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Items: 18


Targeting Cannabinoid 1 and Delta Opioid Receptor Heteromers Alleviates Chemotherapy-Induced Neuropathic Pain.

Sierra S, Gupta A, Gomes I, Fowkes M, Ram A, Bobeck EN, Devi LA.

ACS Pharmacol Transl Sci. 2019 Aug 9;2(4):219-229. doi: 10.1021/acsptsci.9b00008. Epub 2019 Jun 5.


Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171.

McDermott MV, Afrose L, Gomes I, Devi LA, Bobeck EN.

J Pharmacol Exp Ther. 2019 Oct;371(1):56-62. doi: 10.1124/jpet.119.259242. Epub 2019 Jul 15.


Lack of Antinociceptive Cross-Tolerance With Co-Administration of Morphine and Fentanyl Into the Periaqueductal Gray of Male Sprague-Dawley Rats.

Bobeck EN, Schoo SM, Ingram SL, Morgan MM.

J Pain. 2019 Sep;20(9):1040-1047. doi: 10.1016/j.jpain.2019.03.002. Epub 2019 Mar 7.


The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance.

Lueptow LM, Fakira AK, Bobeck EN.

Front Neurosci. 2018 Nov 27;12:886. doi: 10.3389/fnins.2018.00886. eCollection 2018.


Enhanced antinociception with repeated microinjections of apomorphine into the periaqueductal gray of male and female rats.

Schoo SM, Bobeck EN, Morgan MM.

Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):234-240. doi: 10.1097/FBP.0000000000000373.


The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning.

Bobeck EN, Gomes I, Pena D, Cummings KA, Clem RL, Mezei M, Devi LA.

Neuropsychopharmacology. 2017 Dec;42(13):2527-2536. doi: 10.1038/npp.2017.79. Epub 2017 Apr 20.


Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake.

Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, Gupta A, Mezei M, Kumar S, Filizola M, Devi LA.

Sci Signal. 2016 May 31;9(430):ra55. doi: 10.1126/scisignal.aac8035.


Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.

Gupta A, Gomes I, Bobeck EN, Fakira AK, Massaro NP, Sharma I, Cavé A, Hamm HE, Parello J, Devi LA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6041-6. doi: 10.1073/pnas.1521825113. Epub 2016 May 9.


Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA.

Sci Signal. 2016 Apr 26;9(425):ra43. doi: 10.1126/scisignal.aad0694.


Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.

Bobeck EN, Ingram SL, Hermes SM, Aicher SA, Morgan MM.

Behav Brain Res. 2016 Feb 1;298(Pt B):17-24. doi: 10.1016/j.bbr.2015.10.032. Epub 2015 Oct 20.


Change in functional selectivity of morphine with the development of antinociceptive tolerance.

Macey TA, Bobeck EN, Suchland KL, Morgan MM, Ingram SL.

Br J Pharmacol. 2015 Jan;172(2):549-61. doi: 10.1111/bph.12703. Epub 2014 Jul 1.


Contribution of adenylyl cyclase modulation of pre- and postsynaptic GABA neurotransmission to morphine antinociception and tolerance.

Bobeck EN, Chen Q, Morgan MM, Ingram SL.

Neuropsychopharmacology. 2014 Aug;39(9):2142-52. doi: 10.1038/npp.2014.62. Epub 2014 Mar 13.


Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat.

Bobeck EN, Haseman RA, Hong D, Ingram SL, Morgan MM.

J Pain. 2012 Aug;13(8):799-807. doi: 10.1016/j.jpain.2012.05.005. Epub 2012 Jul 3.


The influence of non-nociceptive factors on hot-plate latency in rats.

Gunn A, Bobeck EN, Weber C, Morgan MM.

J Pain. 2011 Feb;12(2):222-7. doi: 10.1016/j.jpain.2010.06.011. Epub 2010 Aug 25.


Opioid receptor internalization contributes to dermorphin-mediated antinociception.

Macey TA, Ingram SL, Bobeck EN, Hegarty DM, Aicher SA, Arttamangkul S, Morgan MM.

Neuroscience. 2010 Jun 30;168(2):543-50. doi: 10.1016/j.neuroscience.2010.04.003. Epub 2010 Apr 13.


Drug dependent sex-differences in periaqueducatal gray mediated antinociception in the rat.

Bobeck EN, McNeal AL, Morgan MM.

Pain. 2009 Dec 15;147(1-3):210-6. doi: 10.1016/j.pain.2009.09.008. Epub 2009 Sep 30.


Extracellular signal-regulated kinase 1/2 activation counteracts morphine tolerance in the periaqueductal gray of the rat.

Macey TA, Bobeck EN, Hegarty DM, Aicher SA, Ingram SL, Morgan MM.

J Pharmacol Exp Ther. 2009 Nov;331(2):412-8. doi: 10.1124/jpet.109.152157. Epub 2009 Aug 14.


Glutamate modulation of antinociception, but not tolerance, produced by morphine microinjection into the periaqueductal gray of the rat.

Morgan MM, Bobeck EN, Ingram SL.

Brain Res. 2009 Oct 27;1295:59-66. doi: 10.1016/j.brainres.2009.07.100. Epub 2009 Aug 5.

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