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Transdermal Delivery of the Free Base of 3-Fluoroamphetamine: In Vitro Skin Permeation and Irritation Potential.

Jiang Y, Murnane KS, Blough BE, Banga AK.

AAPS PharmSciTech. 2020 Mar 25;21(3):109. doi: 10.1208/s12249-020-01649-5.


Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells.

Hwang ST, Um JY, Chinnathambi A, Alharbi SA, Narula AS, Namjoshi OA, Blough BE, Ahn KS.

Molecules. 2020 Mar 13;25(6). pii: E1320. doi: 10.3390/molecules25061320.


Effects of chronic treatment with bupropion on self-administration of nicotine + cocaine mixtures in nonhuman primates.

de Moura FB, Barkin CE, Blough BE, Carroll FI, Mello NK, Kohut SJ.

Exp Clin Psychopharmacol. 2019 Dec 2. doi: 10.1037/pha0000333. [Epub ahead of print]


Effects of the mGluR2/3 receptor agonist LY379268 on the reinforcing strength of cocaine in rhesus monkeys.

Czoty PW, Blough BE, Landavazo A, Nader MA.

Psychopharmacology (Berl). 2020 Feb;237(2):409-417. doi: 10.1007/s00213-019-05377-y. Epub 2019 Nov 9.


The pharmacokinetics of 3-fluoroamphetamine following delivery using clinically relevant routes of administration.

Jiang Y, Ray A, Junaid MSA, Bhattaccharjee SA, Kelley K, Banga AK, Blough BE, Murnane KS.

Drug Deliv Transl Res. 2020 Feb;10(1):271-281. doi: 10.1007/s13346-019-00685-4.


Synthetic cathinone self-administration in female rats modulates neurotransmitter levels in addiction-related brain regions.

Marusich JA, Gay EA, Watson SL, Blough BE.

Behav Brain Res. 2019 Dec 30;376:112211. doi: 10.1016/j.bbr.2019.112211. Epub 2019 Sep 4.


Effects of methamphetamine isomers on d-methamphetamine self-administration and food-maintained responding in male rats.

Bardo MT, Denehy ED, Hammerslag LR, Dwoskin LP, Blough BE, Landavazo A, Bergman J, Kohut SJ.

Psychopharmacology (Berl). 2019 Dec;236(12):3557-3565. doi: 10.1007/s00213-019-05327-8. Epub 2019 Jul 26.


Effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on ethanol consumption and place conditioning in male mice.

Oppong-Damoah A, Curry KE, Blough BE, Rice KC, Murnane KS.

Psychopharmacology (Berl). 2019 Dec;236(12):3567-3578. doi: 10.1007/s00213-019-05328-7. Epub 2019 Jul 15.


The sesquiterpene beta-caryophyllene oxide attenuates ethanol drinking and place conditioning in mice.

Oppong-Damoah A, Blough BE, Makriyannis A, Murnane KS.

Heliyon. 2019 Jun 12;5(6):e01915. doi: 10.1016/j.heliyon.2019.e01915. eCollection 2019 Jun.


Skin Delivery and Irritation Potential of Phenmetrazine as a Candidate Transdermal Formulation for Repurposed Indications.

Jiang Y, Murnane KS, Bhattaccharjee SA, Blough BE, Banga AK.

AAPS J. 2019 May 31;21(4):70. doi: 10.1208/s12248-019-0335-9.


Correction to: Analysis of neurotransmitter levels in addiction-related brain regions during synthetic cathinone self-administration in male Sprague-Dawley rats.

Marusich JA, Gay EA, Blough BE.

Psychopharmacology (Berl). 2019 Apr;236(4):1405-1406. doi: 10.1007/s00213-019-05266-4.


Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems.

Luethi D, Kolaczynska KE, Walter M, Suzuki M, Rice KC, Blough BE, Hoener MC, Baumann MH, Liechti ME.

J Psychopharmacol. 2019 Jul;33(7):831-841. doi: 10.1177/0269881119844185. Epub 2019 Apr 30.


The synthetic cathinone psychostimulant α-PPP antagonizes serotonin 5-HT2A receptors: In vitro and in vivo evidence.

Chen Y, Blough BE, Murnane KS, Canal CE.

Drug Test Anal. 2019 Jul;11(7):990-998. doi: 10.1002/dta.2582. Epub 2019 Apr 22.


Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats.

Schwienteck KL, Faunce KE, Rice KC, Obeng S, Zhang Y, Blough BE, Grim TW, Negus SS, Banks ML.

Neuropharmacology. 2019 May 15;150:200-209. doi: 10.1016/j.neuropharm.2019.01.020. Epub 2019 Jan 18.


Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model.

Jung YY, Shanmugam MK, Narula AS, Kim C, Lee JH, Namjoshi OA, Blough BE, Sethi G, Ahn KS.

Cancers (Basel). 2019 Jan 7;11(1). pii: E49. doi: 10.3390/cancers11010049.


Further pharmacological comparison of D-methamphetamine and L-methamphetamine in rats: abuse-related behavioral and physiological indices.

Xue Z, Siemian JN, Zhu Q, Blough BE, Li JX.

Behav Pharmacol. 2019 Aug;30(5):422-428. doi: 10.1097/FBP.0000000000000453.


The dopamine, serotonin and norepinephrine releasing activities of a series of methcathinone analogs in male rat brain synaptosomes.

Blough BE, Decker AM, Landavazo A, Namjoshi OA, Partilla JS, Baumann MH, Rothman RB.

Psychopharmacology (Berl). 2019 Mar;236(3):915-924. doi: 10.1007/s00213-018-5063-9. Epub 2018 Oct 20.


Effects of the second-generation "bath salt" cathinone alpha-pyrrolidinopropiophenone (α-PPP) on behavior and monoamine neurochemistry in male mice.

Ray A, Chitre NM, Daphney CM, Blough BE, Canal CE, Murnane KS.

Psychopharmacology (Berl). 2019 Mar;236(3):1107-1117. doi: 10.1007/s00213-018-5044-z. Epub 2018 Oct 1.


The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats.

Austin Zamarripa C, Edwards SR, Qureshi HN, Yi JN, Blough BE, Freeman KB.

Drug Alcohol Depend. 2018 Nov 1;192:158-162. doi: 10.1016/j.drugalcdep.2018.08.002. Epub 2018 Sep 18.


Analysis of neurotransmitter levels in addiction-related brain regions during synthetic cathinone self-administration in male Sprague-Dawley rats.

Marusich JA, Gay EA, Blough BE.

Psychopharmacology (Berl). 2019 Mar;236(3):903-914. doi: 10.1007/s00213-018-5011-8. Epub 2018 Sep 6. Erratum in: Psychopharmacology (Berl). 2019 May 17;:.


Formulation and evaluation of 4-benzylpiperidine drug-in-adhesive matrix type transdermal patch.

Ganti SS, Bhattaccharjee SA, Murnane KS, Blough BE, Banga AK.

Int J Pharm. 2018 Oct 25;550(1-2):71-78. doi: 10.1016/j.ijpharm.2018.08.033. Epub 2018 Aug 17.


Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade.

Jung YY, Lee JH, Nam D, Narula AS, Namjoshi OA, Blough BE, Um JY, Sethi G, Ahn KS.

Front Pharmacol. 2018 May 30;9:531. doi: 10.3389/fphar.2018.00531. eCollection 2018.


Development of norepinephrine transporter reuptake inhibition assays using SK-N-BE(2)C cells.

Decker AM, Blough BE.

Heliyon. 2018 May 31;4(5):e00633. doi: 10.1016/j.heliyon.2018.e00633. eCollection 2018 May.


Development of serotonin transporter reuptake inhibition assays using JAR cells.

Decker AM, Blough BE.

J Pharmacol Toxicol Methods. 2018 Jul - Aug;92:52-56. doi: 10.1016/j.vascn.2018.03.003. Epub 2018 Mar 16.


Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats.

Elmore JS, Decker AM, Sulima A, Rice KC, Partilla JS, Blough BE, Baumann MH.

Neuropharmacology. 2018 Nov;142:240-250. doi: 10.1016/j.neuropharm.2018.02.033. Epub 2018 Mar 1.


Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family.

Mayer FP, Burchardt NV, Decker AM, Partilla JS, Li Y, McLaughlin G, Kavanagh PV, Sandtner W, Blough BE, Brandt SD, Baumann MH, Sitte HH.

Neuropharmacology. 2018 May 15;134(Pt A):149-157. doi: 10.1016/j.neuropharm.2017.10.006. Epub 2017 Oct 6.


N-(2-methoxyphenyl) benzenesulfonamide, a novel regulator of neuronal G protein-gated inward rectifier K+ channels.

Walsh KB, Gay EA, Blough BE, Geurkink DW.

Eur J Pharmacol. 2017 Nov 15;815:233-240. doi: 10.1016/j.ejphar.2017.09.020. Epub 2017 Sep 18.


Cocaine-like discriminative stimulus effects of "norepinephrine-preferring" monoamine releasers: time course and interaction studies in rhesus monkeys.

Kohut SJ, Jacobs DS, Rothman RB, Partilla JS, Bergman J, Blough BE.

Psychopharmacology (Berl). 2017 Dec;234(23-24):3455-3465. doi: 10.1007/s00213-017-4731-5. Epub 2017 Sep 9.


Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M.

J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23.


Effects of chemical and physical enhancement techniques on transdermal delivery of 3-fluoroamphetamine hydrochloride.

Puri A, Murnane KS, Blough BE, Banga AK.

Int J Pharm. 2017 Aug 7;528(1-2):452-462. doi: 10.1016/j.ijpharm.2017.06.041. Epub 2017 Jun 19.


Comparison of some behavioral effects of d- and l-methamphetamine in adult male rats.

Siemian JN, Xue Z, Blough BE, Li JX.

Psychopharmacology (Berl). 2017 Jul;234(14):2167-2176. doi: 10.1007/s00213-017-4623-8. Epub 2017 Apr 6.


Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents.

Altarifi AA, David B, Muchhala KH, Blough BE, Akbarali H, Negus SS.

J Psychopharmacol. 2017 Jun;31(6):730-739. doi: 10.1177/0269881116689257. Epub 2017 Feb 1.


Natural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells.

Neveux S, Smith NK, Roche A, Blough BE, Pathmasiri W, Coffin AB.

J Assoc Res Otolaryngol. 2017 Apr;18(2):275-289. doi: 10.1007/s10162-016-0604-6. Epub 2016 Nov 28.


Self-administration and behavioral economics of second-generation synthetic cathinones in male rats.

Huskinson SL, Naylor JE, Townsend EA, Rowlett JK, Blough BE, Freeman KB.

Psychopharmacology (Berl). 2017 Feb;234(4):589-598. doi: 10.1007/s00213-016-4492-6. Epub 2016 Nov 28.


Cocaine-like discriminative stimulus effects of amphetamine, cathinone, methamphetamine, and their 3,4-methylenedioxy analogs in male rhesus monkeys.

Smith DA, Blough BE, Banks ML.

Psychopharmacology (Berl). 2017 Jan;234(1):117-127. doi: 10.1007/s00213-016-4444-1. Epub 2016 Oct 5.


Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters.

Solis E Jr, Suyama JA, Lazenka MF, DeFelice LJ, Negus SS, Blough BE, Banks ML.

Sci Rep. 2016 Aug 12;6:31385. doi: 10.1038/srep31385.


The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine.

Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ.

Drug Alcohol Depend. 2016 Sep 1;166:51-60. doi: 10.1016/j.drugalcdep.2016.06.020. Epub 2016 Jun 25.


Development of a translational model to screen medications for cocaine use disorder I: Choice between cocaine and food in rhesus monkeys.

Johnson AR, Banks ML, Blough BE, Lile JA, Nicholson KL, Negus SS.

Drug Alcohol Depend. 2016 Aug 1;165:103-10. doi: 10.1016/j.drugalcdep.2016.05.021. Epub 2016 May 28.


Pharmacological effects of methamphetamine and alpha-PVP vapor and injection.

Marusich JA, Lefever TW, Blough BE, Thomas BF, Wiley JL.

Neurotoxicology. 2016 Jul;55:83-91. doi: 10.1016/j.neuro.2016.05.015. Epub 2016 May 26.


Cocaine-like discriminative stimulus effects of alpha-pyrrolidinovalerophenone, methcathinone and their 3,4-methylenedioxy or 4-methyl analogs in rhesus monkeys.

Smith DA, Negus SS, Poklis JL, Blough BE, Banks ML.

Addict Biol. 2017 Sep;22(5):1169-1178. doi: 10.1111/adb.12399. Epub 2016 Apr 6.


Attenuation of cocaine self-administration by chronic oral phendimetrazine in rhesus monkeys.

Czoty PW, Blough BE, Fennell TR, Snyder RW, Nader MA.

Neuroscience. 2016 Jun 2;324:367-76. doi: 10.1016/j.neuroscience.2016.03.002. Epub 2016 Mar 7.


Methamphetamine-like discriminative stimulus effects of bupropion and its two hydroxy metabolites in male rhesus monkeys.

Banks ML, Smith DA, Blough BE.

Behav Pharmacol. 2016 Apr;27(2-3 Spec Issue):196-203. doi: 10.1097/FBP.0000000000000224.


Cocaine-like discriminative stimulus effects of phendimetrazine and phenmetrazine in rats.

Bauer CT, Negus SS, Blough BE, Banks ML.

Behav Pharmacol. 2016 Apr;27(2-3 Spec Issue):192-5. doi: 10.1097/FBP.0000000000000225.


Preclinical Abuse Potential Assessment of Flibanserin: Effects on Intracranial Self-Stimulation in Female and Male Rats.

Lazenka MF, Blough BE, Negus SS.

J Sex Med. 2016 Mar;13(3):338-49. doi: 10.1016/j.jsxm.2015.12.031. Epub 2016 Jan 28.


Effects of L-methamphetamine treatment on cocaine- and food-maintained behavior in rhesus monkeys.

Kohut SJ, Bergman J, Blough BE.

Psychopharmacology (Berl). 2016 Mar;233(6):1067-75. doi: 10.1007/s00213-015-4186-5. Epub 2015 Dec 29.


The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue.

Marusich JA, Antonazzo KR, Blough BE, Brandt SD, Kavanagh PV, Partilla JS, Baumann MH.

Neuropharmacology. 2016 Feb;101:68-75. doi: 10.1016/j.neuropharm.2015.09.004. Epub 2015 Sep 8.


Role of 5-HT₂C receptors in effects of monoamine releasers on intracranial self-stimulation in rats.

Bauer CT, Banks ML, Blough BE, Negus SS.

Psychopharmacology (Berl). 2015 Sep;232(17):3249-58. doi: 10.1007/s00213-015-3982-2. Epub 2015 Jun 5.


Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response.

Hambuchen MD, Carroll FI, Rüedi-Bettschen D, Hendrickson HP, Hennings LJ, Blough BE, Brieaddy LE, Pidaparthi RR, Owens SM.

J Med Chem. 2015 Jun 11;58(11):4665-77. doi: 10.1021/acs.jmedchem.5b00220. Epub 2015 May 22.


Effects of Environmental Manipulations and Treatment with Bupropion and Risperidone on Choice between Methamphetamine and Food in Rhesus Monkeys.

Banks ML, Blough BE.

Neuropsychopharmacology. 2015 Aug;40(9):2198-206. doi: 10.1038/npp.2015.63. Epub 2015 Mar 6.

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