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Items: 1 to 50 of 116

1.

The interdependence of gene-regulatory elements and the 3D genome.

Vermunt MW, Zhang D, Blobel GA.

J Cell Biol. 2018 Nov 15. pii: jcb.201809040. doi: 10.1083/jcb.201809040. [Epub ahead of print] Review.

PMID:
30442643
2.

Charting a noncoding gene for γ-globin activation.

Blobel GA, Crossley M.

Blood. 2018 Nov 1;132(18):1865-1867. doi: 10.1182/blood-2018-09-873620. No abstract available.

PMID:
30385490
3.

Robust erythroid differentiation system for rhesus hematopoietic progenitor cells allowing preclinical screening of genetic treatment strategies for the hemoglobinopathies.

Demirci S, Bhardwaj SK, Uchida N, Haro-Mora JJ, Ryu B, Blobel GA, Tisdale JF.

Cytotherapy. 2018 Oct;20(10):1278-1287. doi: 10.1016/j.jcyt.2018.07.002. Epub 2018 Sep 22.

PMID:
30249524
4.

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.

Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA.

Science. 2018 Jul 20;361(6399):285-290. doi: 10.1126/science.aao0932.

5.

The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.

Wai DCC, Szyszka TN, Campbell AE, Kwong C, Wilkinson-White LE, Silva APG, Low JKK, Kwan AH, Gamsjaeger R, Chalmers JD, Patrick WM, Lu B, Vakoc CR, Blobel GA, Mackay JP.

J Biol Chem. 2018 May 11;293(19):7160-7175. doi: 10.1074/jbc.RA117.000678. Epub 2018 Mar 22.

PMID:
29567837
6.

Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility.

Behera V, Evans P, Face CJ, Hamagami N, Sankaranarayanan L, Keller CA, Giardine B, Tan K, Hardison RC, Shi J, Blobel GA.

Nat Commun. 2018 Feb 22;9(1):782. doi: 10.1038/s41467-018-03082-6.

7.

The Role of Bromodomain and Extraterminal Motif (BET) Proteins in Chromatin Structure.

Hsu SC, Blobel GA.

Cold Spring Harb Symp Quant Biol. 2017;82:37-43. doi: 10.1101/sqb.2017.82.033829. Epub 2017 Dec 1.

PMID:
29196562
8.

A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.

Gallagher MD, Posavi M, Huang P, Unger TL, Berlyand Y, Gruenewald AL, Chesi A, Manduchi E, Wells AD, Grant SFA, Blobel GA, Brown CD, Chen-Plotkin AS.

Am J Hum Genet. 2017 Nov 2;101(5):643-663. doi: 10.1016/j.ajhg.2017.09.004. Epub 2017 Oct 19.

9.

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.

Huang P, Keller CA, Giardine B, Grevet JD, Davies JOJ, Hughes JR, Kurita R, Nakamura Y, Hardison RC, Blobel GA.

Genes Dev. 2017 Aug 15;31(16):1704-1713. doi: 10.1101/gad.303461.117. Epub 2017 Sep 15.

10.

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.

Hsu SC, Gilgenast TG, Bartman CR, Edwards CR, Stonestrom AJ, Huang P, Emerson DJ, Evans P, Werner MT, Keller CA, Giardine B, Hardison RC, Raj A, Phillips-Cremins JE, Blobel GA.

Mol Cell. 2017 Apr 6;66(1):102-116.e7. doi: 10.1016/j.molcel.2017.02.027.

11.

A new bookmark of the mitotic genome in embryonic stem cells.

Hsiung CC, Blobel GA.

Nat Cell Biol. 2016 Oct 27;18(11):1124-1125. doi: 10.1038/ncb3432. Review.

12.

Erythropoiesis provides a BRD's eye view of BET protein function.

Stonestrom AJ, Hsu SC, Werner MT, Blobel GA.

Drug Discov Today Technol. 2016 Mar;19:23-28. doi: 10.1016/j.ddtec.2016.05.004. Epub 2016 Jul 20. Review.

13.

Detecting Long-Range Enhancer-Promoter Interactions by Quantitative Chromosome Conformation Capture.

Deng W, Blobel GA.

Methods Mol Biol. 2017;1468:51-62. doi: 10.1007/978-1-4939-4035-6_6.

PMID:
27662870
14.

The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

Xia Q, Chesi A, Manduchi E, Johnston BT, Lu S, Leonard ME, Parlin UW, Rappaport EF, Huang P, Wells AD, Blobel GA, Johnson ME, Grant SFA.

Diabetologia. 2016 Nov;59(11):2360-2368. doi: 10.1007/s00125-016-4077-2. Epub 2016 Aug 18.

PMID:
27539148
15.

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.

Traxler EA, Yao Y, Wang YD, Woodard KJ, Kurita R, Nakamura Y, Hughes JR, Hardison RC, Blobel GA, Li C, Weiss MJ.

Nat Med. 2016 Sep;22(9):987-90. doi: 10.1038/nm.4170. Epub 2016 Aug 15.

16.

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.

Breda L, Motta I, Lourenco S, Gemmo C, Deng W, Rupon JW, Abdulmalik OY, Manwani D, Blobel GA, Rivella S.

Blood. 2016 Aug 25;128(8):1139-43. doi: 10.1182/blood-2016-01-691089. Epub 2016 Jul 12.

17.

Chromatin architecture underpinning transcription elongation.

Lee K, Blobel GA.

Nucleus. 2016 Jul 3;7(4):1-8. doi: 10.1080/19491034.2016.1200770. Epub 2016 Jul 1. Review.

18.

A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.

Hsiung CC, Bartman CR, Huang P, Ginart P, Stonestrom AJ, Keller CA, Face C, Jahn KS, Evans P, Sankaranarayanan L, Giardine B, Hardison RC, Raj A, Blobel GA.

Genes Dev. 2016 Jun 15;30(12):1423-39. doi: 10.1101/gad.280859.116.

19.

Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.

Bartman CR, Hsu SC, Hsiung CC, Raj A, Blobel GA.

Mol Cell. 2016 Apr 21;62(2):237-247. doi: 10.1016/j.molcel.2016.03.007. Epub 2016 Apr 7.

20.

Unlinking an lncRNA from Its Associated cis Element.

Paralkar VR, Taborda CC, Huang P, Yao Y, Kossenkov AV, Prasad R, Luan J, Davies JO, Hughes JR, Hardison RC, Blobel GA, Weiss MJ.

Mol Cell. 2016 Apr 7;62(1):104-10. doi: 10.1016/j.molcel.2016.02.029. Epub 2016 Mar 31.

21.

A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages.

Edwards CR, Ritchie W, Wong JJ, Schmitz U, Middleton R, An X, Mohandas N, Rasko JE, Blobel GA.

Blood. 2016 Apr 28;127(17):e24-e34. doi: 10.1182/blood-2016-01-692764. Epub 2016 Mar 9.

22.

Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas.

Naraparaju K, Kolla V, Zhuang T, Higashi M, Iyer R, Kolla S, Okawa ER, Blobel GA, Brodeur GM.

Oncotarget. 2016 Mar 29;7(13):15977-85. doi: 10.18632/oncotarget.7434.

23.

Corrigendum: Dynamic enhancer-gene body contacts during transcription elongation.

Lee K, Hsiung CC, Huang P, Raj A, Blobel GA.

Genes Dev. 2015 Oct 15;29(20):2217. No abstract available.

24.

Dynamic enhancer-gene body contacts during transcription elongation.

Lee K, Hsiung CC, Huang P, Raj A, Blobel GA.

Genes Dev. 2015 Oct 1;29(19):1992-7. doi: 10.1101/gad.255265.114. Erratum in: Genes Dev. 2015 Oct 15;29(20):2217.

25.

Perturbing Chromatin Structure to Understand Mechanisms of Gene Expression.

Bartman CR, Blobel GA.

Cold Spring Harb Symp Quant Biol. 2015;80:207-12. doi: 10.1101/sqb.2015.80.027359. Epub 2015 Sep 14. Review.

PMID:
26370411
26.

An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.

Blobel GA, Bodine D, Brand M, Crispino J, de Bruijn MF, Nathan D, Papayannopoulou T, Porcher C, Strouboulis J, Zon L, Higgs DR, Stamatoyannopoulos G, Engel JD.

Exp Hematol. 2015 Oct;43(10):821-37. doi: 10.1016/j.exphem.2015.06.008. Epub 2015 Jul 2. Review.

27.

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.

Dogan N, Wu W, Morrissey CS, Chen KB, Stonestrom A, Long M, Keller CA, Cheng Y, Jain D, Visel A, Pennacchio LA, Weiss MJ, Blobel GA, Hardison RC.

Epigenetics Chromatin. 2015 Apr 23;8:16. doi: 10.1186/s13072-015-0009-5. eCollection 2015.

28.

The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.

Kolla V, Naraparaju K, Zhuang T, Higashi M, Kolla S, Blobel GA, Brodeur GM.

Biochem J. 2015 Jun 1;468(2):345-52. doi: 10.1042/BJ20150030.

29.

Functions of BET proteins in erythroid gene expression.

Stonestrom AJ, Hsu SC, Jahn KS, Huang P, Keller CA, Giardine BM, Kadauke S, Campbell AE, Evans P, Hardison RC, Blobel GA.

Blood. 2015 Apr 30;125(18):2825-34. doi: 10.1182/blood-2014-10-607309. Epub 2015 Feb 18.

30.

Characterization of BRD4 during mammalian postmeiotic sperm development.

Bryant JM, Donahue G, Wang X, Meyer-Ficca M, Luense LJ, Weller AH, Bartolomei MS, Blobel GA, Meyer RG, Garcia BA, Berger SL.

Mol Cell Biol. 2015 Apr;35(8):1433-48. doi: 10.1128/MCB.01328-14. Epub 2015 Feb 17.

31.

Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.

Byrska-Bishop M, VanDorn D, Campbell AE, Betensky M, Arca PR, Yao Y, Gadue P, Costa FF, Nemiroff RL, Blobel GA, French DL, Hardison RC, Weiss MJ, Chou ST.

J Clin Invest. 2015 Mar 2;125(3):993-1005. doi: 10.1172/JCI75714. Epub 2015 Jan 26.

32.

Keeping fetal hemoglobin in the loop.

Grevet JD, Blobel GA.

Cell Cycle. 2014;13(20):3153-4. doi: 10.4161/15384101.2014.969995. No abstract available.

33.

A comparative encyclopedia of DNA elements in the mouse genome.

Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel GA, Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou XQ, Pazin MJ, Feingold EA, Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos JA, Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer MA, Ren B; Mouse ENCODE Consortium.

Nature. 2014 Nov 20;515(7527):355-64. doi: 10.1038/nature13992.

34.

Genome accessibility is widely preserved and locally modulated during mitosis.

Hsiung CC, Morrissey CS, Udugama M, Frank CL, Keller CA, Baek S, Giardine B, Crawford GE, Sung MH, Hardison RC, Blobel GA.

Genome Res. 2015 Feb;25(2):213-25. doi: 10.1101/gr.180646.114. Epub 2014 Nov 4.

35.

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4946-53. doi: 10.1073/pnas.1407079111. Epub 2014 Nov 4.

36.

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis.

Pimkin M, Kossenkov AV, Mishra T, Morrissey CS, Wu W, Keller CA, Blobel GA, Lee D, Beer MA, Hardison RC, Weiss MJ.

Genome Res. 2014 Dec;24(12):1932-44. doi: 10.1101/gr.164178.113. Epub 2014 Oct 15.

37.

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.

Wu W, Morrissey CS, Keller CA, Mishra T, Pimkin M, Blobel GA, Weiss MJ, Hardison RC.

Genome Res. 2014 Dec;24(12):1945-62. doi: 10.1101/gr.164830.113. Epub 2014 Oct 15.

38.

The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.

Clifton MK, Westman BJ, Thong SY, O'Connell MR, Webster MW, Shepherd NE, Quinlan KG, Crossley M, Blobel GA, Mackay JP.

PLoS One. 2014 Aug 27;9(8):e106011. doi: 10.1371/journal.pone.0106011. eCollection 2014.

39.

Reactivation of developmentally silenced globin genes by forced chromatin looping.

Deng W, Rupon JW, Krivega I, Breda L, Motta I, Jahn KS, Reik A, Gregory PD, Rivella S, Dean A, Blobel GA.

Cell. 2014 Aug 14;158(4):849-860. doi: 10.1016/j.cell.2014.05.050.

40.

Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex.

Alqarni SS, Murthy A, Zhang W, Przewloka MR, Silva AP, Watson AA, Lejon S, Pei XY, Smits AH, Kloet SL, Wang H, Shepherd NE, Stokes PH, Blobel GA, Vermeulen M, Glover DM, Mackay JP, Laue ED.

J Biol Chem. 2014 Aug 8;289(32):21844-55. doi: 10.1074/jbc.M114.558940. Epub 2014 Jun 11.

41.

Manipulating nuclear architecture.

Deng W, Blobel GA.

Curr Opin Genet Dev. 2014 Apr;25:1-7. doi: 10.1016/j.gde.2013.10.014. Epub 2013 Dec 12. Review.

42.

Comparative analysis of mitosis-specific antibodies for bulk purification of mitotic populations by fluorescence-activated cell sorting.

Campbell AE, Hsiung CC, Blobel GA.

Biotechniques. 2014 Feb 1;56(2):90-94. doi: 10.2144/000114137. eCollection 2014.

43.

Function of GATA factors in the adult mouse liver.

Zheng R, Rebolledo-Jaramillo B, Zong Y, Wang L, Russo P, Hancock W, Stanger BZ, Hardison RC, Blobel GA.

PLoS One. 2013 Dec 18;8(12):e83723. doi: 10.1371/journal.pone.0083723. eCollection 2013.

44.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, Muhar M, Haslinger C, Yu M, Roeder RG, Wigler MH, Blobel GA, Zuber J, Spector DL, Young RA, Vakoc CR.

Genes Dev. 2013 Dec 15;27(24):2648-62. doi: 10.1101/gad.232710.113. Epub 2013 Nov 27.

45.

Genetics. GWAS to therapy by genome edits?

Hardison RC, Blobel GA.

Science. 2013 Oct 11;342(6155):206-7. doi: 10.1126/science.1245813. No abstract available.

46.

A cluster to remember.

Blobel GA, Hardison RC.

Cell. 2013 Aug 15;154(4):718-20. doi: 10.1016/j.cell.2013.07.041.

47.

Analysis of disease-causing GATA1 mutations in murine gene complementation systems.

Campbell AE, Wilkinson-White L, Mackay JP, Matthews JM, Blobel GA.

Blood. 2013 Jun 27;121(26):5218-27. doi: 10.1182/blood-2013-03-488080. Epub 2013 May 23.

48.

Mitotic bookmarking by transcription factors.

Kadauke S, Blobel GA.

Epigenetics Chromatin. 2013 Apr 2;6(1):6. doi: 10.1186/1756-8935-6-6.

49.

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription.

Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shiekhattar R.

Nature. 2013 Feb 28;494(7438):497-501. doi: 10.1038/nature11884. Epub 2013 Feb 17.

50.

"Remembering" tissue-specific transcription patterns through mitosis.

Kadauke S, Blobel GA.

Cell Cycle. 2012 Nov 1;11(21):3911-2. doi: 10.4161/cc.22237. Epub 2012 Oct 3. No abstract available.

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