Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 494

1.

The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells.

Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA.

Blood Adv. 2019 May 28;3(10):1586-1597. doi: 10.1182/bloodadvances.2019032318.

2.

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription.

Behera V, Stonestrom AJ, Hamagami N, Hsiung CC, Keller CA, Giardine B, Sidoli S, Yuan ZF, Bhanu NV, Werner MT, Wang H, Garcia BA, Hardison RC, Blobel GA.

Cell Rep. 2019 Apr 9;27(2):400-415.e5. doi: 10.1016/j.celrep.2019.03.057.

3.

Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation.

Bartman CR, Hamagami N, Keller CA, Giardine B, Hardison RC, Blobel GA, Raj A.

Mol Cell. 2019 Feb 7;73(3):519-532.e4. doi: 10.1016/j.molcel.2018.11.004. Epub 2018 Dec 13.

PMID:
30554946
4.

The interdependence of gene-regulatory elements and the 3D genome.

Vermunt MW, Zhang D, Blobel GA.

J Cell Biol. 2019 Jan 7;218(1):12-26. doi: 10.1083/jcb.201809040. Epub 2018 Nov 15. Review.

5.

Charting a noncoding gene for γ-globin activation.

Blobel GA, Crossley M.

Blood. 2018 Nov 1;132(18):1865-1867. doi: 10.1182/blood-2018-09-873620. No abstract available.

PMID:
30385490
6.

Robust erythroid differentiation system for rhesus hematopoietic progenitor cells allowing preclinical screening of genetic treatment strategies for the hemoglobinopathies.

Demirci S, Bhardwaj SK, Uchida N, Haro-Mora JJ, Ryu B, Blobel GA, Tisdale JF.

Cytotherapy. 2018 Oct;20(10):1278-1287. doi: 10.1016/j.jcyt.2018.07.002. Epub 2018 Sep 22.

PMID:
30249524
7.

Electron microscopy of Chaetomium pom152 shows the assembly of ten-bead string.

Hao Q, Zhang B, Yuan K, Shi H, Blobel G.

Cell Discov. 2018 Sep 18;4:56. doi: 10.1038/s41421-018-0057-7. eCollection 2018. No abstract available.

8.

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.

Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA.

Science. 2018 Jul 20;361(6399):285-290. doi: 10.1126/science.aao0932.

9.

The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.

Wai DCC, Szyszka TN, Campbell AE, Kwong C, Wilkinson-White LE, Silva APG, Low JKK, Kwan AH, Gamsjaeger R, Chalmers JD, Patrick WM, Lu B, Vakoc CR, Blobel GA, Mackay JP.

J Biol Chem. 2018 May 11;293(19):7160-7175. doi: 10.1074/jbc.RA117.000678. Epub 2018 Mar 22.

10.

Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility.

Behera V, Evans P, Face CJ, Hamagami N, Sankaranarayanan L, Keller CA, Giardine B, Tan K, Hardison RC, Shi J, Blobel GA.

Nat Commun. 2018 Feb 22;9(1):782. doi: 10.1038/s41467-018-03082-6.

11.

The Role of Bromodomain and Extraterminal Motif (BET) Proteins in Chromatin Structure.

Hsu SC, Blobel GA.

Cold Spring Harb Symp Quant Biol. 2017;82:37-43. doi: 10.1101/sqb.2017.82.033829. Epub 2017 Dec 1.

PMID:
29196562
12.

A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.

Gallagher MD, Posavi M, Huang P, Unger TL, Berlyand Y, Gruenewald AL, Chesi A, Manduchi E, Wells AD, Grant SFA, Blobel GA, Brown CD, Chen-Plotkin AS.

Am J Hum Genet. 2017 Nov 2;101(5):643-663. doi: 10.1016/j.ajhg.2017.09.004. Epub 2017 Oct 19.

13.

Human TRPML1 channel structures in open and closed conformations.

Schmiege P, Fine M, Blobel G, Li X.

Nature. 2017 Oct 19;550(7676):366-370. doi: 10.1038/nature24036. Epub 2017 Oct 11.

14.

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.

Huang P, Keller CA, Giardine B, Grevet JD, Davies JOJ, Hughes JR, Kurita R, Nakamura Y, Hardison RC, Blobel GA.

Genes Dev. 2017 Aug 15;31(16):1704-1713. doi: 10.1101/gad.303461.117. Epub 2017 Sep 15.

15.

3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.

Li X, Lu F, Trinh MN, Schmiege P, Seemann J, Wang J, Blobel G.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9116-9121. doi: 10.1073/pnas.1711716114. Epub 2017 Aug 7.

16.

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.

Hsu SC, Gilgenast TG, Bartman CR, Edwards CR, Stonestrom AJ, Huang P, Emerson DJ, Evans P, Werner MT, Keller CA, Giardine B, Hardison RC, Raj A, Phillips-Cremins JE, Blobel GA.

Mol Cell. 2017 Apr 6;66(1):102-116.e7. doi: 10.1016/j.molcel.2017.02.027.

17.

Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1.

Ren Y, Schmiege P, Blobel G.

Elife. 2017 Jan 6;6. pii: e20070. doi: 10.7554/eLife.20070.

18.

A new bookmark of the mitotic genome in embryonic stem cells.

Hsiung CC, Blobel GA.

Nat Cell Biol. 2016 Oct 27;18(11):1124-1125. doi: 10.1038/ncb3432. Review.

19.

Erythropoiesis provides a BRD's eye view of BET protein function.

Stonestrom AJ, Hsu SC, Werner MT, Blobel GA.

Drug Discov Today Technol. 2016 Mar;19:23-28. doi: 10.1016/j.ddtec.2016.05.004. Epub 2016 Jul 20. Review.

20.

Detecting Long-Range Enhancer-Promoter Interactions by Quantitative Chromosome Conformation Capture.

Deng W, Blobel GA.

Methods Mol Biol. 2017;1468:51-62. doi: 10.1007/978-1-4939-4035-6_6.

PMID:
27662870
21.

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.

Li X, Saha P, Li J, Blobel G, Pfeffer SR.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10079-84. doi: 10.1073/pnas.1611956113. Epub 2016 Aug 22.

22.

The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

Xia Q, Chesi A, Manduchi E, Johnston BT, Lu S, Leonard ME, Parlin UW, Rappaport EF, Huang P, Wells AD, Blobel GA, Johnson ME, Grant SFA.

Diabetologia. 2016 Nov;59(11):2360-2368. doi: 10.1007/s00125-016-4077-2. Epub 2016 Aug 18.

PMID:
27539148
23.

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.

Traxler EA, Yao Y, Wang YD, Woodard KJ, Kurita R, Nakamura Y, Hughes JR, Hardison RC, Blobel GA, Li C, Weiss MJ.

Nat Med. 2016 Sep;22(9):987-90. doi: 10.1038/nm.4170. Epub 2016 Aug 15.

24.

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.

Breda L, Motta I, Lourenco S, Gemmo C, Deng W, Rupon JW, Abdulmalik OY, Manwani D, Blobel GA, Rivella S.

Blood. 2016 Aug 25;128(8):1139-43. doi: 10.1182/blood-2016-01-691089. Epub 2016 Jul 12.

25.

Chromatin architecture underpinning transcription elongation.

Lee K, Blobel GA.

Nucleus. 2016 Jul 3;7(4):1-8. doi: 10.1080/19491034.2016.1200770. Epub 2016 Jul 1. Review.

26.

A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.

Hsiung CC, Bartman CR, Huang P, Ginart P, Stonestrom AJ, Keller CA, Face C, Jahn KS, Evans P, Sankaranarayanan L, Giardine B, Hardison RC, Raj A, Blobel GA.

Genes Dev. 2016 Jun 15;30(12):1423-39. doi: 10.1101/gad.280859.116.

27.

Structure of human Niemann-Pick C1 protein.

Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8212-7. doi: 10.1073/pnas.1607795113. Epub 2016 Jun 15.

28.

Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.

Bartman CR, Hsu SC, Hsiung CC, Raj A, Blobel GA.

Mol Cell. 2016 Apr 21;62(2):237-247. doi: 10.1016/j.molcel.2016.03.007. Epub 2016 Apr 7.

29.

Unlinking an lncRNA from Its Associated cis Element.

Paralkar VR, Taborda CC, Huang P, Yao Y, Kossenkov AV, Prasad R, Luan J, Davies JO, Hughes JR, Hardison RC, Blobel GA, Weiss MJ.

Mol Cell. 2016 Apr 7;62(1):104-10. doi: 10.1016/j.molcel.2016.02.029. Epub 2016 Mar 31.

30.

A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages.

Edwards CR, Ritchie W, Wong JJ, Schmitz U, Middleton R, An X, Mohandas N, Rasko JE, Blobel GA.

Blood. 2016 Apr 28;127(17):e24-e34. doi: 10.1182/blood-2016-01-692764. Epub 2016 Mar 9.

31.

Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas.

Naraparaju K, Kolla V, Zhuang T, Higashi M, Iyer R, Kolla S, Okawa ER, Blobel GA, Brodeur GM.

Oncotarget. 2016 Mar 29;7(13):15977-85. doi: 10.18632/oncotarget.7434.

32.

A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase.

Debler EW, Jain K, Warmack RA, Feng Y, Clarke SG, Blobel G, Stavropoulos P.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2068-73. doi: 10.1073/pnas.1525783113. Epub 2016 Feb 8.

33.

Corrigendum: Dynamic enhancer-gene body contacts during transcription elongation.

Lee K, Hsiung CC, Huang P, Raj A, Blobel GA.

Genes Dev. 2015 Oct 15;29(20):2217. No abstract available.

34.

Dynamic enhancer-gene body contacts during transcription elongation.

Lee K, Hsiung CC, Huang P, Raj A, Blobel GA.

Genes Dev. 2015 Oct 1;29(19):1992-7. doi: 10.1101/gad.255265.114. Erratum in: Genes Dev. 2015 Oct 15;29(20):2217.

35.

Perturbing Chromatin Structure to Understand Mechanisms of Gene Expression.

Bartman CR, Blobel GA.

Cold Spring Harb Symp Quant Biol. 2015;80:207-12. doi: 10.1101/sqb.2015.80.027359. Epub 2015 Sep 14. Review.

PMID:
26370411
36.

An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.

Blobel GA, Bodine D, Brand M, Crispino J, de Bruijn MF, Nathan D, Papayannopoulou T, Porcher C, Strouboulis J, Zon L, Higgs DR, Stamatoyannopoulos G, Engel JD.

Exp Hematol. 2015 Oct;43(10):821-37. doi: 10.1016/j.exphem.2015.06.008. Epub 2015 Jul 2. Review.

37.

Allosteric Regulation in Gating the Central Channel of the Nuclear Pore Complex.

Koh J, Blobel G.

Cell. 2015 Jun 4;161(6):1361-73. doi: 10.1016/j.cell.2015.05.013.

38.

Ordered Regions of Channel Nucleoporins Nup62, Nup54, and Nup58 Form Dynamic Complexes in Solution.

Sharma A, Solmaz SR, Blobel G, Melčák I.

J Biol Chem. 2015 Jul 24;290(30):18370-8. doi: 10.1074/jbc.M115.663500. Epub 2015 May 29.

39.

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.

Dogan N, Wu W, Morrissey CS, Chen KB, Stonestrom A, Long M, Keller CA, Cheng Y, Jain D, Visel A, Pennacchio LA, Weiss MJ, Blobel GA, Hardison RC.

Epigenetics Chromatin. 2015 Apr 23;8:16. doi: 10.1186/s13072-015-0009-5. eCollection 2015.

40.

The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.

Kolla V, Naraparaju K, Zhuang T, Higashi M, Kolla S, Blobel GA, Brodeur GM.

Biochem J. 2015 Jun 1;468(2):345-52. doi: 10.1042/BJ20150030.

41.

Functions of BET proteins in erythroid gene expression.

Stonestrom AJ, Hsu SC, Jahn KS, Huang P, Keller CA, Giardine BM, Kadauke S, Campbell AE, Evans P, Hardison RC, Blobel GA.

Blood. 2015 Apr 30;125(18):2825-34. doi: 10.1182/blood-2014-10-607309. Epub 2015 Feb 18.

42.

Characterization of BRD4 during mammalian postmeiotic sperm development.

Bryant JM, Donahue G, Wang X, Meyer-Ficca M, Luense LJ, Weller AH, Bartolomei MS, Blobel GA, Meyer RG, Garcia BA, Berger SL.

Mol Cell Biol. 2015 Apr;35(8):1433-48. doi: 10.1128/MCB.01328-14. Epub 2015 Feb 17.

43.

Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.

Byrska-Bishop M, VanDorn D, Campbell AE, Betensky M, Arca PR, Yao Y, Gadue P, Costa FF, Nemiroff RL, Blobel GA, French DL, Hardison RC, Weiss MJ, Chou ST.

J Clin Invest. 2015 Mar 2;125(3):993-1005. doi: 10.1172/JCI75714. Epub 2015 Jan 26.

44.

Hooking She3p onto She2p for myosin-mediated cytoplasmic mRNA transport.

Singh N, Blobel G, Shi H.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):142-7. doi: 10.1073/pnas.1423194112. Epub 2014 Dec 22.

45.

Keeping fetal hemoglobin in the loop.

Grevet JD, Blobel GA.

Cell Cycle. 2014;13(20):3153-4. doi: 10.4161/15384101.2014.969995. No abstract available.

46.

A comparative encyclopedia of DNA elements in the mouse genome.

Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel GA, Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou XQ, Pazin MJ, Feingold EA, Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos JA, Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer MA, Ren B; Mouse ENCODE Consortium.

Nature. 2014 Nov 20;515(7527):355-64. doi: 10.1038/nature13992.

47.

Genome accessibility is widely preserved and locally modulated during mitosis.

Hsiung CC, Morrissey CS, Udugama M, Frank CL, Keller CA, Baek S, Giardine B, Crawford GE, Sung MH, Hardison RC, Blobel GA.

Genome Res. 2015 Feb;25(2):213-25. doi: 10.1101/gr.180646.114. Epub 2014 Nov 4.

48.

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4946-53. doi: 10.1073/pnas.1407079111. Epub 2014 Nov 4.

49.

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis.

Pimkin M, Kossenkov AV, Mishra T, Morrissey CS, Wu W, Keller CA, Blobel GA, Lee D, Beer MA, Hardison RC, Weiss MJ.

Genome Res. 2014 Dec;24(12):1932-44. doi: 10.1101/gr.164178.113. Epub 2014 Oct 15.

50.

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.

Wu W, Morrissey CS, Keller CA, Mishra T, Pimkin M, Blobel GA, Weiss MJ, Hardison RC.

Genome Res. 2014 Dec;24(12):1945-62. doi: 10.1101/gr.164830.113. Epub 2014 Oct 15.

Supplemental Content

Loading ...
Support Center