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Items: 1 to 50 of 136

1.

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing.

Shoaib M, Walter D, Gillespie PJ, Izard F, Fahrenkrog B, Lleres D, Lerdrup M, Johansen JV, Hansen K, Julien E, Blow JJ, Sørensen CS.

Nat Commun. 2018 Sep 12;9(1):3704. doi: 10.1038/s41467-018-06066-8.

2.

Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.

Carroll TD, Newton IP, Chen Y, Blow JJ, Näthke I.

J Cell Biol. 2018 May 7;217(5):1667-1685. doi: 10.1083/jcb.201708023. Epub 2018 Mar 29.

3.

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.

Barini E, Miccoli A, Tinarelli F, Mulholland K, Kadri H, Khanim F, Stojanovski L, Read KD, Burness K, Blow JJ, Mehellou Y, Muqit MMK.

Chembiochem. 2018 Mar 2;19(5):425-429. doi: 10.1002/cbic.201700500. Epub 2018 Jan 24.

4.

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.

Gardner NJ, Gillespie PJ, Carrington JT, Shanks EJ, McElroy SP, Haagensen EJ, Frearson JA, Woodland A, Blow JJ.

Cell Chem Biol. 2017 Aug 17;24(8):981-992.e4. doi: 10.1016/j.chembiol.2017.06.019. Epub 2017 Aug 3.

5.

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.

Alver RC, Chadha GS, Gillespie PJ, Blow JJ.

Cell Rep. 2017 Mar 7;18(10):2508-2520. doi: 10.1016/j.celrep.2017.02.042.

6.
7.

Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase.

Al Mamun M, Albergante L, Moreno A, Carrington JT, Blow JJ, Newman TJ.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5765-74. doi: 10.1073/pnas.1603241113. Epub 2016 Sep 14.

8.

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells.

Moreno A, Carrington JT, Albergante L, Al Mamun M, Haagensen EJ, Komseli ES, Gorgoulis VG, Newman TJ, Blow JJ.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5757-64. doi: 10.1073/pnas.1603252113. Epub 2016 Aug 11.

9.

Xenopus Mcm10 is a CDK-substrate required for replication fork stability.

Chadha GS, Gambus A, Gillespie PJ, Blow JJ.

Cell Cycle. 2016 Aug 17;15(16):2183-2195. Epub 2016 Jun 21.

10.

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG.

Nat Cell Biol. 2016 Jul;18(7):777-89. doi: 10.1038/ncb3378. Epub 2016 Jun 20.

PMID:
27323328
11.

The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability.

Ho TLF, Guilbaud G, Blow JJ, Sale JE, Watson CJ.

Cell Rep. 2016 Apr 26;15(4):724-734. doi: 10.1016/j.celrep.2016.03.078. Epub 2016 Apr 14.

12.

The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis.

Hong Y, Sonneville R, Agostinho A, Meier B, Wang B, Blow JJ, Gartner A.

PLoS Genet. 2016 Mar 24;12(3):e1005872. doi: 10.1371/journal.pgen.1005872. eCollection 2016 Mar.

13.

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.

Lachaud C, Moreno A, Marchesi F, Toth R, Blow JJ, Rouse J.

Science. 2016 Feb 19;351(6275):846-9. doi: 10.1126/science.aad5634. Epub 2016 Jan 21.

14.

Direct non transcriptional role of NF-Y in DNA replication.

Benatti P, Belluti S, Miotto B, Neusiedler J, Dolfini D, Drac M, Basile V, Schwob E, Mantovani R, Blow JJ, Imbriano C.

Biochim Biophys Acta. 2016 Apr;1863(4):673-85. doi: 10.1016/j.bbamcr.2015.12.019. Epub 2015 Dec 28.

15.

Cell Cycle Synchronization in Xenopus Egg Extracts.

Gillespie PJ, Neusiedler J, Creavin K, Chadha GS, Blow JJ.

Methods Mol Biol. 2016;1342:101-47. doi: 10.1007/978-1-4939-2957-3_6.

PMID:
26254920
16.

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos.

Sonneville R, Craig G, Labib K, Gartner A, Blow JJ.

Cell Rep. 2015 Jul 21;12(3):405-17. doi: 10.1016/j.celrep.2015.06.046. Epub 2015 Jul 9.

17.

Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.

Pelisch F, Sonneville R, Pourkarimi E, Agostinho A, Blow JJ, Gartner A, Hay RT.

Nat Commun. 2015 Feb 12;6:6352. doi: 10.1038/ncomms7352. No abstract available.

18.

Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.

Pelisch F, Sonneville R, Pourkarimi E, Agostinho A, Blow JJ, Gartner A, Hay RT.

Nat Commun. 2014 Dec 5;5:5485. doi: 10.1038/ncomms6485. Erratum in: Nat Commun. 2015;6:6352.

19.

Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks.

Albergante L, Blow JJ, Newman TJ.

Elife. 2014 Sep 2;3:e02863. doi: 10.7554/eLife.02863.

20.

The contribution of dormant origins to genome stability: from cell biology to human genetics.

Alver RC, Chadha GS, Blow JJ.

DNA Repair (Amst). 2014 Jul;19:182-9. doi: 10.1016/j.dnarep.2014.03.012. Epub 2014 Apr 24. Review.

21.

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.

Poh WT, Chadha GS, Gillespie PJ, Kaldis P, Blow JJ.

Open Biol. 2014 Jan 8;4:130138. doi: 10.1098/rsob.130138.

22.

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template.

Neelsen KJ, Zanini IM, Mijic S, Herrador R, Zellweger R, Ray Chaudhuri A, Creavin KD, Blow JJ, Lopes M.

Genes Dev. 2013 Dec 1;27(23):2537-42. doi: 10.1101/gad.226373.113.

23.

The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.

Caillat C, Pefani DE, Gillespie PJ, Taraviras S, Blow JJ, Lygerou Z, Perrakis A.

J Biol Chem. 2013 Nov 1;288(44):31624-34. doi: 10.1074/jbc.M113.491928. Epub 2013 Sep 24.

24.

Stochastic association of neighboring replicons creates replication factories in budding yeast.

Saner N, Karschau J, Natsume T, Gierlinski M, Retkute R, Hawkins M, Nieduszynski CA, Blow JJ, de Moura AP, Tanaka TU.

J Cell Biol. 2013 Sep 30;202(7):1001-12. doi: 10.1083/jcb.201306143. Epub 2013 Sep 23.

25.

Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts.

Newman TJ, Mamun MA, Nieduszynski CA, Blow JJ.

Nucleic Acids Res. 2013 Nov;41(21):9705-18. doi: 10.1093/nar/gkt728. Epub 2013 Aug 19.

26.

PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.

Moser SC, Bensaddek D, Ortmann B, Maure JF, Mudie S, Blow JJ, Lamond AI, Swedlow JR, Rocha S.

Dev Cell. 2013 Aug 26;26(4):381-92. doi: 10.1016/j.devcel.2013.06.014. Epub 2013 Aug 8.

27.

Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment.

Natsume T, Müller CA, Katou Y, Retkute R, Gierliński M, Araki H, Blow JJ, Shirahige K, Nieduszynski CA, Tanaka TU.

Mol Cell. 2013 Jun 6;50(5):661-74. doi: 10.1016/j.molcel.2013.05.011.

28.

Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.

Gambus A, Blow JJ.

Cell Cycle. 2013 Apr 15;12(8):1225-32. doi: 10.4161/cc.24310. Epub 2013 Mar 21.

29.

Dormant origins, the licensing checkpoint, and the response to replicative stresses.

McIntosh D, Blow JJ.

Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a012955. doi: 10.1101/cshperspect.a012955. Review.

30.

Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins.

Gillespie PJ, Gambus A, Blow JJ.

Methods. 2012 Jun;57(2):203-13. doi: 10.1016/j.ymeth.2012.03.029. Epub 2012 Apr 19.

31.

Optimal placement of origins for DNA replication.

Karschau J, Blow JJ, de Moura AP.

Phys Rev Lett. 2012 Feb 3;108(5):058101. Epub 2012 Jan 30.

32.

Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.

Klotz-Noack K, McIntosh D, Schurch N, Pratt N, Blow JJ.

J Cell Sci. 2012 May 15;125(Pt 10):2436-45. doi: 10.1242/jcs.100883. Epub 2012 Feb 24.

33.

The dynamics of replication licensing in live Caenorhabditis elegans embryos.

Sonneville R, Querenet M, Craig A, Gartner A, Blow JJ.

J Cell Biol. 2012 Jan 23;196(2):233-46. doi: 10.1083/jcb.201110080. Epub 2012 Jan 16.

34.

Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos.

Kisielewska J, Blow JJ.

Development. 2012 Jan;139(1):63-74. doi: 10.1242/dev.068676. Epub 2011 Nov 17.

35.

Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity.

Sasaki T, Li A, Gillespie PJ, Blow JJ, Gilbert DM.

Nucleus. 2011 Sep-Oct;2(5):455-64. doi: 10.4161/nucl.2.5.17859. Epub 2011 Sep 1.

36.

CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.

Franz A, Orth M, Pirson PA, Sonneville R, Blow JJ, Gartner A, Stemmann O, Hoppe T.

Mol Cell. 2011 Oct 7;44(1):85-96. doi: 10.1016/j.molcel.2011.08.028.

37.

How dormant origins promote complete genome replication.

Blow JJ, Ge XQ, Jackson DA.

Trends Biochem Sci. 2011 Aug;36(8):405-14. doi: 10.1016/j.tibs.2011.05.002. Epub 2011 Jun 7. Review.

38.

A role for dormant origins in tumor suppression.

Klotz-Noack K, Blow JJ.

Mol Cell. 2011 Mar 4;41(5):495-6. doi: 10.1016/j.molcel.2011.02.014. No abstract available.

39.

MCM2-7 form double hexamers at licensed origins in Xenopus egg extract.

Gambus A, Khoudoli GA, Jones RC, Blow JJ.

J Biol Chem. 2011 Apr 1;286(13):11855-64. doi: 10.1074/jbc.M110.199521. Epub 2011 Jan 31.

40.

Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication.

Kundu LR, Seki M, Watanabe N, Murofushi H, Furukohri A, Waga S, Score AJ, Blow JJ, Horikoshi M, Enomoto T, Tada S.

Biochim Biophys Acta. 2011 Jun;1813(6):1129-36. doi: 10.1016/j.bbamcr.2011.01.002. Epub 2011 Jan 11.

41.

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories.

Ge XQ, Blow JJ.

J Cell Biol. 2010 Dec 27;191(7):1285-97. doi: 10.1083/jcb.201007074. Epub 2010 Dec 20.

42.

Clusters, factories and domains: The complex structure of S-phase comes into focus.

Gillespie PJ, Blow JJ.

Cell Cycle. 2010 Aug 15;9(16):3218-26. doi: 10.4161/cc.9.16.12644. Epub 2010 Aug 11.

43.

Histone acetylation by HBO1 tightens replication licensing.

Chadha GS, Blow JJ.

Mol Cell. 2010 Jan 15;37(1):5-6. doi: 10.1016/j.molcel.2009.12.028.

44.

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels.

Thomson AM, Gillespie PJ, Blow JJ.

J Cell Biol. 2010 Jan 25;188(2):209-21. doi: 10.1083/jcb.200911037. Epub 2010 Jan 18.

45.

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.

De Marco V, Gillespie PJ, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19807-12. doi: 10.1073/pnas.0905281106. Epub 2009 Nov 11.

46.

The licensing checkpoint opens up.

Ge XQ, Blow JJ.

Cell Cycle. 2009 Aug;8(15):2320-2. Epub 2009 Aug 1. No abstract available.

47.

A model for DNA replication showing how dormant origins safeguard against replication fork failure.

Blow JJ, Ge XQ.

EMBO Rep. 2009 Apr;10(4):406-12. doi: 10.1038/embor.2009.5. Epub 2009 Feb 13.

48.

Replication forks, chromatin loops and dormant replication origins.

Blow JJ, Ge XQ.

Genome Biol. 2008;9(12):244. doi: 10.1186/gb-2008-9-12-244. Epub 2008 Dec 30. Review.

49.

Replication licensing and cancer--a fatal entanglement?

Blow JJ, Gillespie PJ.

Nat Rev Cancer. 2008 Oct;8(10):799-806. doi: 10.1038/nrc2500. Epub 2008 Aug 29. Review.

50.

Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts.

Bru T, Clarke C, McGrew MJ, Sang HM, Wilmut I, Blow JJ.

Exp Cell Res. 2008 Aug 15;314(14):2634-42. doi: 10.1016/j.yexcr.2008.05.009. Epub 2008 May 29.

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