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HCV modifies EGF signalling and upregulates production of CXCR2 ligands: Role in inflammation and antiviral immune response.

Groepper C, Rufinatscha K, Schröder N, Stindt S, Ehlting C, Albrecht U, Bock HH, Bartenschlager R, Häussinger D, Bode JG.

J Hepatol. 2018 Sep;69(3):594-602. doi: 10.1016/j.jhep.2018.04.005. Epub 2018 Apr 27.


Mathematical model of early Reelin-induced Src family kinase-mediated signaling.

Hass H, Kipkeew F, Gauhar A, Bouché E, May P, Timmer J, Bock HH.

PLoS One. 2017 Oct 19;12(10):e0186927. doi: 10.1371/journal.pone.0186927. eCollection 2017.


Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.

Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M.

Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21.


Detection of a genetic footprint of the sofosbuvir resistance-associated substitution S282T after HCV treatment failure.

Walker A, Filke S, Lübke N, Obermeier M, Kaiser R, Häussinger D, Timm J, Bock HH.

Virol J. 2017 Jun 8;14(1):106. doi: 10.1186/s12985-017-0779-4.


Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.

Jakob B, Kochlamazashvili G, Jäpel M, Gauhar A, Bock HH, Maritzen T, Haucke V.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5533-5538. doi: 10.1073/pnas.1704447114. Epub 2017 May 8.


Ephrin Bs and canonical Reelin signalling.

Pohlkamp T, Xiao L, Sultana R, Bepari A, Bock HH, Henkemeyer M, Herz J.

Nature. 2016 Nov 24;539(7630):E4-E6. doi: 10.1038/nature20129. No abstract available.


Driving the Model to Its Limit: Profile Likelihood Based Model Reduction.

Maiwald T, Hass H, Steiert B, Vanlier J, Engesser R, Raue A, Kipkeew F, Bock HH, Kaschek D, Kreutz C, Timmer J.

PLoS One. 2016 Sep 2;11(9):e0162366. doi: 10.1371/journal.pone.0162366. eCollection 2016.


Canonical and Non-canonical Reelin Signaling.

Bock HH, May P.

Front Cell Neurosci. 2016 Jun 30;10:166. doi: 10.3389/fncel.2016.00166. eCollection 2016. Review.


Reelin protects against amyloid β toxicity in vivo.

Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J.

Sci Signal. 2015 Jul 7;8(384):ra67. doi: 10.1126/scisignal.aaa6674.


The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.

Nakajima C, Haffner P, Goerke SM, Zurhove K, Adelmann G, Frotscher M, Herz J, Bock HH, May P.

Development. 2014 Dec;141(23):4513-25. doi: 10.1242/dev.109124. Epub 2014 Nov 5.


CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal-Retzius Cells.

Trousse F, Poluch S, Pierani A, Dutriaux A, Bock HH, Nagasawa T, Verdier JM, Rossel M.

Cereb Cortex. 2015 Oct;25(10):3446-57. doi: 10.1093/cercor/bhu164. Epub 2014 Aug 1.


Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells.

Pohlkamp T, Steller L, May P, Günther T, Schüle R, Frotscher M, Herz J, Bock HH.

PLoS One. 2014 Jun 20;9(6):e100384. doi: 10.1371/journal.pone.0100384. eCollection 2014.


LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Schorch B, Song S, van Diemen FR, Bock HH, May P, Herz J, Brummelkamp TR, Papatheodorou P, Aktories K.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6431-6. doi: 10.1073/pnas.1323790111. Epub 2014 Apr 15.


ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons.

Sharaf A, Bock HH, Spittau B, Bouché E, Krieglstein K.

PLoS One. 2013 Aug 16;8(8):e71091. doi: 10.1371/journal.pone.0071091. eCollection 2013.


Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages.

May P, Bock HH, Nofer JR.

Cell Tissue Res. 2013 Dec;354(3):887-9. doi: 10.1007/s00441-013-1699-2. Epub 2013 Aug 21.


Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice.

Brunne B, Franco S, Bouché E, Herz J, Howell BW, Pahle J, Müller U, May P, Frotscher M, Bock HH.

Glia. 2013 Aug;61(8):1347-63. doi: 10.1002/glia.22519. Epub 2013 Jul 4.


Characterization and distribution of Reelin-positive interneuron subtypes in the rat barrel cortex.

Pohlkamp T, Dávid C, Cauli B, Gallopin T, Bouché E, Karagiannis A, May P, Herz J, Frotscher M, Staiger JF, Bock HH.

Cereb Cortex. 2014 Nov;24(11):3046-58. doi: 10.1093/cercor/bht161. Epub 2013 Jun 26.


Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.

Nakajima C, Kulik A, Frotscher M, Herz J, Schäfer M, Bock HH, May P.

J Biol Chem. 2013 Jul 26;288(30):21909-23. doi: 10.1074/jbc.M112.444364. Epub 2013 Jun 11.


Reelin induces EphB activation.

Bouché E, Romero-Ortega MI, Henkemeyer M, Catchpole T, Leemhuis J, Frotscher M, May P, Herz J, Bock HH.

Cell Res. 2013 Apr;23(4):473-90. doi: 10.1038/cr.2013.7. Epub 2013 Jan 15.


Reelin modulates cytoskeletal organization by regulating Rho GTPases.

Leemhuis J, Bock HH.

Commun Integr Biol. 2011 May;4(3):254-7. doi: 10.4161/cib.4.3.14890.


Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy.

Volz F, Bock HH, Gierthmuehlen M, Zentner J, Haas CA, Freiman TM.

Epilepsia. 2011 Sep;52(9):1579-89. doi: 10.1111/j.1528-1167.2011.03086.x. Epub 2011 Jun 2.


Apolipoprotein E induces antiinflammatory phenotype in macrophages.

Baitsch D, Bock HH, Engel T, Telgmann R, Müller-Tidow C, Varga G, Bot M, Herz J, Robenek H, von Eckardstein A, Nofer JR.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):1160-8. doi: 10.1161/ATVBAHA.111.222745. Epub 2011 Feb 24.


Role for Reelin in neurotransmitter release.

Hellwig S, Hack I, Kowalski J, Brunne B, Jarowyj J, Unger A, Bock HH, Junghans D, Frotscher M.

J Neurosci. 2011 Feb 16;31(7):2352-60. doi: 10.1523/JNEUROSCI.3984-10.2011.


Identification of alternatively spliced Dab1 and Fyn isoforms in pig.

Long H, Bock HH, Lei T, Chai X, Yuan J, Herz J, Frotscher M, Yang Z.

BMC Neurosci. 2011 Feb 5;12:17. doi: 10.1186/1471-2202-12-17.


Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation.

Leemhuis J, Bouché E, Frotscher M, Henle F, Hein L, Herz J, Meyer DK, Pichler M, Roth G, Schwan C, Bock HH.

J Neurosci. 2010 Nov 3;30(44):14759-72. doi: 10.1523/JNEUROSCI.4036-10.2010.


Role for Reelin-induced cofilin phosphorylation in the assembly of sympathetic preganglionic neurons in the murine intermediolateral column.

Krüger MT, Zhao S, Chai X, Brunne B, Bouché E, Bock HH, Frotscher M.

Eur J Neurosci. 2010 Nov;32(10):1611-7. doi: 10.1111/j.1460-9568.2010.07433.x. Epub 2010 Oct 7.


L1 syndrome mutations impair neuronal L1 function at different levels by divergent mechanisms.

Schäfer MK, Nam YC, Moumen A, Keglowich L, Bouché E, Küffner M, Bock HH, Rathjen FG, Raoul C, Frotscher M.

Neurobiol Dis. 2010 Oct;40(1):222-37. doi: 10.1016/j.nbd.2010.05.029. Epub 2010 May 31.


Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus.

Brunne B, Zhao S, Derouiche A, Herz J, May P, Frotscher M, Bock HH.

Glia. 2010 Oct;58(13):1553-69. doi: 10.1002/glia.21029.


Emerging topics in Reelin function.

Förster E, Bock HH, Herz J, Chai X, Frotscher M, Zhao S.

Eur J Neurosci. 2010 May;31(9):1511-8. doi: 10.1111/j.1460-9568.2010.07222.x. Review.


Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge.

Chai X, Förster E, Zhao S, Bock HH, Frotscher M.

Commun Integr Biol. 2009 Jul;2(4):375-7.


Role of Reelin in the development and maintenance of cortical lamination.

Frotscher M, Chai X, Bock HH, Haas CA, Förster E, Zhao S.

J Neural Transm (Vienna). 2009 Nov;116(11):1451-5. doi: 10.1007/s00702-009-0228-7. Epub 2009 Apr 25. Review.


Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3.

Chai X, Förster E, Zhao S, Bock HH, Frotscher M.

J Neurosci. 2009 Jan 7;29(1):288-99. doi: 10.1523/JNEUROSCI.2934-08.2009.


Gamma-secretase limits the inflammatory response through the processing of LRP1.

Zurhove K, Nakajima C, Herz J, Bock HH, May P.

Sci Signal. 2008 Nov 25;1(47):ra15. doi: 10.1126/scisignal.1164263.


Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans.

Kovacs P, Kress R, Rocha J, Kurtz U, Miquel JF, Nervi F, Méndez-Sánchez N, Uribe M, Bock HH, Schirin-Sokhan R, Stumvoll M, Mössner J, Lammert F, Wittenburg H.

J Hepatol. 2008 Jan;48(1):116-24. Epub 2007 Oct 1.


Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons.

Hack I, Hellwig S, Junghans D, Brunne B, Bock HH, Zhao S, Frotscher M.

Development. 2007 Nov;134(21):3883-91. Epub 2007 Oct 3.


Conditional animal models for the study of lipid metabolism and lipid disorders.

Bock HH, Herz J, May P.

Handb Exp Pharmacol. 2007;(178):407-39. Review.


Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons.

Henle F, Leemhuis J, Fischer C, Bock HH, Lindemeyer K, Feuerstein TJ, Meyer DK.

J Pharmacol Exp Ther. 2006 Oct;319(1):181-91. Epub 2006 Jul 14.


Modulation of lipoprotein receptor functions by intracellular adaptor proteins.

Stolt PC, Bock HH.

Cell Signal. 2006 Oct;18(10):1560-71. Epub 2006 May 24. Review.


Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated by lipoprotein receptors for Reelin and Disabled 1.

Zhao S, Chai X, Bock HH, Brunne B, Förster E, Frotscher M.

J Comp Neurol. 2006 Mar 1;495(1):1-9.


Molecular mechanisms of lipoprotein receptor signalling.

May P, Herz J, Bock HH.

Cell Mol Life Sci. 2005 Oct;62(19-20):2325-38. Review.


Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction.

Stolt PC, Chen Y, Liu P, Bock HH, Blacklow SC, Herz J.

J Biol Chem. 2005 Mar 11;280(10):9671-7. Epub 2005 Jan 4.


Two-mode clustering methods: a structured overview.

Van Mechelen I, Bock HH, De Boeck P.

Stat Methods Med Res. 2004 Oct;13(5):363-94. Review.


Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.

May P, Rohlmann A, Bock HH, Zurhove K, Marth JD, Schomburg ED, Noebels JL, Beffert U, Sweatt JD, Weeber EJ, Herz J.

Mol Cell Biol. 2004 Oct;24(20):8872-83.


Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1.

Bock HH, Jossin Y, May P, Bergner O, Herz J.

J Biol Chem. 2004 Aug 6;279(32):33471-9. Epub 2004 Jun 2.


Receptor clustering is involved in Reelin signaling.

Strasser V, Fasching D, Hauser C, Mayer H, Bock HH, Hiesberger T, Herz J, Weeber EJ, Sweatt JD, Pramatarova A, Howell B, Schneider WJ, Nimpf J.

Mol Cell Biol. 2004 Feb;24(3):1378-86.


Reelin signaling directly affects radial glia morphology and biochemical maturation.

Hartfuss E, Förster E, Bock HH, Hack MA, Leprince P, Luque JM, Herz J, Frotscher M, Götz M.

Development. 2003 Oct;130(19):4597-609. Erratum in: Development. 2003 Nov;130(21):5291.


Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination.

Bock HH, Jossin Y, Liu P, Förster E, May P, Goffinet AM, Herz J.

J Biol Chem. 2003 Oct 3;278(40):38772-9. Epub 2003 Jul 25.


Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.

May P, Bock HH, Nimpf J, Herz J.

J Biol Chem. 2003 Sep 26;278(39):37386-92. Epub 2003 Jul 18.


Integration of endocytosis and signal transduction by lipoprotein receptors.

May P, Bock HH, Herz J.

Sci STKE. 2003 Apr 1;2003(176):PE12. Review.


Reelin activates SRC family tyrosine kinases in neurons.

Bock HH, Herz J.

Curr Biol. 2003 Jan 8;13(1):18-26.

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