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Items: 1 to 50 of 1693

1.

Glucagon-like peptide 1 (GLP-1).

Müller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH.

Mol Metab. 2019 Dec;30:72-130. doi: 10.1016/j.molmet.2019.09.010. Epub 2019 Sep 30. Review.

2.

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

Buenaventura T, Bitsi S, Laughlin WE, Burgoyne T, Lyu Z, Oqua AI, Norman H, McGlone ER, Klymchenko AS, Corrêa IR Jr, Walker A, Inoue A, Hanyaloglu A, Grimes J, Koszegi Z, Calebiro D, Rutter GA, Bloom SR, Jones B, Tomas A.

PLoS Biol. 2019 Aug 20;17(8):e3000097. doi: 10.1371/journal.pbio.3000097. eCollection 2019 Aug.

3.

Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study.

Behary P, Tharakan G, Alexiadou K, Johnson N, Wewer Albrechtsen NJ, Kenkre J, Cuenco J, Hope D, Anyiam O, Choudhury S, Alessimii H, Poddar A, Minnion J, Doyle C, Frost G, Le Roux C, Purkayastha S, Moorthy K, Dhillo W, Holst JJ, Ahmed AR, Prevost AT, Bloom SR, Tan TM.

Diabetes Care. 2019 Aug;42(8):1446-1453. doi: 10.2337/dc19-0449. Epub 2019 Jun 8.

4.

Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial.

Miras AD, Pérez-Pevida B, Aldhwayan M, Kamocka A, McGlone ER, Al-Najim W, Chahal H, Batterham RL, McGowan B, Khan O, Greener V, Ahmed AR, Petrie A, Scholtz S, Bloom SR, Tan TM.

Lancet Diabetes Endocrinol. 2019 Jul;7(7):549-559. doi: 10.1016/S2213-8587(19)30157-3. Epub 2019 Jun 4.

PMID:
31174993
5.

What Can We Learn From Mouse Models About Bile Acid-Mediated Changes After Bariatric Surgery?

McGlone ER, Tan T, Bloom SR, Walters JRF.

Gastroenterology. 2019 Jul;157(1):4-8. doi: 10.1053/j.gastro.2019.02.048. Epub 2019 Mar 28. No abstract available.

PMID:
30930023
6.

Bile acids and the metabolic syndrome.

McGlone ER, Bloom SR.

Ann Clin Biochem. 2019 May;56(3):326-337. doi: 10.1177/0004563218817798. Epub 2019 Mar 4.

7.

L-Arginine Increases Postprandial Circulating GLP-1 and PYY Levels in Humans.

Amin A, Neophytou C, Thein S, Martin NM, Alamshah A, Spreckley E, Bloom SR, Murphy KG.

Obesity (Silver Spring). 2018 Nov;26(11):1721-1726. doi: 10.1002/oby.22323.

8.

Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions.

Comninos AN, Demetriou L, Wall MB, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Yang L, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, McGonigle J, Rabiner EA, Bloom SR, Dhillo WS.

JCI Insight. 2018 Oct 18;3(20). pii: 121958. doi: 10.1172/jci.insight.121958.

9.

No Guts, No Loss: Toward the Ideal Treatment for Obesity in the Twenty-First Century.

Hope DCD, Tan TMM, Bloom SR.

Front Endocrinol (Lausanne). 2018 Aug 15;9:442. doi: 10.3389/fendo.2018.00442. eCollection 2018. Review.

10.

Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons.

Anand U, Yiangou Y, Akbar A, Quick T, MacQuillan A, Fox M, Sinisi M, Korchev YE, Jones B, Bloom SR, Anand P.

PLoS One. 2018 May 29;13(5):e0198024. doi: 10.1371/journal.pone.0198024. eCollection 2018.

11.

Targeting GLP-1 receptor trafficking to improve agonist efficacy.

Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Corrêa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR.

Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2.

12.

Oxyntomodulin analogue increases energy expenditure via the glucagon receptor.

Scott R, Minnion J, Tan T, Bloom SR.

Peptides. 2018 Jun;104:70-77. doi: 10.1016/j.peptides.2018.04.008. Epub 2018 Apr 20.

13.

Influence of Cholecystokinin-8 on Compound Nerve Action Potentials from Ventral Gastric Vagus in Rats.

Mirza KB, Alenda A, Eftekhar A, Grossman N, Nikolic K, Bloom SR, Toumazou C.

Int J Neural Syst. 2018 Nov;28(9):1850006. doi: 10.1142/S0129065718500065. Epub 2018 Feb 22.

14.

Control of insulin secretion by GLP-1.

Jones B, Bloom SR, Buenaventura T, Tomas A, Rutter GA.

Peptides. 2018 Feb;100:75-84. doi: 10.1016/j.peptides.2017.12.013. Review.

15.

Problem or solution: The strange story of glucagon.

Scott RV, Bloom SR.

Peptides. 2018 Feb;100:36-41. doi: 10.1016/j.peptides.2017.11.013. Review.

16.

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.

Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Corrêa IR Jr, Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A.

Diabetes. 2018 Mar;67(3):385-399. doi: 10.2337/db17-0639. Epub 2017 Dec 28.

17.

Reply: Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.

Abbara A, Clarke S, Islam R, Prague JK, Comninos A, Narayanaswamy S, Papadopoulou DA, Roberts RE, Izzi-Engbeaya CN, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery SA, Bloom SR, Huson L, Trew GH, Dhillo WS.

Hum Reprod. 2018 Feb 1;33(2):342-344. doi: 10.1093/humrep/dex360. No abstract available.

18.

Roles of increased glycaemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass.

Tharakan G, Behary P, Wewer Albrechtsen NJ, Chahal H, Kenkre J, Miras AD, Ahmed AR, Holst JJ, Bloom SR, Tan T.

Eur J Endocrinol. 2017 Dec;177(6):455-464. doi: 10.1530/EJE-17-0446. Epub 2017 Aug 30.

19.

A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.

Abbara A, Clarke S, Islam R, Prague JK, Comninos AN, Narayanaswamy S, Papadopoulou D, Roberts R, Izzi-Engbeaya C, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery SA, Bloom SR, Huson L, Trew GH, Dhillo WS.

Hum Reprod. 2017 Sep 1;32(9):1915-1924. doi: 10.1093/humrep/dex253.

20.

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor.

Jones BJ, Scopelliti R, Tomas A, Bloom SR, Hodson DJ, Broichhagen J.

ChemistryOpen. 2017 Jun 5;6(4):501-505. doi: 10.1002/open.201700062. eCollection 2017 Aug.

21.

l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents.

Alamshah A, Spreckley E, Norton M, Kinsey-Jones JS, Amin A, Ramgulam A, Cao Y, Johnson R, Saleh K, Akalestou E, Malik Z, Gonzalez-Abuin N, Jomard A, Amarsi R, Moolla A, Sargent PR, Gray GW, Bloom SR, Murphy KG.

Int J Obes (Lond). 2017 Nov;41(11):1693-1701. doi: 10.1038/ijo.2017.164. Epub 2017 Jul 13.

22.

Extracellular pH monitoring for use in closed-loop vagus nerve stimulation.

Cork SC, Eftekhar A, Mirza KB, Zuliani C, Nikolic K, Gardiner JV, Bloom SR, Toumazou C.

J Neural Eng. 2018 Feb;15(1):016001. doi: 10.1088/1741-2552/aa8239.

23.

Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight.

Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV.

Cell Rep. 2017 Jun 13;19(11):2202-2209. doi: 10.1016/j.celrep.2017.05.066.

24.

RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling.

Cegla J, Jones BJ, Gardiner JV, Hodson DJ, Marjot T, McGlone ER, Tan TM, Bloom SR.

Endocrinology. 2017 Aug 1;158(8):2680-2693. doi: 10.1210/en.2016-1755.

25.

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial.

Prague JK, Roberts RE, Comninos AN, Clarke S, Jayasena CN, Nash Z, Doyle C, Papadopoulou DA, Bloom SR, Mohideen P, Panay N, Hunter MS, Veldhuis JD, Webber LC, Huson L, Dhillo WS.

Lancet. 2017 May 6;389(10081):1809-1820. doi: 10.1016/S0140-6736(17)30823-1. Epub 2017 Apr 3.

26.

The Effect of a Subcutaneous Infusion of GLP-1, OXM, and PYY on Energy Intake and Expenditure in Obese Volunteers.

Tan T, Behary P, Tharakan G, Minnion J, Al-Najim W, Albrechtsen NJW, Holst JJ, Bloom SR.

J Clin Endocrinol Metab. 2017 Jul 1;102(7):2364-2372. doi: 10.1210/jc.2017-00469.

27.

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety.

Brooks L, Viardot A, Tsakmaki A, Stolarczyk E, Howard JK, Cani PD, Everard A, Sleeth ML, Psichas A, Anastasovskaj J, Bell JD, Bell-Anderson K, Mackay CR, Ghatei MA, Bloom SR, Frost G, Bewick GA.

Mol Metab. 2016 Nov 4;6(1):48-60. doi: 10.1016/j.molmet.2016.10.011. eCollection 2017 Jan.

28.

Kisspeptin modulates sexual and emotional brain processing in humans.

Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, Rabiner EA, Hönigsperger C, Silva MR, Brandtzaeg OK, Lundanes E, Wilson SR, Brown RC, Thomas SA, Bloom SR, Dhillo WS.

J Clin Invest. 2017 Feb 1;127(2):709-719. doi: 10.1172/JCI89519. Epub 2017 Jan 23.

29.

The preanalytical stability of glucagon as measured by liquid chromatography tandem mass spectrometry and two commercially available immunoassays.

Cegla J, Jones BJ, Howard J, Kay R, Creaser CS, Bloom SR, Tan TM.

Ann Clin Biochem. 2017 Mar;54(2):293-296. doi: 10.1177/0004563216675648. Epub 2016 Nov 2.

30.

Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and association with late miscarriage.

Jayasena CN, Abbara A, Comninos AN, Narayanaswamy S, Gonzalez Maffe J, Izzi-Engbeaya C, Oldham J, Lee TT, Sarang Z, Malik Z, Dhanjal MK, Williamson C, Regan L, Bloom SR, Dhillo WS.

Hum Reprod. 2016 Dec;31(12):2681-2688. Epub 2016 Sep 22.

31.

Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon.

Polyviou T, MacDougall K, Chambers ES, Viardot A, Psichas A, Jawaid S, Harris HC, Edwards CA, Simpson L, Murphy KG, Zac-Varghese SE, Blundell JE, Dhillo WS, Bloom SR, Frost GS, Preston T, Tedford MC, Morrison DJ.

Aliment Pharmacol Ther. 2016 Oct;44(7):662-72. doi: 10.1111/apt.13749. Epub 2016 Jul 28.

32.

Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men.

Narayanaswamy S, Prague JK, Jayasena CN, Papadopoulou DA, Mizamtsidi M, Shah AJ, Bassett P, Comninos AN, Abbara A, Bloom SR, Veldhuis JD, Dhillo WS.

J Clin Endocrinol Metab. 2016 Sep;101(9):3429-36. doi: 10.1210/jc.2016-1911. Epub 2016 Jul 5.

33.

Insights into the role of neuronal glucokinase.

De Backer I, Hussain SS, Bloom SR, Gardiner JV.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E42-55. doi: 10.1152/ajpendo.00034.2016. Epub 2016 May 17. Review.

34.

Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.

Broichhagen J, Johnston NR, von Ohlen Y, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJ.

Angew Chem Int Ed Engl. 2016 May 4;55(19):5865-8. doi: 10.1002/anie.201600957. Epub 2016 Apr 5.

35.

Kisspeptin Expression in the Human Infundibular Nucleus in Relation to Sex, Gender Identity, and Sexual Orientation.

Taziaux M, Staphorsius AS, Ghatei MA, Bloom SR, Swaab DF, Bakker J.

J Clin Endocrinol Metab. 2016 Jun;101(6):2380-9. doi: 10.1210/jc.2015-4175. Epub 2016 Apr 5.

36.

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA.

PLoS One. 2016 Mar 24;11(3):e0149549. doi: 10.1371/journal.pone.0149549. eCollection 2016.

37.

L-arginine promotes gut hormone release and reduces food intake in rodents.

Alamshah A, McGavigan AK, Spreckley E, Kinsey-Jones JS, Amin A, Tough IR, O'Hara HC, Moolla A, Banks K, France R, Hyberg G, Norton M, Cheong W, Lehmann A, Bloom SR, Cox HM, Murphy KG.

Diabetes Obes Metab. 2016 May;18(5):508-18. doi: 10.1111/dom.12644. Epub 2016 Apr 1.

38.

Investigating the Glucagon Receptor and Glucagon-Like Peptide 1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats.

Price SL, Minnion JS, Bloom SR.

Curr Ther Res Clin Exp. 2015 Nov 2;77:111-5. doi: 10.1016/j.curtheres.2015.10.003. eCollection 2015 Dec.

39.

Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats.

Akalestou E, Christakis I, Solomou AM, Minnion JS, Rutter GA, Bloom SR.

Pancreas. 2016 Aug;45(7):967-73. doi: 10.1097/MPA.0000000000000585.

40.

Gastrointestinal hormones and their role in obesity.

Choudhury SM, Tan TM, Bloom SR.

Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):18-22. doi: 10.1097/MED.0000000000000216. Review.

PMID:
26702847
41.

Optical Control of Insulin Secretion Using an Incretin Switch.

Broichhagen J, Podewin T, Meyer-Berg H, von Ohlen Y, Johnston NR, Jones BJ, Bloom SR, Rutter GA, Hoffmann-Röder A, Hodson DJ, Trauner D.

Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15565-9. doi: 10.1002/anie.201506384. Epub 2015 Nov 2.

42.

Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels.

Narayanaswamy S, Jayasena CN, Ng N, Ratnasabapathy R, Prague JK, Papadopoulou D, Abbara A, Comninos AN, Bassett P, Bloom SR, Veldhuis JD, Dhillo WS.

Clin Endocrinol (Oxf). 2016 Jun;84(6):939-45. doi: 10.1111/cen.12977. Epub 2015 Dec 17.

43.

Impact of Duodenal-Jejunal Exclusion on Satiety Hormones.

de Jonge C, Rensen SS, Verdam FJ, Vincent RP, Bloom SR, Buurman WA, le Roux CW, Bouvy ND, Greve JW.

Obes Surg. 2016 Mar;26(3):672-8. doi: 10.1007/s11695-015-1889-y.

PMID:
26446491
44.

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans.

Salem V, Izzi-Engbeaya C, Coello C, Thomas DB, Chambers ES, Comninos AN, Buckley A, Win Z, Al-Nahhas A, Rabiner EA, Gunn RN, Budge H, Symonds ME, Bloom SR, Tan TM, Dhillo WS.

Diabetes Obes Metab. 2016 Jan;18(1):72-81. doi: 10.1111/dom.12585. Epub 2015 Nov 20.

45.

Increased food intake with oxyntomodulin analogues.

Price SL, Minnion JS, Bloom SR.

Peptides. 2015 Nov;73:95-100. doi: 10.1016/j.peptides.2015.09.006. Epub 2015 Sep 30.

46.

Arcuate nucleus glucokinase and dietary glucose intake.

Ma Y, Bloom SR, Gardiner JV.

Oncotarget. 2015 Aug 21;6(24):19926-7. No abstract available.

47.

Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy.

Abbara A, Jayasena CN, Christopoulos G, Narayanaswamy S, Izzi-Engbeaya C, Nijher GM, Comninos AN, Peters D, Buckley A, Ratnasabapathy R, Prague JK, Salim R, Lavery SA, Bloom SR, Szigeti M, Ashby DA, Trew GH, Dhillo WS.

J Clin Endocrinol Metab. 2015 Sep;100(9):3322-31. doi: 10.1210/jc.2015-2332. Epub 2015 Jul 20.

48.

Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men.

Jayasena CN, Abbara A, Narayanaswamy S, Comninos AN, Ratnasabapathy R, Bassett P, Mogford JT, Malik Z, Calley J, Ghatei MA, Bloom SR, Dhillo WS.

Hum Reprod. 2015 Aug;30(8):1934-41. doi: 10.1093/humrep/dev143. Epub 2015 Jun 18.

49.

Obesity: Lifestyle management, bariatric surgery, drugs, and the therapeutic exploitation of gut hormones.

Behary P, Cegla J, Tan TM, Bloom SR.

Postgrad Med. 2015 Jun;127(5):494-502. doi: 10.1080/00325481.2015.1048181. Review.

PMID:
26040552
50.

The New Era of Drug Therapy for Obesity: The Evidence and the Expectations.

Jones BJ, Bloom SR.

Drugs. 2015 Jun;75(9):935-45. doi: 10.1007/s40265-015-0410-1. Review.

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