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Items: 1 to 50 of 162

1.

The dynamic conformational landscape of the protein methyltransferase SETD8.

Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H, Zou H, Wang J, Fan S, Blum G, Pittella-Silva F, Beauchamp KA, Tempel W, Jiang H, Chen K, Skene RJ, Zheng YG, Brown PJ, Jin J, Luo C, Chodera JD, Luo M.

Elife. 2019 May 13;8. pii: e45403. doi: 10.7554/eLife.45403.

2.

Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation.

Weiss-Sadan T, Itzhak G, Kaschani F, Yu Z, Mahameed M, Anaki A, Ben-Nun Y, Merquiol E, Tirosh B, Kessler B, Kaiser M, Blum G.

Mol Cell Proteomics. 2019 Jul;18(7):1330-1344. doi: 10.1074/mcp.RA119.001392. Epub 2019 Apr 22.

3.

Preferences of ICT among Patients with Chronic Kidney Disease Undergoing Hemodialysis: An Ecuadorian Cross-Sectional Study.

Cherrez-Ojeda I, Felix M, Mata VL, Vanegas E, Gavilanes AWD, Chedraui P, Simancas-Racines D, Calderon JC, Ortiz F, Blum G, Plua A, Gonzalez G, Moscoso G, Morquecho W.

Healthc Inform Res. 2018 Oct;24(4):292-299. doi: 10.4258/hir.2018.24.4.292. Epub 2018 Oct 31.

4.

CT Imaging of Enzymatic Activity in Cancer Using Covalent Probes Reveal a Size-Dependent Pattern.

Tsvirkun D, Ben-Nun Y, Merquiol E, Zlotver I, Meir K, Weiss-Sadan T, Matok I, Popovtzer R, Blum G.

J Am Chem Soc. 2018 Sep 26;140(38):12010-12020. doi: 10.1021/jacs.8b05817. Epub 2018 Sep 18.

5.

mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity.

Meena NK, Pattanayak SP, Ben-Nun Y, Benhamron S, Kumar S, Merquiol E, Hövelmeyer N, Blum G, Tirosh B.

Immunology. 2018 Dec;155(4):505-518. doi: 10.1111/imm.12996. Epub 2018 Sep 16.

PMID:
30144045
6.

Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins.

Blau R, Epshtein Y, Pisarevsky E, Tiram G, Israeli Dangoor S, Yeini E, Krivitsky A, Eldar-Boock A, Ben-Shushan D, Gibori H, Scomparin A, Green O, Ben-Nun Y, Merquiol E, Doron H, Blum G, Erez N, Grossman R, Ram Z, Shabat D, Satchi-Fainaro R.

Theranostics. 2018 May 24;8(13):3437-3460. doi: 10.7150/thno.23853. eCollection 2018.

7.

Molecular Imaging of Cancer Using X-ray Computed Tomography with Protease Targeted Iodinated Activity-Based Probes.

Gaikwad HK, Tsvirkun D, Ben-Nun Y, Merquiol E, Popovtzer R, Blum G.

Nano Lett. 2018 Mar 14;18(3):1582-1591. doi: 10.1021/acs.nanolett.7b03813. Epub 2018 Feb 22.

8.

Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer.

Gibori H, Eliyahu S, Krivitsky A, Ben-Shushan D, Epshtein Y, Tiram G, Blau R, Ofek P, Lee JS, Ruppin E, Landsman L, Barshack I, Golan T, Merquiol E, Blum G, Satchi-Fainaro R.

Nat Commun. 2018 Jan 2;9(1):16. doi: 10.1038/s41467-017-02283-9.

9.

New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.

Amit U, Kain D, Wagner A, Sahu A, Nevo-Caspi Y, Gonen N, Molotski N, Konfino T, Landa N, Naftali-Shani N, Blum G, Merquiol E, Karo-Atar D, Kanfi Y, Paret G, Munitz A, Cohen HY, Ruppin E, Hannenhalli S, Leor J.

J Am Heart Assoc. 2017 May 20;6(5). pii: e005108. doi: 10.1161/JAHA.116.005108.

10.

Cysteine proteases in atherosclerosis.

Weiss-Sadan T, Gotsman I, Blum G.

FEBS J. 2017 May;284(10):1455-1472. doi: 10.1111/febs.14043. Epub 2017 Mar 9. Review.

11.

Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.

Linscott JA, Kapilashrami K, Wang Z, Senevirathne C, Bothwell IR, Blum G, Luo M.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8369-E8378. doi: 10.1073/pnas.1609032114. Epub 2016 Dec 9.

12.

Cathepsin nanofiber substrates as potential agents for targeted drug delivery.

Ben-Nun Y, Fichman G, Adler-Abramovich L, Turk B, Gazit E, Blum G.

J Control Release. 2017 Jul 10;257:60-67. doi: 10.1016/j.jconrel.2016.11.028. Epub 2016 Nov 28.

PMID:
27908759
13.

Comparative evaluation of polycyanoacrylates.

Barkan Y, Levinman M, Veprinsky-Zuzuliya I, Tsach T, Merqioul E, Blum G, Domb AJ, Basu A.

Acta Biomater. 2017 Jan 15;48:390-400. doi: 10.1016/j.actbio.2016.11.011. Epub 2016 Nov 5.

PMID:
27826005
14.

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.

Alishekevitz D, Gingis-Velitski S, Kaidar-Person O, Gutter-Kapon L, Scherer SD, Raviv Z, Merquiol E, Ben-Nun Y, Miller V, Rachman-Tzemah C, Timaner M, Mumblat Y, Ilan N, Loven D, Hershkovitz D, Satchi-Fainaro R, Blum G, Sleeman JP, Vlodavsky I, Shaked Y.

Cell Rep. 2016 Oct 25;17(5):1344-1356. doi: 10.1016/j.celrep.2016.09.083.

15.

Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion.

Abd-Elrahman I, Kosuge H, Wises Sadan T, Ben-Nun Y, Meir K, Rubinstein C, Bogyo M, McConnell MV, Blum G.

PLoS One. 2016 Aug 17;11(8):e0160522. doi: 10.1371/journal.pone.0160522. eCollection 2016.

16.

[Cystocele and perineal ultrasound : Comparison of reliability and patient satisfaction].

Blum R, Blum G, Link G, Meinhold-Heerlein I, Najjari L.

Urologe A. 2016 Dec;55(12):1595-1600. German.

PMID:
27352272
17.

Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".

LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov AV, Chung YR, Khodos I, de Stanchina E, Ouerfelli O, Adusumilli PS, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong SA, Levine RL.

Nat Med. 2016 Jun 7;22(6):578-9. doi: 10.1038/nm.4094. No abstract available.

PMID:
27270773
18.

Characterizing Cathepsin Activity and Macrophage Subtypes in Excised Human Carotid Plaques.

Abd-Elrahman I, Meir K, Kosuge H, Ben-Nun Y, Weiss Sadan T, Rubinstein C, Samet Y, McConnell MV, Blum G.

Stroke. 2016 Apr;47(4):1101-8. doi: 10.1161/STROKEAHA.115.011573. Epub 2016 Mar 3.

PMID:
26941255
19.

A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis.

Shaulov-Rotem Y, Merquiol E, Weiss-Sadan T, Moshel O, Salpeter S, Shabat D, Kaschani F, Kaiser M, Blum G.

Chem Sci. 2016 Feb 1;7(2):1322-1337. doi: 10.1039/c5sc03207e. Epub 2015 Nov 11.

20.

α-Defensins Induce a Post-translational Modification of Low Density Lipoprotein (LDL) That Promotes Atherosclerosis at Normal Levels of Plasma Cholesterol.

Abu-Fanne R, Maraga E, Abd-Elrahman I, Hankin A, Blum G, Abdeen S, Hijazi N, Cines DB, Higazi AA.

J Biol Chem. 2016 Feb 5;291(6):2777-86. doi: 10.1074/jbc.M115.669812. Epub 2015 Oct 30.

21.

Loss of BAP1 function leads to EZH2-dependent transformation.

LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov AV, Chung YR, Khodos I, de Stanchina E, Ouerfelli O, Adusumilli PS, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong SA, Levine RL.

Nat Med. 2015 Nov;21(11):1344-9. doi: 10.1038/nm.3947. Epub 2015 Oct 5.

22.

Amphotericin B Resistance in Aspergillus terreus Is Overpowered by Coapplication of Pro-oxidants.

Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D.

Antioxid Redox Signal. 2015 Dec 20;23(18):1424-38. doi: 10.1089/ars.2014.6220. Epub 2015 Oct 8.

PMID:
26054424
23.

Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy.

Ben-Nun Y, Merquiol E, Brandis A, Turk B, Scherz A, Blum G.

Theranostics. 2015 Apr 27;5(8):847-62. doi: 10.7150/thno.10854. eCollection 2015.

24.

Detecting cathepsin activity in human osteoarthritis via activity-based probes.

Ben-Aderet L, Merquiol E, Fahham D, Kumar A, Reich E, Ben-Nun Y, Kandel L, Haze A, Liebergall M, Kosińska MK, Steinmeyer J, Turk B, Blum G, Dvir-Ginzberg M.

Arthritis Res Ther. 2015 Mar 20;17:69. doi: 10.1186/s13075-015-0586-5.

25.

Insoluble fibrinogen particles for harvesting and expanding attachment-dependent cells and for trapping suspended cancer cells in the presence of blood.

Fahham D, Merquiol E, Gilon T, Marx G, Blum G.

Biomed Mater. 2015 Apr 17;10(2):025010. doi: 10.1088/1748-6041/10/2/025010.

PMID:
25886560
26.

Evaluation of a modified EUCAST fragmented-mycelium inoculum method for in vitro susceptibility testing of dermatophytes and the activity of novel antifungal agents.

Risslegger B, Lass-Flörl C, Blum G, Lackner M.

Antimicrob Agents Chemother. 2015;59(6):3675-82. doi: 10.1128/AAC.04381-14. Epub 2015 Apr 13.

27.

Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains.

Blatzer M, Blum G, Jukic E, Posch W, Gruber P, Nagl M, Binder U, Maurer E, Sarg B, Lindner H, Lass-Flörl C, Wilflingseder D.

Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88. doi: 10.1128/AAC.05164-14. Epub 2015 Apr 13.

28.

Identification of Aspergillus fumigatus Surface Components That Mediate Interaction of Conidia and Hyphae With Human Platelets.

Rambach G, Blum G, Latgé JP, Fontaine T, Heinekamp T, Hagleitner M, Jeckström H, Weigel G, Würtinger P, Pfaller K, Krappmann S, Löffler J, Lass-Flörl C, Speth C.

J Infect Dis. 2015 Oct 1;212(7):1140-9. doi: 10.1093/infdis/jiv191. Epub 2015 Mar 25.

PMID:
25810442
29.

A novel cysteine cathepsin inhibitor yields macrophage cell death and mammary tumor regression.

Salpeter SJ, Pozniak Y, Merquiol E, Ben-Nun Y, Geiger T, Blum G.

Oncogene. 2015 Dec 10;34(50):6066-78. doi: 10.1038/onc.2015.51. Epub 2015 Mar 23.

PMID:
25798843
30.

Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner.

Riahi Y, Kaiser N, Cohen G, Abd-Elrahman I, Blum G, Shapira OM, Koler T, Simionescu M, Sima AV, Zarkovic N, Zarkovic K, Orioli M, Aldini G, Cerasi E, Leibowitz G, Sasson S.

J Cell Mol Med. 2015 Aug;19(8):1887-99. doi: 10.1111/jcmm.12561. Epub 2015 Mar 5.

31.

Small-molecule inhibitors of SETD8 with cellular activity.

Blum G, Ibáñez G, Rao X, Shum D, Radu C, Djaballah H, Rice JC, Luo M.

ACS Chem Biol. 2014 Nov 21;9(11):2471-8. doi: 10.1021/cb500515r. Epub 2014 Sep 3.

32.

Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues.

Guo H, Wang R, Zheng W, Chen Y, Blum G, Deng H, Luo M.

ACS Chem Biol. 2014 Feb 21;9(2):476-84. doi: 10.1021/cb4008259. Epub 2013 Dec 9.

33.

Acid-mediated tumor proteolysis: contribution of cysteine cathepsins.

Rothberg JM, Bailey KM, Wojtkowiak JW, Ben-Nun Y, Bogyo M, Weber E, Moin K, Blum G, Mattingly RR, Gillies RJ, Sloane BF.

Neoplasia. 2013 Oct;15(10):1125-37.

34.

Oral and maxillofacial pathology case of the month. Cemental tear and chronic periodontitis.

Blum G, Bouquot J, Dorn S.

Tex Dent J. 2013 Jun;130(6):534-8. No abstract available.

PMID:
24195195
35.

Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.

Islam K, Chen Y, Wu H, Bothwell IR, Blum GJ, Zeng H, Dong A, Zheng W, Min J, Deng H, Luo M.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16778-83. doi: 10.1073/pnas.1216365110. Epub 2013 Sep 30.

36.

Macrophage subpopulations are essential for infarct repair with and without stem cell therapy.

Ben-Mordechai T, Holbova R, Landa-Rouben N, Harel-Adar T, Feinberg MS, Abd Elrahman I, Blum G, Epstein FH, Silman Z, Cohen S, Leor J.

J Am Coll Cardiol. 2013 Nov 12;62(20):1890-901. doi: 10.1016/j.jacc.2013.07.057. Epub 2013 Aug 21.

37.

Proposal of a Nonlinear Interaction of Person and Situation (NIPS) model.

Schmitt M, Gollwitzer M, Baumert A, Blum G, Gschwendner T, Hofmann W, Rothmund T.

Front Psychol. 2013 Aug 2;4:499. doi: 10.3389/fpsyg.2013.00499. eCollection 2013.

38.

Profiling protein methylation with cofactor analog containing terminal alkyne functionality.

Blum G, Bothwell IR, Islam K, Luo M.

Curr Protoc Chem Biol. 2013;5(1):67-88. doi: 10.1002/9780470559277.ch120241.

39.

Rep-PCR and RAPD-PCR fingerprinting of Aspergillus terreus.

Mutschlechner W, Grif K, Blum G, Lass-Flörl C.

Med Mycol. 2013 Nov;51(8):876-9. doi: 10.3109/13693786.2013.793458. Epub 2013 Jun 13.

PMID:
23758105
40.

Virulence and thrombocyte affectation of two Aspergillus terreus isolates differing in amphotericin B susceptibility.

Speth C, Blum G, Hagleitner M, Hörtnagl C, Pfaller K, Posch B, Ott HW, Würzner R, Lass-Flörl C, Rambach G.

Med Microbiol Immunol. 2013 Oct;202(5):379-89. doi: 10.1007/s00430-013-0300-7. Epub 2013 May 31.

PMID:
23722593
41.

Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins.

Mullins SR, Sameni M, Blum G, Bogyo M, Sloane BF, Moin K.

Biol Chem. 2012 Dec;393(12):1405-16.

42.
43.

Ready, set, cleave: proteases in action.

Salpeter SJ, Blum G.

Chem Biol. 2013 Feb 21;20(2):137-8. doi: 10.1016/j.chembiol.2013.02.004.

44.

New insight into amphotericin B resistance in Aspergillus terreus.

Blum G, Hörtnagl C, Jukic E, Erbeznik T, Pümpel T, Dietrich H, Nagl M, Speth C, Rambach G, Lass-Flörl C.

Antimicrob Agents Chemother. 2013 Apr;57(4):1583-8. doi: 10.1128/AAC.01283-12. Epub 2013 Jan 14.

45.

Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells.

Wang R, Islam K, Liu Y, Zheng W, Tang H, Lailler N, Blum G, Deng H, Luo M.

J Am Chem Soc. 2013 Jan 23;135(3):1048-56. doi: 10.1021/ja309412s. Epub 2013 Jan 10.

46.

Functional imaging of legumain in cancer using a new quenched activity-based probe.

Edgington LE, Verdoes M, Ortega A, Withana NP, Lee J, Syed S, Bachmann MH, Blum G, Bogyo M.

J Am Chem Soc. 2013 Jan 9;135(1):174-82. doi: 10.1021/ja307083b. Epub 2012 Dec 18.

47.

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.

Zheng W, Ibáñez G, Wu H, Blum G, Zeng H, Dong A, Li F, Hajian T, Allali-Hassani A, Amaya MF, Siarheyeva A, Yu W, Brown PJ, Schapira M, Vedadi M, Min J, Luo M.

J Am Chem Soc. 2012 Oct 31;134(43):18004-14. doi: 10.1021/ja307060p. Epub 2012 Oct 23.

48.

Nexplanon, a radiopaque etonogestrel implant in combination with a next-generation applicator: 3-year results of a noncomparative multicenter trial.

Mommers E, Blum GF, Gent TG, Peters KP, Sørdal TS, Marintcheva-Petrova M.

Am J Obstet Gynecol. 2012 Nov;207(5):388.e1-6. doi: 10.1016/j.ajog.2012.08.002. Epub 2012 Aug 10.

PMID:
22939402
49.

Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation.

Bothwell IR, Islam K, Chen Y, Zheng W, Blum G, Deng H, Luo M.

J Am Chem Soc. 2012 Sep 12;134(36):14905-12. doi: 10.1021/ja304782r. Epub 2012 Sep 4.

50.

Susceptibility screening of hyphae-forming fungi with a new, easy, and fast inoculum preparation method.

Schmalreck A, Willinger B, Czaika V, Fegeler W, Becker K, Blum G, Lass-Flörl C.

Mycopathologia. 2012 Dec;174(5-6):467-74. doi: 10.1007/s11046-012-9570-7. Epub 2012 Aug 4.

PMID:
22864604

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