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Items: 1 to 50 of 92

1.

Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding.

Sun X, Singh S, Blumer KJ, Bowman GR.

Elife. 2018 Oct 5;7. pii: e38465. doi: 10.7554/eLife.38465.

2.

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells.

Onken MD, Makepeace CM, Kaltenbronn KM, Kanai SM, Todd TD, Wang S, Broekelmann TJ, Rao PK, Cooper JA, Blumer KJ.

Sci Signal. 2018 Sep 4;11(546). pii: eaao6852. doi: 10.1126/scisignal.aao6852.

PMID:
30181242
3.

Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction.

Kanai SM, Edwards AJ, Rurik JG, Osei-Owusu P, Blumer KJ.

J Biol Chem. 2017 Nov 24;292(47):19266-19278. doi: 10.1074/jbc.M117.797134. Epub 2017 Oct 3.

PMID:
28974581
4.

Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13.

Scherer SL, Cain MD, Kanai SM, Kaltenbronn KM, Blumer KJ.

J Biol Chem. 2017 Jun 16;292(24):9906-9918. doi: 10.1074/jbc.M116.771923. Epub 2017 Apr 21.

5.

Renal DCE-MRI Model Selection Using Bayesian Probability Theory.

Beeman SC, Osei-Owusu P, Duan C, Engelbach J, Bretthorst GL, Ackerman JJH, Blumer KJ, Garbow JR.

Tomography. 2015 Sep;1(1):61-68. doi: 10.18383/j.tom.2015.00133.

6.

Regulation of Renal Hemodynamics and Function by RGS2.

Osei-Owusu P, Owens EA, Jie L, Reis JS, Forrester SJ, Kawai T, Eguchi S, Singh H, Blumer KJ.

PLoS One. 2015 Jul 20;10(7):e0132594. doi: 10.1371/journal.pone.0132594. eCollection 2015.

7.

Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function.

Osei-Owusu P, Blumer KJ.

Prog Mol Biol Transl Sci. 2015;133:77-92. doi: 10.1016/bs.pmbts.2015.02.001. Epub 2015 Apr 16. Review.

8.

Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-254890 Analog.

Rensing DT, Uppal S, Blumer KJ, Moeller KD.

Org Lett. 2015 May 1;17(9):2270-3. doi: 10.1021/acs.orglett.5b00944. Epub 2015 Apr 15.

PMID:
25875152
9.

Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.

Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Nakamura R, Lavine KJ, Blumer KJ, Choi K, Apte RS, Ornitz DM.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13379-84. doi: 10.1073/pnas.1324235111. Epub 2014 Aug 19.

10.

Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency.

Osei-Owusu P, Knutsen RH, Kozel BA, Dietrich HH, Blumer KJ, Mecham RP.

Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H654-66. doi: 10.1152/ajpheart.00601.2013. Epub 2014 Jan 10.

11.

A mechanism regulating G protein-coupled receptor signaling that requires cycles of protein palmitoylation and depalmitoylation.

Jia L, Chisari M, Maktabi MH, Sobieski C, Zhou H, Konopko AM, Martin BR, Mennerick SJ, Blumer KJ.

J Biol Chem. 2014 Feb 28;289(9):6249-57. doi: 10.1074/jbc.M113.531475. Epub 2014 Jan 2.

12.

An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina.

Cain MD, Vo BQ, Kolesnikov AV, Kefalov VJ, Culican SM, Kerschensteiner D, Blumer KJ.

PLoS One. 2013 Dec 9;8(12):e82276. doi: 10.1371/journal.pone.0082276. eCollection 2013.

13.

Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.

Li A, Knutsen RH, Zhang H, Osei-Owusu P, Moreno-Dominguez A, Harter TM, Uchida K, Remedi MS, Dietrich HH, Bernal-Mizrachi C, Blumer KJ, Mecham RP, Koster JC, Nichols CG.

J Am Heart Assoc. 2013 Aug 23;2(4):e000365. doi: 10.1161/JAHA.113.000365.

14.

GIRK channel modulation by assembly with allosterically regulated RGS proteins.

Zhou H, Chisari M, Raehal KM, Kaltenbronn KM, Bohn LM, Mennerick SJ, Blumer KJ.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19977-82. doi: 10.1073/pnas.1214337109. Epub 2012 Nov 19.

15.

Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter.

Chinault SL, Prior JL, Kaltenbronn KM, Penly A, Weilbaecher KN, Piwnica-Worms D, Blumer KJ.

Clin Cancer Res. 2012 Aug 1;18(15):4136-44. doi: 10.1158/1078-0432.CCR-12-0642. Epub 2012 Jun 12.

16.

Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.

Osei-Owusu P, Sabharwal R, Kaltenbronn KM, Rhee MH, Chapleau MW, Dietrich HH, Blumer KJ.

J Biol Chem. 2012 Apr 6;287(15):12541-9. doi: 10.1074/jbc.M111.332130. Epub 2012 Feb 21.

17.

Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.

Jia L, Linder ME, Blumer KJ.

J Biol Chem. 2011 Apr 15;286(15):13695-703. doi: 10.1074/jbc.M110.193763. Epub 2011 Feb 22.

18.

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.

Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP.

J Mol Cell Cardiol. 2011 Jun;50(6):1000-7. doi: 10.1016/j.yjmcc.2011.01.015. Epub 2011 Feb 1.

19.

Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine.

Dietrich HH, Abendschein DR, Moon SH, Nayeb-Hashemi N, Mancuso DJ, Jenkins CM, Kaltenbronn KM, Blumer KJ, Turk J, Gross RW.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2208-20. doi: 10.1152/ajpheart.00839.2009. Epub 2010 Apr 9.

20.

RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival.

Inoue-Mochita M, Inoue T, Epstein DL, Blumer KJ, Rao PV.

Mol Vis. 2009;15:495-504. Epub 2009 Mar 6.

21.

R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling.

Jayaraman M, Zhou H, Jia L, Cain MD, Blumer KJ.

Trends Pharmacol Sci. 2009 Jan;30(1):17-24. doi: 10.1016/j.tips.2008.10.002. Epub 2008 Nov 29. Review.

22.

Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain.

Grabowska D, Jayaraman M, Kaltenbronn KM, Sandiford SL, Wang Q, Jenkins S, Slepak VZ, Smith Y, Blumer KJ.

Neuroscience. 2008 Feb 19;151(4):969-82. doi: 10.1016/j.neuroscience.2007.11.045. Epub 2007 Dec 8.

23.

An adrenaline (and gold?) rush for the GPCR community.

Blumer KJ, Thorner J.

ACS Chem Biol. 2007 Dec 21;2(12):783-6.

PMID:
18154265
24.

Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins.

Gu S, Anton A, Salim S, Blumer KJ, Dessauer CW, Heximer SP.

Mol Pharmacol. 2008 Jan;73(1):1-11. Epub 2007 Sep 27.

25.

Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase.

Osei-Owusu P, Sun X, Drenan RM, Steinberg TH, Blumer KJ.

J Biol Chem. 2007 Oct 26;282(43):31656-65. Epub 2007 Aug 6.

26.

Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice.

Tank J, Obst M, Diedrich A, Brychta RJ, Blumer KJ, Heusser K, Jordan J, Luft FC, Gross V.

Auton Neurosci. 2007 Oct 30;136(1-2):52-7. Epub 2007 May 15.

PMID:
17507294
27.

RGS proteins: Swiss army knives in seven-transmembrane domain receptor signaling networks.

Heximer SP, Blumer KJ.

Sci STKE. 2007 Jan 23;2007(370):pe2.

PMID:
17244887
28.

R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.

Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ.

J Biol Chem. 2006 Sep 22;281(38):28222-31. Epub 2006 Jul 25.

29.

Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.

Huber TB, Kwoh C, Wu H, Asanuma K, Gödel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS.

J Clin Invest. 2006 May;116(5):1337-45. Epub 2006 Apr 20.

30.

Actin-based motility during endocytosis in budding yeast.

Kim K, Galletta BJ, Schmidt KO, Chang FS, Blumer KJ, Cooper JA.

Mol Biol Cell. 2006 Mar;17(3):1354-63. Epub 2006 Jan 4.

31.

Oligomerization of G-protein-coupled receptors: lessons from the yeast Saccharomyces cerevisiae.

Overton MC, Chinault SL, Blumer KJ.

Eukaryot Cell. 2005 Dec;4(12):1963-70. Review. No abstract available.

32.

NO-dependent blood pressure regulation in RGS2-deficient mice.

Obst M, Tank J, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC, Gross V.

Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R1012-9. Epub 2005 Nov 3.

33.
34.

Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.

Drenan RM, Doupnik CA, Boyle MP, Muglia LJ, Huettner JE, Linder ME, Blumer KJ.

J Cell Biol. 2005 May 23;169(4):623-33. Epub 2005 May 16.

35.

Autonomic nervous system and blood pressure regulation in RGS2-deficient mice.

Gross V, Tank J, Obst M, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC.

Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1134-42. Epub 2005 Jan 20.

36.

RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.

Sun X, Kaltenbronn KM, Steinberg TH, Blumer KJ.

Mol Pharmacol. 2005 Mar;67(3):631-9. Epub 2004 Nov 24.

37.

G-protein signaling participates in the development of diabetic cardiomyopathy.

Harris IS, Treskov I, Rowley MW, Heximer S, Kaltenbronn K, Finck BN, Gross RW, Kelly DP, Blumer KJ, Muslin AJ.

Diabetes. 2004 Dec;53(12):3082-90.

38.

Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.

Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M.

Brain Res Mol Brain Res. 2004 Mar 17;122(1):24-34.

PMID:
14992813
39.

The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate.

Wild AC, Yu JW, Lemmon MA, Blumer KJ.

J Biol Chem. 2004 Apr 23;279(17):17101-10. Epub 2004 Feb 6.

40.
41.

Vision: the need for speed.

Blumer KJ.

Nature. 2004 Jan 1;427(6969):20-1. No abstract available.

PMID:
14702067
42.

Go ahead, break my symmetry!

Blumer KJ, Cooper JA.

Nat Cell Biol. 2003 Dec;5(12):1048-9. No abstract available.

43.

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.

Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME.

Nat Med. 2003 Dec;9(12):1506-12. Epub 2003 Nov 9. Erratum in: Nat Med. 2004 Jan;10(1):105. Tang, Mary [corrected to Tang, K Mary]; Wang, Guang [corrected to Wang, Guang-rong].

PMID:
14608379
44.

Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

Faury G, Pezet M, Knutsen RH, Boyle WA, Heximer SP, McLean SE, Minkes RK, Blumer KJ, Kovacs A, Kelly DP, Li DY, Starcher B, Mecham RP.

J Clin Invest. 2003 Nov;112(9):1419-28.

45.
46.

C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast.

Floyd DH, Geva A, Bruinsma SP, Overton MC, Blumer KJ, Baranski TJ.

J Biol Chem. 2003 Sep 12;278(37):35354-61. Epub 2003 Jun 30.

47.

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ.

J Clin Invest. 2003 Apr;111(8):1259. No abstract available.

48.
49.

A WASp homolog powers actin polymerization-dependent motility of endosomes in vivo.

Chang FS, Stefan CJ, Blumer KJ.

Curr Biol. 2003 Mar 18;13(6):455-63.

50.

Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphine.

Garnier M, Zaratin PF, Ficalora G, Valente M, Fontanella L, Rhee MH, Blumer KJ, Scheideler MA.

J Pharmacol Exp Ther. 2003 Mar;304(3):1299-306. Erratum in: J Pharmacol Exp Ther. 2003 May;305(2):797.

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