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Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.

Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL.

J Immunol. 2018 May 1;200(9):3244-3258. doi: 10.4049/jimmunol.1701733. Epub 2018 Apr 2.


A Neglected Epidemic.

Bloom BR.

N Engl J Med. 2018 Jan 18;378(3):291-293. doi: 10.1056/NEJMe1714609. No abstract available.


Universal health coverage and intersectoral action for health: key messages from Disease Control Priorities, 3rd edition.

Jamison DT, Alwan A, Mock CN, Nugent R, Watkins D, Adeyi O, Anand S, Atun R, Bertozzi S, Bhutta Z, Binagwaho A, Black R, Blecher M, Bloom BR, Brouwer E, Bundy DAP, Chisholm D, Cieza A, Cullen M, Danforth K, de Silva N, Debas HT, Donkor P, Dua T, Fleming KA, Gallivan M, Garcia PJ, Gawande A, Gaziano T, Gelband H, Glass R, Glassman A, Gray G, Habte D, Holmes KK, Horton S, Hutton G, Jha P, Knaul FM, Kobusingye O, Krakauer EL, Kruk ME, Lachmann P, Laxminarayan R, Levin C, Looi LM, Madhav N, Mahmoud A, Mbanya JC, Measham A, Medina-Mora ME, Medlin C, Mills A, Mills JA, Montoya J, Norheim O, Olson Z, Omokhodion F, Oppenheim B, Ord T, Patel V, Patton GC, Peabody J, Prabhakaran D, Qi J, Reynolds T, Ruacan S, Sankaranarayanan R, Sepúlveda J, Skolnik R, Smith KR, Temmerman M, Tollman S, Verguet S, Walker DG, Walker N, Wu Y, Zhao K.

Lancet. 2018 Mar 17;391(10125):1108-1120. doi: 10.1016/S0140-6736(17)32906-9. Epub 2017 Nov 25. Review.


A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L.

Cell. 2017 Aug 24;170(5):973-985.e10. doi: 10.1016/j.cell.2017.07.030.


High-Dose Vitamin D3 during Tuberculosis Treatment in Mongolia. A Randomized Controlled Trial.

Ganmaa D, Munkhzul B, Fawzi W, Spiegelman D, Willett WC, Bayasgalan P, Baasansuren E, Buyankhishig B, Oyun-Erdene S, Jolliffe DA, Xenakis T, Bromage S, Bloom BR, Martineau AR.

Am J Respir Crit Care Med. 2017 Sep 1;196(5):628-637. doi: 10.1164/rccm.201705-0936OC.


Geospatial analysis of nonmedical vaccine exemptions and pertussis outbreaks in the United States.

Aloe C, Kulldorff M, Bloom BR.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7101-7105. doi: 10.1073/pnas.1700240114. Epub 2017 Jun 20.


Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets.

Wang L, Liu SY, Chen HW, Xu J, Chapon M, Zhang T, Zhou F, Wang YE, Quanquin N, Wang G, Tian X, He Z, Liu L, Yu W, Sanchez DJ, Liang Y, Jiang T, Modlin R, Bloom BR, Li Q, Deng JC, Zhou P, Qin FX, Cheng G.

Cell Host Microbe. 2017 Mar 8;21(3):334-343. doi: 10.1016/j.chom.2017.02.007.


Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL.

JCI Insight. 2016 Sep 22;1(15):e88843.


Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages.

Bloom BR, Modlin RL.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0006-2015. Review.


Rethinking how to address the world's largest infectious killer in the world's largest country.

Bloom BR.

J Public Health Policy. 2016 May 6. doi: 10.1057/jphp.2016.16. [Epub ahead of print]


Back to the future: Rethinking global control of tuberculosis.

Bloom BR, Atun R.

Sci Transl Med. 2016 Mar 9;8(329):329ps7. doi: 10.1126/scitranslmed.aaf2944. Review.


Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis.

Busch M, Herzmann C, Kallert S, Zimmermann A, Höfer C, Mayer D, Zenk SF, Muche R, Lange C, Bloom BR, Modlin RL, Stenger S; TBornotTB Network.

Am J Respir Crit Care Med. 2016 Aug 1;194(3):345-55. doi: 10.1164/rccm.201509-1746OC.


IL-32 is a molecular marker of a host defense network in human tuberculosis.

Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL.

Sci Transl Med. 2014 Aug 20;6(250):250ra114. doi: 10.1126/scitranslmed.3009546.


Dr. Jacinto Convit (1913-2014).

Paniz Mondolfi AE, Bloom BR.

Am J Trop Med Hyg. 2014 Aug;91(2):435-6. doi: 10.4269/ajtmh.14-0316. No abstract available.


Addressing vaccine hesitancy.

Bloom BR, Marcuse E, Mnookin S.

Science. 2014 Apr 25;344(6182):339. doi: 10.1126/science.1254834. No abstract available.


TB or not TB: that is no longer the question.

Modlin RL, Bloom BR.

Sci Transl Med. 2013 Nov 27;5(213):213sr6. doi: 10.1126/scitranslmed.3007402. Review.


Bettering BCG: a tough task for a TB vaccine?

Bishai W, Sullivan Z, Bloom BR, Andersen P.

Nat Med. 2013 Apr;19(4):410-1. doi: 10.1038/nm.3153. No abstract available.


Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.

Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL.

Science. 2013 Mar 22;339(6126):1448-53. doi: 10.1126/science.1233665. Epub 2013 Feb 28.


Public health. From financing to fevers: lessons of an antimalarial subsidy program.

Laxminarayan R, Arrow K, Jamison D, Bloom BR.

Science. 2012 Nov 2;338(6107):615-6. doi: 10.1126/science.1231010. No abstract available.


Rethinking biosafety in research on potential pandemic pathogens.

Lipsitch M, Bloom BR.

MBio. 2012 Oct 9;3(5). pii: e00360-12. doi: 10.1128/mBio.00360-12.


Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial.

Ganmaa D, Giovannucci E, Bloom BR, Fawzi W, Burr W, Batbaatar D, Sumberzul N, Holick MF, Willett WC.

Am J Clin Nutr. 2012 Aug;96(2):391-6. doi: 10.3945/ajcn.112.034967. Epub 2012 Jul 3.


Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.

Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL.

Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.


Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care.

Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL.

PLoS Negl Trop Dis. 2011;5(5):e1145. doi: 10.1371/journal.pntd.0001145. Epub 2011 May 31. Review. No abstract available.


WHO needs change.

Bloom BR.

Nature. 2011 May 12;473(7346):143-5. doi: 10.1038/473143a. No abstract available.


Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate.

Sampson SL, Mansfield KG, Carville A, Magee DM, Quitugua T, Howerth EW, Bloom BR, Hondalus MK.

Vaccine. 2011 Jun 24;29(29-30):4839-47. doi: 10.1016/j.vaccine.2011.04.066. Epub 2011 May 5.


Priorities for Global Research and Development of Interventions.

Bloom BR, Michaud CM, La Montagne JR, Simonsen L.

In: Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P, editors. Disease Control Priorities in Developing Countries. 2nd edition. Washington (DC): World Bank; 2006. Chapter 4.


Support for global health.

Bloom BR.

Science. 2010 May 14;328(5980):791. doi: 10.1126/science.1189538. No abstract available.


The global health system: lessons for a stronger institutional framework.

Moon S, Szlezák NA, Michaud CM, Jamison DT, Keusch GT, Clark WC, Bloom BR.

PLoS Med. 2010 Jan 26;7(1):e1000193. doi: 10.1371/journal.pmed.1000193. No abstract available.


The global health system: actors, norms, and expectations in transition.

Szlezák NA, Bloom BR, Jamison DT, Keusch GT, Michaud CM, Moon S, Clark WC.

PLoS Med. 2010 Jan;7(1):e1000183. doi: 10.1371/journal.pmed.1000183. Epub 2010 Jan 5.


The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence.

Goldstone RM, Goonesekera SD, Bloom BR, Sampson SL.

Infect Immun. 2009 Oct;77(10):4654-67. doi: 10.1128/IAI.01495-08. Epub 2009 Aug 3.


Dry-powder pulmonary insufflation in the mouse for application to vaccine or drug studies.

Morello M, Krone CL, Dickerson S, Howerth E, Germishuizen WA, Wong YL, Edwards D, Bloom BR, Hondalus MK.

Tuberculosis (Edinb). 2009 Sep;89(5):371-7. doi: 10.1016/ Epub 2009 Jul 26.


Asian flus in ethnographic and political context: A biosocial approach.

Kleinman AM, Bloom BR, Saich A, Mason KA, Aulino F.

Anthropol Med. 2008 Apr;15(1):1-5. doi: 10.1080/13648470801918968.


Avian and pandemic influenza: a biosocial approach. Introduction.

Kleinman AM, Bloom BR, Saich A, Mason KA, Aulino F.

J Infect Dis. 2008 Feb 15;197 Suppl 1:S1-3. doi: 10.1086/524992.


Immunization by a bacterial aerosol.

Garcia-Contreras L, Wong YL, Muttil P, Padilla D, Sadoff J, Derousse J, Germishuizen WA, Goonesekera S, Elbert K, Bloom BR, Miller R, Fourie PB, Hickey A, Edwards D.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4656-60. doi: 10.1073/pnas.0800043105. Epub 2008 Mar 14.


Mycobacterium tuberculosis Rv2224c modulates innate immune responses.

Rengarajan J, Murphy E, Park A, Krone CL, Hett EC, Bloom BR, Glimcher LH, Rubin EJ.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):264-9. doi: 10.1073/pnas.0710601105. Epub 2008 Jan 2.


Sustainable health: a new dimension of sustainability science.

Bloom BR.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):15969. Epub 2007 Oct 3. No abstract available.


Drying a tuberculosis vaccine without freezing.

Wong YL, Sampson S, Germishuizen WA, Goonesekera S, Caponetti G, Sadoff J, Bloom BR, Edwards D.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2591-5. Epub 2007 Feb 13.


Medical morals: an exchange.

Bloom BR.

New York Rev Books. 2001 Mar 8;48(4):E1-E3; author reply E3-E5. No abstract available.


Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens.

Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S.

J Immunol. 2006 Aug 1;177(3):1864-71. Erratum in: J Immunol. 2008 Jan 1;180(1):664.


Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.

Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL.

Science. 2006 Mar 24;311(5768):1770-3. Epub 2006 Feb 23.


Enlightened self-interest and the control of tuberculosis.

Bloom BR, Salomon JA.

N Engl J Med. 2005 Sep 8;353(10):1057-9. No abstract available.


Public health in transition.

Bloom BR.

Sci Am. 2005 Sep;293(3):92-9. No abstract available.


Mutually dependent secretion of proteins required for mycobacterial virulence.

Fortune SM, Jaeger A, Sarracino DA, Chase MR, Sassetti CM, Sherman DR, Bloom BR, Rubin EJ.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10676-81. Epub 2005 Jul 19.


A TB scientist reflects on the continuing struggle against a global threat. Interview by Mike Mitka.

Bloom BR.

JAMA. 2005 Jun 8;293(22):2708. No abstract available.


Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.

Rengarajan J, Bloom BR, Rubin EJ.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8327-32. Epub 2005 May 31.


TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.

Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL.

Nat Med. 2005 Jun;11(6):653-60. Epub 2005 May 8.


Ipr1 gene mediates innate immunity to tuberculosis.

Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, Higgins DE, Daly MJ, Bloom BR, Kramnik I.

Nature. 2005 Apr 7;434(7034):767-72.


The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria.

Rengarajan J, Sassetti CM, Naroditskaya V, Sloutsky A, Bloom BR, Rubin EJ.

Mol Microbiol. 2004 Jul;53(1):275-82.

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