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Items: 1 to 50 of 55

1.

High LDL levels lessen bone destruction during antigen-induced arthritis by inhibiting osteoclast formation and function.

Ascone G, Di Ceglie I, Walgreen B, Sloetjes AW, Lindhout E, Bot I, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van den Bosch MHJ, van Lent PLEM.

Bone. 2019 Nov 9;130:115140. doi: 10.1016/j.bone.2019.115140. [Epub ahead of print]

PMID:
31712132
2.

The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK.

Di Ceglie I, Blom AB, Davar R, Logie C, Martens JHA, Habibi E, Böttcher LM, Roth J, Vogl T, Goodyear CS, van der Kraan PM, van Lent PL, van den Bosch MH.

FASEB J. 2019 Sep;33(9):10104-10115. doi: 10.1096/fj.201802691RR. Epub 2019 Jun 14.

PMID:
31199668
3.

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology.

van Dalen SCM, Blom AB, Walgreen B, Slöetjes AW, Helsen MMA, Geven EJW, Ter Huurne M, Vogl T, Roth J, van de Loo FAJ, Koenders MI, Casteilla L, van der Kraan PM, van den Bosch MHJ, van Lent PLEM.

Front Immunol. 2019 May 27;10:1075. doi: 10.3389/fimmu.2019.01075. eCollection 2019.

4.

High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.

Ascone G, Di Ceglie I, van den Bosch MHJ, Kruisbergen NNL, Walgreen B, Sloetjes AW, Lindhout E, Joosten LAB, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van Lent PLEM.

Clin Exp Rheumatol. 2019 May 7. [Epub ahead of print]

PMID:
31074720
5.

Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production.

van den Bosch MHJ, Ramos YFM, den Hollander W, Bomer N, Nelissen RGHH, Bovée JVMG, van den Berg WB, van Lent PLEM, Blom AB, van der Kraan PM, Meulenbelt I.

Rheumatology (Oxford). 2019 Jun 1;58(6):1065-1074. doi: 10.1093/rheumatology/key426.

PMID:
30649473
6.

The role of NOX2-derived reactive oxygen species in collagenase-induced osteoarthritis.

van Dalen SCM, Kruisbergen NNL, Walgreen B, Helsen MMA, Slöetjes AW, Cremers NAJ, Koenders MI, van de Loo FAJ, Roth J, Vogl T, Blom AB, van der Kraan PM, van Lent PLEM, van den Bosch MHJ.

Osteoarthritis Cartilage. 2018 Dec;26(12):1722-1732. doi: 10.1016/j.joca.2018.08.014. Epub 2018 Sep 5.

PMID:
30195046
7.

Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis.

Di Ceglie I, Ascone G, Cremers NAJ, Sloetjes AW, Walgreen B, Vogl T, Roth J, Verbeek JS, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van den Bosch MHJ, van Lent PLEM.

Arthritis Res Ther. 2018 May 2;20(1):80. doi: 10.1186/s13075-018-1584-1.

8.

S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis.

Cremers NAJ, van den Bosch MHJ, van Dalen S, Di Ceglie I, Ascone G, van de Loo F, Koenders M, van der Kraan P, Sloetjes A, Vogl T, Roth J, Geven EJW, Blom AB, van Lent PLEM.

Arthritis Res Ther. 2017 Sep 29;19(1):217. doi: 10.1186/s13075-017-1426-6.

9.

WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis.

van den Bosch MH, Blom AB, Kram V, Maeda A, Sikka S, Gabet Y, Kilts TM, van den Berg WB, van Lent PL, van der Kraan PM, Young MF.

Osteoarthritis Cartilage. 2017 Nov;25(11):1900-1911. doi: 10.1016/j.joca.2017.07.012. Epub 2017 Jul 19.

10.

Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis.

van den Bosch MH, Blom AB, van de Loo FA, Koenders MI, Lafeber FP, van den Berg WB, van der Kraan PM, van Lent PL.

Arthritis Rheumatol. 2017 Oct;69(10):1978-1983. doi: 10.1002/art.40206. Epub 2017 Aug 29.

11.

Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis.

van Dalen SC, Blom AB, Slöetjes AW, Helsen MM, Roth J, Vogl T, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, van den Bosch MH, van Lent PL.

Osteoarthritis Cartilage. 2017 Mar;25(3):385-396. doi: 10.1016/j.joca.2016.09.009. Epub 2016 Sep 18.

12.

Synovial macrophages promote TGF-β signaling and protect against influx of S100A8/S100A9-producing cells after intra-articular injections of oxidized low-density lipoproteins.

de Munter W, Geven EJ, Blom AB, Walgreen B, Helsen MM, Joosten LA, Roth J, Vogl T, van de Loo FA, Koenders MI, van den Berg WB, van der Kraan PM, van Lent PL.

Osteoarthritis Cartilage. 2017 Jan;25(1):118-127. doi: 10.1016/j.joca.2016.07.020. Epub 2016 Aug 8.

13.

Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium.

van den Bosch MH, Blom AB, Schelbergen RF, Koenders MI, van de Loo FA, van den Berg WB, Vogl T, Roth J, van der Kraan PM, van Lent PL.

J Rheumatol. 2016 Oct;43(10):1874-1884. Epub 2016 Aug 1.

PMID:
27481901
14.

Disease-Regulated Gene Therapy with Anti-Inflammatory Interleukin-10 Under the Control of the CXCL10 Promoter for the Treatment of Rheumatoid Arthritis.

Broeren MG, de Vries M, Bennink MB, Arntz OJ, Blom AB, Koenders MI, van Lent PL, van der Kraan PM, van den Berg WB, van de Loo FA.

Hum Gene Ther. 2016 Mar;27(3):244-54. doi: 10.1089/hum.2015.127. Epub 2016 Feb 16.

PMID:
26711533
15.

Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis.

van den Bosch MH, Gleissl TA, Blom AB, van den Berg WB, van Lent PL, van der Kraan PM.

Rheumatology (Oxford). 2016 Sep;55(9):1536-47. doi: 10.1093/rheumatology/kev402. Epub 2015 Dec 14. Review.

PMID:
26667213
16.

Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis.

van den Bosch MH, Blom AB, Schelbergen RF, Vogl T, Roth JP, Slöetjes AW, van den Berg WB, van der Kraan PM, van Lent PL.

Arthritis Rheumatol. 2016 Jan;68(1):152-63. doi: 10.1002/art.39420.

17.

Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage.

van den Bosch MH, Blom AB, Sloetjes AW, Koenders MI, van de Loo FA, van den Berg WB, van Lent PL, van der Kraan PM.

Am J Pathol. 2015 Jul;185(7):1970-80. doi: 10.1016/j.ajpath.2015.03.013. Epub 2015 May 12.

PMID:
25976248
18.

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

Schelbergen RF, Geven EJ, van den Bosch MH, Eriksson H, Leanderson T, Vogl T, Roth J, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, Blom AB, van Lent PL.

Ann Rheum Dis. 2015 Dec;74(12):2254-8. doi: 10.1136/annrheumdis-2014-206517. Epub 2015 May 12.

PMID:
25969431
19.

Survey nonresponse among ethnic minorities in a national health survey--a mixed-method study of participation, barriers, and potentials.

Ahlmark N, Algren MH, Holmberg T, Norredam ML, Nielsen SS, Blom AB, Bo A, Juel K.

Ethn Health. 2015;20(6):611-32. doi: 10.1080/13557858.2014.979768. Epub 2014 Nov 20.

PMID:
25411892
20.

Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.

Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, Roth J, van den Berg WB, van der Kraan PM, Blom AB, van Lent PL.

Ann Rheum Dis. 2016 Jan;75(1):218-25. doi: 10.1136/annrheumdis-2014-205480. Epub 2014 Sep 1.

PMID:
25180294
21.

Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis.

Mahler EA, Zweers MC, van Lent PL, Blom AB, van den Hoogen FH, van den Berg WB, Roth J, Vogl T, Bijlsma JW, van den Ende CH, den Broeder AA.

Scand J Rheumatol. 2015;44(1):56-60. doi: 10.3109/03009742.2014.918176. Epub 2014 Sep 2.

PMID:
25179566
22.

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels.

Schelbergen RF, van Dalen S, ter Huurne M, Roth J, Vogl T, Noël D, Jorgensen C, van den Berg WB, van de Loo FA, Blom AB, van Lent PL.

Osteoarthritis Cartilage. 2014 Aug;22(8):1158-66. doi: 10.1016/j.joca.2014.05.022. Epub 2014 Jun 10.

23.

In vivo molecular imaging of cathepsin and matrix metalloproteinase activity discriminates between arthritic and osteoarthritic processes in mice.

Vermeij EA, Koenders MI, Blom AB, Arntz OJ, Bennink MB, van den Berg WB, van Lent PL, van de Loo FA.

Mol Imaging. 2014;13:1-10.

PMID:
24881106
24.

Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor β-responsive genes in osteoarthritis-related fibrosis.

Remst DF, Blom AB, Vitters EL, Bank RA, van den Berg WB, Blaney Davidson EN, van der Kraan PM.

Arthritis Rheumatol. 2014 Mar;66(3):647-56. doi: 10.1002/art.38266.

25.

Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8.

van den Bosch MH, Blom AB, van Lent PL, van Beuningen HM, Blaney Davidson EN, van der Kraan PM, van den Berg WB.

Cell Signal. 2014 May;26(5):951-8. doi: 10.1016/j.cellsig.2014.01.021. Epub 2014 Jan 23.

PMID:
24463008
26.

Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage.

Blaney Davidson EN, Vitters EL, Bennink MB, van Lent PL, van Caam AP, Blom AB, van den Berg WB, van de Loo FA, van der Kraan PM.

Ann Rheum Dis. 2015 Jun;74(6):1257-64. doi: 10.1136/annrheumdis-2013-204528. Epub 2014 Jan 21.

PMID:
24448347
27.

Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis.

de Munter W, Blom AB, Helsen MM, Walgreen B, van der Kraan PM, Joosten LA, van den Berg WB, van Lent PL.

Arthritis Res Ther. 2013 Nov 4;15(6):R178. doi: 10.1186/ar4367.

28.

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression.

Remst DF, Blaney Davidson EN, Vitters EL, Blom AB, Stoop R, Snabel JM, Bank RA, van den Berg WB, van der Kraan PM.

Osteoarthritis Cartilage. 2013 Jan;21(1):157-64. doi: 10.1016/j.joca.2012.10.002. Epub 2012 Oct 13.

29.

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis.

van Lent PL, Blom AB, Schelbergen RF, Slöetjes A, Lafeber FP, Lems WF, Cats H, Vogl T, Roth J, van den Berg WB.

Arthritis Rheum. 2012 May;64(5):1466-76. doi: 10.1002/art.34315.

30.

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4.

Schelbergen RF, Blom AB, van den Bosch MH, Slöetjes A, Abdollahi-Roodsaz S, Schreurs BW, Mort JS, Vogl T, Roth J, van den Berg WB, van Lent PL.

Arthritis Rheum. 2012 May;64(5):1477-87. doi: 10.1002/art.33495.

31.

To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy.

Blom AB, van Lent PL, van der Kraan PM, van den Berg WB.

Curr Drug Targets. 2010 May;11(5):620-9. Review.

PMID:
20199388
32.

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis.

Bondeson J, Blom AB, Wainwright S, Hughes C, Caterson B, van den Berg WB.

Arthritis Rheum. 2010 Mar;62(3):647-57. doi: 10.1002/art.27290. Review. No abstract available.

33.

Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis.

van Lent PL, Hofkens W, Blom AB, Grevers L, Sloetjes A, Takahashi N, van Tits LJ, Vogl T, Roth J, de Winther MP, van den Berg WB.

Arthritis Rheum. 2009 Oct;60(10):2954-65. doi: 10.1002/art.24908.

34.

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.

Blaney Davidson EN, Remst DF, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB, van der Kraan PM.

J Immunol. 2009 Jun 15;182(12):7937-45. doi: 10.4049/jimmunol.0803991. Erratum in: J Immunol. 2010 Aug 15;185(4):2629.

35.

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

Blom AB, Brockbank SM, van Lent PL, van Beuningen HM, Geurts J, Takahashi N, van der Kraan PM, van de Loo FA, Schreurs BW, Clements K, Newham P, van den Berg WB.

Arthritis Rheum. 2009 Feb;60(2):501-12. doi: 10.1002/art.24247.

36.

Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis.

van Lent PL, Grevers LC, Blom AB, Arntz OJ, van de Loo FA, van der Kraan P, Abdollahi-Roodsaz S, Srikrishna G, Freeze H, Sloetjes A, Nacken W, Vogl T, Roth J, van den Berg WB.

Arthritis Rheum. 2008 Dec;58(12):3776-87. doi: 10.1002/art.24074.

37.

Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis.

van Lent PL, Grevers L, Blom AB, Sloetjes A, Mort JS, Vogl T, Nacken W, van den Berg WB, Roth J.

Ann Rheum Dis. 2008 Dec;67(12):1750-8. Epub 2007 Nov 30.

PMID:
18055478
38.

Cytokine targeting in osteoarthritis.

Blom AB, van der Kraan PM, van den Berg WB.

Curr Drug Targets. 2007 Feb;8(2):283-92. Review.

PMID:
17305506
39.

Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3.

Blom AB, van Lent PL, Libregts S, Holthuysen AE, van der Kraan PM, van Rooijen N, van den Berg WB.

Arthritis Rheum. 2007 Jan;56(1):147-57.

40.

Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation.

van Lent PL, Grevers L, Lubberts E, de Vries TJ, Nabbe KC, Verbeek S, Oppers B, Sloetjes A, Blom AB, van den Berg WB.

Arthritis Rheum. 2006 Dec;54(12):3868-77.

42.

NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis.

van Lent PL, Nabbe KC, Blom AB, Sloetjes A, Holthuysen AE, Kolls J, Van De Loo FA, Holland SM, Van Den Berg WB.

Arthritis Res Ther. 2005;7(4):R885-95. Epub 2005 May 20.

43.

Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis.

Radstake TR, Blom AB, Slöetjes AW, van Gorselen EO, Pesman GJ, Engelen L, Torensma R, van den Berg WB, Figdor CG, van Lent PL, Adema GJ, Barrera P.

Ann Rheum Dis. 2004 Dec;63(12):1556-63.

44.

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis.

Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, van den Berg WB.

Osteoarthritis Cartilage. 2004 Aug;12(8):627-35.

45.

High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering.

Radstake TR, van Lent PL, Pesman GJ, Blom AB, Sweep FG, Rönnelid J, Adema GJ, Barrera P, van den Berg WB.

Ann Rheum Dis. 2004 Jun;63(6):696-702.

46.

Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation.

van Lent PL, Blom AB, van der Kraan P, Holthuysen AE, Vitters E, van Rooijen N, Smeets RL, Nabbe KC, van den Berg WB.

Arthritis Rheum. 2004 Jan;50(1):103-11.

48.
49.

Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.

Blom AB, Radstake TR, Holthuysen AE, Slöetjes AW, Pesman GJ, Sweep FG, van de Loo FA, Joosten LA, Barrera P, van Lent PL, van den Berg WB.

Arthritis Rheum. 2003 Apr;48(4):1002-14.

50.

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