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Items: 45


Mild maternal hyperglycemia in INS C93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.

Renner S, Martins AS, Streckel E, Braun-Reichhart C, Backman M, Prehn C, Klymiuk N, Bähr A, Blutke A, Landbrecht-Schessl C, Wünsch A, Kessler B, Kurome M, Hinrichs A, Koopmans SJ, Krebs S, Kemter E, Rathkolb B, Nagashima H, Blum H, Ritzmann M, Wanke R, Aigner B, Adamski J, Hrabě de Angelis M, Wolf E.

Dis Model Mech. 2019 Aug 12;12(8). pii: dmm039156. doi: 10.1242/dmm.039156.


Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.

Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Ländström E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, de Angelis MH, Wanke R, Fröhlich T, Arnold GJ, Blum H, Wolf E.

Mol Metab. 2019 Aug;26:30-44. doi: 10.1016/j.molmet.2019.05.011. Epub 2019 Jun 4.


Acute Skin Damage and Late Radiation-Induced Fibrosis and Inflammation in Murine Ears after High-Dose Irradiation.

Dombrowsky AC, Schauer J, Sammer M, Blutke A, Walsh DWM, Schwarz B, Bartzsch S, Feuchtinger A, Reindl J, Combs SE, Dollinger G, Schmid TE.

Cancers (Basel). 2019 May 25;11(5). pii: E727. doi: 10.3390/cancers11050727.


Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis.

Ogrinc Wagner A, Friedrich V, Barthels C, Marconi P, Blutke A, Brombacher F, Brocker T.

PLoS One. 2019 Jan 17;14(1):e0210998. doi: 10.1371/journal.pone.0210998. eCollection 2019.


Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Renner S, Blutke A, Dobenecker B, Dhom G, Müller TD, Finan B, Clemmensen C, Bernau M, Novak I, Rathkolb B, Senf S, Zöls S, Roth M, Götz A, Hofmann SM, Hrabĕ de Angelis M, Wanke R, Kienzle E, Scholz AM, DiMarchi R, Ritzmann M, Tschöp MH, Wolf E.

Mol Metab. 2018 Oct;16:180-190. doi: 10.1016/j.molmet.2018.06.015. Epub 2018 Jun 28.


Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.

Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E.

Mol Metab. 2018 May;11:113-128. doi: 10.1016/j.molmet.2018.03.006. Epub 2018 Mar 15.


Sampling Strategies and Processing of Biobank Tissue Samples from Porcine Biomedical Models.

Blutke A, Wanke R.

J Vis Exp. 2018 Mar 6;(133). doi: 10.3791/57276.


Practicable methods for histological section thickness measurement in quantitative stereological analyses.

Matenaers C, Popper B, Rieger A, Wanke R, Blutke A.

PLoS One. 2018 Feb 14;13(2):e0192879. doi: 10.1371/journal.pone.0192879. eCollection 2018.


The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.

Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E.

Mol Metab. 2017 Jun 13;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004. eCollection 2017 Aug.


Retinopathy with central oedema in an INS C94Y transgenic pig model of long-term diabetes.

Kleinwort KJH, Amann B, Hauck SM, Hirmer S, Blutke A, Renner S, Uhl PB, Lutterberg K, Sekundo W, Wolf E, Deeg CA.

Diabetologia. 2017 Aug;60(8):1541-1549. doi: 10.1007/s00125-017-4290-7. Epub 2017 May 8.


Erratum: CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T.

Nat Commun. 2017 Apr 24;8:15439. doi: 10.1038/ncomms15439. No abstract available.


CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T.

Nat Commun. 2017 Mar 9;8:14715. doi: 10.1038/ncomms14715.


Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.

Gimpfl M, Rozman J, Dahlhoff M, Kübeck R, Blutke A, Rathkolb B, Klingenspor M, Hrabě de Angelis M, Öner-Sieben S, Seibt A, Roscher AA, Wolf E, Ensenauer R.

Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1605-1614. doi: 10.1016/j.bbadis.2017.02.021. Epub 2017 Feb 21.


[Detection of Salmonella Choleraesuis var. Kunzendorf in a fattening pig with septicaemic salmonellosis. A case report].

Eddicks M, Hausleitner R, Eddicks L, Blutke A, Straubinger RK, Wolf G, Szabo I, Heizer C, Hermanns W, Ritzmann M.

Tierarztl Prax Ausg G Grosstiere Nutztiere. 2016 Dec 5;44(6):381-387. Epub 2016 Nov 3. German.


Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy.

Fröhlich T, Kemter E, Flenkenthaler F, Klymiuk N, Otte KA, Blutke A, Krause S, Walter MC, Wanke R, Wolf E, Arnold GJ.

Sci Rep. 2016 Sep 16;6:33362. doi: 10.1038/srep33362.


Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle.

Rieger A, Kemter E, Kumar S, Popper B, Aigner B, Wolf E, Wanke R, Blutke A.

PLoS One. 2016 Jul 15;11(7):e0158977. doi: 10.1371/journal.pone.0158977. eCollection 2016.


A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.

Kinzel L, Ernst A, Orth M, Albrecht V, Hennel R, Brix N, Frey B, Gaipl US, Zuchtriegel G, Reichel CA, Blutke A, Schilling D, Multhoff G, Li M, Niyazi M, Friedl AA, Winssinger N, Belka C, Lauber K.

Oncotarget. 2016 Jul 12;7(28):43199-43219. doi: 10.18632/oncotarget.9774.


Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research.

Renner S, Dobenecker B, Blutke A, Zöls S, Wanke R, Ritzmann M, Wolf E.

Theriogenology. 2016 Jul 1;86(1):406-21. doi: 10.1016/j.theriogenology.2016.04.055. Epub 2016 Apr 21. Review.


Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation.

Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S.

J Am Heart Assoc. 2016 Apr 27;5(5). pii: e003429. doi: 10.1161/JAHA.116.003429.


Tissue Sampling Guides for Porcine Biomedical Models.

Albl B, Haesner S, Braun-Reichhart C, Streckel E, Renner S, Seeliger F, Wolf E, Wanke R, Blutke A.

Toxicol Pathol. 2016 Apr;44(3):414-20. doi: 10.1177/0192623316631023. Epub 2016 Feb 16.


Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies.

Klymiuk N, Seeliger F, Bohlooly-Y M, Blutke A, Rudmann DG, Wolf E.

Toxicol Pathol. 2016 Apr;44(3):346-57. doi: 10.1177/0192623315609688. Epub 2015 Oct 27. Review.


Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models.

Renner S, Blutke A, Streckel E, Wanke R, Wolf E.

J Pathol. 2016 Jan;238(2):345-58. doi: 10.1002/path.4655. Epub 2015 Nov 30. Review.


Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition.

Streckel E, Braun-Reichhart C, Herbach N, Dahlhoff M, Kessler B, Blutke A, Bähr A, Übel N, Eddicks M, Ritzmann M, Krebs S, Göke B, Blum H, Wanke R, Wolf E, Renner S.

J Transl Med. 2015 Feb 25;13:73. doi: 10.1186/s12967-015-0431-2.


Acaricide treatment prevents adrenocortical hyperplasia as a long-term stress reaction to psoroptic mange in cattle.

Blutke A, Börjes P, Herbach N, Pfister K, Hamel D, Rehbein S, Wanke R.

Vet Parasitol. 2015 Jan 15;207(1-2):125-33. doi: 10.1016/j.vetpar.2014.10.013. Epub 2014 Oct 24.


Prevalence and characterization of small tympanic bone spicules and drumstick-like hyperostotic tympanic bone spicules in the middle ear cavity of dogs.

Parzefall B, Rieger A, Volk HA, Maierl J, Brühschwein A, Blutke A.

Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):25-32. doi: 10.1111/vru.12197. Epub 2014 Aug 19.


Location-specific expression of chemokines, TNF-α and S100 proteins in a teat explant model.

Lind M, Sipka AS, Schuberth HJ, Blutke A, Wanke R, Sauter-Louis C, Duda KA, Holst O, Rainard P, Germon P, Zerbe H, Petzl W.

Innate Immun. 2015 Apr;21(3):322-31. doi: 10.1177/1753425914539820. Epub 2014 Aug 17.


Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice.

Blutke A, Schneider MR, Renner-Müller I, Herbach N, Wanke R, Wolf E.

Mol Cell Endocrinol. 2014 Aug 25;394(1-2):88-98. doi: 10.1016/j.mce.2014.07.002. Epub 2014 Jul 10.


[Torsion of a liver cyst in a calf].

Wieland M, Blutke A, Mann S.

Tierarztl Prax Ausg G Grosstiere Nutztiere. 2014;42(2):106-11. German.


Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.

Dahlhoff M, Pfister S, Blutke A, Rozman J, Klingenspor M, Deutsch MJ, Rathkolb B, Fink B, Gimpfl M, Hrabě de Angelis M, Roscher AA, Wolf E, Ensenauer R.

Biochim Biophys Acta. 2014 Feb;1842(2):304-17. doi: 10.1016/j.bbadis.2013.11.021. Epub 2013 Nov 23.


Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs.

Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, Reichart B, Wanke R, Schwinzer R, Nagashima H, Rieben R, Ayares D, Wolf E, Klymiuk N.

Transplantation. 2014 Jan 27;97(2):138-47. doi: 10.1097/TP.0b013e3182a95cbc.


Polycystic kidney disease in a European roe deer (Capreolus capreolus).

Blutke A, März K, Matenaers C, Oswald K, Hermanns W, Wanke R.

J Zoo Wildl Med. 2013 Jun;44(2):487-90.


Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.

Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmüller H, Walter MC, Wolf E.

Hum Mol Genet. 2013 Nov 1;22(21):4368-82. doi: 10.1093/hmg/ddt287. Epub 2013 Jun 19.


Permanent neonatal diabetes in INS(C94Y) transgenic pigs.

Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wünsch A, Kessler B, Kurome M, Bähr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E.

Diabetes. 2013 May;62(5):1505-11. doi: 10.2337/db12-1065. Epub 2012 Dec 28.


Opening a treasure chest: glomerular proteome analyses of formalin-fixed paraffin-embedded kidney tissue in the investigation of diabetic nephropathy.

Blutke A.

Nephrol Dial Transplant. 2012 May;27(5):1695-8. doi: 10.1093/ndt/gfs082. No abstract available.


A case of congenital unilateral hip dysplasia in a newborn calf.

Mann S, Blutke A, Brühschwein A, Feist M.

Schweiz Arch Tierheilkd. 2011 Oct;153(10):457-61. doi: 10.1024/0036-7281/a000248.


In vivo evidence for epidermal growth factor receptor (EGFR)-mediated release of prolactin from the pituitary gland.

Dahlhoff M, Blutke A, Wanke R, Wolf E, Schneider MR.

J Biol Chem. 2011 Nov 11;286(45):39297-306. doi: 10.1074/jbc.M111.243493. Epub 2011 Sep 13.


Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria.

Blutke A, Block C, Berendt F, Herbach N, Kemter E, Amann K, Fröhlich T, Arnold GJ, Wanke R.

Proteomics Clin Appl. 2011 Jun;5(5-6):375-81. doi: 10.1002/prca.201000103. Epub 2011 Apr 29.


Naturally-occurring canine herpesvirus-1 infection of the vestibular labyrinth and ganglion of dogs.

Parzefall B, Fischer A, Blutke A, Schmahl W, Matiasek K.

Vet J. 2011 Jul;189(1):100-2. doi: 10.1016/j.tvjl.2010.06.014. Epub 2010 Aug 8.


Cystic echinococcosis due to Echinococcus equinus in a horse from southern Germany.

Blutke A, Hamel D, Hüttner M, Gehlen H, Romig T, Pfister K, Hermanns W.

J Vet Diagn Invest. 2010 May;22(3):458-62.


Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).

van Bürck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabé de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E512-23. doi: 10.1152/ajpendo.00465.2009. Epub 2009 Dec 1.


Evidence of feline herpesvirus-1 DNA in the vestibular ganglion of domestic cats.

Parzefall B, Schmahl W, Fischer A, Blutke A, Truyen U, Matiasek K.

Vet J. 2010 Jun;184(3):371-2. doi: 10.1016/j.tvjl.2009.03.030. Epub 2009 Apr 25.


Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.

Herbach N, Schairer I, Blutke A, Kautz S, Siebert A, Göke B, Wolf E, Wanke R.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F819-29. doi: 10.1152/ajprenal.90665.2008. Epub 2009 Feb 11.


A rapid approach to ultrastructural evaluation and DNA analysis of the vestibular labyrinth and ganglion in dogs and cats.

Parzefall B, Schmahl W, Blutke A, Baiker K, Matiasek K.

J Neurosci Methods. 2009 Feb 15;177(1):217-24. doi: 10.1016/j.jneumeth.2008.10.003. Epub 2008 Oct 17.


Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight.

Moerth C, Schneider MR, Renner-Mueller I, Blutke A, Elmlinger MW, Erben RG, Camacho-Hübner C, Hoeflich A, Wolf E.

Endocrinology. 2007 Jan;148(1):441-51. Epub 2006 Sep 28.


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