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Items: 1 to 50 of 53

1.

Whole Genome Sequencing and Metabolomic Study of Cave Streptomyces Isolates ICC1 and ICC4.

Gosse JT, Ghosh S, Sproule A, Overy D, Cheeptham N, Boddy CN.

Front Microbiol. 2019 May 10;10:1020. doi: 10.3389/fmicb.2019.01020. eCollection 2019.

2.

Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.

Huguenin-Dezot N, Alonzo DA, Heberlig GW, Mahesh M, Nguyen DP, Dornan MH, Boddy CN, Schmeing TM, Chin JW.

Nature. 2019 Jan;565(7737):112-117. doi: 10.1038/s41586-018-0781-z. Epub 2018 Dec 12.

PMID:
30542153
3.

Draft Genome Sequence of the Type Strain Streptomyces armeniacus ATCC 15676.

Labana P, Gosse JT, Boddy CN.

Microbiol Resour Announc. 2018 Sep 20;7(11). pii: e01107-18. doi: 10.1128/MRA.01107-18. eCollection 2018 Sep.

4.

Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains.

Heberlig GW, Brown JTC, Simard RD, Wirz M, Zhang W, Wang M, Susser LI, Horsman ME, Boddy CN.

Org Biomol Chem. 2018 Aug 15;16(32):5771-5779. doi: 10.1039/c8ob01512k.

PMID:
30052255
5.

Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide.

Payne SR, Pau DI, Whiting AL, Kim YJ, Pharoah BM, Moi C, Boddy CN, Bernal F.

Cell Chem Biol. 2018 Sep 20;25(9):1059-1066.e4. doi: 10.1016/j.chembiol.2018.05.007. Epub 2018 Jun 7.

PMID:
29887265
6.

Inducible T7 RNA Polymerase-mediated Multigene Expression System, pMGX.

Hassan MI, McSorley FR, Hotta K, Boddy CN.

J Vis Exp. 2017 Jun 27;(124). doi: 10.3791/55187.

PMID:
28715370
7.

Sampling Terrestrial Environments for Bacterial Polyketides.

Hill P, Heberlig GW, Boddy CN.

Molecules. 2017 Apr 29;22(5). pii: E707. doi: 10.3390/molecules22050707. Review.

8.

Natural products: Mapping an amazing thicket.

Horsman ME, Boddy CN.

Nat Chem Biol. 2016 Dec 16;13(1):6-7. doi: 10.1038/nchembio.2265. No abstract available.

PMID:
27984578
9.

Portable, On-Demand Biomolecular Manufacturing.

Pardee K, Slomovic S, Nguyen PQ, Lee JW, Donghia N, Burrill D, Ferrante T, McSorley FR, Furuta Y, Vernet A, Lewandowski M, Boddy CN, Joshi NS, Collins JJ.

Cell. 2016 Sep 22;167(1):248-259.e12. doi: 10.1016/j.cell.2016.09.013.

10.

Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue.

Hassan MI, Lundgren BR, Chaumun M, Whitfield DM, Clark B, Schoenhofen IC, Boddy CN.

Angew Chem Int Ed Engl. 2016 Sep 19;55(39):12018-21. doi: 10.1002/anie.201606006. Epub 2016 Aug 19.

PMID:
27538580
11.

First-in-class small molecule potentiators of cancer virotherapy.

Dornan MH, Krishnan R, Macklin AM, Selman M, El Sayes N, Son HH, Davis C, Chen A, Keillor K, Le PJ, Moi C, Ou P, Pardin C, Canez CR, Le Boeuf F, Bell JC, Smith JC, Diallo JS, Boddy CN.

Sci Rep. 2016 May 26;6:26786. doi: 10.1038/srep26786.

12.

The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways.

Tremblay N, Hill P, Conway KR, Boddy CN.

Methods Mol Biol. 2016;1401:233-52. doi: 10.1007/978-1-4939-3375-4_15.

PMID:
26831712
13.

Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide.

Hari TP, Wilke BI, Davey JA, Boddy CN.

J Org Chem. 2016 Jan 15;81(2):415-23. doi: 10.1021/acs.joc.5b02014. Epub 2015 Dec 29.

PMID:
26675500
14.

Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis.

Argyropoulos P, Bergeret F, Pardin C, Reimer JM, Pinto A, Boddy CN, Schmeing TM.

Biochim Biophys Acta. 2016 Mar;1860(3):486-97. doi: 10.1016/j.bbagen.2015.11.007. Epub 2015 Nov 22.

PMID:
26592346
15.

Thermoplasmonic ssDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy.

Simoncelli S, de Alwis Weerasekera H, Fasciani C, Boddy CN, Aramendia PF, Alarcon EI, Scaiano JC.

J Phys Chem Lett. 2015 Apr 16;6(8):1499-503. doi: 10.1021/acs.jpclett.5b00272. Epub 2015 Apr 8.

PMID:
26263158
16.

Draft Genome Sequence of Streptomyces sp. Strain PBH53, Isolated from an Urban Environment.

Gosse JT, Hill P, Dowd SE, Boddy CN.

Genome Announc. 2015 Jul 30;3(4). pii: e00859-15. doi: 10.1128/genomeA.00859-15.

17.

Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

Horsman ME, Hari TP, Boddy CN.

Nat Prod Rep. 2016 Feb;33(2):183-202. doi: 10.1039/c4np00148f. Review.

PMID:
25642666
18.

Modulation of antifreeze activity and the effect upon post-thaw HepG2 cell viability after cryopreservation.

Capicciotti CJ, Poisson JS, Boddy CN, Ben RN.

Cryobiology. 2015 Apr;70(2):79-89. doi: 10.1016/j.cryobiol.2015.01.002. Epub 2015 Jan 13.

PMID:
25595636
19.

Resorcylic acid lactone biosynthesis relies on a stereotolerant macrocyclizing thioesterase.

Heberlig GW, Wirz M, Wang M, Boddy CN.

Org Lett. 2014 Nov 21;16(22):5858-61. doi: 10.1021/ol502747t. Epub 2014 Nov 5.

PMID:
25372311
20.

An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases.

Hari TP, Labana P, Boileau M, Boddy CN.

Chembiochem. 2014 Dec 15;15(18):2656-61. doi: 10.1002/cbic.201402475. Epub 2014 Oct 29.

PMID:
25354333
21.

Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp.

Jamison MT, Boddy CN, Molinski TF.

J Org Chem. 2014 Nov 7;79(21):9992-7. doi: 10.1021/jo501486p. Epub 2014 Oct 20.

22.

Genetic analysis of the assimilation of C5-dicarboxylic acids in Pseudomonas aeruginosa PAO1.

Lundgren BR, Villegas-Peñaranda LR, Harris JR, Mottern AM, Dunn DM, Boddy CN, Nomura CT.

J Bacteriol. 2014 Jul;196(14):2543-51. doi: 10.1128/JB.01615-14. Epub 2014 May 2.

23.

Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations.

Young J, Stevens DC, Carmichael R, Tan J, Rachid S, Boddy CN, Müller R, Taylor RE.

J Nat Prod. 2013 Dec 27;76(12):2269-76. doi: 10.1021/np400629v. Epub 2013 Dec 3.

PMID:
24298873
24.

Habitat-specific type I polyketide synthases in soils and street sediments.

Hill P, Piel J, Aris-Brosou S, Krištůfek V, Boddy CN, Dijkhuizen L.

J Ind Microbiol Biotechnol. 2014 Jan;41(1):75-85. doi: 10.1007/s10295-013-1362-7. Epub 2013 Nov 16.

PMID:
24241933
25.

Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.

Boddy CN.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):443-50. doi: 10.1007/s10295-013-1368-1. Epub 2013 Oct 31. Review.

PMID:
24174214
26.

The role of transcription in heterologous expression of polyketides in bacterial hosts.

Stevens DC, Hari TP, Boddy CN.

Nat Prod Rep. 2013 Oct 11;30(11):1391-411. doi: 10.1039/c3np70060g. Review.

PMID:
24061690
27.

Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone.

Wyatt MA, Ahilan Y, Argyropoulos P, Boddy CN, Magarvey NA, Harrison PH.

J Antibiot (Tokyo). 2013 Jul;66(7):421-30. doi: 10.1038/ja.2013.48. Epub 2013 Jun 26.

PMID:
23801186
28.

Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli.

Stevens DC, Conway KR, Pearce N, Villegas-Peñaranda LR, Garza AG, Boddy CN.

PLoS One. 2013 May 28;8(5):e64858. doi: 10.1371/journal.pone.0064858. Print 2013.

29.

Gene PA2449 is essential for glycine metabolism and pyocyanin biosynthesis in Pseudomonas aeruginosa PAO1.

Lundgren BR, Thornton W, Dornan MH, Villegas-Peñaranda LR, Boddy CN, Nomura CT.

J Bacteriol. 2013 May;195(9):2087-100. doi: 10.1128/JB.02205-12. Epub 2013 Mar 1.

30.

ClusterMine360: a database of microbial PKS/NRPS biosynthesis.

Conway KR, Boddy CN.

Nucleic Acids Res. 2013 Jan;41(Database issue):D402-7. doi: 10.1093/nar/gks993. Epub 2012 Oct 26.

31.

Non-canonical regioisomerizations and a 'Diels-Alderase' are likely essential in the biosynthesis of spiculoic acid A.

Pinto A, Boddy CN.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5253-6. doi: 10.1016/j.bmcl.2012.06.052. Epub 2012 Jun 23.

PMID:
22801647
32.

6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective.

Pinto A, Wang M, Horsman M, Boddy CN.

Org Lett. 2012 May 4;14(9):2278-81. doi: 10.1021/ol300707j. Epub 2012 Apr 22.

PMID:
22519860
33.

Reinvestigation of coenzyme Q10 isolation from Sporidiobolus johnsonii.

Dixson DD, Boddy CN, Doyle RP.

Chem Biodivers. 2011 Jun;8(6):1033-51. doi: 10.1002/cbdv.201000278.

PMID:
21674778
34.

Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.

Stevens DC, Henry MR, Murphy KA, Boddy CN.

Appl Environ Microbiol. 2010 Apr;76(8):2681-3. doi: 10.1128/AEM.02841-09. Epub 2010 Mar 5.

36.

Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters.

Wang M, Opare P, Boddy CN.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1413-5. doi: 10.1016/j.bmcl.2009.01.040. Epub 2009 Jan 19.

PMID:
19188064
37.
38.

Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains.

Wang M, Boddy CN.

Biochemistry. 2008 Nov 11;47(45):11793-803. doi: 10.1021/bi800963y. Epub 2008 Oct 14.

PMID:
18850723
39.

Orthogonal ligation: a three piece assembly of a PNA-peptide-PNA conjugate.

Burlina F, Dixson DD, Doyle RP, Chassaing G, Boddy CN, Dawson P, Offer J.

Chem Commun (Camb). 2008 Jun 28;(24):2785-7. doi: 10.1039/b801242c. Epub 2008 Apr 14.

PMID:
18688310
40.

A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis.

Zhang W, Wilke BI, Zhan J, Watanabe K, Boddy CN, Tang Y.

J Am Chem Soc. 2007 Aug 1;129(30):9304-5. Epub 2007 Jul 11. No abstract available.

PMID:
17625867
41.

Sialic acid and N-acyl sialic acid analog production by fermentation of metabolically and genetically engineered Escherichia coli.

Lundgren BR, Boddy CN.

Org Biomol Chem. 2007 Jun 21;5(12):1903-9. Epub 2007 May 11.

PMID:
17551639
42.
43.

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang CC, Oguri H, Oikawa H.

Nat Chem Biol. 2006 Aug;2(8):423-8. Epub 2006 Jun 25.

PMID:
16799553
44.

Sweetening cyclic peptide libraries.

Boddy CN.

Chem Biol. 2004 Dec;11(12):1599-600. Review.

45.

Precursor-directed biosynthesis of epothilone in Escherichia coli.

Boddy CN, Hotta K, Tse ML, Watts RE, Khosla C.

J Am Chem Soc. 2004 Jun 23;126(24):7436-7.

PMID:
15198579
46.

Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C.

J Biol Chem. 2003 Oct 24;278(43):42020-6. Epub 2003 Aug 15.

47.

Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase.

Boddy CN, Schneider TL, Hotta K, Walsh CT, Khosla C.

J Am Chem Soc. 2003 Mar 26;125(12):3428-9.

PMID:
12643694
48.
49.

Extending synthetic access to proteins with a removable acyl transfer auxiliary.

Offer J, Boddy CN, Dawson PE.

J Am Chem Soc. 2002 May 1;124(17):4642-6.

PMID:
11971712
50.

Behind enemy lines.

Nicolaou KC, Boddy CN.

Sci Am. 2001 May;284(5):54-61. Review. No abstract available.

PMID:
11341163

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