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Recruitment, loading, and activation of the Smc5-Smc6 SUMO ligase.

Oravcová M, Boddy MN.

Curr Genet. 2019 Jun;65(3):669-676. doi: 10.1007/s00294-018-0922-9. Epub 2019 Jan 2. Review.


Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.

Oravcová M, Gadaleta MC, Nie M, Reubens MC, Limbo O, Russell P, Boddy MN.

Mol Cell Biol. 2019 Jan 3;39(2). pii: e00271-18. doi: 10.1128/MCB.00271-18. Print 2019 Jan 15.


Maternal fetal medicine: recent developments and moving forward.

Lyell DJ, Boddy M, Rode M.

Curr Opin Obstet Gynecol. 2018 Apr;30(2):100-101. doi: 10.1097/GCO.0000000000000447. No abstract available.


The Development of a Provincial Food and Nutrition Strategy through Cross-Sector Collaboration.

Roblin L, Truscott R, Boddy MR.

Can J Diet Pract Res. 2018 Mar 1;79(1):28-34. doi: 10.3148/cjdpr-2017-033. Epub 2018 Feb 1.


The Ontario Food and Nutrition Strategy: identifying indicators of food access and food literacy for early monitoring of the food environment.

Boucher BA, Manafò E, Boddy MR, Roblin L, Truscott R.

Health Promot Chronic Dis Prev Can. 2017 Sep;37(9):313-319. doi: 10.24095/hpcdp.37.9.06. English, French.


SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.

Nie M, Moser BA, Nakamura TM, Boddy MN.

PLoS Genet. 2017 May 5;13(5):e1006776. doi: 10.1371/journal.pgen.1006776. eCollection 2017 May.


Large-Scale Purification of Small Ubiquitin-Like Modifier (SUMO)-Modified Proteins from Schizosaccharomyces pombe.

Nie M, Boddy MN.

Cold Spring Harb Protoc. 2017 Mar 1;2017(3). doi: 10.1101/pdb.prot091603.


Stability of apomorphine in solutions containing selected antioxidant agents.

Ang ZY, Boddy M, Liu Y, Sunderland B.

Drug Des Devel Ther. 2016 Oct 3;10:3253-3265. eCollection 2016.


Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.

Nie M, Arner E, Prudden J, Schaffer L, Head S, Boddy MN.

PLoS Genet. 2016 Jul 11;12(7):e1006165. doi: 10.1371/journal.pgen.1006165. eCollection 2016 Jul.


Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids.

Czarniak P, Boddy M, Sunderland B, Hughes JD.

Drug Des Devel Ther. 2016 Mar 7;10:1029-34. doi: 10.2147/DDDT.S94710. eCollection 2016.


Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability.

Nie M, Boddy MN.

Biomolecules. 2016 Feb 25;6(1):14. doi: 10.3390/biom6010014. Review.


High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M, Vashisht AA, Wohlschlegel JA, Boddy MN.

Sci Rep. 2015 Sep 25;5:14389. doi: 10.1038/srep14389.


Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1SENP1/2.

Nie M, Boddy MN.

J Biol Chem. 2015 Sep 11;290(37):22678-85. doi: 10.1074/jbc.M115.673038. Epub 2015 Jul 28.


A novel histone deacetylase complex in the control of transcription and genome stability.

Zilio N, Codlin S, Vashisht AA, Bitton DA, Head SR, Wohlschlegel JA, Bähler J, Boddy MN.

Mol Cell Biol. 2014 Sep 15;34(18):3500-14. doi: 10.1128/MCB.00519-14. Epub 2014 Jul 7.


RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response.

Groocock LM, Nie M, Prudden J, Moiani D, Wang T, Cheltsov A, Rambo RP, Arvai AS, Hitomi C, Tainer JA, Luger K, Perry JJ, Lazzerini-Denchi E, Boddy MN.

EMBO Rep. 2014 May;15(5):601-8. doi: 10.1002/embr.201338369. Epub 2014 Apr 8.


Match performance and physical capacity of players in the top three competitive standards of English professional soccer.

Bradley PS, Carling C, Gomez Diaz A, Hood P, Barnes C, Ade J, Boddy M, Krustrup P, Mohr M.

Hum Mov Sci. 2013 Aug;32(4):808-21. doi: 10.1016/j.humov.2013.06.002. Epub 2013 Aug 24.


A new versatile system for rapid control of gene expression in the fission yeast Schizosaccharomyces pombe.

Zilio N, Wehrkamp-Richter S, Boddy MN.

Yeast. 2012 Oct;29(10):425-34. doi: 10.1002/yea.2920. Epub 2012 Sep 12. Erratum in: Yeast. 2013 Jul;30(7):291.


Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex.

Wehrkamp-Richter S, Hyppa RW, Prudden J, Smith GR, Boddy MN.

Nucleic Acids Res. 2012 Oct;40(19):9633-46. doi: 10.1093/nar/gks713. Epub 2012 Aug 1.


Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Nie M, Aslanian A, Prudden J, Heideker J, Vashisht AA, Wohlschlegel JA, Yates JR 3rd, Boddy MN.

J Biol Chem. 2012 Aug 24;287(35):29610-9. doi: 10.1074/jbc.M112.379768. Epub 2012 Jun 22.


The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

Groocock LM, Prudden J, Perry JJ, Boddy MN.

Mol Cell Biol. 2012 Jan;32(2):276-87. doi: 10.1128/MCB.06184-11. Epub 2011 Nov 7.


DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.

Prudden J, Perry JJ, Nie M, Vashisht AA, Arvai AS, Hitomi C, Guenther G, Wohlschlegel JA, Tainer JA, Boddy MN.

Mol Cell Biol. 2011 Jun;31(11):2299-310. doi: 10.1128/MCB.05188-11. Epub 2011 Mar 28.


SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.

Heideker J, Prudden J, Perry JJ, Tainer JA, Boddy MN.

PLoS Genet. 2011 Mar;7(3):e1001320. doi: 10.1371/journal.pgen.1001320. Epub 2011 Mar 3.


The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases.

Békés M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen GS.

J Biol Chem. 2011 Mar 25;286(12):10238-47. doi: 10.1074/jbc.M110.205153. Epub 2011 Jan 19.


Molecular mimicry of SUMO promotes DNA repair.

Prudden J, Perry JJ, Arvai AS, Tainer JA, Boddy MN.

Nat Struct Mol Biol. 2009 May;16(5):509-16. doi: 10.1038/nsmb.1582. Epub 2009 Apr 12.


Genome stability roles of SUMO-targeted ubiquitin ligases.

Heideker J, Perry JJ, Boddy MN.

DNA Repair (Amst). 2009 Apr 5;8(4):517-24. doi: 10.1016/j.dnarep.2009.01.010. Epub 2009 Feb 23. Review.


Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively.

Pebernard S, Schaffer L, Campbell D, Head SR, Boddy MN.

EMBO J. 2008 Nov 19;27(22):3011-23. doi: 10.1038/emboj.2008.220. Epub 2008 Oct 16.


Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.

Pebernard S, Perry JJ, Tainer JA, Boddy MN.

Mol Biol Cell. 2008 Oct;19(10):4099-109. doi: 10.1091/mbc.E08-02-0226. Epub 2008 Jul 30.


Bilateral dermoid cysts of the ovary in a pregnant woman: case report and review of the literature.

Walid MS, Boddy MG.

Arch Gynecol Obstet. 2009 Feb;279(2):105-8. doi: 10.1007/s00404-008-0695-3. Epub 2008 May 29. Review.


A SIM-ultaneous role for SUMO and ubiquitin.

Perry JJ, Tainer JA, Boddy MN.

Trends Biochem Sci. 2008 May;33(5):201-8. doi: 10.1016/j.tibs.2008.02.001. Epub 2008 Apr 9. Review.


SUMO-targeted ubiquitin ligases in genome stability.

Prudden J, Pebernard S, Raffa G, Slavin DA, Perry JJ, Tainer JA, McGowan CH, Boddy MN.

EMBO J. 2007 Sep 19;26(18):4089-101. Epub 2007 Aug 30.


SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association.

Raffa GD, Wohlschlegel J, Yates JR 3rd, Boddy MN.

J Biol Chem. 2006 Sep 22;281(38):27973-81. Epub 2006 Jul 31.


The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.

Pebernard S, Wohlschlegel J, McDonald WH, Yates JR 3rd, Boddy MN.

Mol Cell Biol. 2006 Mar;26(5):1617-30. Erratum in: Mol Cell Biol. 2006 Apr;26(8):3336.


Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.

Kai M, Boddy MN, Russell P, Wang TS.

Genes Dev. 2005 Apr 15;19(8):919-32. Epub 2005 Apr 1.


Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.

Pebernard S, McDonald WH, Pavlova Y, Yates JR 3rd, Boddy MN.

Mol Biol Cell. 2004 Nov;15(11):4866-76. Epub 2004 Aug 25.


RNA interference inhibition of Mus81 reduces mitotic recombination in human cells.

Blais V, Gao H, Elwell CA, Boddy MN, Gaillard PH, Russell P, McGowan CH.

Mol Biol Cell. 2004 Feb;15(2):552-62. Epub 2003 Nov 14.


Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.

McDonald WH, Pavlova Y, Yates JR 3rd, Boddy MN.

J Biol Chem. 2003 Nov 14;278(46):45460-7. Epub 2003 Sep 8.


Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60.

Boddy MN, Shanahan P, McDonald WH, Lopez-Girona A, Noguchi E, Yates III JR, Russell P.

Mol Cell Biol. 2003 Aug;23(16):5939-46.


DNA damage checkpoint control of mitosis in fission yeast.

Rhind N, Baber-Furnari BA, Lopez-Girona A, Boddy MN, Brondello JM, Moser B, Shanahan P, Blasina A, McGowan C, Russell P.

Cold Spring Harb Symp Quant Biol. 2000;65:353-9. Review. No abstract available.


Congenital urethral stricture.

Lendvay TS, Smith EA, Kirsch AJ, Boddy M, Dewan P.

J Urol. 2002 Sep;168(3):1156-7. No abstract available.


Plasmodium: assessment of the antimalarial potential of trifluralin and related compounds using a rat model of malaria, Rattus norvegicus.

Dow GS, Armson A, Boddy MR, Itenge T, McCarthy D, Parkin JE, Thompson RC, Reynoldson JA.

Exp Parasitol. 2002 Mar;100(3):155-60.


Human Mus81-associated endonuclease cleaves Holliday junctions in vitro.

Chen XB, Melchionna R, Denis CM, Gaillard PH, Blasina A, Van de Weyer I, Boddy MN, Russell P, Vialard J, McGowan CH.

Mol Cell. 2001 Nov;8(5):1117-27.


DNA replication checkpoint.

Boddy MN, Russell P.

Curr Biol. 2001 Nov 27;11(23):R953-6. No abstract available.


Mus81-Eme1 are essential components of a Holliday junction resolvase.

Boddy MN, Gaillard PH, McDonald WH, Shanahan P, Yates JR 3rd, Russell P.

Cell. 2001 Nov 16;107(4):537-48.


Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1.

Tanaka K, Boddy MN, Chen XB, McGowan CH, Russell P.

Mol Cell Biol. 2001 May;21(10):3398-404.


Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.

Boddy MN, Lopez-Girona A, Shanahan P, Interthal H, Heyer WD, Russell P.

Mol Cell Biol. 2000 Dec;20(23):8758-66.


Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint.

Baber-Furnari BA, Rhind N, Boddy MN, Shanahan P, Lopez-Girona A, Russell P.

Mol Biol Cell. 2000 Jan;11(1):1-11.


DNA replication checkpoint control.

Boddy MN, Russell P.

Front Biosci. 1999 Dec 1;4:D841-8. Review.


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