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Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.

Rogers RT, Sun MA, Yue Q, Bao HF, Sands JM, Blount MA, Eaton DC.

Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F539-F549. doi: 10.1152/ajprenal.00166.2018. Epub 2018 Dec 12.


Chronic lithium treatment induces novel patterns of pendrin localization and expression.

Himmel NJ, Wang Y, Rodriguez DA, Sun MA, Blount MA.

Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F313-F322. doi: 10.1152/ajprenal.00065.2018. Epub 2018 Apr 18.


Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts.

Klein JD, Wang Y, Blount MA, Molina PA, LaRocque LM, Ruiz JA, Sands JM.

Am J Physiol Renal Physiol. 2016 May 15;310(10):F1008-12. doi: 10.1152/ajprenal.00102.2016. Epub 2016 Mar 9.


Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function.

Kleinhenz JM, Murphy TC, Pokutta-Paskaleva AP, Gleason RL, Lyle AN, Taylor WR, Blount MA, Cheng J, Yang Q, Sutliff RL, Hart CM.

PLoS One. 2015 Oct 9;10(10):e0139756. doi: 10.1371/journal.pone.0139756. eCollection 2015.


Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.

Klein JD, Wang Y, Mistry A, LaRocque LM, Molina PA, Rogers RT, Blount MA, Sands JM.

J Am Soc Nephrol. 2016 May;27(5):1448-55. doi: 10.1681/ASN.2014121267. Epub 2015 Sep 25.


Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct.

Blount MA, Cipriani P, Redd SK, Ordas RJ, Black LN, Gumina DL, Hoban CA, Klein JD, Sands JM.

Am J Physiol Cell Physiol. 2015 Nov 1;309(9):C608-15. doi: 10.1152/ajpcell.00171.2014. Epub 2015 Sep 2.


Vasopressin regulation of multisite phosphorylation of UT-A1 in the inner medullary collecting duct.

Hoban CA, Black LN, Ordas RJ, Gumina DL, Pulous FE, Sim JH, Sands JM, Blount MA.

Am J Physiol Renal Physiol. 2015 Jan 1;308(1):F49-55. doi: 10.1152/ajprenal.00642.2013. Epub 2014 Nov 5.


Genes and proteins of urea transporters.

Sands JM, Blount MA.

Subcell Biochem. 2014;73:45-63. doi: 10.1007/978-94-017-9343-8_4. Review.


Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus.

Sim JH, Himmel NJ, Redd SK, Pulous FE, Rogers RT, Black LN, Hong SM, von Bergen TN, Blount MA.

PLoS One. 2014 Jul 9;9(7):e101753. doi: 10.1371/journal.pone.0101753. eCollection 2014.


Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure.

Kittikulsuth W, Stuart D, Van Hoek AN, Stockand JD, Bugaj V, Mironova E, Blount MA, Kohan DE.

Am J Physiol Renal Physiol. 2014 Mar 15;306(6):F597-607. doi: 10.1152/ajprenal.00505.2013. Epub 2014 Jan 15.


miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export.

Hudson MB, Woodworth-Hobbs ME, Zheng B, Rahnert JA, Blount MA, Gooch JL, Searles CD, Price SR.

Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C551-8. doi: 10.1152/ajpcell.00266.2013. Epub 2013 Dec 11.


Real-time multidimensional temporal analysis of complex high volume physiological data streams in the neonatal intensive care unit.

McGregor C, James A, Eklund M, Sow D, Ebling M, Blount M.

Stud Health Technol Inform. 2013;192:362-6.


The equilibria of vesicles adhered to substrates by short-ranged potentials.

Blount MJ, Miksis MJ, Davis SH.

Proc Math Phys Eng Sci. 2013 May 8;469(2153):20120729.


Urine concentration in the diabetic mouse requires both urea and water transporters.

Ilori TO, Blount MA, Martin CF, Sands JM, Klein JD.

Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F103-11. doi: 10.1152/ajprenal.00385.2012. Epub 2012 Nov 7.


Molecular mechanisms of urea transport in health and disease.

Klein JD, Blount MA, Sands JM.

Pflugers Arch. 2012 Dec;464(6):561-72. doi: 10.1007/s00424-012-1157-0. Epub 2012 Sep 25. Review.


Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo.

Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešič M, Urade Y, Griffin JL, Vidal-Puig A.

PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5.


Chronic use of chloroquine disrupts the urine concentration mechanism by lowering cAMP levels in the inner medulla.

von Bergen TN, Blount MA.

Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F900-5. doi: 10.1152/ajprenal.00547.2011. Epub 2012 Jul 11.


Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response.

Camacho A, Rodriguez-Cuenca S, Blount M, Prieur X, Barbarroja N, Fuller M, Hardingham GE, Vidal-Puig A.

Exp Neurol. 2012 Oct;237(2):396-406. doi: 10.1016/j.expneurol.2012.06.031. Epub 2012 Jul 6. Erratum in: Exp Neurol. 2013 Jan;239:101.


The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus.

Cipriani P, Kim SL, Klein JD, Sim JH, von Bergen TN, Blount MA.

Front Physiol. 2012 Jun 6;3:176. doi: 10.3389/fphys.2012.00176. eCollection 2012.


Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension.

Thai TL, Blount MA, Klein JD, Sands JM.

Am J Physiol Renal Physiol. 2012 Jul 1;303(1):F37-44. doi: 10.1152/ajprenal.00098.2012. Epub 2012 Apr 4.


Fluid flow beneath a semipermeable membrane during drying processes.

Blount MJ, Miksis MJ, Davis SH.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jan;85(1 Pt 2):016330. Epub 2012 Jan 31.


Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1.

Ilori TO, Wang Y, Blount MA, Martin CF, Sands JM, Klein JD.

Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F998-F1004. doi: 10.1152/ajprenal.00358.2011. Epub 2011 Dec 28.


Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice.

Roos KP, Strait KA, Raphael KL, Blount MA, Kohan DE.

Am J Physiol Renal Physiol. 2012 Jan 1;302(1):F78-84. doi: 10.1152/ajprenal.00397.2011. Epub 2011 Sep 21.


Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions.

Francis SH, Blount MA, Corbin JD.

Physiol Rev. 2011 Apr;91(2):651-90. doi: 10.1152/physrev.00030.2010. Review.


Urea transport in the kidney.

Klein JD, Blount MA, Sands JM.

Compr Physiol. 2011 Apr;1(2):699-729. doi: 10.1002/cphy.c100030. Review.


Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil.

Corbin JD, Foster TL, Bessay E, Busch J, Blount M, Francis SH.

Cell Signal. 2011 May;23(5):778-84. doi: 10.1016/j.cellsig.2010.12.005. Epub 2010 Dec 25.


Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans.

Schoenmakers E, Agostini M, Mitchell C, Schoenmakers N, Papp L, Rajanayagam O, Padidela R, Ceron-Gutierrez L, Doffinger R, Prevosto C, Luan J, Montano S, Lu J, Castanet M, Clemons N, Groeneveld M, Castets P, Karbaschi M, Aitken S, Dixon A, Williams J, Campi I, Blount M, Burton H, Muntoni F, O'Donovan D, Dean A, Warren A, Brierley C, Baguley D, Guicheney P, Fitzgerald R, Coles A, Gaston H, Todd P, Holmgren A, Khanna KK, Cooke M, Semple R, Halsall D, Wareham N, Schwabe J, Grasso L, Beck-Peccoz P, Ogunko A, Dattani M, Gurnell M, Chatterjee K.

J Clin Invest. 2010 Dec;120(12):4220-35. doi: 10.1172/JCI43653. Epub 2010 Nov 15.


Real-time analysis for intensive care: development and deployment of the artemis analytic system.

Blount M, Ebling MR, Eklund JM, James AG, McGregor C, Percival N, Smith KP, Sow D.

IEEE Eng Med Biol Mag. 2010 Mar-Apr;29(2):110-8. doi: 10.1109/MEMB.2010.936454.


Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells.

Klein JD, Blount MA, Fröhlich O, Denson CE, Tan X, Sim JH, Martin CF, Sands JM.

Am J Physiol Renal Physiol. 2010 Apr;298(4):F935-40. doi: 10.1152/ajprenal.00682.2009. Epub 2010 Jan 13.


Regulation of renal urea transport by vasopressin.

Sands JM, Blount MA, Klein JD.

Trans Am Clin Climatol Assoc. 2011;122:82-92.


Expression of transporters involved in urine concentration recovers differently after cessation of lithium treatment.

Blount MA, Sim JH, Zhou R, Martin CF, Lu W, Sands JM, Klein JD.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F601-8. doi: 10.1152/ajprenal.00424.2009. Epub 2009 Dec 23.


A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting duct.

Blount MA.

Am J Physiol Renal Physiol. 2010 Apr;298(4):F857-8. doi: 10.1152/ajprenal.00725.2009. Epub 2009 Dec 23. No abstract available.


Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome.

Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A.

Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. doi: 10.1242/dmm.003251. Epub 2009 Oct 19.


Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.

Wang Y, Klein JD, Blount MA, Martin CF, Kent KJ, Pech V, Wall SM, Sands JM.

J Am Soc Nephrol. 2009 Sep;20(9):2018-24. doi: 10.1681/ASN.2008121225. Epub 2009 Aug 6.


Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice.

Kis A, Murdoch C, Zhang M, Siva A, Rodriguez-Cuenca S, Carobbio S, Lukasik A, Blount M, O'Rahilly S, Gray SL, Shah AM, Vidal-Puig A.

Eur J Heart Fail. 2009 Jun;11(6):533-41. doi: 10.1093/eurjhf/hfp048. Epub 2009 Apr 24.


Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity.

Blessing NW, Blount MA, Sands JM, Martin CF, Klein JD.

Am J Physiol Renal Physiol. 2008 Nov;295(5):F1336-41. doi: 10.1152/ajprenal.90228.2008. Epub 2008 Aug 20.


Small-scale testing of RFID in a hospital setting: RFID as bed trigger.

Kannry J, Emro S, Blount M, Ebling M.

AMIA Annu Symp Proc. 2007 Oct 11:384-8.


Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation.

Blount MA, Mistry AC, Fröhlich O, Price SR, Chen G, Sands JM, Klein JD.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F295-9. doi: 10.1152/ajprenal.00102.2008. Epub 2008 May 21.


Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney.

Blount MA, Sands JM, Kent KJ, Smith TD, Price SR, Klein JD.

Am J Physiol Renal Physiol. 2008 Jun;294(6):F1448-52. doi: 10.1152/ajprenal.00600.2007. Epub 2008 Apr 16.


Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil.

Bessay EP, Blount MA, Zoraghi R, Beasley A, Grimes KA, Francis SH, Corbin JD.

J Pharmacol Exp Ther. 2008 Apr;325(1):62-8. doi: 10.1124/jpet.107.133405. Epub 2008 Jan 16.


In vitro degradation of the inner root sheath in human hair follicles lacking sebaceous glands.

Blount M, Goff S, Slusarewicz P.

Br J Dermatol. 2008 Jan;158(1):22-30. Epub 2007 Oct 26.


Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors.

Blount MA, Zoraghi R, Bessay EP, Beasley A, Francis SH, Corbin JD.

J Pharmacol Exp Ther. 2007 Nov;323(2):730-7. Epub 2007 Aug 9.


Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.

Blount MA, Klein JD, Martin CF, Tchapyjnikov D, Sands JM.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1308-13. Epub 2007 Aug 8.


PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.

PLoS Genet. 2007 Apr 27;3(4):e64.


Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.

Bessay EP, Zoraghi R, Blount MA, Grimes KA, Beasley A, Francis SH, Corbin JD.

Front Biosci. 2007 Jan 1;12:1899-910.


Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

PLoS Biol. 2006 Nov;4(11):e369.


Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts.

Klein JD, Fröhlich O, Blount MA, Martin CF, Smith TD, Sands JM.

J Am Soc Nephrol. 2006 Oct;17(10):2680-6. Epub 2006 Sep 7.


A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

Blount MA, Zoraghi R, Ke H, Bessay EP, Corbin JD, Francis SH.

Mol Pharmacol. 2006 Nov;70(5):1822-31. Epub 2006 Aug 22.


Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA.

López M, Lelliott CJ, Tovar S, Kimber W, Gallego R, Virtue S, Blount M, Vázquez MJ, Finer N, Powles TJ, O'Rahilly S, Saha AK, Diéguez C, Vidal-Puig AJ.

Diabetes. 2006 May;55(5):1327-36.

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