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Analysis of RNA Methylation by Phylogenetically Diverse Cfr Radical S-Adenosylmethionine Enzymes Reveals an Iron-Binding Accessory Domain in a Clostridial Enzyme.

Gumkowski JD, Martinie RJ, Corrigan PS, Pan J, Bauerle MR, Almarei M, Booker SJ, Silakov A, Krebs C, Boal AK.

Biochemistry. 2019 Jul 23;58(29):3169-3184. doi: 10.1021/acs.biochem.9b00197. Epub 2019 Jul 12.


Hydrogen Donation but not Abstraction by a Tyrosine (Y68) during Endoperoxide Installation by Verruculogen Synthase (FtmOx1).

Dunham NP, Del Río Pantoja JM, Zhang B, Rajakovich LJ, Allen BD, Krebs C, Boal AK, Bollinger JM Jr.

J Am Chem Soc. 2019 Jun 26;141(25):9964-9979. doi: 10.1021/jacs.9b03567. Epub 2019 Jun 12.


Biochemical and Structural Characterization of XoxG and XoxJ and Their Roles in Lanthanide-Dependent Methanol Dehydrogenase Activity.

Featherston ER, Rose HR, McBride MJ, Taylor EM, Boal AK, Cotruvo JA Jr.

Chembiochem. 2019 Apr 24. doi: 10.1002/cbic.201900184. [Epub ahead of print]


Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis.

Rose HR, Maggiolo AO, McBride MJ, Palowitch GM, Pandelia ME, Davis KM, Yennawar NH, Boal AK.

Biochemistry. 2019 Apr 9;58(14):1845-1860. doi: 10.1021/acs.biochem.8b01252. Epub 2019 Mar 22.


A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.

Rajakovich LJ, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM Jr.

Biochemistry. 2019 Mar 26;58(12):1627-1647. doi: 10.1021/acs.biochem.9b00044. Epub 2019 Mar 7.


An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin.

Ng TL, Rohac R, Mitchell AJ, Boal AK, Balskus EP.

Nature. 2019 Feb;566(7742):94-99. doi: 10.1038/s41586-019-0894-z. Epub 2019 Feb 6.


α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC.

Dunham NP, Mitchell AJ, Del Río Pantoja JM, Krebs C, Bollinger JM Jr, Boal AK.

Biochemistry. 2018 Nov 20;57(46):6479-6488. doi: 10.1021/acs.biochem.8b00901. Epub 2018 Nov 7.


Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical.

Blaesi EJ, Palowitch GM, Hu K, Kim AJ, Rose HR, Alapati R, Lougee MG, Kim HJ, Taguchi AT, Tan KO, Laremore TN, Griffin RG, Krebs C, Matthews ML, Silakov A, Bollinger JM Jr, Allen BD, Boal AK.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10022-10027. doi: 10.1073/pnas.1811993115. Epub 2018 Sep 17.


An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.

Parker MJ, Maggiolo AO, Thomas WC, Kim A, Meisburger SP, Ando N, Boal AK, Stubbe J.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4594-E4603. doi: 10.1073/pnas.1800356115. Epub 2018 Apr 30.


Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance.

Dunham NP, Chang WC, Mitchell AJ, Martinie RJ, Zhang B, Bergman JA, Rajakovich LJ, Wang B, Silakov A, Krebs C, Boal AK, Bollinger JM Jr.

J Am Chem Soc. 2018 Jun 13;140(23):7116-7126. doi: 10.1021/jacs.8b01933. Epub 2018 Jun 4.


Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor.

Rose HR, Ghosh MK, Maggiolo AO, Pollock CJ, Blaesi EJ, Hajj V, Wei Y, Rajakovich LJ, Chang WC, Han Y, Hajj M, Krebs C, Silakov A, Pandelia ME, Bollinger JM Jr, Boal AK.

Biochemistry. 2018 May 8;57(18):2679-2693. doi: 10.1021/acs.biochem.8b00247. Epub 2018 Apr 17.


Mechanism-Based Strategies for Structural Characterization of Radical SAM Reaction Intermediates.

Davis KM, Boal AK.

Methods Enzymol. 2017;595:331-359. doi: 10.1016/bs.mie.2017.07.008. Epub 2017 Aug 31. Review.


Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase.

Mitchell AJ, Dunham NP, Martinie RJ, Bergman JA, Pollock CJ, Hu K, Allen BD, Chang WC, Silakov A, Bollinger JM Jr, Krebs C, Boal AK.

J Am Chem Soc. 2017 Oct 4;139(39):13830-13836. doi: 10.1021/jacs.7b07374. Epub 2017 Sep 20.


AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress.

Liu Y, Fares M, Dunham NP, Gao Z, Miao K, Jiang X, Bollinger SS, Boal AK, Zhang X.

Angew Chem Int Ed Engl. 2017 Jul 17;56(30):8672-8676. doi: 10.1002/anie.201702417. Epub 2017 Jun 19.


Rerouting the Pathway for the Biosynthesis of the Side Ring System of Nosiheptide: The Roles of NosI, NosJ, and NosK.

Badding ED, Grove TL, Gadsby LK, LaMattina JW, Boal AK, Booker SJ.

J Am Chem Soc. 2017 Apr 26;139(16):5896-5905. doi: 10.1021/jacs.7b01497. Epub 2017 Apr 17.


Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers.

Fuller FD, Gul S, Chatterjee R, Burgie ES, Young ID, Lebrette H, Srinivas V, Brewster AS, Michels-Clark T, Clinger JA, Andi B, Ibrahim M, Pastor E, de Lichtenberg C, Hussein R, Pollock CJ, Zhang M, Stan CA, Kroll T, Fransson T, Weninger C, Kubin M, Aller P, Lassalle L, Bräuer P, Miller MD, Amin M, Koroidov S, Roessler CG, Allaire M, Sierra RG, Docker PT, Glownia JM, Nelson S, Koglin JE, Zhu D, Chollet M, Song S, Lemke H, Liang M, Sokaras D, Alonso-Mori R, Zouni A, Messinger J, Bergmann U, Boal AK, Bollinger JM Jr, Krebs C, Högbom M, Phillips GN Jr, Vierstra RD, Sauter NK, Orville AM, Kern J, Yachandra VK, Yano J.

Nat Methods. 2017 Apr;14(4):443-449. doi: 10.1038/nmeth.4195. Epub 2017 Feb 27.


The Cation-π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification.

Liu Y, Miao K, Dunham NP, Liu H, Fares M, Boal AK, Li X, Zhang X.

Biochemistry. 2017 Mar 21;56(11):1585-1595. doi: 10.1021/acs.biochem.7b00056. Epub 2017 Mar 13.


Structure-Guided Reprogramming of a Hydroxylase To Halogenate Its Small Molecule Substrate.

Mitchell AJ, Dunham NP, Bergman JA, Wang B, Zhu Q, Chang WC, Liu X, Boal AK.

Biochemistry. 2017 Jan 24;56(3):441-444. doi: 10.1021/acs.biochem.6b01173. Epub 2017 Jan 11.


Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.

Mitchell AJ, Zhu Q, Maggiolo AO, Ananth NR, Hillwig ML, Liu X, Boal AK.

Nat Chem Biol. 2016 Aug;12(8):636-40. doi: 10.1038/nchembio.2112. Epub 2016 Jun 27.


Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.

Schwalm EL, Grove TL, Booker SJ, Boal AK.

Science. 2016 Apr 15;352(6283):309-12. doi: 10.1126/science.aad5367.


Assembly of the unusual oxacycles in the orthosomycin antibiotics.

Boal AK, Bollinger JM Jr, Chang WC.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):11989-90. doi: 10.1073/pnas.1514689112. Epub 2015 Sep 16. No abstract available.


Response from Boal and Rosenzweig to Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.

Boal AK, Rosenzweig AC.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1984-6. doi: 10.1107/S1399004715014352. Epub 2015 Aug 28. No abstract available.


Characterization of a cross-linked protein-nucleic acid substrate radical in the reaction catalyzed by RlmN.

Silakov A, Grove TL, Radle MI, Bauerle MR, Green MT, Rosenzweig AC, Boal AK, Booker SJ.

J Am Chem Soc. 2014 Jun 11;136(23):8221-8. doi: 10.1021/ja410560p. Epub 2014 Jun 2.


Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics.

Chang WC, Guo Y, Wang C, Butch SE, Rosenzweig AC, Boal AK, Krebs C, Bollinger JM Jr.

Science. 2014 Mar 7;343(6175):1140-4. doi: 10.1126/science.1248000.


Streptococcus sanguinis class Ib ribonucleotide reductase: high activity with both iron and manganese cofactors and structural insights.

Makhlynets O, Boal AK, Rhodes DV, Kitten T, Rosenzweig AC, Stubbe J.

J Biol Chem. 2014 Feb 28;289(9):6259-72. doi: 10.1074/jbc.M113.533554. Epub 2013 Dec 31.


Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases.

Wörsdörfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18874-9. doi: 10.1073/pnas.1315927110. Epub 2013 Nov 6.


Structural basis for assembly of the Mn(IV)/Fe(III) cofactor in the class Ic ribonucleotide reductase from Chlamydia trachomatis.

Dassama LM, Krebs C, Bollinger JM Jr, Rosenzweig AC, Boal AK.

Biochemistry. 2013 Sep 17;52(37):6424-36. doi: 10.1021/bi400819x. Epub 2013 Sep 3.


Templated nanocrystal assembly on biodynamic artificial microtubule asters.

Spoerke ED, Boal AK, Bachand GD, Bunker BC.

ACS Nano. 2013 Mar 26;7(3):2012-9. doi: 10.1021/nn303998k. Epub 2013 Feb 18.


Biochemistry. A radical route for nitrogenase carbide insertion.

Boal AK, Rosenzweig AC.

Science. 2012 Sep 28;337(6102):1617-8. No abstract available.


The dimanganese(II) site of Bacillus subtilis class Ib ribonucleotide reductase.

Boal AK, Cotruvo JA Jr, Stubbe J, Rosenzweig AC.

Biochemistry. 2012 May 8;51(18):3861-71. doi: 10.1021/bi201925t. Epub 2012 Apr 25.


Evidence that the β subunit of Chlamydia trachomatis ribonucleotide reductase is active with the manganese ion of its manganese(IV)/iron(III) cofactor in site 1.

Dassama LM, Boal AK, Krebs C, Rosenzweig AC, Bollinger JM Jr.

J Am Chem Soc. 2012 Feb 8;134(5):2520-3. doi: 10.1021/ja211314p. Epub 2012 Jan 25.


Structural basis for methyl transfer by a radical SAM enzyme.

Boal AK, Grove TL, McLaughlin MI, Yennawar NH, Booker SJ, Rosenzweig AC.

Science. 2011 May 27;332(6033):1089-92. doi: 10.1126/science.1205358. Epub 2011 Apr 28.


Structural basis for activation of class Ib ribonucleotide reductase.

Boal AK, Cotruvo JA Jr, Stubbe J, Rosenzweig AC.

Science. 2010 Sep 17;329(5998):1526-30. doi: 10.1126/science.1190187. Epub 2010 Aug 5.


DNA-mediated charge transport in redox sensing and signaling.

Genereux JC, Boal AK, Barton JK.

J Am Chem Soc. 2010 Jan 27;132(3):891-905. doi: 10.1021/ja907669c.


Structural biology of copper trafficking.

Boal AK, Rosenzweig AC.

Chem Rev. 2009 Oct;109(10):4760-79. doi: 10.1021/cr900104z. Review. No abstract available.


Crystal structures of cisplatin bound to a human copper chaperone.

Boal AK, Rosenzweig AC.

J Am Chem Soc. 2009 Oct 14;131(40):14196-7. doi: 10.1021/ja906363t.


Redox signaling between DNA repair proteins for efficient lesion detection.

Boal AK, Genereux JC, Sontz PA, Gralnick JA, Newman DK, Barton JK.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15237-42. doi: 10.1073/pnas.0908059106. Epub 2009 Aug 31.


Metalloporphyrin assemblies on pyridine-functionalized titanium dioxide.

Brumbach MT, Boal AK, Wheeler DR.

Langmuir. 2009 Sep 15;25(18):10685-90. doi: 10.1021/la901130a.


Biological contexts for DNA charge transport chemistry.

Merino EJ, Boal AK, Barton JK.

Curr Opin Chem Biol. 2008 Apr;12(2):229-37. doi: 10.1016/j.cbpa.2008.01.046. Epub 2008 Mar 17. Review.


DNA repair glycosylases with a [4Fe-4S] cluster: a redox cofactor for DNA-mediated charge transport?

Boal AK, Yavin E, Barton JK.

J Inorg Biochem. 2007 Nov;101(11-12):1913-21. Epub 2007 May 17. Review.


Facile and E-selective intramolecular ring-closing metathesis reactions in 3(10)-helical peptides: a 3D structural study.

Boal AK, Guryanov I, Moretto A, Crisma M, Lanni EL, Toniolo C, Grubbs RH, O'Leary DJ.

J Am Chem Soc. 2007 Jun 6;129(22):6986-7. Epub 2007 May 11. No abstract available.


The stability and functionality of chemically crosslinked microtubules.

Boal AK, Tellez H, Rivera SB, Miller NE, Bachand GD, Bunker BC.

Small. 2006 Jun;2(6):793-803.


Direct electrochemistry of endonuclease III in the presence and absence of DNA.

Gorodetsky AA, Boal AK, Barton JK.

J Am Chem Soc. 2006 Sep 20;128(37):12082-3.


Direct control of the magnetic interaction between iron oxide nanoparticles through dendrimer-mediated self-assembly.

Frankamp BL, Boal AK, Tuominen MT, Rotello VM.

J Am Chem Soc. 2005 Jul 13;127(27):9731-5.


DNA-bound redox activity of DNA repair glycosylases containing [4Fe-4S] clusters.

Boal AK, Yavin E, Lukianova OA, O'Shea VL, David SS, Barton JK.

Biochemistry. 2005 Jun 14;44(23):8397-407.


Electrochemical detection of lesions in DNA.

Boal AK, Barton JK.

Bioconjug Chem. 2005 Mar-Apr;16(2):312-21.


Protein-DNA charge transport: redox activation of a DNA repair protein by guanine radical.

Yavin E, Boal AK, Stemp ED, Boon EM, Livingston AL, O'Shea VL, David SS, Barton JK.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3546-51. Epub 2005 Feb 28.


Controlled interparticle spacing through self-assembly of Au nanoparticles and poly(amidoamine) dendrimers.

Frankamp BL, Boal AK, Rotello VM.

J Am Chem Soc. 2002 Dec 25;124(51):15146-7.


Supramolecular assembly on surfaces: manipulating conductance in noncovalently modified mesoscale structures.

Credo GM, Boal AK, Das K, Galow TH, Rotello VM, Feldheim DL, Gorman CB.

J Am Chem Soc. 2002 Aug 7;124(31):9036-7.


Radial control of recognition and redox processes with multivalent nanoparticle hosts.

Boal AK, Rotello VM.

J Am Chem Soc. 2002 May 8;124(18):5019-24.


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