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Items: 35


Disease-linked mutations alter the stoichiometries of HCN-KCNE2 complexes.

Lussier Y, Fürst O, Fortea E, Leclerc M, Priolo D, Moeller L, Bichet DG, Blunck R, D'Avanzo N.

Sci Rep. 2019 Jun 24;9(1):9113. doi: 10.1038/s41598-019-45592-3.


S4-S5 linker movement during activation and inactivation in voltage-gated K+ channels.

Kalstrup T, Blunck R.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6751-E6759. doi: 10.1073/pnas.1719105115. Epub 2018 Jun 29.


Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.

Liebsch F, Aurousseau MRP, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G.

J Biol Chem. 2017 Aug 11;292(32):13258-13270. doi: 10.1074/jbc.M117.779165. Epub 2017 Jun 21.


Voltage-clamp Fluorometry in Xenopus Oocytes Using Fluorescent Unnatural Amino Acids.

Kalstrup T, Blunck R.

J Vis Exp. 2017 May 27;(123). doi: 10.3791/55598.


The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.

Zhao J, Blunck R.

Elife. 2016 Oct 6;5. pii: e18130. doi: 10.7554/eLife.18130.


Structure of anthrax lethal toxin prepore complex suggests a pathway for efficient cell entry.

Fabre L, Santelli E, Mountassif D, Donoghue A, Biswas A, Blunck R, Hanein D, Volkmann N, Liddington R, Rouiller I.

J Gen Physiol. 2016 Oct;148(4):313-24. doi: 10.1085/jgp.201611617.


The Human Sodium-Glucose Cotransporter (hSGLT1) Is a Disulfide-Bridged Homodimer with a Re-Entrant C-Terminal Loop.

Sasseville LJ, Morin M, Coady MJ, Blunck R, Lapointe JY.

PLoS One. 2016 May 3;11(5):e0154589. doi: 10.1371/journal.pone.0154589. eCollection 2016.


A Disease Mutation Causing Episodic Ataxia Type I in the S1 Links Directly to the Voltage Sensor and the Selectivity Filter in Kv Channels.

Petitjean D, Kalstrup T, Zhao J, Blunck R.

J Neurosci. 2015 Sep 2;35(35):12198-206. doi: 10.1523/JNEUROSCI.1419-15.2015.


Do lipids show state-dependent affinity to the voltage-gated potassium channel KvAP?

Faure É, Thompson C, Blunck R.

J Biol Chem. 2014 Jun 6;289(23):16452-61. doi: 10.1074/jbc.M113.537134. Epub 2014 Apr 17.


Dynamics of internal pore opening in K(V) channels probed by a fluorescent unnatural amino acid.

Kalstrup T, Blunck R.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8272-7. doi: 10.1073/pnas.1220398110. Epub 2013 Apr 29.


A limited 4 Å radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels.

Faure É, Starek G, McGuire H, Bernèche S, Blunck R.

J Biol Chem. 2012 Nov 16;287(47):40091-8. doi: 10.1074/jbc.M112.415497. Epub 2012 Sep 27.


Mechanism of electromechanical coupling in voltage-gated potassium channels.

Blunck R, Batulan Z.

Front Pharmacol. 2012 Sep 12;3:166. doi: 10.3389/fphar.2012.00166. eCollection 2012.


Automating single subunit counting of membrane proteins in mammalian cells.

McGuire H, Aurousseau MR, Bowie D, Blunck R.

J Biol Chem. 2012 Oct 19;287(43):35912-21. doi: 10.1074/jbc.M112.402057. Epub 2012 Aug 28.


Single molecule fluorescence study of the Bacillus thuringiensis toxin Cry1Aa reveals tetramerization.

Groulx N, McGuire H, Laprade R, Schwartz JL, Blunck R.

J Biol Chem. 2011 Dec 9;286(49):42274-82. doi: 10.1074/jbc.M111.296103. Epub 2011 Oct 17.


Double mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel.

Wall-Lacelle S, Hossain MI, Sauvé R, Blunck R, Parent L.

J Biol Chem. 2011 Aug 5;286(31):27197-205. doi: 10.1074/jbc.M111.237412. Epub 2011 Jun 7.


Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain.

Haddad GA, Blunck R.

J Gen Physiol. 2011 May;137(5):455-72. doi: 10.1085/jgp.201010573.


An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K+ channels.

Batulan Z, Haddad GA, Blunck R.

J Biol Chem. 2010 Apr 30;285(18):14005-19. doi: 10.1074/jbc.M109.097717. Epub 2010 Mar 4.


[Single-channel fluorescence spectroscopy to study conformational changes of ion channels].

McGuire H, Blunck R.

Med Sci (Paris). 2009 Nov;25(11):951-4. doi: 10.1051/medsci/20092511951. Review. French. No abstract available.


Fluorescence detection of the movement of single KcsA subunits reveals cooperativity.

Blunck R, McGuire H, Hyde HC, Bezanilla F.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20263-8. doi: 10.1073/pnas.0807056106. Epub 2008 Dec 11.


Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer.

Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15865-70. Epub 2006 Oct 16.


Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction.

Blunck R, Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F.

J Gen Physiol. 2006 Nov;128(5):569-81. Epub 2006 Oct 16.


Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages.

Scheel O, Papavlassopoulos M, Blunck R, Gebert A, Hartung T, Zähringer U, Seydel U, Schromm AB.

Infect Immun. 2006 Jul;74(7):4354-6.


Nano to micro -- fluorescence measurements of electric fields in molecules and genetically specified neurons.

Blunck R, Chanda B, Bezanilla F.

J Membr Biol. 2005 Nov;208(2):91-102.


A hybrid approach to measuring electrical activity in genetically specified neurons.

Chanda B, Blunck R, Faria LC, Schweizer FE, Mody I, Bezanilla F.

Nat Neurosci. 2005 Nov;8(11):1619-26. Epub 2005 Oct 2.


Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement.

Chanda B, Asamoah OK, Blunck R, Roux B, Bezanilla F.

Nature. 2005 Aug 11;436(7052):852-6.


Silicon chip-based patch-clamp electrodes integrated with PDMS microfluidics.

Pantoja R, Nagarah JM, Starace DM, Melosh NA, Blunck R, Bezanilla F, Heath JR.

Biosens Bioelectron. 2004 Oct 15;20(3):509-17.


A K+ channel is involved in LPS signaling.

Seydel U, Scheel O, Müller M, Brandenburg K, Blunck R.

J Endotoxin Res. 2001;7(3):243-7.


Bilayer reconstitution of voltage-dependent ion channels using a microfabricated silicon chip.

Pantoja R, Sigg D, Blunck R, Bezanilla F, Heath JR.

Biophys J. 2001 Oct;81(4):2389-94.


New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling.

Blunck R, Scheel O, Müller M, Brandenburg K, Seitzer U, Seydel U.

J Immunol. 2001 Jan 15;166(2):1009-15.


Chemical structure, molecular conformation, and bioactivity of endotoxins.

Seydel U, Schromm AB, Blunck R, Brandenburg K.

Chem Immunol. 2000;74:5-24. Review. No abstract available.


How powerful is the dwell-time analysis of multichannel records?

Blunck R, Kirst U, Riessner T, Hansen U.

J Membr Biol. 1998 Sep 1;165(1):19-35.


Gating and permeation models of plant channels.

Hansen UP, Keunecke M, Blunck R.

J Exp Bot. 1997 Mar;48 Spec No:365-82. doi: 10.1093/jxb/48.Special_Issue.365.


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