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Items: 1 to 50 of 471

1.

Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses.

Berthoux C, Barre A, Bockaert J, Marin P, Bécamel C.

Cereb Cortex. 2018 Jun 16. doi: 10.1093/cercor/bhy064. [Epub ahead of print]

PMID:
29917056
2.

5-HT2A receptor-dependent phosphorylation of mGlu2 receptor at Serine 843 promotes mGlu2 receptor-operated Gi/o signaling.

Murat S, Bigot M, Chapron J, König GM, Kostenis E, Battaglia G, Nicoletti F, Bourinet E, Bockaert J, Marin P, Vandermoere F.

Mol Psychiatry. 2018 Jun 1. doi: 10.1038/s41380-018-0069-6. [Epub ahead of print]

PMID:
29858599
3.

Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease.

Baranger K, Giannoni P, Girard SD, Girot S, Gaven F, Stephan D, Migliorati M, Khrestchatisky M, Bockaert J, Marchetti-Gauthier E, Rivera S, Claeysen S, Roman FS.

Neuropharmacology. 2017 Nov;126:128-141. doi: 10.1016/j.neuropharm.2017.08.031. Epub 2017 Aug 26.

PMID:
28844596
4.

Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs.

Cassier E, Gallay N, Bourquard T, Claeysen S, Bockaert J, Crépieux P, Poupon A, Reiter E, Marin P, Vandermoere F.

Elife. 2017 Feb 7;6. pii: e23777. doi: 10.7554/eLife.23777.

5.

[The anxiogenic effects of SSRI are mediated by 5-HT2c receptors of the stria terminalis].

Bockaert J, Bécamel C.

Med Sci (Paris). 2017 Jan;33(1):87-89. doi: 10.1051/medsci/20173301015. Epub 2017 Jan 25. French. No abstract available.

6.

Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2.

Seyer P, Vandermoere F, Cassier E, Bockaert J, Marin P.

Biochem J. 2016 Jul 1;473(13):1953-65. doi: 10.1042/BCJ20160315. Epub 2016 May 3.

PMID:
27143784
7.

Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning.

Barre A, Berthoux C, De Bundel D, Valjent E, Bockaert J, Marin P, Bécamel C.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1382-91. doi: 10.1073/pnas.1525586113. Epub 2016 Feb 22.

8.

mTOR in Brain Physiology and Pathologies.

Bockaert J, Marin P.

Physiol Rev. 2015 Oct;95(4):1157-87. doi: 10.1152/physrev.00038.2014. Review.

9.

Serotonin: A New Hope in Alzheimer's Disease?

Claeysen S, Bockaert J, Giannoni P.

ACS Chem Neurosci. 2015 Jul 15;6(7):940-3. doi: 10.1021/acschemneuro.5b00135. Epub 2015 May 26.

PMID:
26011650
10.

Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis.

Hinsinger G, Galéotti N, Nabholz N, Urbach S, Rigau V, Demattei C, Lehmann S, Camu W, Labauge P, Castelnovo G, Brassat D, Loussouarn D, Salou M, Laplaud D, Casez O, Bockaert J, Marin P, Thouvenot E.

Mult Scler. 2015 Sep;21(10):1251-61. doi: 10.1177/1352458514561906. Epub 2015 Feb 19.

PMID:
25698171
11.

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth.

Duhr F, Déléris P, Raynaud F, Séveno M, Morisset-Lopez S, Mannoury la Cour C, Millan MJ, Bockaert J, Marin P, Chaumont-Dubel S.

Nat Chem Biol. 2014 Jul;10(7):590-7. doi: 10.1038/nchembio.1547. Epub 2014 Jun 1.

PMID:
24880860
12.

Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists.

Karaki S, Becamel C, Murat S, Mannoury la Cour C, Millan MJ, Prézeau L, Bockaert J, Marin P, Vandermoere F.

Mol Cell Proteomics. 2014 May;13(5):1273-85. doi: 10.1074/mcp.M113.036558. Epub 2014 Mar 17.

13.

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease.

Giannoni P, Gaven F, de Bundel D, Baranger K, Marchetti-Gauthier E, Roman FS, Valjent E, Marin P, Bockaert J, Rivera S, Claeysen S.

Front Aging Neurosci. 2013 Dec 24;5:96. doi: 10.3389/fnagi.2013.00096. eCollection 2013.

14.

β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice.

Ravier MA, Leduc M, Richard J, Linck N, Varrault A, Pirot N, Roussel MM, Bockaert J, Dalle S, Bertrand G.

Diabetologia. 2014 Mar;57(3):532-41. doi: 10.1007/s00125-013-3130-7. Epub 2013 Dec 7.

PMID:
24317793
15.

Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake.

Seimandi M, Seyer P, Park CS, Vandermoere F, Chanrion B, Bockaert J, Mansuy IM, Marin P.

J Neurosci. 2013 Oct 9;33(41):16189-99. doi: 10.1523/JNEUROSCI.0076-13.2013.

16.

Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation.

Raynaud F, Janossy A, Dahl J, Bertaso F, Perroy J, Varrault A, Vidal M, Worley PF, Boeckers TM, Bockaert J, Marin P, Fagni L, Homburger V.

J Neurosci. 2013 Jun 5;33(23):9699-715. doi: 10.1523/JNEUROSCI.2725-12.2013.

17.

Gαo is required for L-canavanine detection in Drosophila.

Devambez I, Ali Agha M, Mitri C, Bockaert J, Parmentier ML, Marion-Poll F, Grau Y, Soustelle L.

PLoS One. 2013 May 6;8(5):e63484. doi: 10.1371/journal.pone.0063484. Print 2013.

18.

[The mTOR pathway: a new target for treating cognitive deficits of schizophrenia?].

Marin P, Meffre J, Bockaert J.

Med Sci (Paris). 2013 Jan;29(1):28-30. doi: 10.1051/medsci/2013291009. Epub 2013 Jan 25. French. No abstract available.

19.

5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

Cochet M, Donneger R, Cassier E, Gaven F, Lichtenthaler SF, Marin P, Bockaert J, Dumuis A, Claeysen S.

ACS Chem Neurosci. 2013 Jan 16;4(1):130-40. doi: 10.1021/cn300095t. Epub 2012 Oct 13.

20.

[G-protein coupled receptors. Nobel Prize 2012 for chemistry to Robert J. Lefkowitz and Brian Kobilka].

Bockaert J.

Med Sci (Paris). 2012 Dec;28(12):1133-7. doi: 10.1051/medsci/20122812026. Epub 2012 Dec 21. French.

21.

The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity.

Jean A, Laurent L, Bockaert J, Charnay Y, Dusticier N, Nieoullon A, Barrot M, Neve R, Compan V.

Transl Psychiatry. 2012 Dec 11;2:e203. doi: 10.1038/tp.2012.131.

22.

[G-protein-coupled receptors: general features and activation mechanisms].

Bockaert J.

Bull Acad Natl Med. 2012 Dec;196(9):1765-75. Review. French.

PMID:
24552100
23.

Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands.

Gaven F, Pellissier LP, Queffeulou E, Cochet M, Bockaert J, Dumuis A, Claeysen S.

Brain Res. 2013 May 20;1511:65-72. doi: 10.1016/j.brainres.2012.11.005. Epub 2012 Nov 10. Review.

PMID:
23148949
24.

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

Meffre J, Chaumont-Dubel S, Mannoury la Cour C, Loiseau F, Watson DJ, Dekeyne A, Séveno M, Rivet JM, Gaven F, Déléris P, Hervé D, Fone KC, Bockaert J, Millan MJ, Marin P.

EMBO Mol Med. 2012 Oct;4(10):1043-56. doi: 10.1002/emmm.201201410.

25.

Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis.

Thouvenot E, Urbach S, Vigy O, Séveno M, Galéotti N, Nguyen G, Bockaert J, Marin P.

J Proteomics. 2012 Dec 21;77:394-405. doi: 10.1016/j.jprot.2012.09.013. Epub 2012 Sep 23.

PMID:
23009950
26.

Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability.

Moutin E, Raynaud F, Roger J, Pellegrino E, Homburger V, Bertaso F, Ollendorff V, Bockaert J, Fagni L, Perroy J.

J Cell Biol. 2012 Jul 23;198(2):251-63. doi: 10.1083/jcb.201110101. Epub 2012 Jul 16.

27.

Alzheimer culprits: cellular crossroads and interplay.

Claeysen S, Cochet M, Donneger R, Dumuis A, Bockaert J, Giannoni P.

Cell Signal. 2012 Sep;24(9):1831-40. doi: 10.1016/j.cellsig.2012.05.008. Epub 2012 May 22. Review.

PMID:
22627093
28.

S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.

Millan MJ, Mannoury la Cour C, Chanrion B, Dupuis DS, Di Cara B, Audinot V, Cussac D, Newman-Tancredi A, Kamal M, Boutin JA, Jockers R, Marin P, Bockaert J, Muller O, Dekeyne A, Lavielle G.

J Pharmacol Exp Ther. 2012 Mar;340(3):750-64. doi: 10.1124/jpet.111.187468. Epub 2011 Dec 16.

29.

5-HT receptor-associated protein networks: new targets for drug discovery in psychiatric disorders?

Marin P, Becamel C, Dumuis A, Bockaert J.

Curr Drug Targets. 2012 Jan;13(1):28-52. Review.

PMID:
21777185
30.

Epileptiform activity induces vascular remodeling and zonula occludens 1 downregulation in organotypic hippocampal cultures: role of VEGF signaling pathways.

Morin-Brureau M, Lebrun A, Rousset MC, Fagni L, Bockaert J, de Bock F, Lerner-Natoli M.

J Neurosci. 2011 Jul 20;31(29):10677-88. doi: 10.1523/JNEUROSCI.5692-10.2011.

31.

Enhancement of reference memory in aged rats by specific activation of 5-HT(4) receptors using an olfactory associative discrimination task.

Marchetti E, Jacquet M, Escoffier G, Miglioratti M, Dumuis A, Bockaert J, Roman FS.

Brain Res. 2011 Aug 8;1405:49-56. doi: 10.1016/j.brainres.2011.06.020. Epub 2011 Jun 17.

PMID:
21745655
32.

Systems medicine and integrated care to combat chronic noncommunicable diseases.

Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, Agusti A, Brightling C, Cambon-Thomsen A, Cesario A, Abdelhak S, Antonarakis SE, Avignon A, Ballabio A, Baraldi E, Baranov A, Bieber T, Bockaert J, Brahmachari S, Brambilla C, Bringer J, Dauzat M, Ernberg I, Fabbri L, Froguel P, Galas D, Gojobori T, Hunter P, Jorgensen C, Kauffmann F, Kourilsky P, Kowalski ML, Lancet D, Pen CL, Mallet J, Mayosi B, Mercier J, Metspalu A, Nadeau JH, Ninot G, Noble D, Oztürk M, Palkonen S, Préfaut C, Rabe K, Renard E, Roberts RG, Samolinski B, Schünemann HJ, Simon HU, Soares MB, Superti-Furga G, Tegner J, Verjovski-Almeida S, Wellstead P, Wolkenhauer O, Wouters E, Balling R, Brookes AJ, Charron D, Pison C, Chen Z, Hood L, Auffray C.

Genome Med. 2011 Jul 6;3(7):43. doi: 10.1186/gm259.

33.

5-HT(4) receptors, a place in the sun: act two.

Bockaert J, Claeysen S, Compan V, Dumuis A.

Curr Opin Pharmacol. 2011 Feb;11(1):87-93. doi: 10.1016/j.coph.2011.01.012. Epub 2011 Feb 20. Review.

PMID:
21342787
34.

G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.

Pellissier LP, Barthet G, Gaven F, Cassier E, Trinquet E, Pin JP, Marin P, Dumuis A, Bockaert J, Banères JL, Claeysen S.

J Biol Chem. 2011 Mar 25;286(12):9985-97. doi: 10.1074/jbc.M110.201939. Epub 2011 Jan 19.

35.

Techniques for studying inverse agonist activity of antidepressants at recombinant nonedited 5-HT(₂C-INI) receptor and native neuronal 5-HT(₂C) receptors.

Seimandi M, Bockaert J, Marin P.

Methods Enzymol. 2010;485:61-79. doi: 10.1016/B978-0-12-381296-4.00004-X.

PMID:
21050911
36.

Metabotropic glutamate receptors: from the workbench to the bedside.

Nicoletti F, Bockaert J, Collingridge GL, Conn PJ, Ferraguti F, Schoepp DD, Wroblewski JT, Pin JP.

Neuropharmacology. 2011 Jun;60(7-8):1017-41. doi: 10.1016/j.neuropharm.2010.10.022. Epub 2010 Oct 29. Review.

37.

The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT(2C) receptors.

Millan MJ, Marin P, Kamal M, Jockers R, Chanrion B, Labasque M, Bockaert J, Mannoury la Cour C.

Int J Neuropsychopharmacol. 2011 Jul;14(6):768-83. doi: 10.1017/S1461145710001045. Epub 2010 Oct 15.

PMID:
20946699
38.

Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants.

Labasque M, Meffre J, Carrat G, Becamel C, Bockaert J, Marin P.

Mol Pharmacol. 2010 Nov;78(5):818-26. doi: 10.1124/mol.110.066035. Epub 2010 Aug 10.

39.

Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain.

Pichon X, Wattiez AS, Becamel C, Ehrlich I, Bockaert J, Eschalier A, Marin P, Courteix C.

Mol Ther. 2010 Aug;18(8):1462-70. doi: 10.1038/mt.2010.101. Epub 2010 Jun 8.

40.

Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons.

Bertaso F, Roussignol G, Worley P, Bockaert J, Fagni L, Ango F.

PLoS One. 2010 Mar 18;5(3):e9755. doi: 10.1371/journal.pone.0009755.

41.

Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice.

Segu L, Lecomte MJ, Wolff M, Santamaria J, Hen R, Dumuis A, Berrard S, Bockaert J, Buhot MC, Compan V.

PLoS One. 2010 Mar 4;5(3):e9529. doi: 10.1371/journal.pone.0009529.

42.

GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies.

Bockaert J, Perroy J, Bécamel C, Marin P, Fagni L.

Annu Rev Pharmacol Toxicol. 2010;50:89-109. doi: 10.1146/annurev.pharmtox.010909.105705. Review.

PMID:
20055699
43.

GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells.

Quoyer J, Longuet C, Broca C, Linck N, Costes S, Varin E, Bockaert J, Bertrand G, Dalle S.

J Biol Chem. 2010 Jan 15;285(3):1989-2002. doi: 10.1074/jbc.M109.067207. Epub 2009 Nov 13.

44.

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A.

EMBO J. 2009 Sep 16;28(18):2706-18. doi: 10.1038/emboj.2009.215. Epub 2009 Aug 6.

45.

Plant insecticide L-canavanine repels Drosophila via the insect orphan GPCR DmX.

Mitri C, Soustelle L, Framery B, Bockaert J, Parmentier ML, Grau Y.

PLoS Biol. 2009 Jun 30;7(6):e1000147. doi: 10.1371/journal.pbio.1000147. Epub 2009 Jun 30.

46.

Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.

Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S.

Diabetes. 2009 May;58(5):1105-15. doi: 10.2337/db08-0926. Epub 2009 Feb 17.

47.

Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.

Pellissier LP, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L.

Mol Pharmacol. 2009 Apr;75(4):982-90. doi: 10.1124/mol.108.053686. Epub 2009 Jan 23.

48.

beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells.

Broca C, Quoyer J, Costes S, Linck N, Varrault A, Deffayet PM, Bockaert J, Dalle S, Bertrand G.

J Biol Chem. 2009 Feb 13;284(7):4332-42. doi: 10.1074/jbc.M807595200. Epub 2008 Dec 11.

49.

Epac mediates PACAP-dependent long-term depression in the hippocampus.

Ster J, de Bock F, Bertaso F, Abitbol K, Daniel H, Bockaert J, Fagni L.

J Physiol. 2009 Jan 15;587(1):101-13. doi: 10.1113/jphysiol.2008.157461. Epub 2008 Nov 10.

50.

An alpha40 subunit of a GTP-binding protein immunologically related to G0 mediates a dopamine-induced decrease of Ca2+ current in snail neurons..

Harris-Warrick RM, Paupardin-Tritsch D, Bockaert J.

Neuron. 2008 Nov 6;60(3):396-7. doi: 10.1016/j.neuron.2008.10.026. No abstract available.

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