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Self-cleavage of the glmS ribozyme core is controlled by a fragile folding element.

Savinov A, Block SM.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):11976-11981. doi: 10.1073/pnas.1812122115. Epub 2018 Nov 5.


KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics.

Milic B, Chakraborty A, Han K, Bassik MC, Block SM.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4613-E4622. doi: 10.1073/pnas.1801242115. Epub 2018 Apr 27.


Restoring Faculty Vitality in Academic Medicine When Burnout Threatens.

Shah DT, Williams VN, Thorndyke LE, Marsh EE, Sonnino RE, Block SM, Viggiano TR.

Acad Med. 2018 Jul;93(7):979-984. doi: 10.1097/ACM.0000000000002013.


Real-time observation of polymerase-promoter contact remodeling during transcription initiation.

Meng CA, Fazal FM, Block SM.

Nat Commun. 2017 Oct 27;8(1):1178. doi: 10.1038/s41467-017-01041-1.


Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.

Milic B, Andreasson JOL, Hogan DW, Block SM.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6830-E6838. doi: 10.1073/pnas.1708157114. Epub 2017 Jul 31.


Observing Single RNA Polymerase Molecules Down to Base-Pair Resolution.

Chakraborty A, Meng CA, Block SM.

Methods Mol Biol. 2017;1486:391-409. doi: 10.1007/978-1-4939-6421-5_15.


Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer.

Duesterberg VK, Fischer-Hwang IT, Perez CF, Hogan DW, Block SM.

Elife. 2015 Dec 28;4. pii: e12362. doi: 10.7554/eLife.12362.


Direct observation of processive exoribonuclease motion using optical tweezers.

Fazal FM, Koslover DJ, Luisi BF, Block SM.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15101-6. doi: 10.1073/pnas.1514028112. Epub 2015 Nov 23.


Real-time observation of the initiation of RNA polymerase II transcription.

Fazal FM, Meng CA, Murakami K, Kornberg RD, Block SM.

Nature. 2015 Sep 10;525(7568):274-7. doi: 10.1038/nature14882. Epub 2015 Sep 2.


RNA BIOCHEMISTRY. Factor-dependent processivity in human eIF4A DEAD-box helicase.

García-García C, Frieda KL, Feoktistova K, Fraser CS, Block SM.

Science. 2015 Jun 26;348(6242):1486-8. doi: 10.1126/science.aaa5089.


Examining kinesin processivity within a general gating framework.

Andreasson JO, Milic B, Chen GY, Guydosh NR, Hancock WO, Block SM.

Elife. 2015 Apr 22;4. doi: 10.7554/eLife.07403.


The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load.

Andreasson JO, Shastry S, Hancock WO, Block SM.

Curr Biol. 2015 May 4;25(9):1166-75. doi: 10.1016/j.cub.2015.03.013. Epub 2015 Apr 9.


Defining "faculty" in academic medicine: responding to the challenges of a changing environment.

Block SM, Sonnino RE, Bellini L.

Acad Med. 2015 Mar;90(3):279-82. doi: 10.1097/ACM.0000000000000575.


A DNA-based molecular probe for optically reporting cellular traction forces.

Blakely BL, Dumelin CE, Trappmann B, McGregor LM, Choi CK, Anthony PC, Duesterberg VK, Baker BM, Block SM, Liu DR, Chen CS.

Nat Methods. 2014 Dec;11(12):1229-32. doi: 10.1038/nmeth.3145. Epub 2014 Oct 12.


Kinesin processivity is gated by phosphate release.

Milic B, Andreasson JO, Hancock WO, Block SM.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14136-40. doi: 10.1073/pnas.1410943111. Epub 2014 Sep 2.


Reconstructing folding energy landscapes by single-molecule force spectroscopy.

Woodside MT, Block SM.

Annu Rev Biophys. 2014;43:19-39. doi: 10.1146/annurev-biophys-051013-022754. Review.


A pause sequence enriched at translation start sites drives transcription dynamics in vivo.

Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS.

Science. 2014 May 30;344(6187):1042-7. doi: 10.1126/science.1251871. Epub 2014 May 1.


Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms.

Schweikhard V, Meng C, Murakami K, Kaplan CD, Kornberg RD, Block SM.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6642-7. doi: 10.1073/pnas.1405181111. Epub 2014 Apr 14.


Single-molecule studies of riboswitch folding.

Savinov A, Perez CF, Block SM.

Biochim Biophys Acta. 2014 Oct;1839(10):1030-1045. doi: 10.1016/j.bbagrm.2014.04.005. Epub 2014 Apr 13. Review.


Direct observation of cotranscriptional folding in an adenine riboswitch.

Frieda KL, Block SM.

Science. 2012 Oct 19;338(6105):397-400. doi: 10.1126/science.1225722.


Single-molecule studies of RNAPII elongation.

Zhou J, Schweikhard V, Block SM.

Biochim Biophys Acta. 2013 Jan;1829(1):29-38. doi: 10.1016/j.bbagrm.2012.08.006. Epub 2012 Sep 6. Review.


Binding and translocation of termination factor rho studied at the single-molecule level.

Koslover DJ, Fazal FM, Mooney RA, Landick R, Block SM.

J Mol Biol. 2012 Nov 9;423(5):664-76. doi: 10.1016/j.jmb.2012.07.027. Epub 2012 Aug 9.


Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II.

Palangat M, Larson MH, Hu X, Gnatt A, Block SM, Landick R.

Transcription. 2012 May-Jun;3(3):146-53. doi: 10.4161/trns.20269.


Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.

Larson MH, Zhou J, Kaplan CD, Palangat M, Kornberg RD, Landick R, Block SM.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6555-60. doi: 10.1073/pnas.1200939109. Epub 2012 Apr 9.


Electrostatics of nucleic acid folding under conformational constraint.

Anthony PC, Sim AY, Chu VB, Doniach S, Block SM, Herschlag D.

J Am Chem Soc. 2012 Mar 14;134(10):4607-14. doi: 10.1021/ja208466h. Epub 2012 Feb 27.


Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer.

Anthony PC, Perez CF, García-García C, Block SM.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1485-9. doi: 10.1073/pnas.1115045109. Epub 2012 Jan 4.


Optical tweezers study life under tension.

Fazal FM, Block SM.

Nat Photonics. 2011 May 31;5:318-321.


Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA.

Zhou J, Ha KS, La Porta A, Landick R, Block SM.

Mol Cell. 2011 Nov 18;44(4):635-46. doi: 10.1016/j.molcel.2011.09.018.


A universal pathway for kinesin stepping.

Clancy BE, Behnke-Parks WM, Andreasson JO, Rosenfeld SS, Block SM.

Nat Struct Mol Biol. 2011 Aug 14;18(9):1020-7. doi: 10.1038/nsmb.2104.


Single-molecule studies of RNA polymerase: one singular sensation, every little step it takes.

Larson MH, Landick R, Block SM.

Mol Cell. 2011 Feb 4;41(3):249-62. doi: 10.1016/j.molcel.2011.01.008. Review.


Antibodies to influenza A virus (H1 and H3) in companion animals in Iowa, USA.

Seiler BM, Yoon KJ, Andreasen CB, Block SM, Marsden S, Blitvich BJ.

Vet Rec. 2010 Oct 30;167(18):705-7. doi: 10.1136/vr.c5120. No abstract available.


An optical apparatus for rotation and trapping.

Gutiérrez-Medina B, Andreasson JO, Greenleaf WJ, Laporta A, Block SM.

Methods Enzymol. 2010;475:377-404. doi: 10.1016/S0076-6879(10)75015-1.


E. coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase.

Herbert KM, Zhou J, Mooney RA, Porta AL, Landick R, Block SM.

J Mol Biol. 2010 May 28;399(1):17-30. doi: 10.1016/j.jmb.2010.03.051. Epub 2010 Apr 8.


UK defence group's structure could limit its usefulness.

Block SM.

Nature. 2009 Dec 17;462(7275):847. doi: 10.1038/462847c. No abstract available.


Direct measurements of kinesin torsional properties reveal flexible domains and occasional stalk reversals during stepping.

Gutiérrez-Medina B, Fehr AN, Block SM.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17007-12. doi: 10.1073/pnas.0907133106. Epub 2009 Sep 23.


Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers.

Valentine MT, Block SM.

Biophys J. 2009 Sep 16;97(6):1671-7. doi: 10.1016/j.bpj.2009.07.013.


On the origin of kinesin limping.

Fehr AN, Gutiérrez-Medina B, Asbury CL, Block SM.

Biophys J. 2009 Sep 16;97(6):1663-70. doi: 10.1016/j.bpj.2009.07.004.


Direct observation of the binding state of the kinesin head to the microtubule.

Guydosh NR, Block SM.

Nature. 2009 Sep 3;461(7260):125-8. doi: 10.1038/nature08259. Epub 2009 Aug 19.


Folding and unfolding single RNA molecules under tension.

Woodside MT, García-García C, Block SM.

Curr Opin Chem Biol. 2008 Dec;12(6):640-6. doi: 10.1016/j.cbpa.2008.08.011. Epub 2008 Sep 9. Review.


Single-molecule studies of RNA polymerase: motoring along.

Herbert KM, Greenleaf WJ, Block SM.

Annu Rev Biochem. 2008;77:149-76. doi: 10.1146/annurev.biochem.77.073106.100741. Review.


Applied force reveals mechanistic and energetic details of transcription termination.

Larson MH, Greenleaf WJ, Landick R, Block SM.

Cell. 2008 Mar 21;132(6):971-82. doi: 10.1016/j.cell.2008.01.027.


Precision steering of an optical trap by electro-optic deflection.

Valentine MT, Guydosh NR, Gutiérrez-Medina B, Fehr AN, Andreasson JO, Block SM.

Opt Lett. 2008 Mar 15;33(6):599-601.


Direct observation of hierarchical folding in single riboswitch aptamers.

Greenleaf WJ, Frieda KL, Foster DA, Woodside MT, Block SM.

Science. 2008 Feb 1;319(5863):630-3. doi: 10.1126/science.1151298. Epub 2008 Jan 3.


Kinesin steps do not alternate in size.

Fehr AN, Asbury CL, Block SM.

Biophys J. 2008 Feb 1;94(3):L20-2. Epub 2007 Dec 14.


Not so lame after all: kinesin still walks with a hobbled head.

Guydosh NR, Block SM.

J Gen Physiol. 2007 Nov;130(5):441-4. No abstract available.


Molecule by molecule, the physics and chemistry of life: SMB 2007.

Block SM, Larson MH, Greenleaf WJ, Herbert KM, Guydosh NR, Anthony PC.

Nat Chem Biol. 2007 Apr;3(4):193-7.


High-resolution, single-molecule measurements of biomolecular motion.

Greenleaf WJ, Woodside MT, Block SM.

Annu Rev Biophys Biomol Struct. 2007;36:171-90. Review.


Kinesin motor mechanics: binding, stepping, tracking, gating, and limping.

Block SM.

Biophys J. 2007 May 1;92(9):2986-95. Epub 2007 Feb 26. Review. No abstract available.


Eg5 steps it up!

Valentine MT, Fordyce PM, Block SM.

Cell Div. 2006 Dec 15;1:31.


Direct measurement of the full, sequence-dependent folding landscape of a nucleic acid.

Woodside MT, Anthony PC, Behnke-Parks WM, Larizadeh K, Herschlag D, Block SM.

Science. 2006 Nov 10;314(5801):1001-4. Erratum in: Science. 2007 Feb 9;315(5813):766.

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