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Items: 14


Discovery of a series of 5-AzaQuinazolines as orally efficacious IRAK4 inhibitors targeting MyD88L265P mutant Diffuse Large B Cell Lymphoma.

Degorce SL, Anjum R, Bloecher A, Carbajo RJ, Dillman K, Drew L, Halsall CT, Lenz EM, Lindsay NA, Mayo M, Pink J, Robb GR, Rosen A, Scott JS, Xue Y.

J Med Chem. 2019 Oct 17. doi: 10.1021/acs.jmedchem.9b01346. [Epub ahead of print]


Rapid Identification of Novel Allosteric PRC2 Inhibitors.

Read JA, Tart J, Rawlins PB, Gregson C, Jones K, Gao N, Zhu X, Tomlinson R, Code E, Cheung T, Chen H, Kawatkar SP, Bloecher A, Bagal S, O'Donovan DH, Robinson J.

ACS Chem Biol. 2019 Sep 23. doi: 10.1021/acschembio.9b00468. [Epub ahead of print]


An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies.

O'Neil J, Benita Y, Feldman I, Chenard M, Roberts B, Liu Y, Li J, Kral A, Lejnine S, Loboda A, Arthur W, Cristescu R, Haines BB, Winter C, Zhang T, Bloecher A, Shumway SD.

Mol Cancer Ther. 2016 Jun;15(6):1155-62. doi: 10.1158/1535-7163.MCT-15-0843. Epub 2016 Mar 16.


Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition.

Guertin AD, Martin MM, Roberts B, Hurd M, Qu X, Miselis NR, Liu Y, Li J, Feldman I, Benita Y, Bloecher A, Toniatti C, Shumway SD.

Cancer Cell Int. 2012 Nov 13;12(1):45. doi: 10.1186/1475-2867-12-45.


N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).

Chen X, Chi Y, Bloecher A, Aebersold R, Clurman BE, Roberts JM.

Mol Cell. 2004 Dec 3;16(5):839-47.


Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.

Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM.

Mol Cell. 2003 Aug;12(2):381-92.


A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence.

Kozubowski L, Panek H, Rosenthal A, Bloecher A, DeMarini DJ, Tatchell K.

Mol Biol Cell. 2003 Jan;14(1):26-39.


Essential functions of Sds22p in chromosome stability and nuclear localization of PP1.

Peggie MW, MacKelvie SH, Bloecher A, Knatko EV, Tatchell K, Stark MJ.

J Cell Sci. 2002 Jan 1;115(Pt 1):195-206.


A Gip1p-Glc7p phosphatase complex regulates septin organization and spore wall formation.

Tachikawa H, Bloecher A, Tatchell K, Neiman AM.

J Cell Biol. 2001 Nov 26;155(5):797-808. Epub 2001 Nov 26.


Anaphase spindle position is monitored by the BUB2 checkpoint.

Bloecher A, Venturi GM, Tatchell K.

Nat Cell Biol. 2000 Aug;2(8):556-8. No abstract available.


Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae.

Venturi GM, Bloecher A, Williams-Hart T, Tatchell K.

Genetics. 2000 May;155(1):69-83.


Alanine-scanning mutagenesis of protein phosphatase type 1 in the yeast Saccharomyces cerevisiae.

Baker SH, Frederick DL, Bloecher A, Tatchell K.

Genetics. 1997 Mar;145(3):615-26.

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