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High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.

Razavi P, Li BT, Brown DN, Jung B, Hubbell E, Shen R, Abida W, Juluru K, De Bruijn I, Hou C, Venn O, Lim R, Anand A, Maddala T, Gnerre S, Vijaya Satya R, Liu Q, Shen L, Eattock N, Yue J, Blocker AW, Lee M, Sehnert A, Xu H, Hall MP, Santiago-Zayas A, Novotny WF, Isbell JM, Rusch VW, Plitas G, Heerdt AS, Ladanyi M, Hyman DM, Jones DR, Morrow M, Riely GJ, Scher HI, Rudin CM, Robson ME, Diaz LA Jr, Solit DB, Aravanis AM, Reis-Filho JS.

Nat Med. 2019 Dec;25(12):1928-1937. doi: 10.1038/s41591-019-0652-7. Epub 2019 Nov 25.


Erratum for Wood et al., "Initial Characterization of the Two ClpP Paralogs of Chlamydia trachomatis Suggests Unique Functionality for Each".

Wood NA, Chung KY, Blocker AM, Rodrigues de Almeida N, Conda-Sheridan M, Fisher DJ, Ouellette SP.

J Bacteriol. 2019 Nov 20;201(24). pii: e00613-19. doi: 10.1128/JB.00613-19. Print 2019 Dec 15. No abstract available.


Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium.

Li BT, Janku F, Jung B, Hou C, Madwani K, Alden R, Razavi P, Reis-Filho JS, Shen R, Isbell JM, Blocker AW, Eattock N, Gnerre S, Satya RV, Xu H, Zhao C, Hall MP, Hu Y, Sehnert AJ, Brown D, Ladanyi M, Rudin CM, Hunkapiller N, Feeney N, Mills GB, Paweletz CP, Janne PA, Solit DB, Riely GJ, Aravanis A, Oxnard GR.

Ann Oncol. 2019 Apr 1;30(4):597-603. doi: 10.1093/annonc/mdz046.


Initial Characterization of the Two ClpP Paralogs of Chlamydia trachomatis Suggests Unique Functionality for Each.

Wood NA, Chung KY, Blocker AM, Rodrigues de Almeida N, Conda-Sheridan M, Fisher DJ, Ouellette SP.

J Bacteriol. 2018 Dec 20;201(2). pii: e00635-18. doi: 10.1128/JB.00635-18. Print 2019 Jan 15. Erratum in: J Bacteriol. 2019 Nov 20;201(24):.


The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation.

Bandara M, Skehel JM, Kadioglu A, Collinson I, Nobbs AH, Blocker AJ, Jenkinson HF.

Microbes Infect. 2017 Jul - Aug;19(7-8):402-412. doi: 10.1016/j.micinf.2017.04.003. Epub 2017 Apr 27.


How Do the Virulence Factors of Shigella Work Together to Cause Disease?

Mattock E, Blocker AJ.

Front Cell Infect Microbiol. 2017 Mar 24;7:64. doi: 10.3389/fcimb.2017.00064. eCollection 2017. Review.


Assessment of metal contamination in the biota of four rivers experiencing varying degrees of human impact.

Bielmyer-Fraser GK, Waters MN, Duckworth CG, Patel PP, Webster BC, Blocker A, Crummey CH, Duncan AN, Nwokike SN, Picariello CR, Ragan JT, Schumacher EL, Tucker RL, Tuttle EA, Wiggins CR.

Environ Monit Assess. 2017 Jan;189(1):23. Epub 2016 Dec 16.


Steps for Shigella Gatekeeper Protein MxiC Function in Hierarchical Type III Secretion Regulation.

Roehrich AD, Bordignon E, Mode S, Shen DK, Liu X, Pain M, Murillo I, Martinez-Argudo I, Sessions RB, Blocker AJ.

J Biol Chem. 2017 Feb 3;292(5):1705-1723. doi: 10.1074/jbc.M116.746826. Epub 2016 Dec 14.


A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution.

Zhou X, Blocker AW, Airoldi EM, O'Shea EK.

Elife. 2016 Sep 13;5. pii: e16970. doi: 10.7554/eLife.16970.


The Architecture of the Cytoplasmic Region of Type III Secretion Systems.

Makino F, Shen D, Kajimura N, Kawamoto A, Pissaridou P, Oswin H, Pain M, Murillo I, Namba K, Blocker AJ.

Sci Rep. 2016 Sep 30;6:33341. doi: 10.1038/srep33341.


Composition and Activity of the Non-canonical Gram-positive SecY2 Complex.

Bandara M, Corey RA, Martin R, Skehel JM, Blocker AJ, Jenkinson HF, Collinson I.

J Biol Chem. 2016 Oct 7;291(41):21474-21484. Epub 2016 Aug 22.


Genetic Dissection of the Signaling Cascade that Controls Activation of the Shigella Type III Secretion System from the Needle Tip.

Murillo I, Martinez-Argudo I, Blocker AJ.

Sci Rep. 2016 Jun 9;6:27649. doi: 10.1038/srep27649.


MxiA, MxiC and IpaD Regulate Substrate Selection and Secretion Mode in the T3SS of Shigella flexneri.

Shen DK, Blocker AJ.

PLoS One. 2016 May 12;11(5):e0155141. doi: 10.1371/journal.pone.0155141. eCollection 2016.


Reassessment of MxiH subunit orientation and fold within native Shigella T3SS needles using surface labelling and solid-state NMR.

Verasdonck J, Shen DK, Treadgold A, Arthur C, Böckmann A, Meier BH, Blocker AJ.

J Struct Biol. 2015 Dec;192(3):441-448. doi: 10.1016/j.jsb.2015.10.005. Epub 2015 Oct 6.


ExsB is required for correct assembly of the Pseudomonas aeruginosa type III secretion apparatus in the bacterial membrane and full virulence in vivo.

Perdu C, Huber P, Bouillot S, Blocker A, Elsen S, Attrée I, Faudry E.

Infect Immun. 2015 May;83(5):1789-98. doi: 10.1128/IAI.00048-15. Epub 2015 Feb 17.


Three-dimensional electron microscopy reconstruction and cysteine-mediated crosslinking provide a model of the type III secretion system needle tip complex.

Cheung M, Shen DK, Makino F, Kato T, Roehrich AD, Martinez-Argudo I, Walker ML, Murillo I, Liu X, Pain M, Brown J, Frazer G, Mantell J, Mina P, Todd T, Sessions RB, Namba K, Blocker AJ.

Mol Microbiol. 2015 Jan;95(1):31-50. doi: 10.1111/mmi.12843. Epub 2014 Nov 27.


Ten simple rules for the care and feeding of scientific data.

Goodman A, Pepe A, Blocker AW, Borgman CL, Cranmer K, Crosas M, Di Stefano R, Gil Y, Groth P, Hedstrom M, Hogg DW, Kashyap V, Mahabal A, Siemiginowska A, Slavkovic A.

PLoS Comput Biol. 2014 Apr 24;10(4):e1003542. doi: 10.1371/journal.pcbi.1003542. eCollection 2014 Apr. No abstract available.


Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: a dose-dependent relationship.

Hoskin-Parr L, Teyhan A, Blocker A, Henderson AJ.

Pediatr Allergy Immunol. 2013 Dec;24(8):762-71. doi: 10.1111/pai.12153. Epub 2013 Dec 2.


A method to achieve homogeneous dispersion of large transmembrane complexes within the holes of carbon films for electron cryomicroscopy.

Cheung M, Kajimura N, Makino F, Ashihara M, Miyata T, Kato T, Namba K, Blocker AJ.

J Struct Biol. 2013 Apr;182(1):51-6. doi: 10.1016/j.jsb.2013.01.004. Epub 2013 Jan 26.


Shigella IpaD has a dual role: signal transduction from the type III secretion system needle tip and intracellular secretion regulation.

Roehrich AD, Guillossou E, Blocker AJ, Martinez-Argudo I.

Mol Microbiol. 2013 Feb;87(3):690-706. doi: 10.1111/mmi.12124. Epub 2013 Jan 11.


Isolation of Salmonella mutants resistant to the inhibitory effect of Salicylidene acylhydrazides on flagella-mediated motility.

Martinez-Argudo I, Veenendaal AK, Liu X, Roehrich AD, Ronessen MC, Franzoni G, van Rietschoten KN, Morimoto YV, Saijo-Hamano Y, Avison MB, Studholme DJ, Namba K, Minamino T, Blocker AJ.

PLoS One. 2013;8(1):e52179. doi: 10.1371/journal.pone.0052179. Epub 2013 Jan 2.


Needle length control and the secretion substrate specificity switch are only loosely coupled in the type III secretion apparatus of Shigella.

Shen DK, Moriya N, Martinez-Argudo I, Blocker AJ.

Microbiology. 2012 Jul;158(Pt 7):1884-96. doi: 10.1099/mic.0.059618-0. Epub 2012 May 10.


Structure of a type III secretion needle at 7-Å resolution provides insights into its assembly and signaling mechanisms.

Fujii T, Cheung M, Blanco A, Kato T, Blocker AJ, Namba K.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4461-6. doi: 10.1073/pnas.1116126109. Epub 2012 Mar 2.


Structural and functional studies on the N-terminal domain of the Shigella type III secretion protein MxiG.

McDowell MA, Johnson S, Deane JE, Cheung M, Roehrich AD, Blocker AJ, McDonnell JM, Lea SM.

J Biol Chem. 2011 Sep 2;286(35):30606-14. doi: 10.1074/jbc.M111.243865. Epub 2011 Jul 5.


Deconvolution of mixing time series on a graph.

Blocker AW, Airoldi EM.

Uncertain Artif Intell. 2011;2011:51-60.


The Shigella T3SS needle transmits a signal for MxiC release, which controls secretion of effectors.

Martinez-Argudo I, Blocker AJ.

Mol Microbiol. 2010 Dec;78(6):1365-78. doi: 10.1111/j.1365-2958.2010.07413.x. Epub 2010 Oct 12.


Domains of the Shigella flexneri type III secretion system IpaB protein involved in secretion regulation.

Shen DK, Saurya S, Wagner C, Nishioka H, Blocker AJ.

Infect Immun. 2010 Dec;78(12):4999-5010. doi: 10.1128/IAI.00470-10. Epub 2010 Oct 11.


The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding.

Roehrich AD, Martinez-Argudo I, Johnson S, Blocker AJ, Veenendaal AK.

Infect Immun. 2010 Apr;78(4):1682-91. doi: 10.1128/IAI.00645-09. Epub 2010 Jan 19.


Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout.

Hodgkinson JL, Horsley A, Stabat D, Simon M, Johnson S, da Fonseca PC, Morris EP, Wall JS, Lea SM, Blocker AJ.

Nat Struct Mol Biol. 2009 May;16(5):477-85. doi: 10.1038/nsmb.1599. Epub 2009 Apr 26. Erratum in: Nat Struct Mol Biol. 2009 Aug;16(8):897.


Small-molecule type III secretion system inhibitors block assembly of the Shigella type III secreton.

Veenendaal AK, Sundin C, Blocker AJ.

J Bacteriol. 2009 Jan;191(2):563-70. doi: 10.1128/JB.01004-08. Epub 2008 Nov 7.


Characterization of soluble complexes of the Shigella flexneri type III secretion system ATPase.

Johnson S, Blocker A.

FEMS Microbiol Lett. 2008 Sep;286(2):274-8. doi: 10.1111/j.1574-6968.2008.01284.x. Epub 2008 Jul 23.


What's the point of the type III secretion system needle?

Blocker AJ, Deane JE, Veenendaal AK, Roversi P, Hodgkinson JL, Johnson S, Lea SM.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6507-13. doi: 10.1073/pnas.0708344105. Epub 2008 May 5.


Identification of minor inner-membrane components of the Shigella type III secretion system 'needle complex'.

Zenk SF, Stabat D, Hodgkinson JL, Veenendaal AK, Johnson S, Blocker AJ.

Microbiology. 2007 Aug;153(Pt 8):2405-15.


The type III secretion system needle tip complex mediates host cell sensing and translocon insertion.

Veenendaal AK, Hodgkinson JL, Schwarzer L, Stabat D, Zenk SF, Blocker AJ.

Mol Microbiol. 2007 Mar;63(6):1719-30.


Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.

Johnson S, Roversi P, Espina M, Olive A, Deane JE, Birket S, Field T, Picking WD, Blocker AJ, Galyov EE, Picking WL, Lea SM.

J Biol Chem. 2007 Feb 9;282(6):4035-44. Epub 2006 Oct 31.


Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system.

Johnson S, Roversi P, Espina M, Deane JE, Birket S, Picking WD, Blocker A, Picking WL, Lea SM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):865-8. Epub 2006 Aug 11.


Molecular model of a type III secretion system needle: Implications for host-cell sensing.

Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, Lea SM.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12529-33. Epub 2006 Aug 3.


Expression, purification, crystallization and preliminary crystallographic analysis of MxiH, a subunit of the Shigella flexneri type III secretion system needle.

Deane JE, Cordes FS, Roversi P, Johnson S, Kenjale R, Picking WD, Picking WL, Lea SM, Blocker A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):302-5. Epub 2006 Feb 28.


Helical packing of needles from functionally altered Shigella type III secretion systems.

Cordes FS, Daniell S, Kenjale R, Saurya S, Picking WL, Picking WD, Booy F, Lea SM, Blocker A.

J Mol Biol. 2005 Nov 25;354(2):206-11. Epub 2005 Oct 7.


The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus.

Kenjale R, Wilson J, Zenk SF, Saurya S, Picking WL, Picking WD, Blocker A.

J Biol Chem. 2005 Dec 30;280(52):42929-37. Epub 2005 Oct 14.


IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes.

Picking WL, Nishioka H, Hearn PD, Baxter MA, Harrington AT, Blocker A, Picking WD.

Infect Immun. 2005 Mar;73(3):1432-40.


Type III secretion systems and bacterial flagella: insights into their function from structural similarities.

Blocker A, Komoriya K, Aizawa S.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3027-30. Epub 2003 Mar 11. Review.


Helical structure of the needle of the type III secretion system of Shigella flexneri.

Cordes FS, Komoriya K, Larquet E, Yang S, Egelman EH, Blocker A, Lea SM.

J Biol Chem. 2003 May 9;278(19):17103-7. Epub 2003 Feb 5.


Spa32 regulates a switch in substrate specificity of the type III secreton of Shigella flexneri from needle components to Ipa proteins.

Magdalena J, Hachani A, Chamekh M, Jouihri N, Gounon P, Blocker A, Allaoui A.

J Bacteriol. 2002 Jul;184(13):3433-41.


Myosin Va bound to phagosomes binds to F-actin and delays microtubule-dependent motility.

Al-Haddad A, Shonn MA, Redlich B, Blocker A, Burkhardt JK, Yu H, Hammer JA 3rd, Weiss DG, Steffen W, Griffiths G, Kuznetsov SA.

Mol Biol Cell. 2001 Sep;12(9):2742-55.


Type III secretion systems: what is the translocator and what is translocated?

Blocker A, Holden D, Cornelis G.

Cell Microbiol. 2000 Oct;2(5):387-90. No abstract available.


Bacterial signals and cell responses during Shigella entry into epithelial cells.

Tran Van Nhieu G, Bourdet-Sicard R, Duménil G, Blocker A, Sansonetti PJ.

Cell Microbiol. 2000 Jun;2(3):187-93. Review.


Structure and composition of the Shigella flexneri "needle complex", a part of its type III secreton.

Blocker A, Jouihri N, Larquet E, Gounon P, Ebel F, Parsot C, Sansonetti P, Allaoui A.

Mol Microbiol. 2001 Feb;39(3):652-63.


Type III secretion system in Chlamydia species: identified members and candidates.

Subtil A, Blocker A, Dautry-Varsat A.

Microbes Infect. 2000 Apr;2(4):367-9.


The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes.

Blocker A, Gounon P, Larquet E, Niebuhr K, Cabiaux V, Parsot C, Sansonetti P.

J Cell Biol. 1999 Nov 1;147(3):683-93.

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