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Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

Buenaventura T, Bitsi S, Laughlin WE, Burgoyne T, Lyu Z, Oqua AI, Norman H, McGlone ER, Klymchenko AS, Corrêa IR Jr, Walker A, Inoue A, Hanyaloglu A, Grimes J, Koszegi Z, Calebiro D, Rutter GA, Bloom SR, Jones B, Tomas A.

PLoS Biol. 2019 Aug 20;17(8):e3000097. doi: 10.1371/journal.pbio.3000097. [Epub ahead of print]



Bloom SM, Singal IP.

Retin Cases Brief Rep. 2019 Aug 13. doi: 10.1097/ICB.0000000000000911. [Epub ahead of print]


Randomized Clinical Trial of an ICU Recovery Pilot Program for Survivors of Critical Illness.

Bloom SL, Stollings JL, Kirkpatrick O, Wang L, Byrne DW, Sevin CM, Semler MW.

Crit Care Med. 2019 Aug 2. doi: 10.1097/CCM.0000000000003909. [Epub ahead of print]


Novel approaches to anti-obesity drug discovery with gut hormones over the past 10 years.

Rose F, Bloom S, Tan T.

Expert Opin Drug Discov. 2019 Jul 29:1-9. doi: 10.1080/17460441.2019.1646243. [Epub ahead of print]


Language preference and reinforcing efficacy of praise in bilingual children with disabilities.

Clay CJ, Bloom SE, Slocum TA, Samaha AL, Callard CH.

J Appl Behav Anal. 2019 Jul 10. doi: 10.1002/jaba.609. [Epub ahead of print]


Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study.

Behary P, Tharakan G, Alexiadou K, Johnson N, Wewer Albrechtsen NJ, Kenkre J, Cuenco J, Hope D, Anyiam O, Choudhury S, Alessimii H, Poddar A, Minnion J, Doyle C, Frost G, Le Roux C, Purkayastha S, Moorthy K, Dhillo W, Holst JJ, Ahmed AR, Prevost AT, Bloom SR, Tan TM.

Diabetes Care. 2019 Aug;42(8):1446-1453. doi: 10.2337/dc19-0449. Epub 2019 Jun 8.


Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial.

Miras AD, Pérez-Pevida B, Aldhwayan M, Kamocka A, McGlone ER, Al-Najim W, Chahal H, Batterham RL, McGowan B, Khan O, Greener V, Ahmed AR, Petrie A, Scholtz S, Bloom SR, Tan TM.

Lancet Diabetes Endocrinol. 2019 Jul;7(7):549-559. doi: 10.1016/S2213-8587(19)30157-3. Epub 2019 Jun 4.


Nationwide improvement in outcomes of emergency admission for ulcerative colitis in England, 2005-2013.

Shawihdi M, Dodd S, Kallis C, Dixon P, Grainger R, Bloom S, Cummings F, Pearson M, Bodger K.

Aliment Pharmacol Ther. 2019 Jul;50(2):176-192. doi: 10.1111/apt.15315. Epub 2019 May 28.


Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters.

Smith DL, Friedman NMG, Bloom SI, Armero WL, Pence BD, Cook MD, Fernhall B, Horn GP, Woods J.

J Occup Environ Med. 2019 Jul;61(7):617-622. doi: 10.1097/JOM.0000000000001626.


What Can We Learn From Mouse Models About Bile Acid-Mediated Changes After Bariatric Surgery?

McGlone ER, Tan T, Bloom SR, Walters JRF.

Gastroenterology. 2019 Jul;157(1):4-8. doi: 10.1053/j.gastro.2019.02.048. Epub 2019 Mar 28. No abstract available.


A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes.

Yuen LH, Dana S, Liu Y, Bloom SI, Thorsell AG, Neri D, Donato AJ, Kireev D, Schüler H, Franzini RM.

J Am Chem Soc. 2019 Apr 3;141(13):5169-5181. doi: 10.1021/jacs.8b08039. Epub 2019 Mar 19.


Current Practices in Ileal Pouch Surveillance for Patients With Ulcerative Colitis: A Multinational, Retrospective Cohort Study.

Samaan MA, Forsyth K, Segal JP, De Jong D, Vleugels JLA, Elkady S, Kabir M, Campbell S, Kok K, Armstrong DG, Penez L, Arenaza AP, Seward E, Vega R, Mehta S, Rahman F, McCartney S, Bloom S, Patel K, Pollok R, Westcott E, Darakhshan A, Williams A, Koumoutsos I, Ray S, Mawdsley J, Anderson S, Sanderson JD, Dekker E, D'Haens GR, Hart A, Irving PM.

J Crohns Colitis. 2019 May 27;13(6):735-743. doi: 10.1093/ecco-jcc/jjy225.


Funding and services needed to achieve universal health coverage: applications of global, regional, and national estimates of utilisation of outpatient visits and inpatient admissions from 1990 to 2016, and unit costs from 1995 to 2016.

Moses MW, Pedroza P, Baral R, Bloom S, Brown J, Chapin A, Compton K, Eldrenkamp E, Fullman N, Mumford JE, Nandakumar V, Rosettie K, Sadat N, Shonka T, Flaxman A, Vos T, Murray CJL, Weaver MR.

Lancet Public Health. 2019 Jan;4(1):e49-e73. doi: 10.1016/S2468-2667(18)30213-5. Epub 2018 Dec 12.


Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.

Morgan RG, Walker AE, Trott DW, Machin DR, Henson GD, Reihl KD, Cawthon RM, Denchi EL, Liu Y, Bloom SI, Phuong TT, Richardson RS, Lesniewski LA, Donato AJ.

J Mol Cell Cardiol. 2019 Feb;127:74-82. doi: 10.1016/j.yjmcc.2018.11.014. Epub 2018 Nov 29.


Bile acids and the metabolic syndrome.

McGlone ER, Bloom SR.

Ann Clin Biochem. 2019 May;56(3):326-337. doi: 10.1177/0004563218817798. Epub 2019 Mar 4.


L-Arginine Increases Postprandial Circulating GLP-1 and PYY Levels in Humans.

Amin A, Neophytou C, Thein S, Martin NM, Alamshah A, Spreckley E, Bloom SR, Murphy KG.

Obesity (Silver Spring). 2018 Nov;26(11):1721-1726. doi: 10.1002/oby.22323.


Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions.

Comninos AN, Demetriou L, Wall MB, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Yang L, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, McGonigle J, Rabiner EA, Bloom SR, Dhillo WS.

JCI Insight. 2018 Oct 18;3(20). pii: 121958. doi: 10.1172/jci.insight.121958.


Implications of endothelial shear stress on systemic sclerosis vasculopathy and treatment.

Frech TM, Machin DR, Murtaugh MA, Stoddard GJ, Bloom SI, Phibbs JV, Donato AJ.

Clin Exp Rheumatol. 2018 Jul-Aug;36 Suppl 113(4):175-182. Epub 2018 Sep 20. Review.


Implementation of interventions informed by precursor functional analyses with young children: A replication.

Hoffmann AN, Sellers TP, Halversen H, Bloom SE.

J Appl Behav Anal. 2018 Oct;51(4):879-889. doi: 10.1002/jaba.502. Epub 2018 Sep 11.


A New Look at Familial Risk of Inflammatory Bowel Disease in the Ashkenazi Jewish Population.

Schiff ER, Frampton M, Semplici F, Bloom SL, McCartney SA, Vega R, Lovat LB, Wood E, Hart AL, Crespi D, Furman MA, Mann S, Murray CD, Segal AW, Levine AP.

Dig Dis Sci. 2018 Nov;63(11):3049-3057. doi: 10.1007/s10620-018-5219-9. Epub 2018 Sep 3.


Reply: Critical Care Pharmacists and Medication Management in an ICU Recovery Center.

Stollings JL, Bloom SL, Sevin CM.

Ann Pharmacother. 2019 Jan;53(1):106. doi: 10.1177/1060028018799501. Epub 2018 Sep 1. No abstract available.


Rare coding variant analysis in a large cohort of Ashkenazi Jewish families with inflammatory bowel disease.

Schiff ER, Frampton M, Ben-Yosef N, Avila BE, Semplici F, Pontikos N, Bloom SL, McCartney SA, Vega R, Lovat LB, Wood E, Hart A, Israeli E, Crespi D, Furman MA, Mann S, Murray CD, Segal AW, Levine AP.

Hum Genet. 2018 Sep;137(9):723-734. doi: 10.1007/s00439-018-1927-7. Epub 2018 Aug 22.


No Guts, No Loss: Toward the Ideal Treatment for Obesity in the Twenty-First Century.

Hope DCD, Tan TMM, Bloom SR.

Front Endocrinol (Lausanne). 2018 Aug 15;9:442. doi: 10.3389/fendo.2018.00442. eCollection 2018. Review.


Double-Blind Phase III Trial of Adjuvant Chemotherapy With and Without Bevacizumab in Patients With Lymph Node-Positive and High-Risk Lymph Node-Negative Breast Cancer (E5103).

Miller KD, O'Neill A, Gradishar W, Hobday TJ, Goldstein LJ, Mayer IA, Bloom S, Brufsky AM, Tevaarwerk AJ, Sparano JA, Le-Lindqwister NA, Hendricks CB, Northfelt DW, Dang CT, Sledge GW Jr.

J Clin Oncol. 2018 Sep 1;36(25):2621-2629. doi: 10.1200/JCO.2018.79.2028. Epub 2018 Jul 24.


Comprehensive care of ICU survivors: Development and implementation of an ICU recovery center.

Sevin CM, Bloom SL, Jackson JC, Wang L, Ely EW, Stollings JL.

J Crit Care. 2018 Aug;46:141-148. doi: 10.1016/j.jcrc.2018.02.011.


The role of senescence, telomere dysfunction and shelterin in vascular aging.

Liu Y, Bloom SI, Donato AJ.

Microcirculation. 2019 Feb;26(2):e12487. doi: 10.1111/micc.12487. Epub 2018 Sep 12. Review.


Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn's disease (METRIC): a multicentre trial.

Taylor SA, Mallett S, Bhatnagar G, Baldwin-Cleland R, Bloom S, Gupta A, Hamlin PJ, Hart AL, Higginson A, Jacobs I, McCartney S, Miles A, Murray CD, Plumb AA, Pollok RC, Punwani S, Quinn L, Rodriguez-Justo M, Shabir Z, Slater A, Tolan D, Travis S, Windsor A, Wylie P, Zealley I, Halligan S; METRIC study investigators.

Lancet Gastroenterol Hepatol. 2018 Aug;3(8):548-558. doi: 10.1016/S2468-1253(18)30161-4. Epub 2018 Jun 18.


Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain.

Wilhelm CJ, Hashimoto JG, Roberts ML, Zhang X, Goeke CM, Bloom SH, Guizzetti M.

Neuropharmacology. 2018 Aug;138:193-209. doi: 10.1016/j.neuropharm.2018.06.004. Epub 2018 Jun 6.


Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons.

Anand U, Yiangou Y, Akbar A, Quick T, MacQuillan A, Fox M, Sinisi M, Korchev YE, Jones B, Bloom SR, Anand P.

PLoS One. 2018 May 29;13(5):e0198024. doi: 10.1371/journal.pone.0198024. eCollection 2018.


Ballistic tongue projection in a miniaturized salamander.

Deban SM, Bloom SV.

J Exp Zool A Ecol Integr Physiol. 2018 Feb;329(2):62-71. doi: 10.1002/jez.2171. Epub 2018 May 20.


Advanced age results in a diminished endothelial glycocalyx.

Machin DR, Bloom SI, Campbell RA, Phuong TTT, Gates PE, Lesniewski LA, Rondina MT, Donato AJ.

Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H531-H539. doi: 10.1152/ajpheart.00104.2018. Epub 2018 May 11.


Liver stiffness measurement in the primary care setting detects high rates of advanced fibrosis and predicts liver-related events in hepatitis C.

Bloom S, Kemp W, Nicoll A, Roberts SK, Gow P, Dev A, Bell S, Sood S, Kronborg I, Knight V, Lewis D, Lubel J.

J Hepatol. 2018 Sep;69(3):575-583. doi: 10.1016/j.jhep.2018.04.013. Epub 2018 Apr 28.


Targeting GLP-1 receptor trafficking to improve agonist efficacy.

Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Corrêa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR.

Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2.


Oxyntomodulin analogue increases energy expenditure via the glucagon receptor.

Scott R, Minnion J, Tan T, Bloom SR.

Peptides. 2018 Jun;104:70-77. doi: 10.1016/j.peptides.2018.04.008. Epub 2018 Apr 20.


Behavioral Interventions for Inappropriate Sexual Behavior in Individuals With Developmental Disabilities and Acquired Brain Injury: A Review.

Clay CJ, Bloom SE, Lambert JM.

Am J Intellect Dev Disabil. 2018 May;123(3):254-282. doi: 10.1352/1944-7558-123.3.254. Review.


Diagnostic Performance of a Novel Coronary CT Angiography Algorithm: Prospective Multicenter Validation of an Intracycle CT Motion Correction Algorithm for Diagnostic Accuracy.

Andreini D, Lin FY, Rizvi A, Cho I, Heo R, Pontone G, Bartorelli AL, Mushtaq S, Villines TC, Carrascosa P, Choi BW, Bloom S, Wei H, Xing Y, Gebow D, Gransar H, Chang HJ, Leipsic J, Min JK.

AJR Am J Roentgenol. 2018 Jun;210(6):1208-1215. doi: 10.2214/AJR.17.18670. Epub 2018 Apr 18.


Reliability among central readers in the evaluation of endoscopic disease activity in pouchitis.

Samaan MA, Shen B, Mosli MH, Zou G, Sandborn WJ, Shackelton LM, Nelson S, Stitt L, Bloom S, Pardi DS, Gionchetti P, Lindsay J, Travis S, Hart A, Silverberg MS, Feagan BG, D'Haens GR, Jairath V.

Gastrointest Endosc. 2018 Aug;88(2):360-369.e2. doi: 10.1016/j.gie.2018.04.2330. Epub 2018 Apr 13.


Trauma-informed Temporary Assistance for Needy Families (TANF): A Randomized Controlled Trial with a Two-Generation Impact.

Booshehri LG, Dugan J, Patel F, Bloom S, Chilton M.

J Child Fam Stud. 2018;27(5):1594-1604. doi: 10.1007/s10826-017-0987-y. Epub 2018 Jan 1.


Influence of Cholecystokinin-8 on Compound Nerve Action Potentials from Ventral Gastric Vagus in Rats.

Mirza KB, Alenda A, Eftekhar A, Grossman N, Nikolic K, Bloom SR, Toumazou C.

Int J Neural Syst. 2018 Nov;28(9):1850006. doi: 10.1142/S0129065718500065. Epub 2018 Feb 22.


A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis.

Irving PM, Iqbal T, Nwokolo C, Subramanian S, Bloom S, Prasad N, Hart A, Murray C, Lindsay JO, Taylor A, Barron R, Wright S.

Inflamm Bowel Dis. 2018 Mar 19;24(4):714-724. doi: 10.1093/ibd/izy002.


Manipulating parameters of reinforcement to reduce problem behavior without extinction.

Kunnavatana SS, Bloom SE, Samaha AL, Slocum TA, Clay CJ.

J Appl Behav Anal. 2018 Apr;51(2):283-302. doi: 10.1002/jaba.443. Epub 2018 Feb 23.


Critical Care Pharmacists and Medication Management in an ICU Recovery Center.

Stollings JL, Bloom SL, Wang L, Ely EW, Jackson JC, Sevin CM.

Ann Pharmacother. 2018 Aug;52(8):713-723. doi: 10.1177/1060028018759343. Epub 2018 Feb 18.


The Sister Mary Joseph nodule.

Sethi K, Shareef N, Bloom S.

Br J Hosp Med (Lond). 2018 Feb 2;79(2):C27-C29. doi: 10.12968/hmed.2018.79.2.C27. No abstract available.


Control of insulin secretion by GLP-1.

Jones B, Bloom SR, Buenaventura T, Tomas A, Rutter GA.

Peptides. 2018 Feb;100:75-84. doi: 10.1016/j.peptides.2017.12.013. Review.


Problem or solution: The strange story of glucagon.

Scott RV, Bloom SR.

Peptides. 2018 Feb;100:36-41. doi: 10.1016/j.peptides.2017.11.013. Review.


Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials.

Bloom S, Liu C, Kölmel DK, Qiao JX, Zhang Y, Poss MA, Ewing WR, MacMillan DWC.

Nat Chem. 2018 Feb;10(2):205-211. doi: 10.1038/nchem.2888. Epub 2017 Dec 4.


A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.

Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Corrêa IR Jr, Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A.

Diabetes. 2018 Mar;67(3):385-399. doi: 10.2337/db17-0639. Epub 2017 Dec 28.


Reply: Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.

Abbara A, Clarke S, Islam R, Prague JK, Comninos A, Narayanaswamy S, Papadopoulou DA, Roberts RE, Izzi-Engbeaya CN, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery SA, Bloom SR, Huson L, Trew GH, Dhillo WS.

Hum Reprod. 2018 Feb 1;33(2):342-344. doi: 10.1093/humrep/dex360. No abstract available.


A randomised controlled trial of a duodenal-jejunal bypass sleeve device (EndoBarrier) compared with standard medical therapy for the management of obese subjects with type 2 diabetes mellitus.

Glaysher MA, Mohanaruban A, Prechtl CG, Goldstone AP, Miras AD, Lord J, Chhina N, Falaschetti E, Johnson NA, Al-Najim W, Smith C, Li JV, Patel M, Ahmed AR, Moore M, Poulter N, Bloom S, Darzi A, Le Roux C, Byrne JP, Teare JP.

BMJ Open. 2017 Nov 15;7(11):e018598. doi: 10.1136/bmjopen-2017-018598.


Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans.

Law J, Morris DE, Izzi-Engbeaya C, Salem V, Coello C, Robinson L, Jayasinghe M, Scott R, Gunn R, Rabiner E, Tan T, Dhillo WS, Bloom S, Budge H, Symonds ME.

J Nucl Med. 2018 Mar;59(3):516-522. doi: 10.2967/jnumed.117.190546. Epub 2017 Sep 14.

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