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Items: 35

1.

Disease-linked mutations alter the stoichiometries of HCN-KCNE2 complexes.

Lussier Y, Fürst O, Fortea E, Leclerc M, Priolo D, Moeller L, Bichet DG, Blunck R, D'Avanzo N.

Sci Rep. 2019 Jun 24;9(1):9113. doi: 10.1038/s41598-019-45592-3.

2.

S4-S5 linker movement during activation and inactivation in voltage-gated K+ channels.

Kalstrup T, Blunck R.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6751-E6759. doi: 10.1073/pnas.1719105115. Epub 2018 Jun 29.

3.

Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.

Liebsch F, Aurousseau MRP, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G.

J Biol Chem. 2017 Aug 11;292(32):13258-13270. doi: 10.1074/jbc.M117.779165. Epub 2017 Jun 21.

4.

Voltage-clamp Fluorometry in Xenopus Oocytes Using Fluorescent Unnatural Amino Acids.

Kalstrup T, Blunck R.

J Vis Exp. 2017 May 27;(123). doi: 10.3791/55598.

5.

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.

Zhao J, Blunck R.

Elife. 2016 Oct 6;5. pii: e18130. doi: 10.7554/eLife.18130.

6.

Structure of anthrax lethal toxin prepore complex suggests a pathway for efficient cell entry.

Fabre L, Santelli E, Mountassif D, Donoghue A, Biswas A, Blunck R, Hanein D, Volkmann N, Liddington R, Rouiller I.

J Gen Physiol. 2016 Oct;148(4):313-24. doi: 10.1085/jgp.201611617.

7.

The Human Sodium-Glucose Cotransporter (hSGLT1) Is a Disulfide-Bridged Homodimer with a Re-Entrant C-Terminal Loop.

Sasseville LJ, Morin M, Coady MJ, Blunck R, Lapointe JY.

PLoS One. 2016 May 3;11(5):e0154589. doi: 10.1371/journal.pone.0154589. eCollection 2016.

8.

A Disease Mutation Causing Episodic Ataxia Type I in the S1 Links Directly to the Voltage Sensor and the Selectivity Filter in Kv Channels.

Petitjean D, Kalstrup T, Zhao J, Blunck R.

J Neurosci. 2015 Sep 2;35(35):12198-206. doi: 10.1523/JNEUROSCI.1419-15.2015.

9.
10.

Do lipids show state-dependent affinity to the voltage-gated potassium channel KvAP?

Faure É, Thompson C, Blunck R.

J Biol Chem. 2014 Jun 6;289(23):16452-61. doi: 10.1074/jbc.M113.537134. Epub 2014 Apr 17.

11.

Dynamics of internal pore opening in K(V) channels probed by a fluorescent unnatural amino acid.

Kalstrup T, Blunck R.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8272-7. doi: 10.1073/pnas.1220398110. Epub 2013 Apr 29.

12.

A limited 4 Å radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels.

Faure É, Starek G, McGuire H, Bernèche S, Blunck R.

J Biol Chem. 2012 Nov 16;287(47):40091-8. doi: 10.1074/jbc.M112.415497. Epub 2012 Sep 27.

13.

Mechanism of electromechanical coupling in voltage-gated potassium channels.

Blunck R, Batulan Z.

Front Pharmacol. 2012 Sep 12;3:166. doi: 10.3389/fphar.2012.00166. eCollection 2012.

14.

Automating single subunit counting of membrane proteins in mammalian cells.

McGuire H, Aurousseau MR, Bowie D, Blunck R.

J Biol Chem. 2012 Oct 19;287(43):35912-21. doi: 10.1074/jbc.M112.402057. Epub 2012 Aug 28.

15.

Single molecule fluorescence study of the Bacillus thuringiensis toxin Cry1Aa reveals tetramerization.

Groulx N, McGuire H, Laprade R, Schwartz JL, Blunck R.

J Biol Chem. 2011 Dec 9;286(49):42274-82. doi: 10.1074/jbc.M111.296103. Epub 2011 Oct 17.

16.

Double mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel.

Wall-Lacelle S, Hossain MI, Sauvé R, Blunck R, Parent L.

J Biol Chem. 2011 Aug 5;286(31):27197-205. doi: 10.1074/jbc.M111.237412. Epub 2011 Jun 7.

17.

Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain.

Haddad GA, Blunck R.

J Gen Physiol. 2011 May;137(5):455-72. doi: 10.1085/jgp.201010573.

18.
19.

An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K+ channels.

Batulan Z, Haddad GA, Blunck R.

J Biol Chem. 2010 Apr 30;285(18):14005-19. doi: 10.1074/jbc.M109.097717. Epub 2010 Mar 4.

20.

[Single-channel fluorescence spectroscopy to study conformational changes of ion channels].

McGuire H, Blunck R.

Med Sci (Paris). 2009 Nov;25(11):951-4. doi: 10.1051/medsci/20092511951. Review. French. No abstract available.

21.

Fluorescence detection of the movement of single KcsA subunits reveals cooperativity.

Blunck R, McGuire H, Hyde HC, Bezanilla F.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20263-8. doi: 10.1073/pnas.0807056106. Epub 2008 Dec 11.

22.

Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer.

Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15865-70. Epub 2006 Oct 16.

23.

Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction.

Blunck R, Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F.

J Gen Physiol. 2006 Nov;128(5):569-81. Epub 2006 Oct 16.

24.

Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages.

Scheel O, Papavlassopoulos M, Blunck R, Gebert A, Hartung T, Zähringer U, Seydel U, Schromm AB.

Infect Immun. 2006 Jul;74(7):4354-6.

25.

Nano to micro -- fluorescence measurements of electric fields in molecules and genetically specified neurons.

Blunck R, Chanda B, Bezanilla F.

J Membr Biol. 2005 Nov;208(2):91-102.

PMID:
16645739
26.

A hybrid approach to measuring electrical activity in genetically specified neurons.

Chanda B, Blunck R, Faria LC, Schweizer FE, Mody I, Bezanilla F.

Nat Neurosci. 2005 Nov;8(11):1619-26. Epub 2005 Oct 2.

PMID:
16205716
27.

Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement.

Chanda B, Asamoah OK, Blunck R, Roux B, Bezanilla F.

Nature. 2005 Aug 11;436(7052):852-6.

PMID:
16094369
28.

Silicon chip-based patch-clamp electrodes integrated with PDMS microfluidics.

Pantoja R, Nagarah JM, Starace DM, Melosh NA, Blunck R, Bezanilla F, Heath JR.

Biosens Bioelectron. 2004 Oct 15;20(3):509-17.

PMID:
15494233
29.
30.

A K+ channel is involved in LPS signaling.

Seydel U, Scheel O, Müller M, Brandenburg K, Blunck R.

J Endotoxin Res. 2001;7(3):243-7.

PMID:
11581578
31.

Bilayer reconstitution of voltage-dependent ion channels using a microfabricated silicon chip.

Pantoja R, Sigg D, Blunck R, Bezanilla F, Heath JR.

Biophys J. 2001 Oct;81(4):2389-94.

32.

New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling.

Blunck R, Scheel O, Müller M, Brandenburg K, Seitzer U, Seydel U.

J Immunol. 2001 Jan 15;166(2):1009-15.

33.

Chemical structure, molecular conformation, and bioactivity of endotoxins.

Seydel U, Schromm AB, Blunck R, Brandenburg K.

Chem Immunol. 2000;74:5-24. Review. No abstract available.

PMID:
10608079
34.

How powerful is the dwell-time analysis of multichannel records?

Blunck R, Kirst U, Riessner T, Hansen U.

J Membr Biol. 1998 Sep 1;165(1):19-35.

PMID:
9705979
35.

Gating and permeation models of plant channels.

Hansen UP, Keunecke M, Blunck R.

J Exp Bot. 1997 Mar;48 Spec No:365-82. doi: 10.1093/jxb/48.Special_Issue.365.

PMID:
21245216

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