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ADAM10 controls the differentiation of the coronary arterial endothelium.

Farber G, Parks MM, Lustgarten Guahmich N, Zhang Y, Monette S, Blanchard SC, Di Lorenzo A, Blobel CP.

Angiogenesis. 2019 May;22(2):237-250. doi: 10.1007/s10456-018-9653-2. Epub 2018 Nov 16.


A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity.

Shipman WD, Chyou S, Ramanathan A, Izmirly PM, Sharma S, Pannellini T, Dasoveanu DC, Qing X, Magro CM, Granstein RD, Lowes MA, Pamer EG, Kaplan DH, Salmon JE, Mehrara BJ, Young JW, Clancy RM, Blobel CP, Lu TT.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaap9527. doi: 10.1126/scitranslmed.aap9527.


Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds.

Alabi RO, Farber G, Blobel CP.

Physiol Rev. 2018 Oct 1;98(4):2025-2061. doi: 10.1152/physrev.00029.2017. Review.


Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.

Haxaire C, Hakobyan N, Pannellini T, Carballo C, McIlwain D, Mak TW, Rodeo S, Acharya S, Li D, Szymonifka J, Song X, Monette S, Srivastava A, Salmon JE, Blobel CP.

Blood. 2018 Sep 6;132(10):1064-1074. doi: 10.1182/blood-2017-12-820571. Epub 2018 May 18.


The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.

Brummer T, Pigoni M, Rossello A, Wang H, Noy PJ, Tomlinson MG, Blobel CP, Lichtenthaler SF.

FASEB J. 2018 Jul;32(7):3560-3573. doi: 10.1096/fj.201700823RR. Epub 2018 Feb 7.


Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling.

Farber G, Hurtado R, Loh S, Monette S, Mtui J, Kopan R, Quaggin S, Meyer-Schwesinger C, Herzlinger D, Scott RP, Blobel CP.

Angiogenesis. 2018 May;21(2):335-347. doi: 10.1007/s10456-018-9599-4. Epub 2018 Feb 3.


iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.

Qing X, Chinenov Y, Redecha P, Madaio M, Roelofs JJ, Farber G, Issuree PD, Donlin L, Mcllwain DR, Mak TW, Blobel CP, Salmon JE.

J Clin Invest. 2018 Apr 2;128(4):1397-1412. doi: 10.1172/JCI97650. Epub 2018 Mar 5.


Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme.

Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME.

J Biol Chem. 2018 Feb 23;293(8):2725-2734. doi: 10.1074/jbc.RA117.000793. Epub 2018 Jan 9.


The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.

Urriola-Muñoz P, Li X, Maretzky T, McIlwain DR, Mak TW, Reyes JG, Blobel CP, Moreno RD.

J Cell Physiol. 2018 Mar;233(3):2247-2256. doi: 10.1002/jcp.26097. Epub 2017 Aug 25.


Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays.

Maretzky T, Swendeman S, Mogollon E, Weskamp G, Sahin U, Reiss K, Blobel CP.

Biochem J. 2017 Apr 13;474(9):1467-1479. doi: 10.1042/BCJ20170075.


Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.

Li X, Maretzky T, Perez-Aguilar JM, Monette S, Weskamp G, Le Gall S, Beutler B, Weinstein H, Blobel CP.

J Cell Sci. 2017 Mar 1;130(5):868-878. doi: 10.1242/jcs.196436. Epub 2017 Jan 19.


iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice.

Qing X, Rogers L, Mortha A, Lavin Y, Redecha P, Issuree PD, Maretzky T, Merad M, McIlwain D, Mak TW, Overall CM, Blobel CP, Salmon JE.

Eur J Immunol. 2016 Dec;46(12):2737-2748. doi: 10.1002/eji.201646482. Epub 2016 Sep 28.


ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds.

Alabi RO, Glomski K, Haxaire C, Weskamp G, Monette S, Blobel CP.

Circ Res. 2016 Aug 5;119(4):519-31. doi: 10.1161/CIRCRESAHA.115.307738. Epub 2016 Jun 27.


Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA.

Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356.


Blood-induced arthropathy in hemophilia: mechanisms and heterogeneity.

Blobel CP, Haxaire C, Kalliolias GD, DiCarlo E, Salmon J, Srivastava A.

Semin Thromb Hemost. 2015 Nov;41(8):832-7. doi: 10.1055/s-0035-1564445. Epub 2015 Oct 9. Review.


iRhoms in the brain - a new frontier?

Lichtenthaler SF, O'Hara BF, Blobel CP.

Cell Cycle. 2015;14(19):3003-4. doi: 10.1080/15384101.2015.1084187. No abstract available.


Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.

Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB.

Arthritis Res Ther. 2015 May 15;17:126. doi: 10.1186/s13075-015-0647-9.


iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.

Li X, Maretzky T, Weskamp G, Monette S, Qing X, Issuree PD, Crawford HC, McIlwain DR, Mak TW, Salmon JE, Blobel CP.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6080-5. doi: 10.1073/pnas.1505649112. Epub 2015 Apr 27.


The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.

Wong E, Maretzky T, Peleg Y, Blobel CP, Sagi I.

J Biol Chem. 2015 May 8;290(19):12135-46. doi: 10.1074/jbc.M114.624072. Epub 2015 Mar 20.


The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.

Maretzky T, Evers A, Le Gall S, Alabi RO, Speck N, Reiss K, Blobel CP.

J Biol Chem. 2015 Mar 20;290(12):7416-25. doi: 10.1074/jbc.M114.603753. Epub 2015 Jan 20.


Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15.

Maretzky T, Blobel CP, Guaiquil V.

Invest Ophthalmol Vis Sci. 2014 Sep 23;55(10):6774-82. doi: 10.1167/iovs.14-14472.


Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction.

Zhao R, Wang A, Hall KC, Otero M, Weskamp G, Zhao B, Hill D, Goldring MB, Glomski K, Blobel CP.

J Orthop Res. 2014 Feb;32(2):224-30. doi: 10.1002/jor.22492. Epub 2013 Sep 21.


A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease.

Guaiquil VH, Hewing NJ, Chiang MF, Rosenblatt MI, Chan RV, Blobel CP.

Invest Ophthalmol Vis Sci. 2013 Aug 7;54(8):5294-302. doi: 10.1167/iovs.12-11492.


iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.

Maretzky T, McIlwain DR, Issuree PD, Li X, Malapeira J, Amin S, Lang PA, Mak TW, Blobel CP.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11433-8. doi: 10.1073/pnas.1302553110. Epub 2013 Jun 25.


ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.

Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP.

Mol Cell Biol. 2013 Aug;33(16):3077-90. doi: 10.1128/MCB.00291-13. Epub 2013 Jun 3.


Epidermal ADAM17 is dispensable for notch activation.

Groot AJ, Cobzaru C, Weber S, Saftig P, Blobel CP, Kopan R, Vooijs M, Franzke CW.

J Invest Dermatol. 2013 Sep;133(9):2286-8. doi: 10.1038/jid.2013.162. Epub 2013 Apr 3. No abstract available.


iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.

Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP.

J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25.


Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.

Hewing NJ, Weskamp G, Vermaat J, Farage E, Glomski K, Swendeman S, Chan RV, Chiang MF, Khokha R, Anand-Apte B, Blobel CP.

Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):864-70. doi: 10.1167/iovs.12-10954.


Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.

Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, Hu X.

Nat Immunol. 2012 May 20;13(7):642-50. doi: 10.1038/ni.2304.


Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.

Franzke CW, Cobzaru C, Triantafyllopoulou A, Löffek S, Horiuchi K, Threadgill DW, Kurz T, van Rooijen N, Bruckner-Tuderman L, Blobel CP.

J Exp Med. 2012 Jun 4;209(6):1105-19. doi: 10.1084/jem.20112258. Epub 2012 May 7. Erratum in: J Exp Med. 2012 Dec 17;209(13):2517.


Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735.

Hall KC, Blobel CP.

PLoS One. 2012;7(2):e31600. doi: 10.1371/journal.pone.0031600. Epub 2012 Feb 27.


iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW.

Science. 2012 Jan 13;335(6065):229-32. doi: 10.1126/science.1214448.


Lack of ADAM15 in mice is associated with increased osteoblast function and bone mass.

Marzia M, Guaiquil V, Horne WC, Blobel CP, Baron R, Chiusaroli R.

Biol Chem. 2011 Oct;392(10):877-85. doi: 10.1515/BC.2011.080. Epub 2011 Jul 30.


TACE (ADAM17) inhibits Schwann cell myelination.

La Marca R, Cerri F, Horiuchi K, Bachi A, Feltri ML, Wrabetz L, Blobel CP, Quattrini A, Salzer JL, Taveggia C.

Nat Neurosci. 2011 Jun 12;14(7):857-65. doi: 10.1038/nn.2849.


Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.

Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP.

Blood. 2011 Jul 28;118(4):1163-74. doi: 10.1182/blood-2011-04-348557. Epub 2011 Jun 7.


Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.

Maretzky T, Evers A, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP.

Nat Commun. 2011;2:229. doi: 10.1038/ncomms1232.


The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.

Weber S, Niessen MT, Prox J, Lüllmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P.

Development. 2011 Feb;138(3):495-505. doi: 10.1242/dev.055210.


TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells.

Shiomi T, Tschumperlin DJ, Park JA, Sunnarborg SW, Horiuchi K, Blobel CP, Drazen JM.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):376-85. doi: 10.1165/rcmb.2010-0234OC. Epub 2010 Nov 19.


MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.

Brandl K, Sun L, Neppl C, Siggs OM, Le Gall SM, Tomisato W, Li X, Du X, Maennel DN, Blobel CP, Beutler B.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19967-72. doi: 10.1073/pnas.1014669107. Epub 2010 Nov 1.


ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.

Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP.

J Cell Sci. 2010 Nov 15;123(Pt 22):3913-22. doi: 10.1242/jcs.069997. Epub 2010 Oct 27.


A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.

Maretzky T, Zhou W, Huang XY, Blobel CP.

Oncogene. 2011 Feb 3;30(5):611-8. doi: 10.1038/onc.2010.443. Epub 2010 Sep 27.


Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice.

Murthy A, Defamie V, Smookler DS, Di Grappa MA, Horiuchi K, Federici M, Sibilia M, Blobel CP, Khokha R.

J Clin Invest. 2010 Aug;120(8):2731-44. doi: 10.1172/JCI42686. Epub 2010 Jul 12.


3D trumps 2D when studying endothelial cells.

Blobel CP.

Blood. 2010 Jun 24;115(25):5128-30. doi: 10.1182/blood-2010-03-275271. No abstract available.


The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.

Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, Saftig P.

J Neurosci. 2010 Apr 7;30(14):4833-44. doi: 10.1523/JNEUROSCI.5221-09.2010.


The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17.

Hassemer EL, Le Gall SM, Liegel R, McNally M, Chang B, Zeiss CJ, Dubielzig RD, Horiuchi K, Kimura T, Okada Y, Blobel CP, Sidjanin DJ.

Genetics. 2010 May;185(1):245-55. doi: 10.1534/genetics.109.113167. Epub 2010 Mar 1.


ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice.

Guaiquil VH, Swendeman S, Zhou W, Guaiquil P, Weskamp G, Bartsch JW, Blobel CP.

J Mol Med (Berl). 2010 May;88(5):497-505. doi: 10.1007/s00109-010-0591-8. Epub 2010 Jan 30.


Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes.

Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, Blobel CP.

Circ Res. 2010 Mar 19;106(5):932-40. doi: 10.1161/CIRCRESAHA.109.207415. Epub 2010 Jan 28.


Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9.

Franzke CW, Bruckner-Tuderman L, Blobel CP.

J Biol Chem. 2009 Aug 28;284(35):23386-96. doi: 10.1074/jbc.M109.034090. Epub 2009 Jul 1.

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