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Items: 1 to 50 of 276

1.

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.

Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ.

Cell Rep. 2019 Oct 1;29(1):151-161.e5. doi: 10.1016/j.celrep.2019.08.072.

2.

CHAC1 overexpression in human gastric parietal cells with Helicobacter pylori infection in the secretory canaliculi.

Ogawa T, Wada Y, Takemura K, Board PG, Uchida K, Kitagaki K, Tamura T, Suzuki T, Tokairin Y, Nakajima Y, Eishi Y.

Helicobacter. 2019 Aug;24(4):e12598. doi: 10.1111/hel.12598. Epub 2019 May 20.

3.

Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina.

Fernando N, Wooff Y, Aggio-Bruce R, Chu-Tan JA, Jiao H, Dietrich C, Rutar M, Rooke M, Menon D, Eells JT, Valter K, Board PG, Provis J, Natoli R.

Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4362-4374. doi: 10.1167/iovs.18-24627.

PMID:
30193308
4.

Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example.

Xie Y, Dahlin JL, Oakley AJ, Casarotto MG, Board PG, Baell JB.

J Med Chem. 2018 Sep 13;61(17):7448-7470. doi: 10.1021/acs.jmedchem.8b00318. Epub 2018 May 10. Review.

PMID:
29652143
5.

Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells.

Wada Y, Takemura K, Tummala P, Uchida K, Kitagaki K, Furukawa A, Ishige Y, Ito T, Hara Y, Suzuki T, Mimuro H, Board PG, Eishi Y.

FEBS Open Bio. 2018 Mar 9;8(4):671-679. doi: 10.1002/2211-5463.12402. eCollection 2018 Apr.

6.

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Menon D, Innes A, Oakley AJ, Dahlstrom JE, Jensen LM, Brüstle A, Tummala P, Rooke M, Casarotto MG, Baell JB, Nguyen N, Xie Y, Cuellar M, Strasser J, Dahlin JL, Walters MA, Burgio G, O'Neill LAJ, Board PG.

Sci Rep. 2017 Dec 19;7(1):17832. doi: 10.1038/s41598-017-17861-6.

7.

Publisher's Note: Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding. J. Cell Sci. doi: 10.1242/jcs.204461.

Richardson SJ, Steele GA, Gallant EM, Lam A, Schwartz CE, Board PG, Casarotto MG, Beard NA, Dulhunty AF.

J Cell Sci. 2017 Oct 5. pii: jcs.211243. doi: 10.1242/jcs.211243. [Epub ahead of print] No abstract available.

PMID:
28982713
8.

Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding.

Richardson SJ, Steele GA, Gallant EM, Lam A, Schwartz CE, Board PG, Casarotto MG, Beard NA, Dulhunty AF.

J Cell Sci. 2017 Oct 15;130(20):3588-3600. doi: 10.1242/jcs.204461. Epub 2017 Aug 29. Erratum in: J Cell Sci. 2017 Oct 5;:.

9.

Erratum to: Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species.

Pearce SL, Clarke DF, East PD, Elfekih S, Gordon KHJ, Jermiin LS, McGaughran A, Oakeshott JG, Papanicolaou A, Perera OP, Rane RV, Richards S, Tay WT, Walsh TK, Anderson A, Anderson CJ, Asgari S, Board PG, Bretschneider A, Campbell PM, Chertemps T, Christeller JT, Coppin CW, Downes SJ, Duan G, Farnsworth CA, Good RT, Han LB, Han YC, Hatje K, Horne I, Huang YP, Hughes DST, Jacquin-Joly E, James W, Jhangiani S, Kollmar M, Kuwar SS, Li S, Liu NY, Maibeche MT, Miller JR, Montagne N, Perry T, Qu J, Song SV, Sutton GG, Vogel H, Walenz BP, Xu W, Zhang HJ, Zou Z, Batterham P, Edwards OR, Feyereisen R, Gibbs RA, Heckel DG, McGrath A, Robin C, Scherer SE, Worley KC, Wu YD.

BMC Biol. 2017 Aug 15;15(1):69. doi: 10.1186/s12915-017-0413-3. No abstract available.

10.

Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species.

Pearce SL, Clarke DF, East PD, Elfekih S, Gordon KHJ, Jermiin LS, McGaughran A, Oakeshott JG, Papanicolaou A, Perera OP, Rane RV, Richards S, Tay WT, Walsh TK, Anderson A, Anderson CJ, Asgari S, Board PG, Bretschneider A, Campbell PM, Chertemps T, Christeller JT, Coppin CW, Downes SJ, Duan G, Farnsworth CA, Good RT, Han LB, Han YC, Hatje K, Horne I, Huang YP, Hughes DST, Jacquin-Joly E, James W, Jhangiani S, Kollmar M, Kuwar SS, Li S, Liu NY, Maibeche MT, Miller JR, Montagne N, Perry T, Qu J, Song SV, Sutton GG, Vogel H, Walenz BP, Xu W, Zhang HJ, Zou Z, Batterham P, Edwards OR, Feyereisen R, Gibbs RA, Heckel DG, McGrath A, Robin C, Scherer SE, Worley KC, Wu YD.

BMC Biol. 2017 Jul 31;15(1):63. doi: 10.1186/s12915-017-0402-6. Erratum in: BMC Biol. 2017 Aug 15;15(1):69.

11.

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6480-E6489. doi: 10.1073/pnas.1701868114. Epub 2017 Jul 24.

12.

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels.

Dulhunty AF, Board PG, Beard NA, Casarotto MG.

Adv Pharmacol. 2017;79:287-324. doi: 10.1016/bs.apha.2016.12.001. Epub 2017 Feb 22.

PMID:
28528672
13.

Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability.

Norris NC, Joseph S, Aditya S, Karunasekara Y, Board PG, Dulhunty AF, Oakley AJ, Casarotto MG.

J Biol Chem. 2017 May 19;292(20):8401-8411. doi: 10.1074/jbc.M116.763896. Epub 2017 Mar 28.

14.

Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties.

Galgamuwa R, Hardy K, Dahlstrom JE, Blackburn AC, Wium E, Rooke M, Cappello JY, Tummala P, Patel HR, Chuah A, Tian L, McMorrow L, Board PG, Theodoratos A.

J Am Soc Nephrol. 2016 Nov;27(11):3331-3344. Epub 2016 Mar 9.

15.

The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes.

Hewawasam RP, Liu D, Casarotto MG, Board PG, Dulhunty AF.

PLoS One. 2016 Sep 9;11(9):e0162415. doi: 10.1371/journal.pone.0162415. eCollection 2016.

16.

Structure, function and disease relevance of Omega-class glutathione transferases.

Board PG, Menon D.

Arch Toxicol. 2016 May;90(5):1049-67. doi: 10.1007/s00204-016-1691-1. Epub 2016 Mar 18. Review.

PMID:
26993125
17.

Activation of LINE-1 Retrotransposon Increases the Risk of Epithelial-Mesenchymal Transition and Metastasis in Epithelial Cancer.

Rangasamy D, Lenka N, Ohms S, Dahlstrom JE, Blackburn AC, Board PG.

Curr Mol Med. 2015;15(7):588-97. Review.

18.

Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes.

Samarasinghe K, Liu D, Tummala P, Cappello J, Pace SM, Arnolda L, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2015 Oct 1;97(3):269-80. doi: 10.1016/j.bcp.2015.08.004. Epub 2015 Aug 7.

PMID:
26256076
19.

Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit.

Rebbeck RT, Willemse H, Groom L, Casarotto MG, Board PG, Beard NA, Dirksen RT, Dulhunty AF.

Skelet Muscle. 2015 Jul 22;5:23. doi: 10.1186/s13395-015-0049-3. eCollection 2015.

20.

GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway.

Menon D, Coll R, O'Neill LA, Board PG.

J Cell Sci. 2015 May 15;128(10):1982-90. doi: 10.1242/jcs.167858. Epub 2015 Apr 23.

21.

Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.

Menon D, Coll R, O'Neill LA, Board PG.

Free Radic Biol Med. 2014 Aug;73:318-27. doi: 10.1016/j.freeradbiomed.2014.05.020. Epub 2014 May 27.

PMID:
24873723
22.

Skeletal muscle excitation-contraction coupling: who are the dancing partners?

Rebbeck RT, Karunasekara Y, Board PG, Beard NA, Casarotto MG, Dulhunty AF.

Int J Biochem Cell Biol. 2014 Mar;48:28-38. doi: 10.1016/j.biocel.2013.12.001. Epub 2013 Dec 24. Review.

PMID:
24374102
23.

γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.

Takemura K, Kawachi H, Eishi Y, Kitagaki K, Negi M, Kobayashi M, Uchida K, Inoue J, Inazawa J, Kawano T, Board PG.

Hum Pathol. 2014 Feb;45(2):331-41. doi: 10.1016/j.humpath.2013.09.009. Epub 2013 Oct 3.

PMID:
24342434
24.

A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle.

Menon D, Board PG.

J Biol Chem. 2013 Sep 6;288(36):25769-79. doi: 10.1074/jbc.M113.487785. Epub 2013 Jul 25.

25.

The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force.

Bocedi A, Fabrini R, Farrotti A, Stella L, Ketterman AJ, Pedersen JZ, Allocati N, Lau PC, Grosse S, Eltis LD, Ruzzini A, Edwards TE, Morici L, Del Grosso E, Guidoni L, Bovi D, Lo Bello M, Federici G, Parker MW, Board PG, Ricci G.

J Biol Chem. 2013 Aug 23;288(34):24936-47. doi: 10.1074/jbc.M113.476135. Epub 2013 Jul 3.

26.

Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of a non-catalytic ligandin site.

Brock J, Board PG, Oakley AJ.

PLoS One. 2013 Apr 9;8(4):e60324. doi: 10.1371/journal.pone.0060324. Print 2013.

27.

Characterization of selenium-containing glutathione transferase zeta1-1 with high GPX activity prepared in eukaryotic cells.

Yin L, Song J, Board PG, Yu Y, Han X, Wei J.

J Mol Recognit. 2013 Jan;26(1):38-45. doi: 10.1002/jmr.2241.

PMID:
23280616
28.

Glutathione transferases, regulators of cellular metabolism and physiology.

Board PG, Menon D.

Biochim Biophys Acta. 2013 May;1830(5):3267-88. doi: 10.1016/j.bbagen.2012.11.019. Epub 2012 Nov 29. Review.

PMID:
23201197
29.

A fluorometric method to quantify protein glutathionylation using glutathione derivatization with 2,3-naphthalenedicarboxaldehyde.

Menon D, Board PG.

Anal Biochem. 2013 Feb 15;433(2):132-6. doi: 10.1016/j.ab.2012.10.009. Epub 2012 Oct 13.

PMID:
23072983
30.

An α-helical C-terminal tail segment of the skeletal L-type Ca2+ channel β1a subunit activates ryanodine receptor type 1 via a hydrophobic surface.

Karunasekara Y, Rebbeck RT, Weaver LM, Board PG, Dulhunty AF, Casarotto MG.

FASEB J. 2012 Dec;26(12):5049-59. doi: 10.1096/fj.12-211334. Epub 2012 Sep 7.

PMID:
22962299
31.

An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.

Takano K, Liu D, Tarpey P, Gallant E, Lam A, Witham S, Alexov E, Chaubey A, Stevenson RE, Schwartz CE, Board PG, Dulhunty AF.

Hum Mol Genet. 2012 Oct 15;21(20):4497-507. Epub 2012 Jul 19.

32.

Reduction of benzoquinones to hydroquinones via spontaneous reaction with glutathione and enzymatic reaction by S-glutathionyl-hydroquinone reductases.

Lam LK, Zhang Z, Board PG, Xun L.

Biochemistry. 2012 Jun 26;51(25):5014-21. doi: 10.1021/bi300477z. Epub 2012 Jun 13.

PMID:
22686328
33.

Expression of selenocysteine-containing glutathione S-transferase in eukaryote.

Liu H, Yin L, Board PG, Han X, Fan Z, Fang J, Lu Z, Zhang Y, Wei J.

Protein Expr Purif. 2012 Jul;84(1):59-63. doi: 10.1016/j.pep.2012.04.015. Epub 2012 Apr 27.

PMID:
22561244
34.

Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases.

Zhou H, Brock J, Liu D, Board PG, Oakley AJ.

J Mol Biol. 2012 Jul 13;420(3):190-203. doi: 10.1016/j.jmb.2012.04.014. Epub 2012 Apr 18.

PMID:
22522127
35.

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.

Liu D, Hewawasam R, Karunasekara Y, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2012 Jun 1;83(11):1523-9. doi: 10.1016/j.bcp.2012.02.020. Epub 2012 Mar 1.

PMID:
22406107
36.

The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo.

Theodoratos A, Blackburn AC, Coggan M, Cappello J, Larter CZ, Matthaei KI, Board PG.

Int J Obes (Lond). 2012 Oct;36(10):1366-9. doi: 10.1038/ijo.2011.267. Epub 2012 Jan 17.

PMID:
22249229
37.

Widespread expression of γ-glutamyl cyclotransferase suggests it is not a general tumor marker.

Amano T, Eishi Y, Yamada T, Uchida K, Minegishi K, Tamura T, Kobayashi D, Hiroshi K, Suzuki T, Board PG.

J Histochem Cytochem. 2012 Jan;60(1):76-86. doi: 10.1369/0022155411428468.

38.

Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.

Theodoratos A, Blackburn AC, Cappello J, Tummala P, Dahlstrom JE, Board PG.

Biochem Pharmacol. 2012 Feb 1;83(3):427-33. doi: 10.1016/j.bcp.2011.11.012. Epub 2011 Nov 23.

PMID:
22127296
39.

Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells.

Sun RC, Board PG, Blackburn AC.

Mol Cancer. 2011 Nov 18;10:142. doi: 10.1186/1476-4598-10-142.

40.

A fluorescence-based microtiter plate assay for γ-glutamylcyclotransferase.

Board PG, Hutchinson I.

Anal Biochem. 2012 Jan 15;420(2):177-81. doi: 10.1016/j.ab.2011.09.014. Epub 2011 Sep 22.

PMID:
22001377
41.

3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM.

Perálvarez-Marín A, Tae H, Board PG, Casarotto MG, Dulhunty AF, Samsó M.

PLoS One. 2011;6(10):e25813. doi: 10.1371/journal.pone.0025813. Epub 2011 Oct 5.

42.

Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress.

Blackburn AC, Coggan M, Shield AJ, Cappello J, Theodoratos A, Murray TP, Rooke M, Larter CZ, Koina ME, Dahlstrom JE, Matthaei KI, Board PG.

Lab Invest. 2011 Nov;91(11):1572-83. doi: 10.1038/labinvest.2011.107. Epub 2011 Aug 8.

43.

Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function.

Tae HS, Cui Y, Karunasekara Y, Board PG, Dulhunty AF, Casarotto MG.

J Biol Chem. 2011 Jun 24;286(25):22589-99. doi: 10.1074/jbc.M110.205476. Epub 2011 Apr 27.

44.

The omega-class glutathione transferases: structure, function, and genetics.

Board PG.

Drug Metab Rev. 2011 May;43(2):226-35. doi: 10.3109/03602532.2011.561353. Review.

PMID:
21495794
45.

A structural basis for cellular uptake of GST-fold proteins.

Morris MJ, Liu D, Weaver LM, Board PG, Casarotto MG.

PLoS One. 2011 Mar 24;6(3):e17864. doi: 10.1371/journal.pone.0017864.

46.

Regulation of the cardiac muscle ryanodine receptor by glutathione transferases.

Dulhunty AF, Hewawasam R, Liu D, Casarotto MG, Board PG.

Drug Metab Rev. 2011 May;43(2):236-52. doi: 10.3109/03602532.2010.549134. Epub 2011 Feb 17. Review.

PMID:
21323602
47.

The β(1a) subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail.

Rebbeck RT, Karunasekara Y, Gallant EM, Board PG, Beard NA, Casarotto MG, Dulhunty AF.

Biophys J. 2011 Feb 16;100(4):922-30. doi: 10.1016/j.bpj.2011.01.022.

48.

Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice.

Board PG, Anders MW.

Drug Metab Rev. 2011 May;43(2):215-25. doi: 10.3109/03602532.2010.549132. Epub 2011 Feb 8. Review.

PMID:
21303221
49.

The elusive role of the SPRY2 domain in RyR1.

Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A.

Channels (Austin). 2011 Mar-Apr;5(2):148-60. Epub 2011 Mar 1.

50.

Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1.

Zhou H, Brock J, Casarotto MG, Oakley AJ, Board PG.

J Biol Chem. 2011 Feb 11;286(6):4271-9. doi: 10.1074/jbc.M110.197822. Epub 2010 Nov 24.

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