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Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells.

Bedard M, Shrestha D, Priestman DA, Wang Y, Schneider F, Matute JD, Iyer SS, Gileadi U, Prota G, Kandasamy M, Veerapen N, Besra G, Fritzsche M, Zeissig S, Shevchenko A, Christianson JC, Platt FM, Eggeling C, Blumberg RS, Salio M, Cerundolo V.

Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23671-23681. doi: 10.1073/pnas.1910097116. Epub 2019 Nov 5.


Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.

Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS.

Nat Immunol. 2019 Dec;20(12):1644-1655. doi: 10.1038/s41590-019-0504-0. Epub 2019 Oct 21.


CEACAM1 structure and function in immunity and its therapeutic implications.

Kim WM, Huang YH, Gandhi A, Blumberg RS.

Semin Immunol. 2019 Apr;42:101296. doi: 10.1016/j.smim.2019.101296. Review.


The Neonatal Fc Receptor (FcRn): A Misnomer?

Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS.

Front Immunol. 2019 Jul 10;10:1540. doi: 10.3389/fimmu.2019.01540. eCollection 2019. Review.


Analyzing Antigen Recognition by Natural Killer T Cells.

Zeissig S, Blumberg RS.

Methods Mol Biol. 2019;1988:439-453. doi: 10.1007/978-1-4939-9450-2_30.


SLAM-ing the brakes on iNKT cell selection.

Iyer SS, Huang YH, Blumberg RS.

Nat Immunol. 2019 Apr;20(4):378-379. doi: 10.1038/s41590-019-0355-8. No abstract available.


Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.

Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS.

Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186.


High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.

Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS.

Sci Rep. 2018 Nov 30;8(1):17512. doi: 10.1038/s41598-018-35754-0.


T-cell trafficking plays an essential role in tumor immunity.

Aires DJ, Yoshida M, Richardson SK, Bai M, Liu L, Moreno R, Lazar AJF, Wick JA, Rich BE, Murphy G, Blumberg RS, Fuhlbrigge RC, Kupper TS.

Lab Invest. 2019 Jan;99(1):85-92. doi: 10.1038/s41374-018-0124-6. Epub 2018 Oct 23.


Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells.

Li Y, Guan X, Liu W, Chen HL, Truscott J, Beyatli S, Metwali A, Weiner GJ, Zavazava N, Blumberg RS, Urban JF Jr, Blazar BR, Elliott DE, Ince MN.

J Immunol. 2018 Nov 15;201(10):2910-2922. doi: 10.4049/jimmunol.1700638. Epub 2018 Oct 5.


ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P.

J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25.


Natural killer T cells mediate inflammation in the bile ducts.

Berntsen NL, Fosby B, Tan C, Reims HM, Ogaard J, Jiang X, Schrumpf E, Valestrand L, Karlsen TH, Line PD, Blumberg RS, Melum E.

Mucosal Immunol. 2018 Nov;11(6):1582-1590. doi: 10.1038/s41385-018-0066-8. Epub 2018 Aug 16.


New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1.

Hosomi S, Grootjans J, Huang YH, Kaser A, Blumberg RS.

Front Immunol. 2018 Jun 18;9:1324. doi: 10.3389/fimmu.2018.01324. eCollection 2018. Review.


Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.

Zhao M, Xiong X, Ren K, Xu B, Cheng M, Sahu C, Wu K, Nie Y, Huang Z, Blumberg RS, Han X, Ruan HB.

EMBO Mol Med. 2018 Aug;10(8). pii: e8736. doi: 10.15252/emmm.201708736.


Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.

Iyer SS, Gensollen T, Gandhi A, Oh SF, Neves JF, Collin F, Lavin R, Serra C, Glickman J, de Silva PSA, Sartor RB, Besra G, Hauser R, Maxwell A, Llebaria A, Blumberg RS.

Cell. 2018 May 17;173(5):1123-1134.e11. doi: 10.1016/j.cell.2018.04.037.


Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and preterm newborns.

Lozano NA, Lozano A, Marini V, Saranz RJ, Blumberg RS, Baker K, Agresta MF, Ponzio MF.

Am J Reprod Immunol. 2018 Sep;80(3):e12972. doi: 10.1111/aji.12972. Epub 2018 May 10.


Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia

Blumberg RS, Lillicrap D; IgG Fc Immune Tolerance Group.

Blood. 2018 May 17;131(20):2205-2214. doi: 10.1182/blood-2017-12-822908. Epub 2018 Mar 27. Review.


A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.

Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT.

Nat Commun. 2018 Feb 12;9(1):621. doi: 10.1038/s41467-018-03061-x.


Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.

Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC.

Oncoimmunology. 2017 Nov 9;7(2):e1385690. doi: 10.1080/2162402X.2017.1385690. eCollection 2018.


Correction for Nguyen et al., "Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers".

Nguyen S, Baker K, Padman BS, Patwa R, Dunstan RA, Weston TA, Schlosser K, Bailey B, Lithgow T, Lazarou M, Luque A, Rohwer F, Blumberg RS, Barr JJ.

MBio. 2018 Jan 2;9(1). pii: e02207-17. doi: 10.1128/mBio.02207-17. No abstract available.


The neonatal window of opportunity-early priming for life.

Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW.

J Allergy Clin Immunol. 2018 Apr;141(4):1212-1214. doi: 10.1016/j.jaci.2017.11.019. Epub 2017 Dec 14. No abstract available.


IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells.

Clancy-Thompson E, Ali L, Bruck PT, Exley MA, Blumberg RS, Dranoff G, Dougan M, Dougan SK.

Cancer Immunol Res. 2018 Jan;6(1):25-35. doi: 10.1158/2326-6066.CIR-17-0490. Epub 2017 Nov 29.


Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers.

Nguyen S, Baker K, Padman BS, Patwa R, Dunstan RA, Weston TA, Schlosser K, Bailey B, Lithgow T, Lazarou M, Luque A, Rohwer F, Blumberg RS, Barr JJ.

MBio. 2017 Nov 21;8(6). pii: e01874-17. doi: 10.1128/mBio.01874-17. Erratum in: MBio. 2018 Jan 2;9(1):.


Maternal IgG immune complexes induce food allergen-specific tolerance in offspring.

Ohsaki A, Venturelli N, Buccigrosso TM, Osganian SK, Lee J, Blumberg RS, Oyoshi MK.

J Exp Med. 2018 Jan 2;215(1):91-113. doi: 10.1084/jem.20171163. Epub 2017 Nov 20.


CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation.

Zeissig S, Peuker K, Iyer S, Gensollen T, Dougan SK, Olszak T, Kaser A, Blumberg RS.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10449-10454. doi: 10.1073/pnas.1701428114. Epub 2017 Sep 11.


The road to Crohn's disease.

Kaser A, Blumberg RS.

Science. 2017 Sep 8;357(6355):976-977. doi: 10.1126/science.aao4158. No abstract available.


CEACAM1 as a multi-purpose target for cancer immunotherapy.

Dankner M, Gray-Owen SD, Huang YH, Blumberg RS, Beauchemin N.

Oncoimmunology. 2017 May 16;6(7):e1328336. doi: 10.1080/2162402X.2017.1328336. eCollection 2017. Review.


A role for oncostatin M in inflammatory bowel disease.

Kim WM, Kaser A, Blumberg RS.

Nat Med. 2017 May 5;23(5):535-536. doi: 10.1038/nm.4338. No abstract available.


Correlation between early-life regulation of the immune system by microbiota and allergy development.

Gensollen T, Blumberg RS.

J Allergy Clin Immunol. 2017 Apr;139(4):1084-1091. doi: 10.1016/j.jaci.2017.02.011. Review.


CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.

Ueshima C, Kataoka TR, Takei Y, Hirata M, Sugimoto A, Hirokawa M, Okayama Y, Blumberg RS, Haga H.

Cancer Med. 2017 Apr;6(4):845-856. doi: 10.1002/cam4.1050. Epub 2017 Mar 23.


Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2862-E2871. doi: 10.1073/pnas.1618291114. Epub 2017 Mar 22.


The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation.

Schrumpf E, Jiang X, Zeissig S, Pollheimer MJ, Anmarkrud JA, Tan C, Exley MA, Karlsen TH, Blumberg RS, Melum E.

Physiol Rep. 2017 Feb;5(4). pii: e13117. doi: 10.14814/phy2.13117.


Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A.

J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12.


The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation.

Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Bäckhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E.

J Hepatol. 2017 Feb;66(2):382-389. doi: 10.1016/j.jhep.2016.09.020. Epub 2016 Oct 5.


Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι.

Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J.

Cell Rep. 2016 Sep 20;16(12):3297-3310. doi: 10.1016/j.celrep.2016.08.054.


Rare phenotypes in the understanding of autoimmunity.

Zeissig Y, Petersen BS, Franke A, Blumberg RS, Zeissig S.

Immunol Cell Biol. 2016 Nov;94(10):943-948. doi: 10.1038/icb.2016.76. Epub 2016 Oct 11. Review.


Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.

Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher B, Chamaillard M, Kaser A, Rosenstiel P.

Cell Rep. 2016 Aug 23;16(8):2208-2218. doi: 10.1016/j.celrep.2016.07.054. Epub 2016 Aug 11.


Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models.

Mudde AC, Lexmond WS, Blumberg RS, Nurko S, Fiebiger E.

World Allergy Organ J. 2016 Jul 15;9:23. doi: 10.1186/s40413-016-0114-3. eCollection 2016. Review.


The unfolded protein response in immunity and inflammation.

Grootjans J, Kaser A, Kaufman RJ, Blumberg RS.

Nat Rev Immunol. 2016 Aug;16(8):469-84. doi: 10.1038/nri.2016.62. Epub 2016 Jun 27. Review.


CEACAM1-Mediated Inhibition of Virus Production.

Vitenshtein A, Weisblum Y, Hauka S, Halenius A, Oiknine-Djian E, Tsukerman P, Bauman Y, Bar-On Y, Stern-Ginossar N, Enk J, Ortenberg R, Tai J, Markel G, Blumberg RS, Hengel H, Jonjic S, Wolf DG, Adler H, Kammerer R, Mandelboim O.

Cell Rep. 2016 Jun 14;15(11):2331-9. doi: 10.1016/j.celrep.2016.05.036. Epub 2016 Jun 2.


How colonization by microbiota in early life shapes the immune system.

Gensollen T, Iyer SS, Kasper DL, Blumberg RS.

Science. 2016 Apr 29;352(6285):539-44. doi: 10.1126/science.aad9378. Review.


Epithelial calcineurin controls microbiota-dependent intestinal tumor development.

Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S.

Nat Med. 2016 May;22(5):506-15. doi: 10.1038/nm.4072. Epub 2016 Apr 4.


Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.


Environment and Genes: What Is the Interaction?

Blumberg RS.

Dig Dis. 2016;34(1-2):20-6. doi: 10.1159/000442920. Epub 2016 Mar 16. Review.



Grover S, Lim RM, Blumberg RS, Syngal S.

J Clin Oncol. 2016 Apr 1;34(10):1154-5. doi: 10.1200/JCO.2015.65.7973. Epub 2016 Feb 1. No abstract available.


Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice.

Krishnamoorthy S, Liu T, Drager D, Patarroyo-White S, Chhabra ES, Peters R, Josephson N, Lillicrap D, Blumberg RS, Pierce GF, Jiang H.

Cell Immunol. 2016 Mar;301:30-9. doi: 10.1016/j.cellimm.2015.12.008. Epub 2015 Dec 29.


Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.

Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA.

Cancer Res. 2016 Jan 15;76(2):339-46. doi: 10.1158/0008-5472.CAN-15-1467-T.


Leukotrienes and the other airway: Celiac disease and asthma collide.

Grootjans J, Hosomi S, Blumberg RS.

J Exp Med. 2015 Sep 21;212(10):1485. doi: 10.1084/jem.21210insight4. No abstract available.


Control of intestinal homeostasis through crosstalk between natural killer T cells and the intestinal microbiota.

Dowds CM, Blumberg RS, Zeissig S.

Clin Immunol. 2015 Aug;159(2):128-33. doi: 10.1016/j.clim.2015.05.008. Epub 2015 May 16. Review.


FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.

Pyzik M, Rath T, Lencer WI, Baker K, Blumberg RS.

J Immunol. 2015 May 15;194(10):4595-603. doi: 10.4049/jimmunol.1403014. Review.

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