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Items: 45


Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.

Zhao F, Xiao C, Evans KS, Theivanthiran T, DeVito N, Holtzhausen A, Liu J, Liu X, Boczkowski D, Nair S, Locasale JW, Hanks BA.

Immunity. 2018 Jan 16;48(1):147-160.e7. doi: 10.1016/j.immuni.2017.12.004.


Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.

Brown MC, Holl EK, Boczkowski D, Dobrikova E, Mosaheb M, Chandramohan V, Bigner DD, Gromeier M, Nair SK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaan4220. doi: 10.1126/scitranslmed.aan4220.


Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.

Holl EK, Brown MC, Boczkowski D, McNamara MA, George DJ, Bigner DD, Gromeier M, Nair SK.

Oncotarget. 2016 Nov 29;7(48):79828-79841. doi: 10.18632/oncotarget.12975.


The RNAissance period.

Boczkowski D, Nair SK.

Discov Med. 2016 Aug;22(119):67-72. Review.


Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma.

Nair SK, Driscoll T, Boczkowski D, Schmittling R, Reynolds R, Johnson LA, Grant G, Fuchs H, Bigner DD, Sampson JH, Gururangan S, Mitchell DA.

J Neurooncol. 2015 Oct;125(1):65-74. doi: 10.1007/s11060-015-1890-2. Epub 2015 Aug 27.


High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Nair SK, Tomaras GD, Sales AP, Boczkowski D, Chan C, Plonk K, Cai Y, Dannull J, Kepler TB, Pruitt SK, Weinhold KJ.

Sci Rep. 2014 Apr 23;4:4632. doi: 10.1038/srep04632.


Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells.

Nair SK, De Leon G, Boczkowski D, Schmittling R, Xie W, Staats J, Liu R, Johnson LA, Weinhold K, Archer GE, Sampson JH, Mitchell DA.

Clin Cancer Res. 2014 May 15;20(10):2684-94. doi: 10.1158/1078-0432.CCR-13-3268. Epub 2014 Mar 21.


Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.

Phua KK, Boczkowski D, Dannull J, Pruitt S, Leong KW, Nair SK.

Adv Healthc Mater. 2014 Jun;3(6):837-42. doi: 10.1002/adhm.201300512. Epub 2013 Dec 16.


Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.

Dannull J, Haley NR, Archer G, Nair S, Boczkowski D, Harper M, De Rosa N, Pickett N, Mosca PJ, Burchette J, Selim MA, Mitchell DA, Sampson J, Tyler DS, Pruitt SK.

J Clin Invest. 2013 Jul;123(7):3135-45. doi: 10.1172/JCI67544. Epub 2013 Jun 24.


Immunologic targeting of FOXP3 in inflammatory breast cancer cells.

Nair S, Aldrich AJ, McDonnell E, Cheng Q, Aggarwal A, Patel P, Williams MM, Boczkowski D, Lyerly HK, Morse MA, Devi GR.

PLoS One. 2013;8(1):e53150. doi: 10.1371/journal.pone.0053150. Epub 2013 Jan 14.


Programming human dendritic cells with mRNA.

Lee J, Boczkowski D, Nair S.

Methods Mol Biol. 2013;969:111-25. doi: 10.1007/978-1-62703-260-5_8. Review.


Engineering B cells with mRNA.

Lee J, Boczkowski D, Nair S.

Methods Mol Biol. 2013;969:101-10. doi: 10.1007/978-1-62703-260-5_7. Review.


Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.

Pruitt SK, Boczkowski D, de Rosa N, Haley NR, Morse MA, Tyler DS, Dannull J, Nair S.

Eur J Immunol. 2011 Dec;41(12):3553-63. doi: 10.1002/eji.201141383. Epub 2011 Oct 26.


RNA as performance-enhancers for dendritic cells.

Boczkowski D, Nair S.

Expert Opin Biol Ther. 2010 Apr;10(4):563-74. doi: 10.1517/14712591003614749. Review.


Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy.

Boczkowski D, Lee J, Pruitt S, Nair S.

Cancer Gene Ther. 2009 Dec;16(12):900-11. doi: 10.1038/cgt.2009.39. Epub 2009 Jun 5.


Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer.

Dollins CM, Nair S, Boczkowski D, Lee J, Layzer JM, Gilboa E, Sullenger BA.

Chem Biol. 2008 Jul 21;15(7):675-82. doi: 10.1016/j.chembiol.2008.05.016.


Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses.

Lee J, Dollins CM, Boczkowski D, Sullenger BA, Nair S.

Immunology. 2008 Oct;125(2):229-40. doi: 10.1111/j.1365-2567.2008.02833.x. Epub 2008 Apr 3.


Robust CD4+ and CD8+ T cell responses to SIV using mRNA-transfected DC expressing autologous viral Ag.

Melhem NM, Liu XD, Boczkowski D, Gilboa E, Barratt-Boyes SM.

Eur J Immunol. 2007 Aug;37(8):2164-73.


Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity.

Nair S, Boczkowski D, Fassnacht M, Pisetsky D, Gilboa E.

Cancer Res. 2007 Jan 1;67(1):371-80.


Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts.

Lee J, Fassnacht M, Nair S, Boczkowski D, Gilboa E.

Cancer Res. 2005 Dec 1;65(23):11156-63.


Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.

Kavanagh DG, Kaufmann DE, Sunderji S, Frahm N, Le Gall S, Boczkowski D, Rosenberg ES, Stone DR, Johnston MN, Wagner BS, Zaman MT, Brander C, Gilboa E, Walker BD, Bhardwaj N.

Blood. 2006 Mar 1;107(5):1963-9. Epub 2005 Oct 25.


Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy.

Fassnacht M, Lee J, Milazzo C, Boczkowski D, Su Z, Nair S, Gilboa E.

Clin Cancer Res. 2005 Aug 1;11(15):5566-71.


Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer.

Su Z, Dannull J, Yang BK, Dahm P, Coleman D, Yancey D, Sichi S, Niedzwiecki D, Boczkowski D, Gilboa E, Vieweg J.

J Immunol. 2005 Mar 15;174(6):3798-807.


Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand.

Dannull J, Nair S, Su Z, Boczkowski D, DeBeck C, Yang B, Gilboa E, Vieweg J.

Blood. 2005 Apr 15;105(8):3206-13. Epub 2004 Dec 23.


Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation.

Nair S, McLaughlin C, Weizer A, Su Z, Boczkowski D, Dannull J, Vieweg J, Gilboa E.

J Immunol. 2003 Dec 1;171(11):6275-82.


Inhibition of invariant chain expression in dendritic cells presenting endogenous antigens stimulates CD4+ T-cell responses and tumor immunity.

Zhao Y, Boczkowski D, Nair SK, Gilboa E.

Blood. 2003 Dec 1;102(12):4137-42. Epub 2003 Aug 14.


RNA-transfected dendritic cells.

Nair S, Boczkowski D.

Expert Rev Vaccines. 2002 Dec;1(4):507-13. Review.


Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA.

Morse MA, Nair SK, Mosca PJ, Hobeika AC, Clay TM, Deng Y, Boczkowski D, Proia A, Neidzwiecki D, Clavien PA, Hurwitz HI, Schlom J, Gilboa E, Lyerly HK.

Cancer Invest. 2003 Jun;21(3):341-9.


Synergy between tumor immunotherapy and antiangiogenic therapy.

Nair S, Boczkowski D, Moeller B, Dewhirst M, Vieweg J, Gilboa E.

Blood. 2003 Aug 1;102(3):964-71. Epub 2003 Apr 10.


The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer.

Morse MA, Nair SK, Boczkowski D, Tyler D, Hurwitz HI, Proia A, Clay TM, Schlom J, Gilboa E, Lyerly HK.

Int J Gastrointest Cancer. 2002;32(1):1-6.


Enhanced induction of telomerase-specific CD4(+) T cells using dendritic cells transfected with RNA encoding a chimeric gene product.

Su Z, Vieweg J, Weizer AZ, Dahm P, Yancey D, Turaga V, Higgins J, Boczkowski D, Gilboa E, Dannull J.

Cancer Res. 2002 Sep 1;62(17):5041-8.


Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells.

Nair SK, Morse M, Boczkowski D, Cumming RI, Vasovic L, Gilboa E, Lyerly HK.

Ann Surg. 2002 Apr;235(4):540-9.


Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA.

Heiser A, Maurice MA, Yancey DR, Wu NZ, Dahm P, Pruitt SK, Boczkowski D, Nair SK, Ballo MS, Gilboa E, Vieweg J.

J Immunol. 2001 Mar 1;166(5):2953-60.


Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

Nair SK, Heiser A, Boczkowski D, Majumdar A, Naoe M, Lebkowski JS, Vieweg J, Gilboa E.

Nat Med. 2000 Sep;6(9):1011-7.


Human dendritic cells transfected with RNA encoding prostate-specific antigen stimulate prostate-specific CTL responses in vitro.

Heiser A, Dahm P, Yancey DR, Maurice MA, Boczkowski D, Nair SK, Gilboa E, Vieweg J.

J Immunol. 2000 May 15;164(10):5508-14.


Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA.

Nair SK, Boczkowski D, Morse M, Cumming RI, Lyerly HK, Gilboa E.

Nat Biotechnol. 1998 Apr;16(4):364-9.


Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines.

Nair SK, Boczkowski D, Snyder D, Gilboa E.

Eur J Immunol. 1997 Mar;27(3):589-97.


Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

Boczkowski D, Nair SK, Snyder D, Gilboa E.

J Exp Med. 1996 Aug 1;184(2):465-72.


Efficient gene transfer with adeno-associated virus-based plasmids complexed to cationic liposomes for gene therapy of human prostate cancer.

Vieweg J, Boczkowski D, Roberson KM, Edwards DW, Philip M, Philip R, Rudoll T, Smith C, Robertson C, Gilboa E.

Cancer Res. 1995 Jun 1;55(11):2366-72.


Low rate of Rhesus immunization from Rh-incompatible blood transfusions during liver and heart transplant surgery.

Ramsey G, Hahn LF, Cornell FW, Boczkowski DJ, Staschak S, Clark R, Hardesty RL, Griffith BP, Starzl TE.

Transplantation. 1989 Jun;47(6):993-5.


The Lewis blood group system in liver transplantation.

Ramsey G, Wolford J, Boczkowski DJ, Cornell FW, Larson P, Starzl TE.

Transplant Proc. 1987 Dec;19(6):4591-4. No abstract available.

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