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Human ectoenzyme-expressing ILC3: immunosuppressive innate cells that are depleted in graft-versus-host disease.

Hazenberg MD, Haverkate NJE, van Lier YF, Spits H, Krabbendam L, Bemelman WA, Buskens CJ, Blom B, Shikhagaie MM.

Blood Adv. 2019 Nov 26;3(22):3650-3660. doi: 10.1182/bloodadvances.2019000176.


ILCs in hematologic malignancies: Tumor cell killers and tissue healers.

Blom B, van Hoeven V, Hazenberg MD.

Semin Immunol. 2019 Feb;41:101279. doi: 10.1016/j.smim.2019.06.002. Epub 2019 Jun 12. Review.


The Dutch Hip Fracture Audit: evaluation of the quality of multidisciplinary hip fracture care in the Netherlands.

Voeten SC, Arends AJ, Wouters MWJM, Blom BJ, Heetveld MJ, Slee-Valentijn MS, Krijnen P, Schipper IB, Hegeman JHH; Dutch Hip Fracture Audit (DHFA) Group.

Arch Osteoporos. 2019 Mar 1;14(1):28. doi: 10.1007/s11657-019-0576-3.


Mesenchymal Stromal Cells Stimulate the Proliferation and IL-22 Production of Group 3 Innate Lymphoid Cells.

van Hoeven V, Munneke JM, Cornelissen AS, Omar SZ, Spruit MJ, Kleijer M, Bernink JH, Blom B, Voermans C, Hazenberg MD.

J Immunol. 2018 Aug 15;201(4):1165-1173. doi: 10.4049/jimmunol.1700901. Epub 2018 Jul 6.


Is Clinical Assessment of Addiction Severity of Individuals with Substance Use Disorder, Using the Addiction Severity Index, A Predictor of Future Inpatient Mental Health Hospitalization? A Nine-Year Registry Study.

Padyab M, Armelius BÅ, Armelius K, Nyström S, Blom B, Grönlund AS, Lundgren L.

J Dual Diagn. 2018 Jul-Sep;14(3):187-191. doi: 10.1080/15504263.2018.1466086. Epub 2018 May 29.


Human CD5+ Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34+ Progenitor Cells Is Regulated by Id2.

Nagasawa M, Germar K, Blom B, Spits H.

Front Immunol. 2017 Aug 31;8:1047. doi: 10.3389/fimmu.2017.01047. eCollection 2017.


Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates.

Shikhagaie MM, Björklund ÅK, Mjösberg J, Erjefält JS, Cornelissen AS, Ros XR, Bal SM, Koning JJ, Mebius RE, Mori M, Bruchard M, Blom B, Spits H.

Cell Rep. 2017 Feb 14;18(7):1761-1773. doi: 10.1016/j.celrep.2017.01.063.


CD31, a Valuable Marker to Identify Early and Late Stages of T Cell Differentiation in the Human Thymus.

Douaisi M, Resop RS, Nagasawa M, Craft J, Jamieson BD, Blom B, Uittenbogaart CH.

J Immunol. 2017 Mar 15;198(6):2310-2319. doi: 10.4049/jimmunol.1500350. Epub 2017 Feb 3.


Pathogens Use and Abuse MicroRNAs to Deceive the Immune System.

Flór TB, Blom B.

Int J Mol Sci. 2016 Apr 9;17(4):538. doi: 10.3390/ijms17040538. Review.


Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery.

Resop RS, Douaisi M, Craft J, Jachimowski LC, Blom B, Uittenbogaart CH.

J Allergy Clin Immunol. 2016 Aug;138(2):551-557.e8. doi: 10.1016/j.jaci.2015.12.1339. Epub 2016 Apr 4.


From an Isolable Acyclic Phosphinosilylene Adduct to Donor-Stabilized Si=E Compounds (E=O, S, Se).

Hansen K, Szilvási T, Blom B, Irran E, Driess M.

Chemistry. 2015 Dec 21;21(52):18930-3. doi: 10.1002/chem.201504113. Epub 2015 Nov 23.


A Persistent 1,2-Dihydrophosphasilene Adduct.

Hansen K, Szilvási T, Blom B, Driess M.

Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15060-3. doi: 10.1002/anie.201508149. Epub 2015 Oct 20.


Biomimetic [2Fe-2S] clusters with extensively delocalized mixed-valence iron centers.

Yao S, Meier F, Lindenmaier N, Rudolph R, Blom B, Adelhardt M, Sutter J, Mebs S, Haumann M, Meyer K, Kaupp M, Driess M.

Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12506-10. doi: 10.1002/anie.201506788. Epub 2015 Sep 3.


Alkaline-Earth-Metal-Induced Liberation of Rare Allotropes of Elemental Silicon and Germanium from N-Heterocyclic Metallylenes.

Blom B, Said A, Szilvási T, Menezes PW, Tan G, Baumgartner J, Driess M.

Inorg Chem. 2015 Sep 8;54(17):8840-8. doi: 10.1021/acs.inorgchem.5b01643. Epub 2015 Aug 25.


Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.

Bernink JH, Krabbendam L, Germar K, de Jong E, Gronke K, Kofoed-Nielsen M, Munneke JM, Hazenberg MD, Villaudy J, Buskens CJ, Bemelman WA, Diefenbach A, Blom B, Spits H.

Immunity. 2015 Jul 21;43(1):146-60. doi: 10.1016/j.immuni.2015.06.019. Epub 2015 Jul 14.


Open-shell lanthanide(II+) or -(III+) complexes bearing σ-silyl and silylene ligands: synthesis, structure, and bonding analysis.

Zitz R, Arp H, Hlina J, Walewska M, Marschner C, Szilvási T, Blom B, Baumgartner J.

Inorg Chem. 2015 Apr 6;54(7):3306-15. doi: 10.1021/ic502991p. Epub 2015 Mar 10.


Mortality among a national population sentenced to compulsory care for substance use disorders in Sweden: descriptive study.

Hall T, Chassler D, Blom B, Grahn R, Blom-Nilsson M, Sullivan L, Lundgren L.

Eval Program Plann. 2015 Apr;49:153-62. doi: 10.1016/j.evalprogplan.2014.12.013. Epub 2014 Dec 18.


Register data in the evaluation and program planning of addiction treatment programs: using Sweden as an example.

Blom B, Dukes KA, Lundgren L, Sullivan LM.

Eval Program Plann. 2015 Apr;49:185-91. doi: 10.1016/j.evalprogplan.2014.12.017. Epub 2014 Dec 19.


Synthesis of mixed silylene-carbene chelate ligands from N-heterocyclic silylcarbenes mediated by nickel.

Tan G, Enthaler S, Inoue S, Blom B, Driess M.

Angew Chem Int Ed Engl. 2015 Feb 9;54(7):2214-8. doi: 10.1002/anie.201409739. Epub 2014 Dec 30.


Using register data to examine patterns of compulsory addiction treatment care in Sweden: program planning and methodological implications.

Lundgren L, Blom B, Chassler D, Sullivan LM.

Eval Program Plann. 2015 Apr;49:149-52. doi: 10.1016/j.evalprogplan.2014.12.012. Epub 2014 Dec 18. No abstract available.


The plasmacytoid dendritic cell as the Swiss army knife of the immune system: molecular regulation of its multifaceted functions.

Karrich JJ, Jachimowski LC, Uittenbogaart CH, Blom B.

J Immunol. 2014 Dec 15;193(12):5772-8. doi: 10.4049/jimmunol.1401541. Review.


BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells.

Epeldegui M, Blom B, Uittenbogaart CH.

Eur J Immunol. 2015 Mar;45(3):728-37. doi: 10.1002/eji.201444787. Epub 2014 Dec 16.


Unprecedented silicon(II)→calcium complexes with N-heterocyclic silylenes.

Blom B, Klatt G, Gallego D, Tan G, Driess M.

Dalton Trans. 2015 Jan 14;44(2):639-44. doi: 10.1039/c4dt03148b.


An amplified Ylidic "half-parent" iminosilane LSi═NH.

Hansen K, Szilvási T, Blom B, Driess M.

J Am Chem Soc. 2014 Oct 8;136(40):14207-14. doi: 10.1021/ja507785z. Epub 2014 Sep 29.


An elusive hydridoaluminum(I) complex for facile C-H and C-O bond activation of ethers and access to its isolable hydridogallium(I) analogue: syntheses, structures, and theoretical studies.

Tan G, Szilvási T, Inoue S, Blom B, Driess M.

J Am Chem Soc. 2014 Jul 9;136(27):9732-42. doi: 10.1021/ja504448v. Epub 2014 Jun 26.


Elucidating the effect of the nucleophilicity of the silyl group in the reduction of CO2 to CO mediated by silyl-copper(I) complexes.

Tan G, Blom B, Gallego D, Irran E, Driess M.

Chemistry. 2014 Jul 21;20(30):9400-8. doi: 10.1002/chem.201402017. Epub 2014 May 27.


Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.

Munneke JM, Björklund AT, Mjösberg JM, Garming-Legert K, Bernink JH, Blom B, Huisman C, van Oers MH, Spits H, Malmberg KJ, Hazenberg MD.

Blood. 2014 Jul 31;124(5):812-21. doi: 10.1182/blood-2013-11-536888. Epub 2014 May 22.


A donor-stabilized zwitterionic "half-parent" phosphasilene and its unusual reactivity towards small molecules.

Hansen K, Szilvási T, Blom B, Irran E, Driess M.

Chemistry. 2014 Feb 10;20(7):1947-56. doi: 10.1002/chem.201303906. Epub 2014 Jan 16.


Mechanistic studies of CO2 reduction to methanol mediated by an N-heterocyclic germylene hydride.

Tan G, Wang W, Blom B, Driess M.

Dalton Trans. 2014 Apr 28;43(16):6006-11. doi: 10.1039/c3dt53321b.


Bis-N-heterocyclic carbene (NHC) stabilized η6-arene iron(0) complexes: synthesis, structure, reactivity, and catalytic activity.

Blom B, Tan G, Enthaler S, Inoue S, Epping JD, Driess M.

J Am Chem Soc. 2013 Dec 4;135(48):18108-20. doi: 10.1021/ja410234x. Epub 2013 Nov 20.


Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2.

Gentek R, Munneke JM, Helbig C, Blom B, Hazenberg MD, Spits H, Amsen D.

Front Immunol. 2013 Oct 22;4:334. doi: 10.3389/fimmu.2013.00334. eCollection 2013.


Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.

de Jong VM, Abreu JR, Verrijn Stuart AA, van der Slik AR, Verhaeghen K, Engelse MA, Blom B, Staal FJ, Gorus FK, Roep BO.

Diabetologia. 2013 Dec;56(12):2651-8. doi: 10.1007/s00125-013-3034-6. Epub 2013 Sep 13.


MicroRNA-146a regulates survival and maturation of human plasmacytoid dendritic cells.

Karrich JJ, Jachimowski LC, Libouban M, Iyer A, Brandwijk K, Taanman-Kueter EW, Nagasawa M, de Jong EC, Uittenbogaart CH, Blom B.

Blood. 2013 Oct 24;122(17):3001-9. doi: 10.1182/blood-2012-12-475087. Epub 2013 Sep 6.


Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1.

Centlivre M, Legrand N, Klamer S, Liu YP, Jasmijn von Eije K, Bohne M, Rijnstra ES, Weijer K, Blom B, Voermans C, Spits H, Berkhout B.

Mol Ther Nucleic Acids. 2013 Sep 3;2:e120. doi: 10.1038/mtna.2013.48.


A fragile zwitterionic phosphasilene as a transfer agent of the elusive parent phosphinidene (:PH).

Hansen K, Szilvási T, Blom B, Inoue S, Epping J, Driess M.

J Am Chem Soc. 2013 Aug 14;135(32):11795-8. doi: 10.1021/ja4072699. Epub 2013 Aug 1.


From elusive thio- and selenosilanoic acids to copper(I) complexes with intermolecular Si=E → Cu-O-Si coordination modes (E = S, Se).

Tan G, Xiong Y, Inoue S, Enthaler S, Blom B, Epping JD, Driess M.

Chem Commun (Camb). 2013 Jun 21;49(49):5595-7. doi: 10.1039/c3cc41965g.


Electron-rich N-heterocyclic silylene (NHSi)-iron complexes: synthesis, structures, and catalytic ability of an isolable hydridosilylene-iron complex.

Blom B, Enthaler S, Inoue S, Irran E, Driess M.

J Am Chem Soc. 2013 May 1;135(17):6703-13. doi: 10.1021/ja402480v. Epub 2013 Apr 22.


IL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation.

Karrich JJ, Jachimowski LC, Nagasawa M, Kamp A, Balzarolo M, Wolkers MC, Uittenbogaart CH, Marieke van Ham S, Blom B.

Blood. 2013 Apr 18;121(16):3103-11. doi: 10.1182/blood-2012-08-452995. Epub 2013 Feb 13.


New vistas in N-heterocyclic silylene (NHSi) transition-metal coordination chemistry: syntheses, structures and reactivity towards activation of small molecules.

Blom B, Stoelzel M, Driess M.

Chemistry. 2013 Jan 2;19(1):40-62. doi: 10.1002/chem.201203072. Epub 2012 Dec 11.


The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

Mjösberg J, Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, te Velde AA, Fokkens WJ, van Drunen CM, Spits H.

Immunity. 2012 Oct 19;37(4):649-59. doi: 10.1016/j.immuni.2012.08.015. Epub 2012 Oct 11.


Facile access to silicon-functionalized bis-silylene titanium(II) complexes.

Blom B, Driess M, Gallego D, Inoue S.

Chemistry. 2012 Oct 15;18(42):13355-60. doi: 10.1002/chem.201202399. Epub 2012 Sep 10.


The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs.

Balzarolo M, Karrich JJ, Engels S, Blom B, Medema JP, Wolkers MC.

Eur J Immunol. 2012 Nov;42(11):3019-27. doi: 10.1002/eji.201242385. Epub 2012 Sep 12.


A doxycycline-dependent human immunodeficiency virus type 1 replicates in vivo without inducing CD4+ T-cell depletion.

Legrand N, van der Velden GJ, Ho Tsong Fang R, Douaisi M, Weijer K, Das AT, Blom B, Uittenbogaart CH, Berkhout B, Centlivre M.

J Gen Virol. 2012 Sep;93(Pt 9):2017-27. doi: 10.1099/vir.0.042796-0. Epub 2012 May 30.


Total hip arthroplasty versus hemiarthroplasty for displaced femoral neck fractures in the healthy elderly: a meta-analysis and systematic review of randomized trials.

Burgers PT, Van Geene AR, Van den Bekerom MP, Van Lieshout EM, Blom B, Aleem IS, Bhandari M, Poolman RW.

Int Orthop. 2012 Aug;36(8):1549-60. doi: 10.1007/s00264-012-1569-7. Epub 2012 May 24. Review.


The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.

Karrich JJ, Balzarolo M, Schmidlin H, Libouban M, Nagasawa M, Gentek R, Kamihira S, Maeda T, Amsen D, Wolkers MC, Blom B.

Blood. 2012 May 31;119(22):5191-200. doi: 10.1182/blood-2011-07-370239. Epub 2012 Apr 17.


IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells.

Diehl SA, Schmidlin H, Nagasawa M, Blom B, Spits H.

Immunol Cell Biol. 2012 Sep;90(8):802-11. doi: 10.1038/icb.2012.17. Epub 2012 Apr 10.


The transcription factor encyclopedia.

Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW.

Genome Biol. 2012;13(3):R24. doi: 10.1186/gb-2012-13-3-r24.


Psychoeducation for patients with a psychotic disorder: effects on knowledge and coping.

Bossema ER, de Haar CA, Westerhuis W, Beenackers BP, Blom BC, Appels MC, van Oeveren CJ.

Prim Care Companion CNS Disord. 2011;13(4). pii: PCC.10m01116. doi: 10.4088/PCC.10m01116.


IFN-α is constitutively expressed in the human thymus, but not in peripheral lymphoid organs.

Colantonio AD, Epeldegui M, Jesiak M, Jachimowski L, Blom B, Uittenbogaart CH.

PLoS One. 2011;6(8):e24252. doi: 10.1371/journal.pone.0024252. Epub 2011 Aug 31.


Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development.

Schotte R, Dontje W, Nagasawa M, Yasuda Y, Bakker AQ, Spits H, Blom B.

J Immunol. 2010 Jun 15;184(12):6670-9. doi: 10.4049/jimmunol.0901508. Epub 2010 May 10.

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