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Items: 36


Uncovering tissue-specific binding features from differential deep learning.

Phuycharoen M, Zarrineh P, Bridoux L, Amin S, Losa M, Chen K, Bobola N, Rattray M.

Nucleic Acids Res. 2020 Jan 24. pii: gkaa009. doi: 10.1093/nar/gkaa009. [Epub ahead of print]


Combinatorial action of NF-Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish.

Stanney W 3rd, Ladam F, Donaldson IJ, Parsons TJ, Maehr R, Bobola N, Sagerström CG.

Dev Biol. 2019 Dec 17. pii: S0012-1606(19)30614-1. doi: 10.1016/j.ydbio.2019.12.003. [Epub ahead of print]


TALE factors use two distinct functional modes to control an essential zebrafish gene expression program.

Ladam F, Stanney W, Donaldson IJ, Yildiz O, Bobola N, Sagerström CG.

Elife. 2018 Jun 18;7. pii: e36144. doi: 10.7554/eLife.36144.


Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos.

Jennings RE, Berry AA, Gerrard DT, Wearne SJ, Strutt J, Withey S, Chhatriwala M, Piper Hanley K, Vallier L, Bobola N, Hanley NA.

Stem Cell Reports. 2017 Nov 14;9(5):1387-1394. doi: 10.1016/j.stemcr.2017.09.018. Epub 2017 Oct 19.


A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree.

Losa M, Latorre V, Andrabi M, Ladam F, Sagerström C, Novoa A, Zarrineh P, Bridoux L, Hanley NA, Mallo M, Bobola N.

Elife. 2017 Sep 27;6. pii: e31362. doi: 10.7554/eLife.31362.


From DNA binding to transcriptional activation: Is the TALE complete?

Bobola N.

J Cell Biol. 2017 Sep 4;216(9):2603-2605. doi: 10.1083/jcb.201706113. Epub 2017 Aug 11.


Homeodomain proteins in action: similar DNA binding preferences, highly variable connectivity.

Bobola N, Merabet S.

Curr Opin Genet Dev. 2017 Apr;43:1-8. doi: 10.1016/j.gde.2016.09.008. Epub 2016 Oct 19. Review.


An integrative transcriptomic atlas of organogenesis in human embryos.

Gerrard DT, Berry AA, Jennings RE, Piper Hanley K, Bobola N, Hanley NA.

Elife. 2016 Aug 24;5. pii: e15657. doi: 10.7554/eLife.15657.


A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex.

Rosin JM, Li W, Cox LL, Rolfe SM, Latorre V, Akiyama JA, Visel A, Kuramoto T, Bobola N, Turner EE, Cox TC.

Development. 2016 Jul 15;143(14):2582-92. doi: 10.1242/dev.133736. Epub 2016 Jun 10.


Diabetes Inhibits Gr-1+ Myeloid Cell Maturation via Cebpa Deregulation.

Wicks K, Torbica T, Umehara T, Amin S, Bobola N, Mace KA.

Diabetes. 2015 Dec;64(12):4184-97. doi: 10.2337/db14-1895. Epub 2015 Aug 31.


Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.

Amin S, Donaldson IJ, Zannino DA, Hensman J, Rattray M, Losa M, Spitz F, Ladam F, Sagerström C, Bobola N.

Dev Cell. 2015 Feb 9;32(3):265-77. doi: 10.1016/j.devcel.2014.12.024. Epub 2015 Jan 29.


Chromatin immunoprecipitation and chromatin immunoprecipitation with massively parallel sequencing on mouse embryonic tissue.

Amin S, Bobola N.

Methods Mol Biol. 2014;1196:231-9. doi: 10.1007/978-1-4939-1242-1_14.


Novel cell lines isolated from mouse embryonic stem cells exhibiting de novo methylation of the E-cadherin promoter.

Hawkins K, Keramari M, Soncin F, Segal JM, Mohamet L, Miazga N, Ritson S, Bobola N, Merry CL, Ward CM.

Stem Cells. 2014 Nov;32(11):2869-79. doi: 10.1002/stem.1790.


Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.

Pritchett J, Athwal VS, Harvey E, Martin K, Llewellyn J, Ireland P, Nicolaides A, Humphries MJ, Bobola N, Hanley NA, Piper Hanley K.

PLoS One. 2014 Jun 27;9(6):e100091. doi: 10.1371/journal.pone.0100091. eCollection 2014.


Mouse Hoxa2 mutations provide a model for microtia and auricle duplication.

Minoux M, Kratochwil CF, Ducret S, Amin S, Kitazawa T, Kurihara H, Bobola N, Vilain N, Rijli FM.

Development. 2013 Nov;140(21):4386-97. doi: 10.1242/dev.098046. Epub 2013 Sep 25.


Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2.

Anderson M, Amin S, Luise F, Zeef L, Bobola N.

PLoS One. 2013 May 9;8(5):e63160. doi: 10.1371/journal.pone.0063160. Print 2013.


Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans.

Pritchett J, Harvey E, Athwal V, Berry A, Rowe C, Oakley F, Moles A, Mann DA, Bobola N, Sharrocks AD, Thomson BJ, Zaitoun AM, Irving WL, Guha IN, Hanley NA, Hanley KP.

Hepatology. 2012 Sep;56(3):1108-16. doi: 10.1002/hep.25758.


Genome-wide occupancy links Hoxa2 to Wnt-β-catenin signaling in mouse embryonic development.

Donaldson IJ, Amin S, Hensman JJ, Kutejova E, Rattray M, Lawrence N, Hayes A, Ward CM, Bobola N.

Nucleic Acids Res. 2012 May;40(9):3990-4001. doi: 10.1093/nar/gkr1240. Epub 2012 Jan 5.


E-cadherin acts as a regulator of transcripts associated with a wide range of cellular processes in mouse embryonic stem cells.

Soncin F, Mohamet L, Ritson S, Hawkins K, Bobola N, Zeef L, Merry CL, Ward CM.

PLoS One. 2011;6(7):e21463. doi: 10.1371/journal.pone.0021463. Epub 2011 Jul 14.


Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.

Kirilenko P, He G, Mankoo BS, Mallo M, Jones R, Bobola N.

Mol Cell Biol. 2011 Mar;31(6):1301-8. doi: 10.1128/MCB.00705-10. Epub 2011 Jan 18.


Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.

He G, Tavella S, Hanley KP, Self M, Oliver G, Grifone R, Hanley N, Ward C, Bobola N.

Dev Biol. 2010 Aug 15;344(2):720-30. doi: 10.1016/j.ydbio.2010.05.509. Epub 2010 May 31.


Expressing Hoxa2 across the entire endochondral skeleton alters the shape of the skeletal template in a spatially restricted fashion.

Tavella S, Bobola N.

Differentiation. 2010 Mar;79(3):194-202. doi: 10.1016/j.diff.2009.11.004. Epub 2010 Jan 14.


Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa.

Jones RP, Ridley C, Jowitt TA, Wang MC, Howard M, Bobola N, Wang T, Bishop PN, Kielty CM, Baldock C, Lotery AJ, Trump D.

Invest Ophthalmol Vis Sci. 2010 May;51(5):2356-62. doi: 10.1167/iovs.09-4620. Epub 2009 Dec 10.


Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal.

Soncin F, Mohamet L, Eckardt D, Ritson S, Eastham AM, Bobola N, Russell A, Davies S, Kemler R, Merry CL, Ward CM.

Stem Cells. 2009 Sep;27(9):2069-80. doi: 10.1002/stem.134.


Six2 functions redundantly immediately downstream of Hoxa2.

Kutejova E, Engist B, Self M, Oliver G, Kirilenko P, Bobola N.

Development. 2008 Apr;135(8):1463-70. doi: 10.1242/dev.017624. Epub 2008 Mar 5.


IGFBP5 is a potential regulator of craniofacial skeletogenesis.

Bobola N, Engist B.

Genesis. 2008 Jan;46(1):52-9. doi: 10.1002/dvg.20360.


Hox genes specify vertebral types in the presomitic mesoderm.

Carapuço M, Nóvoa A, Bobola N, Mallo M.

Genes Dev. 2005 Sep 15;19(18):2116-21.


Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.

Kutejova E, Engist B, Mallo M, Kanzler B, Bobola N.

Development. 2005 Feb;132(3):469-78. Epub 2005 Jan 5.


Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1.

Bobola N, Carapuço M, Ohnemus S, Kanzler B, Leibbrandt A, Neubüser A, Drouin J, Mallo M.

Development. 2003 Aug;130(15):3403-14.


Different levels of Hoxa2 are required for particular developmental processes.

Ohnemus S, Bobola N, Kanzler B, Mallo M.

Mech Dev. 2001 Oct;108(1-2):135-47.


OTX2 homeodomain protein binds a DNA element necessary for interphotoreceptor retinoid binding protein gene expression.

Bobola N, Briata P, Ilengo C, Rosatto N, Craft C, Corte G, Ravazzolo R.

Mech Dev. 1999 Apr;82(1-2):165-9.


Binding properties of the human homeodomain protein OTX2 to a DNA target sequence.

Briata P, Ilengo C, Bobola N, Corte G.

FEBS Lett. 1999 Feb 19;445(1):160-4.


The deletion polymorphism of the angiotensin I-converting enzyme gene is associated with target organ damage in essential hypertension.

Pontremoli R, Sofia A, Tirotta A, Ravera M, Nicolella C, Viazzi F, Bezante GP, Borgia L, Bobola N, Ravazzolo R, Sacchi G, Deferrari G.

J Am Soc Nephrol. 1996 Dec;7(12):2550-8.


Use of intermittent pneumatic compression in hemodialysis.

Beninson J, Levin NW, Santiago G, Paparao P, Bobola N.

Proc Clin Dial Transplant Forum. 1974;(4):209-13. No abstract available.


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