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Items: 1 to 50 of 155

1.

RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome.

Rooney N, Mason SM, McDonald L, Däbritz JHM, Campbell KJ, Hedley A, Howard S, Athineos D, Nixon C, Clark W, Leach JDG, Sansom OJ, Edwards J, Cameron ER, Blyth K.

Cancer Res. 2020 Mar 10. pii: canres.3870.2019. doi: 10.1158/0008-5472.CAN-19-3870. [Epub ahead of print]

2.

Somatic base editing to model oncogenic drivers in breast cancer.

Campbell KJ, Blyth K.

Lab Anim (NY). 2020 Apr;49(4):115-116. doi: 10.1038/s41684-020-0510-8. No abstract available.

PMID:
32152514
3.

Follow-up and Clinical Outcomes of Human Immunodeficiency Virus (HIV)-Exposed Infants in A Low-Prevalence Setting in A Multidisciplinary Model of Care in Australia: The Children's HIV Exposure Study 1.

Shepherd K, Giles M, Blyth K, O'Keeffe F, Bordun L, Connell TG, Bryant PA.

J Pediatric Infect Dis Soc. 2020 Feb 18. pii: piaa010. doi: 10.1093/jpids/piaa010. [Epub ahead of print]

PMID:
32067032
4.

DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.

MacKenzie DJ, Robertson NA, Rather I, Reid C, Sendzikaite G, Cruickshanks H, McBryan T, Hodges A, Pritchard C, Blyth K, Adams PD.

iScience. 2020 Feb 21;23(2):100838. doi: 10.1016/j.isci.2020.100838. Epub 2020 Jan 14.

5.

Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night.

Sweeney K, Cameron ER, Blyth K.

Mol Cells. 2020 Feb 29;43(2):188-197. doi: 10.14348/molcells.2019.0310. Review.

6.

A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells.

Ran R, Harrison H, Syamimi Ariffin N, Ayub R, Pegg HJ, Deng W, Mastro A, Ottewell PD, Mason SM, Blyth K, Holen I, Shore P.

Oncogene. 2020 Mar;39(12):2624-2637. doi: 10.1038/s41388-020-1170-2. Epub 2020 Jan 31.

7.

RUNX1 Dosage in Development and Cancer.

Lie-A-Ling M, Mevel R, Patel R, Blyth K, Baena E, Kouskoff V, Lacaud G.

Mol Cells. 2020 Feb 29;43(2):126-138. doi: 10.14348/molcells.2019.0301. Review.

8.

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.

Cheung EC, DeNicola GM, Nixon C, Blyth K, Labuschagne CF, Tuveson DA, Vousden KH.

Cancer Cell. 2020 Feb 10;37(2):168-182.e4. doi: 10.1016/j.ccell.2019.12.012. Epub 2020 Jan 23.

9.

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.

Blagih J, Zani F, Chakravarty P, Hennequart M, Pilley S, Hobor S, Hock AK, Walton JB, Morton JP, Gronroos E, Mason S, Yang M, McNeish I, Swanton C, Blyth K, Vousden KH.

Cell Rep. 2020 Jan 14;30(2):481-496.e6. doi: 10.1016/j.celrep.2019.12.028.

10.

Correction: BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.

Loveridge CJ, Slater S, Campbell KJ, Nam NA, Knight J, Ahmad I, Hedley A, Lilla S, Repiscak P, Patel R, Salji M, Fleming J, Mitchell L, Nixon C, Strathdee D, Neilson M, Ntala C, Bryson S, Zanivan S, Edwards J, Robson CN, Goodyear CS, Blyth K, Leung HY.

Oncogene. 2020 Mar;39(11):2450. doi: 10.1038/s41388-019-1149-z.

PMID:
31857667
11.

Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial.

Bhatnagar R, Piotrowska HEG, Laskawiec-Szkonter M, Kahan BC, Luengo-Fernandez R, Pepperell JCT, Evison MD, Holme J, Al-Aloul M, Psallidas I, Lim WS, Blyth KG, Roberts ME, Cox G, Downer NJ, Herre J, Sivasothy P, Menzies D, Munavvar M, Kyi MM, Ahmed L, West AG, Harrison RN, Prudon B, Hettiarachchi G, Chakrabarti B, Kavidasan A, Sutton BP, Zahan-Evans NJ, Quaddy JL, Edey AJ, Clive AO, Walker SP, Little MHR, Mei XW, Harvey JE, Hooper CE, Davies HE, Slade M, Sivier M, Miller RF, Rahman NM, Maskell NA.

JAMA. 2019 Dec 5. doi: 10.1001/jama.2019.19997. [Epub ahead of print]

PMID:
31804680
12.

Continuous professional development: elevating thoracic oncology education in Europe.

van Geffen WH, Blum TG, Aliberti S, Blyth KG, Bostantzoglou C, Farr A, Grigoriu B, Hardavella G, Huber RM, Maskell N, Massard G, Rahman NM, Stolz D, van Meerbeeck J.

Breathe (Sheff). 2019 Dec;15(4):279-285. doi: 10.1183/20734735.0296-2019.

13.

BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.

Loveridge CJ, Slater S, Campbell KJ, Nam NA, Knight J, Ahmad I, Hedley A, Lilla S, Repiscak P, Patel R, Salji M, Fleming J, Mitchell L, Nixon C, Strathdee D, Neilson M, Ntala C, Bryson S, Zanivan S, Edwards J, Robson CN, Goodyear CS, Blyth K, Leung HY.

Oncogene. 2020 Feb;39(8):1797-1806. doi: 10.1038/s41388-019-1106-x. Epub 2019 Nov 18. Erratum in: Oncogene. 2019 Dec 19;:.

14.

Cancer cachexia in thoracic malignancy: a narrative review.

Kidd AC, Skrzypski M, Jamal-Hanjani M, Blyth KG.

Curr Opin Support Palliat Care. 2019 Dec;13(4):316-322. doi: 10.1097/SPC.0000000000000465.

PMID:
31592847
15.

Inter-observer variation in image interpretation and the prognostic importance of non-expansile lung in malignant pleural effusion.

Martin GA, Kidd AC, Tsim S, Halford P, Bibby A, Maskell NA, Blyth KG.

Respirology. 2020 Mar;25(3):298-304. doi: 10.1111/resp.13681. Epub 2019 Aug 21.

PMID:
31433545
16.

Pre-EDIT: A Randomized Feasibility Trial of Elastance-Directed Intrapleural Catheter or Talc Pleurodesis in Malignant Pleural Effusion.

Martin GA, Tsim S, Kidd AC, Foster JE, McLoone P, Chalmers A, Blyth KG.

Chest. 2019 Dec;156(6):1204-1213. doi: 10.1016/j.chest.2019.07.010. Epub 2019 Jul 30.

PMID:
31374208
17.

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing.

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A, Dhayade S, Athineos D, Caley M, Mannella V, Blyth K, Inman GJ, Leigh IM.

Int J Mol Sci. 2019 Jul 12;20(14). pii: E3428. doi: 10.3390/ijms20143428.

18.

Baseline predictors of negative and incomplete pleural cytology in patients with suspected pleural malignancy - Data supporting 'Direct to LAT' in selected groups.

Tsim S, Paterson S, Cartwright D, Fong CJ, Alexander L, Kelly C, Holme J, Evison M, Blyth KG.

Lung Cancer. 2019 Jul;133:123-129. doi: 10.1016/j.lungcan.2019.05.017. Epub 2019 May 16.

PMID:
31200818
19.

Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization.

Rudzka DA, Spennati G, McGarry DJ, Chim YH, Neilson M, Ptak A, Munro J, Kalna G, Hedley A, Moralli D, Green C, Mason S, Blyth K, Mullin M, Yin H, Olson MF.

J Cell Sci. 2019 May 31;132(11). pii: jcs224071. doi: 10.1242/jcs.224071.

20.

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.

Caraffini V, Geiger O, Rosenberger A, Hatzl S, Perfler B, Berg JL, Lim C, Strobl H, Kashofer K, Schauer S, Beham-Schmid C, Hoefler G, Geissler K, Quehenberger F, Kolch W, Athineos D, Blyth K, Wölfler A, Sill H, Zebisch A.

Haematologica. 2020 Jan 31;105(2):375-386. doi: 10.3324/haematol.2018.209650. Print 2020.

21.

Imaging in pleural mesothelioma: A review of the 14th International Conference of the International Mesothelioma Interest Group.

Armato SG 3rd, Francis RJ, Katz SI, Ak G, Opitz I, Gudmundsson E, Blyth KG, Gupta A.

Lung Cancer. 2019 Apr;130:108-114. doi: 10.1016/j.lungcan.2018.11.033. Epub 2018 Nov 28. Review.

PMID:
30885330
22.

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.

Liko D, Mitchell L, Campbell KJ, Ridgway RA, Jones C, Dudek K, King A, Bryson S, Stevenson D, Blyth K, Strathdee D, Morton JP, Bird TG, Knight JRP, Willis AE, Sansom OJ.

Cell Death Differ. 2019 Dec;26(12):2535-2550. doi: 10.1038/s41418-019-0316-7. Epub 2019 Mar 11.

23.

Author Correction: Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori.

Johnson SA, Ormsby MJ, McIntosh A, Tait SWG, Blyth K, Wall DM.

Cancer Gene Ther. 2020 Feb;27(1-2):112. doi: 10.1038/s41417-019-0086-x.

PMID:
30783214
24.

Lung cancer symptom appraisal among people with chronic obstructive pulmonary disease: A qualitative interview study.

Cunningham Y, Wyke S, Blyth KG, Rigg D, Macdonald S, Macleod U, Harrow S, Robb KA, Whitaker KL.

Psychooncology. 2019 Apr;28(4):718-725. doi: 10.1002/pon.5005. Epub 2019 Feb 12.

25.

Improving the metabolic fidelity of cancer models with a physiological cell culture medium.

Vande Voorde J, Ackermann T, Pfetzer N, Sumpton D, Mackay G, Kalna G, Nixon C, Blyth K, Gottlieb E, Tardito S.

Sci Adv. 2019 Jan 2;5(1):eaau7314. doi: 10.1126/sciadv.aau7314. eCollection 2019 Jan.

26.

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels.

Novo D, Heath N, Mitchell L, Caligiuri G, MacFarlane A, Reijmer D, Charlton L, Knight J, Calka M, McGhee E, Dornier E, Sumpton D, Mason S, Echard A, Klinkert K, Secklehner J, Kruiswijk F, Vousden K, Macpherson IR, Blyth K, Bailey P, Yin H, Carlin LM, Morton J, Zanivan S, Norman JC.

Nat Commun. 2018 Nov 29;9(1):5069. doi: 10.1038/s41467-018-07339-y.

27.

Predicting survival following surgical resection of lung cancer using clinical and pathological variables: The development and validation of the LNC-PATH score.

Balata H, Foden P, Edwards T, Chaturvedi A, Elshafi M, Tempowski A, Teng B, Whittemore P, Blyth KG, Kidd A, Ellames D, Flint LA, Robson J, Teh E, Jones R, Batchelor T, Crosbie P, Booton R, Evison M.

Lung Cancer. 2018 Nov;125:29-34. doi: 10.1016/j.lungcan.2018.08.026. Epub 2018 Aug 31.

PMID:
30429034
28.

Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme.

Lindsay CR, Shaw EC, Blackhall F, Blyth KG, Brenton JD, Chaturvedi A, Clarke N, Dick C, Evans TRJ, Hall G, Hanby AM, Harrison DJ, Johnston SRD, Mason MD, Morton D, Newton-Bishop J, Nicholson AG, Oien KA, Popat S, Rassl D, Sharpe R, Taniere P, Walker I, Wallace WA, West NP, Butler R, Gonzalez de Castro D, Griffiths M, Johnson PWM.

ESMO Open. 2018 Sep 5;3(6):e000408. doi: 10.1136/esmoopen-2018-000408. eCollection 2018.

29.

Correction: Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori.

Johnson SA, Ormsby MJ, McIntosh A, Tait SWG, Blyth K, Wall DM.

Cancer Gene Ther. 2018 Dec;25(11-12):339. doi: 10.1038/s41417-018-0047-9.

PMID:
30232385
30.

Providing safe and effective pleural medicine services in the UK: an aspirational statement from UK pleural physicians.

Evison M, Blyth KG, Bhatnagar R, Corcoran J, Saba T, Duncan T, Hallifax R, Ahmed L, West A, Pepperell JCT, Roberts M, Sivasothy P, Psallidas I, Clive AO, Latham J, Stanton AE, Maskell N, Rahman N.

BMJ Open Respir Res. 2018 Aug 3;5(1):e000307. doi: 10.1136/bmjresp-2018-000307. eCollection 2018.

31.

Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori.

Johnson SA, Ormsby MJ, McIntosh A, Tait SWG, Blyth K, Wall DM.

Cancer Gene Ther. 2019 Jul;26(7-8):183-194. doi: 10.1038/s41417-018-0039-9. Epub 2018 Aug 13. Erratum in: Cancer Gene Ther. 2018 Sep 19;:. Cancer Gene Ther. 2019 Feb 20;:.

32.

An Inconvenient Truth Concerning Surgery for Mesothelioma.

de Fonseka D, Slade M, Blyth KG, Edwards J, Evison M, Roberts M, Rahman N, Woolhouse I, Maskell NA.

J Clin Oncol. 2018 Sep 10;36(26):2745-2746. doi: 10.1200/JCO.2018.78.6590. Epub 2018 Jun 14. No abstract available.

PMID:
29902107
33.

Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion.

Martin GA, Tsim S, Kidd AC, Foster JE, McLoone P, Chalmers A, Blyth KG.

BMJ Open Respir Res. 2018 May 29;5(1):e000293. doi: 10.1136/bmjresp-2018-000293. eCollection 2018.

34.

Author Correction: CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity.

Walton JB, Farquharson M, Mason S, Port J, Kruspig B, Dowson S, Stevenson D, Murphy D, Matzuk M, Kim J, Coffelt S, Blyth K, McNeish IA.

Sci Rep. 2018 Apr 13;8(1):6231. doi: 10.1038/s41598-018-24099-3.

35.

Increased formate overflow is a hallmark of oxidative cancer.

Meiser J, Schuster A, Pietzke M, Vande Voorde J, Athineos D, Oizel K, Burgos-Barragan G, Wit N, Dhayade S, Morton JP, Dornier E, Sumpton D, Mackay GM, Blyth K, Patel KJ, Niclou SP, Vazquez A.

Nat Commun. 2018 Apr 10;9(1):1368. doi: 10.1038/s41467-018-03777-w.

36.

Early Contrast Enhancement: A novel magnetic resonance imaging biomarker of pleural malignancy.

Tsim S, Humphreys CA, Cowell GW, Stobo DB, Noble C, Woodward R, Kelly CA, Alexander L, Foster JE, Dick C, Blyth KG.

Lung Cancer. 2018 Apr;118:48-56. doi: 10.1016/j.lungcan.2018.01.014. Epub 2018 Feb 3.

37.

Survival prediction in mesothelioma using a scalable Lasso regression model: instructions for use and initial performance using clinical predictors.

Kidd AC, McGettrick M, Tsim S, Halligan DL, Bylesjo M, Blyth KG.

BMJ Open Respir Res. 2018 Jan 30;5(1):e000240. doi: 10.1136/bmjresp-2017-000240. eCollection 2018.

38.

Progress and challenges in Mesothelioma: From bench to bedside.

Blyth KG, Murphy DJ.

Respir Med. 2018 Jan;134:31-41. doi: 10.1016/j.rmed.2017.11.015. Epub 2017 Nov 26. Review.

PMID:
29413505
39.

A retrospective cohort study in severe asthma describing commonly measured biomarkers: Eosinophil count and IgE levels.

Haughney J, Morice A, Blyth KG, Lee AJ, Coutts A, McKnight E, Pavord I.

Respir Med. 2018 Jan;134:117-123. doi: 10.1016/j.rmed.2017.12.001. Epub 2017 Dec 5.

PMID:
29413497
40.

MCL-1 is a prognostic indicator and drug target in breast cancer.

Campbell KJ, Dhayade S, Ferrari N, Sims AH, Johnson E, Mason SM, Dickson A, Ryan KM, Kalna G, Edwards J, Tait SWG, Blyth K.

Cell Death Dis. 2018 Jan 16;9(2):19. doi: 10.1038/s41419-017-0035-2.

41.

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.

Dornier E, Rabas N, Mitchell L, Novo D, Dhayade S, Marco S, Mackay G, Sumpton D, Pallares M, Nixon C, Blyth K, Macpherson IR, Rainero E, Norman JC.

Nat Commun. 2017 Dec 21;8(1):2255. doi: 10.1038/s41467-017-02101-2.

42.

RIPK3 promotes adenovirus type 5 activity.

Weigert M, Binks A, Dowson S, Leung EYL, Athineos D, Yu X, Mullin M, Walton JB, Orange C, Ennis D, Blyth K, Tait SWG, McNeish IA.

Cell Death Dis. 2017 Dec 13;8(12):3206. doi: 10.1038/s41419-017-0110-8.

43.

CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity.

Walton JB, Farquharson M, Mason S, Port J, Kruspig B, Dowson S, Stevenson D, Murphy D, Matzuk M, Kim J, Coffelt S, Blyth K, McNeish IA.

Sci Rep. 2017 Dec 4;7(1):16827. doi: 10.1038/s41598-017-17119-1. Erratum in: Sci Rep. 2018 Apr 13;8(1):6231.

44.

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity.

Loveridge CJ, van 't Hof RJ, Charlesworth G, King A, Tan EH, Rose L, Daroszewska A, Prior A, Ahmad I, Welsh M, Mui EJ, Ford C, Salji M, Sansom O, Blyth K, Leung HY.

Sci Rep. 2017 Oct 16;7(1):13241. doi: 10.1038/s41598-017-13346-8.

45.

Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction.

McCarroll CS, He W, Foote K, Bradley A, Mcglynn K, Vidler F, Nixon C, Nather K, Fattah C, Riddell A, Bowman P, Elliott EB, Bell M, Hawksby C, MacKenzie SM, Morrison LJ, Terry A, Blyth K, Smith GL, McBride MW, Kubin T, Braun T, Nicklin SA, Cameron ER, Loughrey CM.

Circulation. 2018 Jan 2;137(1):57-70. doi: 10.1161/CIRCULATIONAHA.117.028911. Epub 2017 Oct 13.

46.

Estimating past inhalation exposure to asbestos: A tool for risk attribution and disease screening.

Cherrie JW, McElvenny D, Blyth KG.

Int J Hyg Environ Health. 2018 Jan;221(1):27-32. doi: 10.1016/j.ijheh.2017.09.013. Epub 2017 Oct 7.

PMID:
29030093
47.

Empyema necessitans and a persistent air leak associated with rupture of an anaerobic lung abscess due to bacteroides.

Sharma V, Blyth KG.

Thorax. 2018 Jan;73(1):91-93. doi: 10.1136/thoraxjnl-2017-210462. Epub 2017 Aug 28. No abstract available. Erratum in: Thorax. 2018 Apr;73(4):404.

PMID:
28847872
48.

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.

Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proïcs E, Rubio-Patiño C, Fort L, Yatim N, Woodham E, Orozco S, Taraborrelli L, Peltzer N, Lecis D, Machesky L, Walczak H, Albert ML, Milling S, Oberst A, Ricci JE, Ryan KM, Blyth K, Tait SWG.

Nat Cell Biol. 2017 Sep;19(9):1116-1129. doi: 10.1038/ncb3596. Epub 2017 Aug 28.

49.

Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH.

Nature. 2017 Aug 2;548(7665):122. doi: 10.1038/nature23471.

PMID:
28770843
50.

Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research.

Morrissey B, Holen I, Chelala C, Carter P, Jones L, Blyth K, Speirs V.

NPJ Breast Cancer. 2016 Jun 29;2:16020. doi: 10.1038/npjbcancer.2016.20. eCollection 2016.

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