 Dec 7;38(12):1228-1240. doi: 10.1093/carcin/bgx108.


A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo.

Shin SH, Lim DY, Reddy K, Malakhova M, Liu F, Wang T, Song M, Chen H, Bae KB, Ryu J, Liu K, Lee MH, Bode AM, Dong Z.

EBioMedicine. 2017 Nov;25:22-31. doi: 10.1016/j.ebiom.2017.09.029. Epub 2017 Sep 27.


Herbacetin suppresses cutaneous squamous cell carcinoma and melanoma cell growth by targeting AKT and ODC.

Kim DJ, Lee MH, Liu K, Lim DY, Roh E, Chen H, Kim SH, Shim JH, Kim MO, Li W, Ma F, Fredimoses M, Bode AM, Dong Z.

Carcinogenesis. 2017 Oct 26;38(11):1136-1146. doi: 10.1093/carcin/bgx082.


A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target.

Yan F, Shen N, Pang JX, Zhao N, Zhang YW, Bode AM, Al-Kali A, Litzow MR, Li B, Liu SJ.

Leukemia. 2018 Apr;32(4):865-873. doi: 10.1038/leu.2017.307. Epub 2017 Oct 10.


Lack of chemopreventive efficacy of metformin in rodent models of urinary bladder, head and neck, and colon/intestine cancer.

Thompson MD, Lubet RA, Mccormick DL, Clapper ML, Bode AM, Juliana MM, Moeinpour F, Grubbs CJ.

Oncol Lett. 2017 Sep;14(3):3480-3486. doi: 10.3892/ol.2017.6632. Epub 2017 Jul 20.


APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model.

Jin G, Yao K, Guo Z, Zhao Z, Liu K, Liu F, Chen H, Gorja DR, Reddy K, Bode AM, Dong Z, Dong Z.

Oncotarget. 2017 Jun 16;8(32):53387-53404. doi: 10.18632/oncotarget.18508. eCollection 2017 Aug 8.

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