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Items: 43

1.

Continuous Adaptive Evolution of a Fast-Growing Corynebacterium glutamicum Strain Independent of Protocatechuate.

Graf M, Haas T, Müller F, Buchmann A, Harm-Bekbenbetova J, Freund A, Nieß A, Persicke M, Kalinowski J, Blombach B, Takors R.

Front Microbiol. 2019 Aug 6;10:1648. doi: 10.3389/fmicb.2019.01648. eCollection 2019.

2.

A synthetic glycerol assimilation pathway demonstrates biochemical constraints of cellular metabolism.

Lindner SN, Aslan S, Müller A, Hoffart E, Behrens P, Edlich-Muth C, Blombach B, Bar-Even A.

FEBS J. 2019 Aug 22. doi: 10.1111/febs.15048. [Epub ahead of print]

PMID:
31436884
3.

Exploiting Hydrogenophaga pseudoflava for aerobic syngas-based production of chemicals.

Grenz S, Baumann PT, Rückert C, Nebel BA, Siebert D, Schwentner A, Eikmanns BJ, Hauer B, Kalinowski J, Takors R, Blombach B.

Metab Eng. 2019 Sep;55:220-230. doi: 10.1016/j.ymben.2019.07.006. Epub 2019 Jul 15.

PMID:
31319152
4.

Generation of a Prophage-Free Variant of the Fast-Growing Bacterium Vibrio natriegens.

Pfeifer E, Michniewski S, Gätgens C, Münch E, Müller F, Polen T, Millard A, Blombach B, Frunzke J.

Appl Environ Microbiol. 2019 Aug 14;85(17). pii: e00853-19. doi: 10.1128/AEM.00853-19. Print 2019 Sep 1.

5.

Identifying the Growth Modulon of Corynebacterium glutamicum.

Haas T, Graf M, Nieß A, Busche T, Kalinowski J, Blombach B, Takors R.

Front Microbiol. 2019 May 8;10:974. doi: 10.3389/fmicb.2019.00974. eCollection 2019.

6.

Modular systems metabolic engineering enables balancing of relevant pathways for l-histidine production with Corynebacterium glutamicum.

Schwentner A, Feith A, Münch E, Stiefelmaier J, Lauer I, Favilli L, Massner C, Öhrlein J, Grund B, Hüser A, Takors R, Blombach B.

Biotechnol Biofuels. 2019 Mar 25;12:65. doi: 10.1186/s13068-019-1410-2. eCollection 2019.

7.

Vibrio natriegens as Host for Expression of Multisubunit Membrane Protein Complexes.

Schleicher L, Muras V, Claussen B, Pfannstiel J, Blombach B, Dibrov P, Fritz G, Steuber J.

Front Microbiol. 2018 Oct 25;9:2537. doi: 10.3389/fmicb.2018.02537. eCollection 2018.

8.

Physiological Response of Corynebacterium glutamicum to Increasingly Nutrient-Rich Growth Conditions.

Graf M, Zieringer J, Haas T, Nieß A, Blombach B, Takors R.

Front Microbiol. 2018 Aug 29;9:2058. doi: 10.3389/fmicb.2018.02058. eCollection 2018.

9.

Cell-Free Protein Synthesis From Fast-Growing Vibrio natriegens.

Failmezger J, Scholz S, Blombach B, Siemann-Herzberg M.

Front Microbiol. 2018 Jun 1;9:1146. doi: 10.3389/fmicb.2018.01146. eCollection 2018.

10.

Deciphering the Adaptation of Corynebacterium glutamicum in Transition from Aerobiosis via Microaerobiosis to Anaerobiosis.

Lange J, Münch E, Müller J, Busche T, Kalinowski J, Takors R, Blombach B.

Genes (Basel). 2018 Jun 13;9(6). pii: E297. doi: 10.3390/genes9060297.

11.

The RamA regulon: complex regulatory interactions in relation to central metabolism in Corynebacterium glutamicum.

Shah A, Blombach B, Gauttam R, Eikmanns BJ.

Appl Microbiol Biotechnol. 2018 Jul;102(14):5901-5910. doi: 10.1007/s00253-018-9085-3. Epub 2018 May 26. Review.

PMID:
29804137
12.

Using gas mixtures of CO, CO2 and H2 as microbial substrates: the do's and don'ts of successful technology transfer from laboratory to production scale.

Takors R, Kopf M, Mampel J, Bluemke W, Blombach B, Eikmanns B, Bengelsdorf FR, Weuster-Botz D, Dürre P.

Microb Biotechnol. 2018 Jul;11(4):606-625. doi: 10.1111/1751-7915.13270. Epub 2018 May 14. Review.

13.

Metabolic engineering to guide evolution - Creating a novel mode for L-valine production with Corynebacterium glutamicum.

Schwentner A, Feith A, Münch E, Busche T, Rückert C, Kalinowski J, Takors R, Blombach B.

Metab Eng. 2018 May;47:31-41. doi: 10.1016/j.ymben.2018.02.015. Epub 2018 Mar 6.

PMID:
29522826
14.

Valorization of pyrolysis water: a biorefinery side stream, for 1,2-propanediol production with engineered Corynebacterium glutamicum.

Lange J, Müller F, Bernecker K, Dahmen N, Takors R, Blombach B.

Biotechnol Biofuels. 2017 Nov 21;10:277. doi: 10.1186/s13068-017-0969-8. eCollection 2017.

15.

Harnessing novel chromosomal integration loci to utilize an organosolv-derived hemicellulose fraction for isobutanol production with engineered Corynebacterium glutamicum.

Lange J, Müller F, Takors R, Blombach B.

Microb Biotechnol. 2018 Jan;11(1):257-263. doi: 10.1111/1751-7915.12879. Epub 2017 Nov 8.

16.

High Substrate Uptake Rates Empower Vibrio natriegens as Production Host for Industrial Biotechnology.

Hoffart E, Grenz S, Lange J, Nitschel R, Müller F, Schwentner A, Feith A, Lenfers-Lücker M, Takors R, Blombach B.

Appl Environ Microbiol. 2017 Oct 31;83(22). pii: e01614-17. doi: 10.1128/AEM.01614-17. Print 2017 Nov 15.

17.

Stereospecificity of Corynebacterium glutamicum 2,3-butanediol dehydrogenase and implications for the stereochemical purity of bioproduced 2,3-butanediol.

Radoš D, Turner DL, Catarino T, Hoffart E, Neves AR, Eikmanns BJ, Blombach B, Santos H.

Appl Microbiol Biotechnol. 2016 Dec;100(24):10573-10583. Epub 2016 Sep 29.

PMID:
27687994
18.

Identification of the agr Peptide of Listeria monocytogenes.

Zetzmann M, Sánchez-Kopper A, Waidmann MS, Blombach B, Riedel CU.

Front Microbiol. 2016 Jun 22;7:989. doi: 10.3389/fmicb.2016.00989. eCollection 2016.

19.

Engineering Corynebacterium glutamicum for the production of 2,3-butanediol.

Radoš D, Carvalho AL, Wieschalka S, Neves AR, Blombach B, Eikmanns BJ, Santos H.

Microb Cell Fact. 2015 Oct 29;14:171. doi: 10.1186/s12934-015-0362-x.

20.

CO2 - Intrinsic Product, Essential Substrate, and Regulatory Trigger of Microbial and Mammalian Production Processes.

Blombach B, Takors R.

Front Bioeng Biotechnol. 2015 Aug 3;3:108. doi: 10.3389/fbioe.2015.00108. eCollection 2015. Review.

21.

CO₂ /HCO₃⁻ perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum.

Buchholz J, Graf M, Freund A, Busche T, Kalinowski J, Blombach B, Takors R.

Appl Microbiol Biotechnol. 2014 Oct;98(20):8563-72. doi: 10.1007/s00253-014-6014-y. Epub 2014 Aug 21. Erratum in: Appl Microbiol Biotechnol. 2014 Oct;98(20):8775.

PMID:
25139448
22.

Application of metabolic engineering for the biotechnological production of L-valine.

Oldiges M, Eikmanns BJ, Blombach B.

Appl Microbiol Biotechnol. 2014 Jul;98(13):5859-70. doi: 10.1007/s00253-014-5782-8. Epub 2014 May 11. Review.

PMID:
24816722
23.

Carbon flux analysis by 13C nuclear magnetic resonance to determine the effect of CO2 on anaerobic succinate production by Corynebacterium glutamicum.

Radoš D, Turner DL, Fonseca LL, Carvalho AL, Blombach B, Eikmanns BJ, Neves AR, Santos H.

Appl Environ Microbiol. 2014 May;80(10):3015-24. doi: 10.1128/AEM.04189-13. Epub 2014 Mar 7.

24.

The pyruvate dehydrogenase complex of Corynebacterium glutamicum: an attractive target for metabolic engineering.

Eikmanns BJ, Blombach B.

J Biotechnol. 2014 Dec 20;192 Pt B:339-45. doi: 10.1016/j.jbiotec.2013.12.019. Epub 2014 Jan 29. Review.

PMID:
24486441
25.

Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains.

Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J.

PLoS One. 2014 Jan 17;9(1):e85731. doi: 10.1371/journal.pone.0085731. eCollection 2014.

26.

Impact of different CO2/HCO3- levels on metabolism and regulation in Corynebacterium glutamicum.

Blombach B, Buchholz J, Busche T, Kalinowski J, Takors R.

J Biotechnol. 2013 Dec;168(4):331-40. doi: 10.1016/j.jbiotec.2013.10.005. Epub 2013 Oct 16.

PMID:
24140290
27.

Platform engineering of Corynebacterium glutamicum with reduced pyruvate dehydrogenase complex activity for improved production of L-lysine, L-valine, and 2-ketoisovalerate.

Buchholz J, Schwentner A, Brunnenkan B, Gabris C, Grimm S, Gerstmeir R, Takors R, Eikmanns BJ, Blombach B.

Appl Environ Microbiol. 2013 Sep;79(18):5566-75. doi: 10.1128/AEM.01741-13. Epub 2013 Jul 8.

28.

Bio-based production of organic acids with Corynebacterium glutamicum.

Wieschalka S, Blombach B, Bott M, Eikmanns BJ.

Microb Biotechnol. 2013 Mar;6(2):87-102. doi: 10.1111/1751-7915.12013. Epub 2012 Dec 2. Review.

29.

Engineering Corynebacterium glutamicum for the production of pyruvate.

Wieschalka S, Blombach B, Eikmanns BJ.

Appl Microbiol Biotechnol. 2012 Apr;94(2):449-59. doi: 10.1007/s00253-011-3843-9. Epub 2012 Jan 8.

PMID:
22228312
30.

Current knowledge on isobutanol production with Escherichia coli, Bacillus subtilis and Corynebacterium glutamicum.

Blombach B, Eikmanns BJ.

Bioeng Bugs. 2011 Nov-Dec;2(6):346-50. doi: 10.4161/bbug.2.6.17845. Epub 2011 Nov 1.

31.

Comparative 13C metabolic flux analysis of pyruvate dehydrogenase complex-deficient, L-valine-producing Corynebacterium glutamicum.

Bartek T, Blombach B, Lang S, Eikmanns BJ, Wiechert W, Oldiges M, Nöh K, Noack S.

Appl Environ Microbiol. 2011 Sep;77(18):6644-52. doi: 10.1128/AEM.00575-11. Epub 2011 Jul 22.

32.

Corynebacterium glutamicum tailored for efficient isobutanol production.

Blombach B, Riester T, Wieschalka S, Ziert C, Youn JW, Wendisch VF, Eikmanns BJ.

Appl Environ Microbiol. 2011 May;77(10):3300-10. doi: 10.1128/AEM.02972-10. Epub 2011 Mar 25.

33.

Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production.

Krause FS, Blombach B, Eikmanns BJ.

Appl Environ Microbiol. 2010 Dec;76(24):8053-61. doi: 10.1128/AEM.01710-10. Epub 2010 Oct 8.

34.

Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of L-lysine production strains.

Blombach B, Seibold GM.

Appl Microbiol Biotechnol. 2010 May;86(5):1313-22. doi: 10.1007/s00253-010-2537-z. Epub 2010 Mar 24. Review.

PMID:
20333512
35.

Studies on substrate utilisation in L-valine-producing Corynebacterium glutamicum strains deficient in pyruvate dehydrogenase complex.

Bartek T, Rudolf C, Kerssen U, Klein B, Blombach B, Lang S, Eikmanns BJ, Oldiges M.

Bioprocess Biosyst Eng. 2010 Sep;33(7):873-83. doi: 10.1007/s00449-010-0410-1. Epub 2010 Mar 5.

PMID:
20204663
36.

Importance of NADPH supply for improved L-valine formation in Corynebacterium glutamicum.

Bartek T, Blombach B, Zönnchen E, Makus P, Lang S, Eikmanns BJ, Oldiges M.

Biotechnol Prog. 2010 Mar-Apr;26(2):361-71. doi: 10.1002/btpr.345.

PMID:
20014412
37.

Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity.

Krause FS, Henrich A, Blombach B, Krämer R, Eikmanns BJ, Seibold GM.

Appl Environ Microbiol. 2010 Jan;76(1):370-4. doi: 10.1128/AEM.01553-09. Epub 2009 Oct 30.

38.

L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR.

Blombach B, Arndt A, Auchter M, Eikmanns BJ.

Appl Environ Microbiol. 2009 Feb;75(4):1197-200. doi: 10.1128/AEM.02351-08. Epub 2008 Dec 16.

39.

Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum.

Blombach B, Hans S, Bathe B, Eikmanns BJ.

Appl Environ Microbiol. 2009 Jan;75(2):419-27. doi: 10.1128/AEM.01844-08. Epub 2008 Dec 1.

40.

Corynebacterium glutamicum tailored for high-yield L-valine production.

Blombach B, Schreiner ME, Bartek T, Oldiges M, Eikmanns BJ.

Appl Microbiol Biotechnol. 2008 Jun;79(3):471-9. doi: 10.1007/s00253-008-1444-z. Epub 2008 Apr 1.

PMID:
18379776
41.

RamB is an activator of the pyruvate dehydrogenase complex subunit E1p gene in Corynebacterium glutamicum.

Blombach B, Cramer A, Eikmanns BJ, Schreiner M.

J Mol Microbiol Biotechnol. 2009;16(3-4):236-9. Epub 2007 Sep 21.

PMID:
17890844
42.

Effect of pyruvate dehydrogenase complex deficiency on L-lysine production with Corynebacterium glutamicum.

Blombach B, Schreiner ME, Moch M, Oldiges M, Eikmanns BJ.

Appl Microbiol Biotechnol. 2007 Sep;76(3):615-23. Epub 2007 Mar 2.

PMID:
17333167
43.

L-valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum.

Blombach B, Schreiner ME, Holátko J, Bartek T, Oldiges M, Eikmanns BJ.

Appl Environ Microbiol. 2007 Apr;73(7):2079-84. Epub 2007 Feb 9.

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