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Virtual screening identified compounds that bind to cyclin dependent kinase 2 and prevent herpes simplex virus type 1 replication and reactivation in neurons.

Viegas DJ, Edwards TG, Bloom DC, Abreu PA.

Antiviral Res. 2019 Dec;172:104621. doi: 10.1016/j.antiviral.2019.104621. Epub 2019 Oct 18.


Personalized viral genomic investigation of herpes simplex virus 1 perinatal viremic transmission with dual fatality.

Shipley MM, Renner DW, Pandey U, Ford B, Bloom DC, Grose C, Szpara ML.

Cold Spring Harb Mol Case Stud. 2019 Oct 3. pii: mcs.a004382. doi: 10.1101/mcs.a004382. [Epub ahead of print]


Perillyl alcohol and perillic acid exert efficient action upon HSV-1 maturation and release of infective virus.

Mello CP, Quirico-Santos T, Amorim LF, Silva VG, Fragel LM, Bloom DC, Paixão IP.

Antivir Ther. 2019 May 16. doi: 10.3851/IMP3315. [Epub ahead of print]


The CCCTC Binding Factor, CTRL2, Modulates Heterochromatin Deposition and the Establishment of Herpes Simplex Virus 1 Latency In Vivo.

Washington SD, Singh P, Johns RN, Edwards TG, Mariani M, Frietze S, Bloom DC, Neumann DM.

J Virol. 2019 Jun 14;93(13). pii: e00415-19. doi: 10.1128/JVI.00415-19. Print 2019 Jul 1.


Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells.

D'Aiuto L, Bloom DC, Naciri JN, Smith A, Edwards TG, McClain L, Callio JA, Jessup M, Wood J, Chowdari K, Demers M, Abrahamson EE, Ikonomovic MD, Viggiano L, De Zio R, Watkins S, Kinchington PR, Nimgaonkar VL.

J Virol. 2019 Apr 17;93(9). pii: e00111-19. doi: 10.1128/JVI.00111-19. Print 2019 May 1.


Peripheral AAV Injection for Retrograde Transduction of Dorsal Root and Trigeminal Ganglia.

Bloom DC, Watson ZL, Neumann DM.

Methods Mol Biol. 2019;1950:237-247. doi: 10.1007/978-1-4939-9139-6_13.


Lund Human Mesencephalic (LUHMES) Neuronal Cell Line Supports Herpes Simplex Virus 1 Latency In Vitro.

Edwards TG, Bloom DC.

J Virol. 2019 Mar 5;93(6). pii: e02210-18. doi: 10.1128/JVI.02210-18. Print 2019 Mar 15.


Reactivation of Latent Epstein-Barr Virus: A Comparison after Exposure to Gamma, Proton, Carbon, and Iron Radiation.

Mehta SK, Bloom DC, Plante I, Stowe R, Feiveson AH, Renner A, Dhummakupt A, Markan D, Zhang Y, Wu H, Scoles B, Cohen JI, Crucian B, Pierson DL.

Int J Mol Sci. 2018 Sep 28;19(10). pii: E2961. doi: 10.3390/ijms19102961.


Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time.

Shipley MM, Renner DW, Ott M, Bloom DC, Koelle DM, Johnston C, Szpara ML.

J Infect Dis. 2018 Jul 13;218(4):595-605. doi: 10.1093/infdis/jiy216.


Immunization by Replication-Competent Controlled Herpesvirus Vectors.

Bloom DC, Tran RK, Feller J, Voellmy R.

J Virol. 2018 Jul 31;92(16). pii: e00616-18. doi: 10.1128/JVI.00616-18. Print 2018 Aug 15.


In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency.

Watson ZL, Washington SD, Phelan DM, Lewin AS, Tuli SS, Schultz GS, Neumann DM, Bloom DC.

J Virol. 2018 Jul 31;92(16). pii: e00812-18. doi: 10.1128/JVI.00812-18. Print 2018 Aug 15.


Depletion of the Insulator Protein CTCF Results in Herpes Simplex Virus 1 Reactivation In Vivo.

Washington SD, Edenfield SI, Lieux C, Watson ZL, Taasan SM, Dhummakupt A, Bloom DC, Neumann DM.

J Virol. 2018 May 14;92(11). pii: e00173-18. doi: 10.1128/JVI.00173-18. Print 2018 Jun 1.


The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication.

Edwards TG, Bloom DC, Fisher C.

J Virol. 2018 Feb 26;92(6). pii: e01884-17. doi: 10.1128/JVI.01884-17. Print 2018 Mar 15.


Reliable Detection of Herpes Simplex Virus Sequence Variation by High-Throughput Resequencing.

Morse AM, Calabro KR, Fear JM, Bloom DC, McIntyre LM.

Viruses. 2017 Aug 16;9(8). pii: E226. doi: 10.3390/v9080226.


Development of Recombinant HSV-Based Vaccine Vectors.

Voellmy R, Bloom DC, Vilaboa N, Feller J.

Methods Mol Biol. 2017;1581:55-78. doi: 10.1007/978-1-4939-6869-5_4.


HSV1 latent transcription and non-coding RNA: A critical retrospective.

Phelan D, Barrozo ER, Bloom DC.

J Neuroimmunol. 2017 Jul 15;308:65-101. doi: 10.1016/j.jneuroim.2017.03.002. Epub 2017 Mar 6. Review.


Comparison of three cell-based drug screening platforms for HSV-1 infection.

D'Aiuto L, Williamson K, Dimitrion P, McNulty J, Brown CE, Dokuburra CB, Nielsen AJ, Lin WJ, Piazza P, Schurdak ME, Wood J, Yolken RH, Kinchington PR, Bloom DC, Nimgaonkar VL.

Antiviral Res. 2017 Jun;142:136-140. doi: 10.1016/j.antiviral.2017.03.016. Epub 2017 Mar 23.


Adeno-associated Virus Vectors Efficiently Transduce Mouse and Rabbit Sensory Neurons Coinfected with Herpes Simplex Virus 1 following Peripheral Inoculation.

Watson ZL, Ertel MK, Lewin AS, Tuli SS, Schultz GS, Neumann DM, Bloom DC.

J Virol. 2016 Aug 12;90(17):7894-901. doi: 10.1128/JVI.01028-16. Print 2016 Sep 1.


Alphaherpesvirus Latency: A Dynamic State of Transcription and Reactivation.

Bloom DC.

Adv Virus Res. 2016;94:53-80. doi: 10.1016/bs.aivir.2015.10.001. Epub 2016 Feb 15. Review.


Simultaneous visualization of two Citrus tristeza virus genotypes provides new insights into the structure of multi-component virus populations in a host.

Bergua M, Phelan DM, Bak A, Bloom DC, Folimonova SY.

Virology. 2016 Apr;491:10-9. doi: 10.1016/j.virol.2016.01.017. Epub 2016 Feb 9.


Herpes simplex virus type-1: replication, latency, reactivation and its antiviral targets.

Pires de Mello CP, Bloom DC, Paixão IC.

Antivir Ther. 2016;21(4):277-86. doi: 10.3851/IMP3018. Epub 2016 Jan 4. Review.


Replication-Competent Controlled Herpes Simplex Virus.

Bloom DC, Feller J, McAnany P, Vilaboa N, Voellmy R.

J Virol. 2015 Oct;89(20):10668-79. doi: 10.1128/JVI.01667-15. Epub 2015 Aug 12.


A Genomic Approach to Unravel Host-Pathogen Interaction in Chelonians: The Example of Testudinid Herpesvirus 3.

Origgi FC, Tecilla M, Pilo P, Aloisio F, Otten P, Aguilar-Bultet L, Sattler U, Roccabianca P, Romero CH, Bloom DC, Jacobson ER.

PLoS One. 2015 Aug 5;10(8):e0134897. doi: 10.1371/journal.pone.0134897. eCollection 2015.


Broad-spectrum non-nucleoside inhibitors of human herpesviruses.

McClain L, Zhi Y, Cheng H, Ghosh A, Piazza P, Yee MB, Kumar S, Milosevic J, Bloom DC, Arav-Boger R, Kinchington PR, Yolken R, Nimgaonkar V, D'Aiuto L.

Antiviral Res. 2015 Sep;121:16-23. doi: 10.1016/j.antiviral.2015.06.005. Epub 2015 Jun 12.


A novel approach for addressing diseases not yielding to effective vaccination? Immunization by replication-competent controlled virus.

Voellmy R, Bloom DC, Vilaboa N.

Expert Rev Vaccines. 2015 May;14(5):637-51. doi: 10.1586/14760584.2015.1013941. Epub 2015 Feb 12. Review.


Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons.

Messer HG, Jacobs D, Dhummakupt A, Bloom DC.

J Virol. 2015 Mar;89(6):3417-20. doi: 10.1128/JVI.03052-14. Epub 2014 Dec 31.


Mutational inactivation of herpes simplex virus 1 microRNAs identifies viral mRNA targets and reveals phenotypic effects in culture.

Flores O, Nakayama S, Whisnant AW, Javanbakht H, Cullen BR, Bloom DC.

J Virol. 2013 Jun;87(12):6589-603. doi: 10.1128/JVI.00504-13. Epub 2013 Mar 27.


LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans.

Bertke AS, Apakupakul K, Ma A, Imai Y, Gussow AM, Wang K, Cohen JI, Bloom DC, Margolis TP.

PLoS One. 2012;7(12):e53281. doi: 10.1371/journal.pone.0053281. Epub 2012 Dec 31.


Regulated protein expression for in vivo gene therapy for neurological disorders: progress, strategies, and issues.

Manfredsson FP, Bloom DC, Mandel RJ.

Neurobiol Dis. 2012 Nov;48(2):212-21. doi: 10.1016/j.nbd.2012.03.001. Epub 2012 Mar 9. Review.


Respiratory function following bilateral mid-cervical contusion injury in the adult rat.

Lane MA, Lee KZ, Salazar K, O'Steen BE, Bloom DC, Fuller DD, Reier PJ.

Exp Neurol. 2012 May;235(1):197-210. doi: 10.1016/j.expneurol.2011.09.024. Epub 2011 Sep 21.


A limited innate immune response is induced by a replication-defective herpes simplex virus vector following delivery to the murine central nervous system.

Zeier Z, Aguilar JS, Lopez CM, Devi-Rao GB, Watson ZL, Baker HV, Wagner EK, Bloom DC.

J Neurovirol. 2009 Sep;15(5-6):411-24. doi: 10.3109/13550280903473452.


Epigenetic regulation of latent HSV-1 gene expression.

Bloom DC, Giordani NV, Kwiatkowski DL.

Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):246-56. doi: 10.1016/j.bbagrm.2009.12.001. Epub 2010 Jan 4. Review.


Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome.

Zeier Z, Kumar A, Bodhinathan K, Feller JA, Foster TC, Bloom DC.

Gene Ther. 2009 Sep;16(9):1122-9. doi: 10.1038/gt.2009.83. Epub 2009 Jul 2.


The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency.

Kwiatkowski DL, Thompson HW, Bloom DC.

J Virol. 2009 Aug;83(16):8173-81. doi: 10.1128/JVI.00686-09. Epub 2009 Jun 10.


Management of lymphatic malformations and macroglossia: results of a national treatment survey.

Bloom DC, Perkins JA, Manning SC.

Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1114-8. doi: 10.1016/j.ijporl.2009.04.016. Epub 2009 Jun 9.


Peripheral primitive neuroectodermal tumour of the anterior tongue in a newborn.

Topp SG, McManaman JF, Bloom DC.

J Otolaryngol Head Neck Surg. 2009 Apr;38(2):E56-60. No abstract available.


Posterior ankyloglossia: a case report.

Chu MW, Bloom DC.

Int J Pediatr Otorhinolaryngol. 2009 Jun;73(6):881-3. doi: 10.1016/j.ijporl.2009.02.011. Epub 2009 Mar 20.


Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy.

Liu J, Saghizadeh M, Tuli SS, Kramerov AA, Lewin AS, Bloom DC, Hauswirth WW, Castro MG, Schultz GS, Ljubimov AV.

Mol Vis. 2008;14:2087-96. Epub 2008 Nov 18.


Ranavirus infection of free-ranging and captive box turtles and tortoises in the United States.

Johnson AJ, Pessier AP, Wellehan JF, Childress A, Norton TM, Stedman NL, Bloom DC, Belzer W, Titus VR, Wagner R, Brooks JW, Spratt J, Jacobson ER.

J Wildl Dis. 2008 Oct;44(4):851-63.


Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat.

Lane MA, White TE, Coutts MA, Jones AL, Sandhu MS, Bloom DC, Bolser DC, Yates BJ, Fuller DD, Reier PJ.

J Comp Neurol. 2008 Dec 10;511(5):692-709. doi: 10.1002/cne.21864.


Multicenter interrater and intrarater reliability in the endoscopic evaluation of velopharyngeal insufficiency.

Sie KC, Starr JR, Bloom DC, Cunningham M, de Serres LM, Drake AF, Elluru RG, Haddad J Jr, Hartnick C, Macarthur C, Milczuk HA, Muntz HR, Perkins JA, Senders C, Smith ME, Tollefson T, Willging JP, Zdanski CJ.

Arch Otolaryngol Head Neck Surg. 2008 Jul;134(7):757-63. doi: 10.1001/archotol.134.7.757.


Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal ganglia.

Clement C, Popp MP, Bloom DC, Schultz G, Liu L, Neumann DM, Bhattacharjee PS, Hill JM.

Mol Vis. 2008 Jul 3;14:1209-21.


Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA.

Liu J, Lewin AS, Tuli SS, Ghivizzani SC, Schultz GS, Bloom DC.

J Virol. 2008 Aug;82(15):7467-74. doi: 10.1128/JVI.02720-07. Epub 2008 May 28.


During herpes simplex virus type 1 infection of rabbits, the ability to express the latency-associated transcript increases latent-phase transcription of lytic genes.

Giordani NV, Neumann DM, Kwiatkowski DL, Bhattacharjee PS, McAnany PK, Hill JM, Bloom DC.

J Virol. 2008 Jun;82(12):6056-60. doi: 10.1128/JVI.02661-07. Epub 2008 Apr 9.


Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic mice.

Gussow AM, Giordani NV, Tran RK, Imai Y, Kwiatkowski DL, Rall GF, Margolis TP, Bloom DC.

J Virol. 2006 Oct;80(19):9414-23.


HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy.

Walwyn WM, Matsuka Y, Arai D, Bloom DC, Lam H, Tran C, Spigelman I, Maidment NT.

Exp Neurol. 2006 Mar;198(1):260-70. Epub 2006 Jan 20.


Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods.

Corso TD, Torres G, Goulah C, Roy I, Gambino AS, Nayda J, Buckley T, Stachowiak EK, Bergey EJ, Pudavar H, Dutta P, Bloom DC, Bowers WJ, Stachowiak MK.

Folia Morphol (Warsz). 2005 Aug;64(3):130-44.


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