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Items: 1 to 50 of 257

1.

A cryptic non-GPI-anchored cytosolic isoform of CD59 controls insulin exocytosis in pancreatic β-cells by interaction with SNARE proteins.

Golec E, Rosberg R, Zhang E, Renström E, Blom AM, King BC.

FASEB J. 2019 Aug 14:fj201901007R. doi: 10.1096/fj.201901007R. [Epub ahead of print]

PMID:
31412214
2.

Measuring plasma C4D to monitor immune complexes in lupus nephritis.

Kraaij T, Nilsson SC, van Kooten C, Okrój M, Blom AM, Teng YO.

Lupus Sci Med. 2019 Jun 3;6(1):e000326. doi: 10.1136/lupus-2019-000326. eCollection 2019.

3.

The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.

Ermert D, Laabei M, Weckel A, Mörgelin M, Lundqvist M, Björck L, Ram S, Linse S, Blom AM.

Front Immunol. 2019 Jun 4;10:1230. doi: 10.3389/fimmu.2019.01230. eCollection 2019.

4.

Interaction of Serum-Derived and Internalized C3 With DNA in Human B Cells-A Potential Involvement in Regulation of Gene Transcription.

Kremlitzka M, Nowacka AA, Mohlin FC, Bompada P, De Marinis Y, Blom AM.

Front Immunol. 2019 Mar 19;10:493. doi: 10.3389/fimmu.2019.00493. eCollection 2019.

5.

A Potential Role for α-Amylase in Amyloid-β-Induced Astrocytic Glycogenolysis and Activation.

Byman E, Schultz N; Netherlands Brain Bank, Blom AM, Wennström M.

J Alzheimers Dis. 2019;68(1):205-217. doi: 10.3233/JAD-180997.

PMID:
30775997
6.

---Intracellular cytosolic complement component C3 regulates cytoprotective autophagy in pancreatic beta cells by interaction with ATG16L1.

King BC, Renström E, Blom AM.

Autophagy. 2019 May;15(5):919-921. doi: 10.1080/15548627.2019.1580515. Epub 2019 Feb 20.

PMID:
30741587
7.

Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment.

Singel KL, Emmons TR, Khan ANH, Mayor PC, Shen S, Wong JT, Morrell K, Eng KH, Mark J, Bankert RB, Matsuzaki J, Koya RC, Blom AM, McLeish KR, Qu J, Ram S, Moysich KB, Abrams SI, Odunsi K, Zsiros E, Segal BH.

JCI Insight. 2019 Mar 7;4(5). pii: 122311. doi: 10.1172/jci.insight.122311. eCollection 2019 Mar 7.

8.

Mutations resulting in the formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics.

Felberg A, Urban A, Borowska A, Stasiłojć G, Taszner M, Hellmann A, Blom AM, Okrój M.

Cancer Immunol Immunother. 2019 Apr;68(4):587-598. doi: 10.1007/s00262-019-02304-0. Epub 2019 Feb 6.

9.

C3 glomerulopathy - understanding a rare complement-driven renal disease.

Smith RJH, Appel GB, Blom AM, Cook HT, D'Agati VD, Fakhouri F, Fremeaux-Bacchi V, Józsi M, Kavanagh D, Lambris JD, Noris M, Pickering MC, Remuzzi G, de Córdoba SR, Sethi S, Van der Vlag J, Zipfel PF, Nester CM.

Nat Rev Nephrol. 2019 Mar;15(3):129-143. doi: 10.1038/s41581-018-0107-2. Review.

PMID:
30692664
10.

The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells.

Golec E, Lind L, Qayyum M, Blom AM, King BC.

J Immunol. 2019 Jan 1;202(1):131-141. doi: 10.4049/jimmunol.1701234. Epub 2018 Dec 5.

PMID:
30518569
11.

Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.

Papadakos KS, Bartoschek M, Rodriguez C, Gialeli C, Jin SB, Lendahl U, Pietras K, Blom AM.

Matrix Biol. 2019 Aug;81:107-121. doi: 10.1016/j.matbio.2018.11.007. Epub 2018 Nov 28.

PMID:
30502484
12.

Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation.

King BC, Kulak K, Krus U, Rosberg R, Golec E, Wozniak K, Gomez MF, Zhang E, O'Connell DJ, Renström E, Blom AM.

Cell Metab. 2019 Jan 8;29(1):202-210.e6. doi: 10.1016/j.cmet.2018.09.009. Epub 2018 Oct 4.

PMID:
30293775
13.

Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen Moraxella catarrhalis.

Laabei M, Liu G, Ermert D, Lambris JD, Riesbeck K, Blom AM.

J Immunol. 2018 Nov 1;201(9):2721-2730. doi: 10.4049/jimmunol.1800734. Epub 2018 Sep 28.

PMID:
30266767
14.

Novel potential inhibitors of complement system and their roles in complement regulation and beyond.

Gialeli C, Gungor B, Blom AM.

Mol Immunol. 2018 Oct;102:73-83. doi: 10.1016/j.molimm.2018.05.023. Epub 2018 Jun 7. Review.

PMID:
30217334
15.

Analysis of C3 Gene Variants in Patients With Idiopathic Recurrent Spontaneous Pregnancy Loss.

Mohlin FC, Gros P, Mercier E, Gris JR, Blom AM.

Front Immunol. 2018 Aug 7;9:1813. doi: 10.3389/fimmu.2018.01813. eCollection 2018.

16.

Streptococcal Endo-β-N-Acetylglucosaminidase Suppresses Antibody-Mediated Inflammation In Vivo.

Nandakumar KS, Collin M, Happonen KE, Lundström SL, Croxford AM, Xu B, Zubarev RA, Rowley MJ, Blom AM, Kjellman C, Holmdahl R.

Front Immunol. 2018 Jul 16;9:1623. doi: 10.3389/fimmu.2018.01623. eCollection 2018.

17.

Functional analyses of rare genetic variants in complement component C9 identified in patients with age-related macular degeneration.

Kremlitzka M, Geerlings MJ, de Jong S, Bakker B, Nilsson SC, Fauser S, Hoyng CB, de Jong EK, den Hollander AI, Blom AM.

Hum Mol Genet. 2018 May 14. doi: 10.1093/hmg/ddy178. [Epub ahead of print]

PMID:
29767720
18.

Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.

Michels MAHM, van de Kar NCAJ, Okrój M, Blom AM, van Kraaij SAW, Volokhina EB, van den Heuvel LPWJ.

Front Immunol. 2018 Apr 4;9:612. doi: 10.3389/fimmu.2018.00612. eCollection 2018.

19.

Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion.

Ermert D, Weckel A, Magda M, Mörgelin M, Shaughnessy J, Rice PA, Björck L, Ram S, Blom AM.

J Immunol. 2018 May 15;200(10):3495-3505. doi: 10.4049/jimmunol.1800090. Epub 2018 Apr 6.

20.

Complement C4d-specific antibodies for the diagnosis of lung cancer.

Ajona D, Okrój M, Pajares MJ, Agorreta J, Lozano MD, Zulueta JJ, Verri C, Roz L, Sozzi G, Pastorino U, Massion PP, Montuenga LM, Blom AM, Pio R.

Oncotarget. 2017 Dec 26;9(5):6346-6355. doi: 10.18632/oncotarget.23690. eCollection 2018 Jan 19.

21.

Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis.

Englund E, Canesin G, Papadakos KS, Vishnu N, Persson E, Reitsma B, Anand A, Jacobsson L, Helczynski L, Mulder H, Bjartell A, Blom AM.

Oncotarget. 2017 Sep 21;8(58):98298-98311. doi: 10.18632/oncotarget.21176. eCollection 2017 Nov 17.

22.

Genetic predisposition to infection in a case of atypical hemolytic uremic syndrome.

van den Heuvel L, Riesbeck K, El Tahir O, Gracchi V, Kremlitzka M, Morré SA, van Furth AM, Singh B, Okrój M, van de Kar N, Blom AM, Volokhina E.

J Hum Genet. 2018 Jan;63(1):93-96. doi: 10.1038/s10038-017-0356-0. Epub 2017 Nov 13.

PMID:
29215086
23.

Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus.

Martin M, Smoląg KI, Björk A, Gullstrand B, Okrój M, Leffler J, Jönsen A, Bengtsson AA, Blom AM.

Arthritis Res Ther. 2017 Dec 6;19(1):266. doi: 10.1186/s13075-017-1470-2.

24.

Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes.

Blom AM, Magda M, Kohl L, Shaughnessy J, Lambris JD, Ram S, Ermert D.

J Immunol. 2017 Dec 1;199(11):3828-3839. doi: 10.4049/jimmunol.1700426. Epub 2017 Oct 30.

25.

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

Pang SS, Wijeyewickrema LC, Hor L, Tan S, Lameignere E, Conway EM, Blom AM, Mohlin FC, Liu X, Payne RJ, Whisstock JC, Pike RN.

J Immunol. 2017 Dec 1;199(11):3883-3891. doi: 10.4049/jimmunol.1700158. Epub 2017 Oct 23.

26.

Complement C3 Associates With Incidence of Diabetes, but No Evidence of a Causal Relationship.

Borné Y, Muhammad IF, Lorés-Motta L, Hedblad B, Nilsson PM, Melander O, de Jong EK, Blom AM, den Hollander AI, Engström G.

J Clin Endocrinol Metab. 2017 Dec 1;102(12):4477-4485. doi: 10.1210/jc.2017-00948. Erratum in: J Clin Endocrinol Metab. 2018 Apr 1;103(4):1650.

PMID:
29029276
27.

The complement system as a potential therapeutic target in rheumatic disease.

Trouw LA, Pickering MC, Blom AM.

Nat Rev Rheumatol. 2017 Sep;13(9):538-547. doi: 10.1038/nrrheum.2017.125. Epub 2017 Aug 10. Review.

PMID:
28794515
28.

Activation of Complement by Pigment Epithelium-Derived Factor in Rheumatoid Arthritis.

Vogt LM, Talens S, Kwasniewicz E, Scavenius C, Struglics A, Enghild JJ, Saxne T, Blom AM.

J Immunol. 2017 Aug 1;199(3):1113-1121. doi: 10.4049/jimmunol.1700018. Epub 2017 Jun 21.

29.

The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation.

Kulak K, Westermark GT, Papac-Milicevic N, Renström E, Blom AM, King BC.

Diabetologia. 2017 Aug;60(8):1522-1533. doi: 10.1007/s00125-017-4286-3. Epub 2017 May 12.

30.

The role of complement inhibitors beyond controlling inflammation.

Blom AM.

J Intern Med. 2017 Aug;282(2):116-128. doi: 10.1111/joim.12606. Epub 2017 Mar 26. Review.

31.

Arterial Blood Pressure Induces Transient C4b-Binding Protein in Human Saphenous Vein Grafts.

Kupreishvili K, Meischl C, Vonk ABA, Stooker W, Eijsman L, Blom AM, Quax PHA, van Hinsbergh VWM, Niessen HWM, Krijnen PAJ.

Ann Vasc Surg. 2017 May;41:259-264. doi: 10.1016/j.avsg.2016.10.033. Epub 2017 Feb 3.

PMID:
28163174
32.

PRELP Enhances Host Innate Immunity against the Respiratory Tract Pathogen Moraxella catarrhalis.

Liu G, Ermert D, Johansson ME, Singh B, Su YC, Paulsson M, Riesbeck K, Blom AM.

J Immunol. 2017 Mar 15;198(6):2330-2340. doi: 10.4049/jimmunol.1601319. Epub 2017 Feb 1.

33.

Non-traditional roles of complement in type 2 diabetes: Metabolism, insulin secretion and homeostasis.

King BC, Blom AM.

Mol Immunol. 2017 Apr;84:34-42. doi: 10.1016/j.molimm.2016.12.009. Epub 2016 Dec 21. Review.

PMID:
28012560
34.

The Functional Effect of Rare Variants in Complement Genes on C3b Degradation in Patients With Age-Related Macular Degeneration.

Geerlings MJ, Kremlitzka M, Bakker B, Nilsson SC, Saksens NT, Lechanteur YT, Pauper M, Corominas J, Fauser S, Hoyng CB, Blom AM, de Jong EK, den Hollander AI.

JAMA Ophthalmol. 2017 Jan 1;135(1):39-46. doi: 10.1001/jamaophthalmol.2016.4604.

PMID:
27918759
35.

Analysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis.

Okrój M, Johansson M, Saxne T, Blom AM, Hesselstrand R.

Arthritis Res Ther. 2016 Nov 18;18(1):267.

36.

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.

Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM.

Oncogene. 2016 Oct 27;35(43):5585-5596. doi: 10.1038/onc.2016.98. Epub 2016 Apr 11.

PMID:
27065333
37.

Decreased Neutrophil Extracellular Trap Degradation in Shiga Toxin-Associated Haemolytic Uraemic Syndrome.

Leffler J, Prohászka Z, Mikes B, Sinkovits G, Ciacma K, Farkas P, Réti M, Kelen K, Reusz GS, Szabó AJ, Martin M, Blom AM.

J Innate Immun. 2017;9(1):12-21. doi: 10.1159/000450609. Epub 2016 Oct 27.

38.

Complement in removal of the dead - balancing inflammation.

Martin M, Blom AM.

Immunol Rev. 2016 Nov;274(1):218-232. doi: 10.1111/imr.12462. Review.

PMID:
27782329
39.

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.

Lundbäck P, Lea JD, Sowinska A, Ottosson L, Fürst CM, Steen J, Aulin C, Clarke JI, Kipar A, Klevenvall L, Yang H, Palmblad K, Park BK, Tracey KJ, Blom AM, Andersson U, Antoine DJ, Erlandsson Harris H.

Hepatology. 2016 Nov;64(5):1699-1710. doi: 10.1002/hep.28736. Epub 2016 Sep 1.

40.

Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.

Escudero-Esparza A, Bartoschek M, Gialeli C, Okroj M, Owen S, Jirström K, Orimo A, Jiang WG, Pietras K, Blom AM.

Oncotarget. 2016 Nov 22;7(47):76920-76933. doi: 10.18632/oncotarget.12729.

41.

The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis.

Struglics A, Okroj M, Swärd P, Frobell R, Saxne T, Lohmander LS, Blom AM.

Arthritis Res Ther. 2016 Oct 6;18(1):223.

42.

FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor.

Jusko M, Miedziak B, Ermert D, Magda M, King BC, Bielecka E, Riesbeck K, Eick S, Potempa J, Blom AM.

J Immunol. 2016 Oct 15;197(8):3245-3259. Epub 2016 Sep 16.

43.

Quantitative Mass Spectrometry To Study Inflammatory Cartilage Degradation and Resulting Interactions with the Complement System.

Melin Fürst C, Åhrman E, Bratteby K, Waldemarson S, Malmström J, Blom AM.

J Immunol. 2016 Oct 15;197(8):3415-3424. Epub 2016 Sep 14.

44.

Complimentary action: C1q increases ganglion cell survival in an in vitro model of retinal degeneration.

Taylor L, Arnér K, Blom AM, Ghosh F.

J Neuroimmunol. 2016 Sep 15;298:117-29. doi: 10.1016/j.jneuroim.2016.07.014. Epub 2016 Jul 18.

PMID:
27609284
45.

C4b-binding Protein Protects β-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity.

Sjölander J, Byman E, Kulak K, Nilsson SC, Zhang E, Krus U, Westermark GT, Storm P, King BC, Renström E, Blom AM.

J Biol Chem. 2016 Oct 7;291(41):21644-21655. Epub 2016 Aug 26.

46.

Indications of underdiagnosis of atypical haemolytic uraemic syndrome in a cohort referred to the Coagulation Unit in Malmo, Sweden, for analysis of ADAMTS13 2007-2012.

Åkesson A, Blom AM, Klintman J, Zetterberg E.

Nephrology (Carlton). 2017 Jul;22(7):555-561. doi: 10.1111/nep.12818.

PMID:
27175932
47.

Testing the Activity of Complement Convertases in Serum/Plasma for Diagnosis of C4NeF-Mediated C3 Glomerulonephritis.

Blom AM, Corvillo F, Magda M, Stasiłojć G, Nozal P, Pérez-Valdivia MÁ, Cabello-Chaves V, Rodríguez de Córdoba S, López-Trascasa M, Okrój M.

J Clin Immunol. 2016 Jul;36(5):517-27. doi: 10.1007/s10875-016-0290-5. Epub 2016 May 5.

48.

Moonlighting of Helicobacter pylori catalase protects against complement-mediated killing by utilising the host molecule vitronectin.

Richter C, Mukherjee O, Ermert D, Singh B, Su YC, Agarwal V, Blom AM, Riesbeck K.

Sci Rep. 2016 Apr 18;6:24391. doi: 10.1038/srep24391.

49.

The Complement Inhibitor Factor H Generates an Anti-Inflammatory and Tolerogenic State in Monocyte-Derived Dendritic Cells.

Olivar R, Luque A, Cárdenas-Brito S, Naranjo-Gómez M, Blom AM, Borràs FE, Rodriguez de Córdoba S, Zipfel PF, Aran JM.

J Immunol. 2016 May 15;196(10):4274-90. doi: 10.4049/jimmunol.1500455. Epub 2016 Apr 13.

50.

New perspectives on complement mediated immunotherapy.

Stasiłojć G, Österborg A, Blom AM, Okrój M.

Cancer Treat Rev. 2016 Apr;45:68-75. doi: 10.1016/j.ctrv.2016.02.009. Epub 2016 Mar 8. Review.

PMID:
26994325

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