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Items: 18


A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents.

Blower TR, Bandak A, Lee ASY, Austin CA, Nitiss JL, Berger JM.

Nucleic Acids Res. 2019 Sep 5;47(15):8163-8179. doi: 10.1093/nar/gkz579.


Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons.

Gibson EG, Blower TR, Cacho M, Bax B, Berger JM, Osheroff N.

ACS Infect Dis. 2018 Aug 10;4(8):1211-1222. doi: 10.1021/acsinfecdis.8b00035. Epub 2018 May 17.


AbiEi Binds Cooperatively to the Type IV abiE Toxin-Antitoxin Operator Via a Positively-Charged Surface and Causes DNA Bending and Negative Autoregulation.

Hampton HG, Jackson SA, Fagerlund RD, Vogel AIM, Dy RL, Blower TR, Fineran PC.

J Mol Biol. 2018 Apr 13;430(8):1141-1156. doi: 10.1016/j.jmb.2018.02.022. Epub 2018 Mar 6.


Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.

Ashley RE, Blower TR, Berger JM, Osheroff N.

Biochemistry. 2017 Oct 10;56(40):5440-5448. doi: 10.1021/acs.biochem.7b00681. Epub 2017 Sep 25.


Evolution of Pectobacterium Bacteriophage ΦM1 To Escape Two Bifunctional Type III Toxin-Antitoxin and Abortive Infection Systems through Mutations in a Single Viral Gene.

Blower TR, Chai R, Przybilski R, Chindhy S, Fang X, Kidman SE, Tan H, Luisi BF, Fineran PC, Salmond GPC.

Appl Environ Microbiol. 2017 Mar 31;83(8). pii: e03229-16. doi: 10.1128/AEM.03229-16. Print 2017 Apr 15.


Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.

Blower TR, Williamson BH, Kerns RJ, Berger JM.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1706-13. doi: 10.1073/pnas.1525047113. Epub 2016 Jan 20.


Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.

Aldred KJ, Blower TR, Kerns RJ, Berger JM, Osheroff N.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E839-46. doi: 10.1073/pnas.1525055113. Epub 2016 Jan 20.


Co-evolution of quaternary organization and novel RNA tertiary interactions revealed in the crystal structure of a bacterial protein-RNA toxin-antitoxin system.

Rao F, Short FL, Voss JE, Blower TR, Orme AL, Whittaker TE, Luisi BF, Salmond GP.

Nucleic Acids Res. 2015 Oct 30;43(19):9529-40. doi: 10.1093/nar/gkv868. Epub 2015 Sep 8.


DNA driven self-assembly of micron-sized rods using DNA-grafted bacteriophage fd virions.

Unwin RR, Cabanas RA, Yanagishima T, Blower TR, Takahashi H, Salmond GP, Edwardson JM, Fraden S, Eiser E.

Phys Chem Chem Phys. 2015 Mar 28;17(12):8194-202. doi: 10.1039/c4cp05405a.


Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot.

Short FL, Pei XY, Blower TR, Ong SL, Fineran PC, Luisi BF, Salmond GP.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E241-9. doi: 10.1073/pnas.1216039110. Epub 2012 Dec 24.


Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism.

Blower TR, Evans TJ, Przybilski R, Fineran PC, Salmond GP.

PLoS Genet. 2012;8(10):e1003023. doi: 10.1371/journal.pgen.1003023. Epub 2012 Oct 18.


Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes.

Blower TR, Short FL, Rao F, Mizuguchi K, Pei XY, Fineran PC, Luisi BF, Salmond GP.

Nucleic Acids Res. 2012 Jul;40(13):6158-73. doi: 10.1093/nar/gks231. Epub 2012 Mar 19.


A promiscuous antitoxin of bacteriophage T4 ensures successful viral replication.

Short FL, Blower TR, Salmond GP.

Mol Microbiol. 2012 Feb;83(4):665-8. doi: 10.1111/j.1365-2958.2012.07974.x. Epub 2012 Jan 29.


Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners.

Blower TR, Salmond GP, Luisi BF.

Curr Opin Struct Biol. 2011 Feb;21(1):109-18. doi: 10.1016/ Review.


A processed noncoding RNA regulates an altruistic bacterial antiviral system.

Blower TR, Pei XY, Short FL, Fineran PC, Humphreys DP, Luisi BF, Salmond GP.

Nat Struct Mol Biol. 2011 Feb;18(2):185-90. doi: 10.1038/nsmb.1981. Epub 2011 Jan 16.


Mutagenesis and functional characterization of the RNA and protein components of the toxIN abortive infection and toxin-antitoxin locus of Erwinia.

Blower TR, Fineran PC, Johnson MJ, Toth IK, Humphreys DP, Salmond GP.

J Bacteriol. 2009 Oct;191(19):6029-39. doi: 10.1128/JB.00720-09. Epub 2009 Jul 24.


The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair.

Fineran PC, Blower TR, Foulds IJ, Humphreys DP, Lilley KS, Salmond GP.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):894-9. doi: 10.1073/pnas.0808832106. Epub 2009 Jan 5.

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