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Items: 17

1.

Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.

Pham AN, Blower PE, Alvarado O, Ravula R, Gout PW, Huang Y.

J Pharmacol Exp Ther. 2010 Mar;332(3):949-58. doi: 10.1124/jpet.109.162248. Epub 2009 Dec 9.

PMID:
20007406
2.

Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins.

Pham AN, Wang J, Fang J, Gao X, Zhang Y, Blower PE, Sadée W, Huang Y.

Pharm Res. 2009 Apr;26(4):936-45. doi: 10.1007/s11095-008-9796-8. Epub 2008 Dec 10.

PMID:
19067123
3.

In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.

Ikediobi ON, Reimers M, Durinck S, Blower PE, Futreal AP, Stratton MR, Weinstein JN.

Mol Cancer Ther. 2008 Jun;7(6):1337-46. doi: 10.1158/1535-7163.MCT-07-2308. Epub 2008 Jun 4.

4.

MicroRNAs modulate the chemosensitivity of tumor cells.

Blower PE, Chung JH, Verducci JS, Lin S, Park JK, Dai Z, Liu CG, Schmittgen TD, Reinhold WC, Croce CM, Weinstein JN, Sadee W.

Mol Cancer Ther. 2008 Jan;7(1):1-9. doi: 10.1158/1535-7163.MCT-07-0573. Epub 2008 Jan 9.

5.

Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin.

Liu R, Blower PE, Pham AN, Fang J, Dai Z, Wise C, Green B, Teitel CH, Ning B, Ling W, Lyn-Cook BD, Kadlubar FF, Sadée W, Huang Y.

Mol Pharmacol. 2007 Dec;72(6):1637-46. Epub 2007 Sep 17.

PMID:
17875604
6.

MicroRNA expression profiles for the NCI-60 cancer cell panel.

Blower PE, Verducci JS, Lin S, Zhou J, Chung JH, Dai Z, Liu CG, Reinhold W, Lorenzi PL, Kaldjian EP, Croce CM, Weinstein JN, Sadee W.

Mol Cancer Ther. 2007 May;6(5):1483-91. Epub 2007 May 4.

7.

Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1.

Huang Y, Blower PE, Liu R, Dai Z, Pham AN, Moon H, Fang J, Sadée W.

Pharm Res. 2007 Sep;24(9):1702-12. Epub 2007 Apr 25.

PMID:
17457659
8.

Comparison of methods for sequential screening of large compound sets.

Blower PE, Cross KP, Eichler GS, Myatt GJ, Weinstein JN, Yang C.

Comb Chem High Throughput Screen. 2006 Feb;9(2):115-22.

PMID:
16475969
9.

Systematic analysis of large screening sets in drug discovery.

Blower PE Jr, Cross KP, Fligner MA, Myatt GJ, Verducci JS, Yang C.

Curr Drug Discov Technol. 2004 Jan;1(1):37-47.

PMID:
16472218
10.

Decision tree methods in pharmaceutical research.

Blower PE, Cross KP.

Curr Top Med Chem. 2006;6(1):31-9. Review.

PMID:
16454756
11.

Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1.

Huang Y, Blower PE, Yang C, Barbacioru C, Dai Z, Zhang Y, Xiao JJ, Chan KK, Sadée W.

Pharmacogenomics J. 2005;5(2):112-25.

PMID:
15668728
12.
13.

Finding discriminating structural features by reassembling common building blocks.

Cross KP, Myatt G, Yang C, Fligner MA, Verducci JS, Blower PE Jr.

J Med Chem. 2003 Oct 23;46(22):4770-5.

PMID:
14561096
14.

Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data.

Blower PE, Yang C, Fligner MA, Verducci JS, Yu L, Richman S, Weinstein JN.

Pharmacogenomics J. 2002;2(4):259-71.

15.

Multiscale and Bayesian approaches to data analysis in genomics high-throughput screening.

Yang C, Bakshi BR, Rathman JF, Blower PE Jr.

Curr Opin Drug Discov Devel. 2002 May;5(3):428-38. Review.

PMID:
12058619
16.

Chem-tox informatics: data mining using a medicinal chemistry building block approach.

Johnson DE, Blower PE Jr, Myatt GJ, Wolfgang GH.

Curr Opin Drug Discov Devel. 2001 Jan;4(1):92-101. Review.

PMID:
11727328
17.

LeadScope: software for exploring large sets of screening data.

Roberts G, Myatt GJ, Johnson WP, Cross KP, Blower PE Jr.

J Chem Inf Comput Sci. 2000 Nov-Dec;40(6):1302-14.

PMID:
11128088

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