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Items: 39


Activator of G protein signaling 3 modulates prostate tumor development and progression.

Adekoya TO, Smith N, Aladeniyi T, Blumer JB, Chen XL, Richardson RM.

Carcinogenesis. 2019 Apr 25. pii: bgz076. doi: 10.1093/carcin/bgz076. [Epub ahead of print]


i2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination.

Vural A, Nabar NR, Hwang IY, Sohn S, Park C, Karlsson MCI, Blumer JB, Kehrl JH.

J Immunol. 2019 Mar 1;202(5):1510-1520. doi: 10.4049/jimmunol.1801145. Epub 2019 Jan 25.


Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4).

Robichaux WG 3rd, Branham-O'Connor M, Hwang IY, Vural A, Kehrl JH, Blumer JB.

J Pharmacol Exp Ther. 2017 Mar;360(3):424-433. doi: 10.1124/jpet.116.238436. Epub 2017 Jan 6.


Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.

Vural A, Al-Khodor S, Cheung GY, Shi CS, Srinivasan L, McQuiston TJ, Hwang IY, Yeh AJ, Blumer JB, Briken V, Williamson PR, Otto M, Fraser ID, Kehrl JH.

J Immunol. 2016 Jan 15;196(2):846-56. doi: 10.4049/jimmunol.1501595. Epub 2015 Dec 14.


Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gαi G-Protein Regulatory Motif Complex.

Robichaux WG 3rd, Oner SS, Lanier SM, Blumer JB.

Mol Pharmacol. 2015 Aug;88(2):231-7. doi: 10.1124/mol.115.097741. Epub 2015 May 13.


Bioluminescence resonance energy transfer to detect protein-protein interactions in live cells.

Brown NE, Blumer JB, Hepler JR.

Methods Mol Biol. 2015;1278:457-65. doi: 10.1007/978-1-4939-2425-7_30.


Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation.

Rasmussen SA, Kwon M, Pressly JD, Blumer JB, Regner KR, Park F.

J Mol Signal. 2015 Nov 27;10:6. doi: 10.5334/1750-2187-10-5.


Glutathione S-transferase P influences redox and migration pathways in bone marrow.

Zhang J, Ye ZW, Gao P, Reyes L, Jones EE, Branham-O'Connor M, Blumer JB, Drake RR, Manevich Y, Townsend DM, Tew KD.

PLoS One. 2014 Sep 12;9(9):e107478. doi: 10.1371/journal.pone.0107478. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119266.


Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3).

Branham-O'Connor M, Robichaux WG 3rd, Zhang XK, Cho H, Kehrl JH, Lanier SM, Blumer JB.

J Biol Chem. 2014 Apr 11;289(15):10738-47. doi: 10.1074/jbc.M113.515031. Epub 2014 Feb 26.


EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.

Bradley A, Zheng H, Ziebarth A, Sakati W, Branham-O'Connor M, Blumer JB, Liu Y, Kistner-Griffin E, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Landen CN Jr, Eblen ST.

Carcinogenesis. 2014 May;35(5):1100-9. doi: 10.1093/carcin/bgt489. Epub 2013 Dec 30.


Normal autophagic activity in macrophages from mice lacking Gαi3, AGS3, or RGS19.

Vural A, McQuiston TJ, Blumer JB, Park C, Hwang IY, Williams-Bey Y, Shi CS, Ma DZ, Kehrl JH.

PLoS One. 2013 Nov 28;8(11):e81886. doi: 10.1371/journal.pone.0081886. eCollection 2013.


Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad.

Blumer JB, Lanier SM.

Mol Pharmacol. 2014 Mar;85(3):388-96. doi: 10.1124/mol.113.090068. Epub 2013 Dec 3. Review.


Group II activators of G-protein signaling: monitoring the interaction of Gα with the G-protein regulatory motif in the intact cell.

Oner SS, Blumer JB, Lanier SM.

Methods Enzymol. 2013;522:153-67. doi: 10.1016/B978-0-12-407865-9.00009-1.


Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.

Vellano CP, Brown NE, Blumer JB, Hepler JR.

J Biol Chem. 2013 Feb 1;288(5):3620-31. doi: 10.1074/jbc.M112.440057. Epub 2012 Dec 17.


G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.

Kwon M, Pavlov TS, Nozu K, Rasmussen SA, Ilatovskaya DV, Lerch-Gaggl A, North LM, Kim H, Qian F, Sweeney WE Jr, Avner ED, Blumer JB, Staruschenko A, Park F.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21462-7. doi: 10.1073/pnas.1216830110. Epub 2012 Dec 10.


Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM.

J Biol Chem. 2013 Feb 1;288(5):3003-15. doi: 10.1074/jbc.M112.418467. Epub 2012 Dec 4.


G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.

Vellano CP, Maher EM, Hepler JR, Blumer JB.

J Biol Chem. 2011 Nov 4;286(44):38659-69. doi: 10.1074/jbc.M111.274928. Epub 2011 Aug 31.


Group II activators of G-protein signalling and proteins containing a G-protein regulatory motif.

Blumer JB, Oner SS, Lanier SM.

Acta Physiol (Oxf). 2012 Feb;204(2):202-18. doi: 10.1111/j.1748-1716.2011.02327.x. Epub 2011 Jul 5. Review.


AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis.

Reissner KJ, Uys JD, Schwacke JH, Comte-Walters S, Rutherford-Bethard JL, Dunn TE, Blumer JB, Schey KL, Kalivas PW.

J Neurosci. 2011 Apr 13;31(15):5648-58. doi: 10.1523/JNEUROSCI.3452-10.2011.


Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents.

Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney WE Jr, Park F.

FASEB J. 2011 Jun;25(6):1844-55. doi: 10.1096/fj.10-169797. Epub 2011 Feb 22.


Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf).

Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG.

J Biol Chem. 2011 Jan 28;286(4):2625-35. doi: 10.1074/jbc.M110.178897. Epub 2010 Nov 29.


Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.

Oner SS, An N, Vural A, Breton B, Bouvier M, Blumer JB, Lanier SM.

J Biol Chem. 2010 Oct 29;285(44):33949-58. doi: 10.1074/jbc.M110.138073. Epub 2010 Aug 17.


Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD.

Nadella R, Blumer JB, Jia G, Kwon M, Akbulut T, Qian F, Sedlic F, Wakatsuki T, Sweeney WE Jr, Wilson PD, Lanier SM, Park F.

J Am Soc Nephrol. 2010 Aug;21(8):1275-80. doi: 10.1681/ASN.2009121224. Epub 2010 May 20.


Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai.

Oner SS, Maher EM, Breton B, Bouvier M, Blumer JB.

J Biol Chem. 2010 Jul 2;285(27):20588-94. doi: 10.1074/jbc.C109.088070. Epub 2010 May 7.


Analysis of partner of inscuteable (mPins) expression in the developing mouse eye.

Raji B, Dansault A, Vieira V, de la Houssaye G, Lacassagne E, Kobetz A, Arbogast L, Dufier JL, Blumer JB, Menasche M, Abitbol M.

Mol Vis. 2008;14:2575-96. Epub 2008 Dec 31.


The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins.

An N, Blumer JB, Bernard ML, Lanier SM.

J Biol Chem. 2008 Sep 5;283(36):24718-28. doi: 10.1074/jbc.M803497200. Epub 2008 Jun 19.


Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function.

Blumer JB, Lord K, Saunders TL, Pacchioni A, Black C, Lazartigues E, Varner KJ, Gettys TW, Lanier SM.

Endocrinology. 2008 Aug;149(8):3842-9. doi: 10.1210/en.2008-0050. Epub 2008 May 1.


Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling.

Blumer JB, Smrcka AV, Lanier SM.

Pharmacol Ther. 2007 Mar;113(3):488-506. Epub 2006 Nov 28. Review.


Identification and characterization of a G-protein regulatory motif in WAVE1.

Song KS, Peterson YK, Freidman A, Blumer JB, Sato M, Lanier SM.

FEBS Lett. 2006 Apr 3;580(8):1993-8. Epub 2006 Mar 6.


Accessory proteins for G proteins: partners in signaling.

Sato M, Blumer JB, Simon V, Lanier SM.

Annu Rev Pharmacol Toxicol. 2006;46:151-87. Review.


mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression.

Sans N, Wang PY, Du Q, Petralia RS, Wang YX, Nakka S, Blumer JB, Macara IG, Wenthold RJ.

Nat Cell Biol. 2005 Dec;7(12):1179-90. Epub 2005 Nov 20. Erratum in: Nat Cell Biol. 2006 Jan;8(1):100.


AGS proteins: receptor-independent activators of G-protein signaling.

Blumer JB, Cismowski MJ, Sato M, Lanier SM.

Trends Pharmacol Sci. 2005 Sep;26(9):470-6. Review.


The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors.

Nair KS, Mendez A, Blumer JB, Rosenzweig DH, Slepak VZ.

Invest Ophthalmol Vis Sci. 2005 Jan;46(1):383-9.


Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha.

Cao X, Cismowski MJ, Sato M, Blumer JB, Lanier SM.

J Biol Chem. 2004 Jun 25;279(26):27567-74. Epub 2004 Apr 19.

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