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Items: 18


HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.

Qiu B, Ackerman D, Sanchez DJ, Li B, Ochocki JD, Grazioli A, Bobrovnikova-Marjon E, Diehl JA, Keith B, Simon MC.

Cancer Discov. 2015 Jun;5(6):652-67. doi: 10.1158/2159-8290.CD-14-1507. Epub 2015 Mar 31.


Targeting metabolic changes in cancer: novel therapeutic approaches.

Bobrovnikova-Marjon E, Hurov JB.

Annu Rev Med. 2014;65:157-70. doi: 10.1146/annurev-med-092012-112344. Review.


Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.

Young RM, Ackerman D, Quinn ZL, Mancuso A, Gruber M, Liu L, Giannoukos DN, Bobrovnikova-Marjon E, Diehl JA, Keith B, Simon MC.

Genes Dev. 2013 May 15;27(10):1115-31. doi: 10.1101/gad.198630.112.


Aluminum-substituted heme domain of P450BM-3 (BMP): introducing a heme-derived fluorescent probe for studies of substrate binding and protein-protein interactions in cytochromes P450.

Davydov DR, Ponomarev GV, Bobrovnikova-Marjon E, Haines DC, Peterson JA.

Biotechnol Appl Biochem. 2013 Jan-Feb;60(1):41-51. doi: 10.1002/bab.1085.


Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.

Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA.

Oncogene. 2013 Oct 10;32(41):4932-40. doi: 10.1038/onc.2012.512. Epub 2012 Nov 19.


miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA.

Mol Cell. 2012 Nov 9;48(3):353-64. doi: 10.1016/j.molcel.2012.08.025. Epub 2012 Sep 27.


PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.

Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA.

Mol Cell Biol. 2012 Jun;32(12):2268-78. doi: 10.1128/MCB.00063-12. Epub 2012 Apr 9.


PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment.

Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA.

Mol Cell Biol. 2011 Sep;31(17):3616-29. doi: 10.1128/MCB.05164-11. Epub 2011 Jun 27.


The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, Bobrovnikova-Marjon E, Diehl JA, Ron D, Koumenis C.

EMBO J. 2010 Jun 16;29(12):2082-96. doi: 10.1038/emboj.2010.81. Epub 2010 May 14.


PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage.

Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, Koumenis C, Cavener D, Diehl JA.

Oncogene. 2010 Jul 8;29(27):3881-95. doi: 10.1038/onc.2010.153. Epub 2010 May 10.


PERK-dependent regulation of IAP translation during ER stress.

Hamanaka RB, Bobrovnikova-Marjon E, Ji X, Liebhaber SA, Diehl JA.

Oncogene. 2009 Feb 12;28(6):910-20. doi: 10.1038/onc.2008.428. Epub 2008 Nov 24.


PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation.

Bobrovnikova-Marjon E, Hatzivassiliou G, Grigoriadou C, Romero M, Cavener DR, Thompson CB, Diehl JA.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16314-9. doi: 10.1073/pnas.0808517105. Epub 2008 Oct 13.


Coping with stress: ATF6alpha takes the stage.

Bobrovnikova-Marjon E, Diehl JA.

Dev Cell. 2007 Sep;13(3):322-4.


Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest.

Zhang F, Hamanaka RB, Bobrovnikova-Marjon E, Gordan JD, Dai MS, Lu H, Simon MC, Diehl JA.

J Biol Chem. 2006 Oct 6;281(40):30036-45. Epub 2006 Aug 7.


Activation of NFkappaB is inhibited by curcumin and related enones.

Weber WM, Hunsaker LA, Roybal CN, Bobrovnikova-Marjon EV, Abcouwer SF, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2006 Apr 1;14(7):2450-61. Epub 2005 Dec 7.


Rat cytochrome P450C24 (CYP24A1) and the role of F249 in substrate binding and catalytic activity.

Annalora A, Bobrovnikova-Marjon E, Serda R, Lansing L, Chiu ML, Pastuszyn A, Iyer S, Marcus CB, Omdahl JL.

Arch Biochem Biophys. 2004 May 15;425(2):133-46.


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