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Items: 24

1.

LZTR1 is a regulator of RAS ubiquitination and signaling.

Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G.

Science. 2018 Dec 7;362(6419):1171-1177. doi: 10.1126/science.aap8210. Epub 2018 Nov 15.

PMID:
30442766
2.

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

Janssen LME, Averink TV, Blomen VA, Brummelkamp TR, Medema RH, Raaijmakers JA.

Curr Biol. 2018 Sep 10;28(17):2685-2696.e4. doi: 10.1016/j.cub.2018.06.026. Epub 2018 Aug 16.

3.

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

Gerhards NM, Blomen VA, Mutlu M, Nieuwenhuis J, Howald D, Guyader C, Jonkers J, Brummelkamp TR, Rottenberg S.

Mol Oncol. 2018 Jun;12(6):953-971. doi: 10.1002/1878-0261.12307. Epub 2018 May 1.

4.

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

Staring J, van den Hengel LG, Raaben M, Blomen VA, Carette JE, Brummelkamp TR.

Cell Host Microbe. 2018 May 9;23(5):636-643.e5. doi: 10.1016/j.chom.2018.03.019. Epub 2018 Apr 19.

PMID:
29681460
5.

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

Raaijmakers JA, van Heesbeen RGHP, Blomen VA, Janssen LME, van Diemen F, Brummelkamp TR, Medema RH.

Cell Rep. 2018 Feb 6;22(6):1424-1438. doi: 10.1016/j.celrep.2018.01.034.

6.

Vasohibins encode tubulin detyrosinating activity.

Nieuwenhuis J, Adamopoulos A, Bleijerveld OB, Mazouzi A, Stickel E, Celie P, Altelaar M, Knipscheer P, Perrakis A, Blomen VA, Brummelkamp TR.

Science. 2017 Dec 15;358(6369):1453-1456. doi: 10.1126/science.aao5676. Epub 2017 Nov 16.

PMID:
29146869
7.

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP.

Cell Host Microbe. 2017 Nov 8;22(5):688-696.e5. doi: 10.1016/j.chom.2017.10.002.

8.

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

Hoffmann HH, Schneider WM, Blomen VA, Scull MA, Hovnanian A, Brummelkamp TR, Rice CM.

Cell Host Microbe. 2017 Oct 11;22(4):460-470.e5. doi: 10.1016/j.chom.2017.09.002.

9.

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.

Brockmann M, Blomen VA, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT, Brummelkamp TR.

Nature. 2017 Jun 8;546(7657):307-311. doi: 10.1038/nature22376. Epub 2017 May 31.

PMID:
28562590
10.

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.

Haarhuis JHI, van der Weide RH, Blomen VA, Yáñez-Cuna JO, Amendola M, van Ruiten MS, Krijger PHL, Teunissen H, Medema RH, van Steensel B, Brummelkamp TR, de Wit E, Rowland BD.

Cell. 2017 May 4;169(4):693-707.e14. doi: 10.1016/j.cell.2017.04.013.

11.

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

Staring J, von Castelmur E, Blomen VA, van den Hengel LG, Brockmann M, Baggen J, Thibaut HJ, Nieuwenhuis J, Janssen H, van Kuppeveld FJ, Perrakis A, Carette JE, Brummelkamp TR.

Nature. 2017 Jan 19;541(7637):412-416. doi: 10.1038/nature21032. Epub 2017 Jan 11.

PMID:
28077878
12.

Enterovirus D68 receptor requirements unveiled by haploid genetics.

Baggen J, Thibaut HJ, Staring J, Jae LT, Liu Y, Guo H, Slager JJ, de Bruin JW, van Vliet AL, Blomen VA, Overduin P, Sheng J, de Haan CA, de Vries E, Meijer A, Rossmann MG, Brummelkamp TR, van Kuppeveld FJ.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1399-404. doi: 10.1073/pnas.1524498113. Epub 2016 Jan 19. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1588. de Haan Xander, Cornelis A M [corrected to de Haan, Cornelis A M].

13.

A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity.

Heijink AM, Blomen VA, Bisteau X, Degener F, Matsushita FY, Kaldis P, Foijer F, van Vugt MA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15160-5. doi: 10.1073/pnas.1505283112. Epub 2015 Nov 23.

14.

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.

Riblett AM, Blomen VA, Jae LT, Altamura LA, Doms RW, Brummelkamp TR, Wojcechowskyj JA.

J Virol. 2015 Nov 18;90(3):1414-23. doi: 10.1128/JVI.02055-15. Print 2016 Feb 1.

15.

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

Planells-Cases R, Lutter D, Guyader C, Gerhards NM, Ullrich F, Elger DA, Kucukosmanoglu A, Xu G, Voss FK, Reincke SM, Stauber T, Blomen VA, Vis DJ, Wessels LF, Brummelkamp TR, Borst P, Rottenberg S, Jentsch TJ.

EMBO J. 2015 Dec 14;34(24):2993-3008. doi: 10.15252/embj.201592409. Epub 2015 Nov 3.

16.

Gene essentiality and synthetic lethality in haploid human cells.

Blomen VA, Májek P, Jae LT, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, Brummelkamp TR.

Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15.

17.

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

Winter GE, Radic B, Mayor-Ruiz C, Blomen VA, Trefzer C, Kandasamy RK, Huber KVM, Gridling M, Chen D, Klampfl T, Kralovics R, Kubicek S, Fernandez-Capetillo O, Brummelkamp TR, Superti-Furga G.

Nat Chem Biol. 2014 Sep;10(9):768-773. doi: 10.1038/nchembio.1590. Epub 2014 Jul 27.

18.

A reversible gene trap collection empowers haploid genetics in human cells.

Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM.

Nat Methods. 2013 Oct;10(10):965-71. doi: 10.1038/nmeth.2609. Epub 2013 Aug 25.

19.

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Wessels MW, Lefeber DJ, Whelan SP, van Bokhoven H, Brummelkamp TR.

Science. 2013 Apr 26;340(6131):479-83. doi: 10.1126/science.1233675. Epub 2013 Mar 21.

20.

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

Jacobson LS, Lima H Jr, Goldberg MF, Gocheva V, Tsiperson V, Sutterwala FS, Joyce JA, Gapp BV, Blomen VA, Chandran K, Brummelkamp TR, Diaz-Griffero F, Brojatsch J.

J Biol Chem. 2013 Mar 15;288(11):7481-91. doi: 10.1074/jbc.M112.400655. Epub 2013 Jan 7.

21.

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing.

Carette JE, Guimaraes CP, Wuethrich I, Blomen VA, Varadarajan M, Sun C, Bell G, Yuan B, Muellner MK, Nijman SM, Ploegh HL, Brummelkamp TR.

Nat Biotechnol. 2011 May 29;29(6):542-6. doi: 10.1038/nbt.1857.

22.

Stable transmission of reversible modifications: maintenance of epigenetic information through the cell cycle.

Blomen VA, Boonstra J.

Cell Mol Life Sci. 2011 Jan;68(1):27-44. doi: 10.1007/s00018-010-0505-5. Epub 2010 Aug 27. Review.

23.

Generation of iPSCs from cultured human malignant cells.

Carette JE, Pruszak J, Varadarajan M, Blomen VA, Gokhale S, Camargo FD, Wernig M, Jaenisch R, Brummelkamp TR.

Blood. 2010 May 20;115(20):4039-42. doi: 10.1182/blood-2009-07-231845. Epub 2010 Mar 16.

24.

Cell fate determination during G1 phase progression.

Blomen VA, Boonstra J.

Cell Mol Life Sci. 2007 Dec;64(23):3084-104. Review.

PMID:
17891333

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